1 y after the Fontan operation appears to have
been well tolerated in 13 to 14 gravidas.
2 CA4P
was well tolerated in 14 of 16 patients at 52 or 68 mg/m
3 Evinacumab
was well-tolerated in 2 Phase 1 studies.
4 AZA and 6-MP
were well tolerated in 82% of patients; of these, predni
5 t in vivo antimyeloma activity at doses that
are well tolerated in a murine model, confirming our in
6 d in vivo antimyeloma activity at doses that
are well tolerated in a murine model.
7 Rhythm disturbances that may
be well tolerated in a normal heart often cause hemodyna
8 our results suggest that VX-765, a drug that
was well tolerated in a 6 wk-long phase II trial in pati
9 azine, a novel molecule that reduces chorea,
was well tolerated in a double-blind, placebo-controlled
10 humanised form of this antibody (ozanezumab)
was well tolerated in a first-in-human trial.
11 Accelerated conformal radiotherapy
was well tolerated in a high-risk population with clinic
12 d cognitive dysfunction in schizophrenia and
was well tolerated in a phase II clinical proof of conce
13 9-Methylation of 12, but not 19,
was well-tolerated in A(3) AR binding.
14 combination of IL-36beta with TT/Alum, which
was well tolerated in AD mice, proved toxic and even let
15 Treatment with BOS
was well tolerated in adolescent and young adult patient
16 dipasvir-sofosbuvir currently used in adults
was well tolerated in adolescents and had an appropriate
17 demonstrate that a conditional KO of Anp32b
is well tolerated in adult animals.
18 to standard therapy causes rapid benefit and
is well tolerated in adults with acute asthma.
19 adual PBA release by pancreatic lipases, and
is well tolerated in adults with cirrhosis, suggesting t
20 PCV20
was well tolerated in adults 60 to 64 years of age, with
21 the selection of an alternative NMBA, which
was well tolerated in all 6 cases.
22 Carbon marking
was well tolerated in all cases.
23 BMS-790052
was well tolerated in all dose groups, with adverse even
24 (188)Re-P2045
was well tolerated in all dose groups, with no adverse c
25 THAL-PRED
was well tolerated in all enrolled patients, with 20 pat
26 Although TIV
was well tolerated in all groups, reactogenicity in chil
27 The vaccine
was well tolerated in all macaques, and all seroconverte
28 oxaliplatin to the maximum dose of 130 mg/m2
was well tolerated in all patient groups with a CrCL > o
29 Despite an increased RAL exposure, RAL
was well tolerated in all patients and no patient had to
30 ved 174 +/- 28 MBq of the radiotracer, which
was well tolerated in all patients over a follow-up peri
31 UDCA
was well tolerated in all patients.
32 sion of gene-modified autologous CD4 T cells
was well tolerated in all patients.
33 Testosterone
was well tolerated in all patients.
34 uthpieces relative to placebo, and treatment
was well tolerated in all study groups.
35 (11)C-CURB
was well tolerated in all subjects, with no radiotracer-
36 The injection of (18)F-D4-FCH
was well tolerated in all subjects, with no radiotracer-
37 Injection of (18)F-ICMT-11
was well tolerated in all subjects, with no serious trac
38 drug-related adverse events, and the tracer
was well tolerated in all subjects.
39 Ventricular arrhythmias
were well tolerated in all patients except in cases of e
40 alpha-Gal A infusions
were well tolerated in all patients.
41 ate cancer cell detachment in vitro, that it
is well tolerated in an older cohort of men with prostat
42 FTase inhibitors have
been well tolerated in animal studies and do not produce
43 L-786,392
was well tolerated in animal safety studies and had sign
44 enetic or pharmacological means was found to
be well tolerated in animals in our studies and to resul
45 RhBGN
is well tolerated in animals dosed for as long as 3 mont
46 PTC124
was well tolerated in animals at plasma exposures substa
47 Intravenous terbutaline
was well tolerated in asthmatic children for < or =305 c
48 his study demonstrates that (67)Cu-CuSarTATE
is well tolerated in BALB/c nude mice and highly efficac
49 Available data show DLX
is well tolerated in both intravenous and oral formulati
50 DSR
was well tolerated in both animals and human subjects an
51 Treatment
was well tolerated in both arms.
52 PA101
was well tolerated in both cohorts.
53 Treatment
was well tolerated in both groups.
54 rFVIIIFc
was well tolerated in both species.
55 Stretches of 4'-thio-RNA
were well tolerated in both the antisense and sense stra
56 uryl]-m ethyl)-sulfanyl]ethyl]urea) (CAP-1),
is well tolerated in cell cultures, enabling in vivo ant
57 , and (c) additional negative sulfate groups
are well tolerated in certain cases, such as on C-6 of t
58 All
are well tolerated in children and can increase peak cou
59 Vbl and Mtx
are well tolerated in children with desmoid-type fibroma
60 Furthermore, the vaccine appears to
be well tolerated in children with a diagnosis of asthma
61 Cefixime administered with oral irinotecan
is well tolerated in children and allows greater dose es
62 We found that our paradigm
is well tolerated in children as young as 6 years, that
63 Prophylactic HDM oral immunotherapy
is well tolerated in children at high heredity risk.
64 Oral tipifarnib
is well tolerated in children receiving the drug twice d
65 Lapatinib
is well tolerated in children with recurrent CNS maligna
66 Continuous, orally administered everolimus
is well tolerated in children with recurrent or refracto
67 Depsipeptide
is well tolerated in children with recurrent or refracto
68 Bortezomib
is well tolerated in children with recurrent or refracto
69 Weekly intravenous temsirolimus
is well tolerated in children with recurrent solid tumor
70 Cixutumumab
is well tolerated in children with refractory solid tumo
71 usion Vinblastine administered once per week
is well tolerated in children with treatment naive PLGG.
72 Pazopanib
is well tolerated in children, with evidence of antiangi
73 notecan given with 12 days of oral gefitinib
is well tolerated in children.
74 Oral gefitinib
is well tolerated in children.
75 This protracted schedule
is well tolerated in children.
76 ATO
is well-tolerated in children at the recommended dose of
77 MK-0752
is well-tolerated in children with recurrent CNS maligna
78 Pemetrexed
is well-tolerated in children with refractory solid tumo
79 Moxifloxacin
was well tolerated in children treated for MDR tuberculo
80 Empagliflozin
was well tolerated in CKD patients.
81 Given that ampakines
are well tolerated in clinical trials and were effective
82 Conclusion Abexinostat
is well tolerated in combination with pazopanib, allowin
83 RAD001 at 5 or 10 mg/d
was well tolerated in combination with octreotide LAR, w
84 Erlotinib
was well tolerated in combination with WBRT, with a favo
85 Full doses of each agent
were well tolerated in combination, although in this pre
86 BRAF mutation at the doses of two drugs that
were well tolerated in combination.
87 Subcutaneous administration of r-metHuSCF
was well tolerated in conjunction with a multi-agent pre
88 s concluded that regarding safety, rofecoxib
is "well tolerated." In contrast, in April 2001, the com
89 vancomycin/aztreonam combination therapy and
was well tolerated in each Phase III study, as well as i
90 d SVR12 in a high proportion of patients and
was well tolerated in Egyptian patients with HCV genotyp
91 Remarkably, PHP.eB-iMecp2 administration
was well tolerated in female Mecp2 mutant or in wild-typ
92 atinum doublets had activity and appeared to
be well-tolerated in first-line ES-SCLC.
93 day with peginterferon alfa-2a and ribavirin
was well tolerated in HCV genotype 1-infected previous n
94 d homologous Ad26,MVA Ebola vaccine regimens
are well tolerated in healthy adults, regardless of inte
95 Inhalation of hyperpolarized (129)Xe
is well tolerated in healthy subjects and in those with
96 of CFs in amounts up to 2000 mg/d for 12 wk
was well tolerated in healthy men and women.
97 Glembatumumab vedotin
is well tolerated in heavily pretreated patients with br
98 ry heavy chain of immunoglobulin M (micros),
is well-tolerated in HeLa cells.
99 virulence in vivo The fusion also proved to
be well tolerated in herpes simplex virus.
100 HIVIG
is well-tolerated in HIV-infected pregnant women and the
101 p-defective strain, was recently reported to
be well tolerated in human volunteers, suggesting a role
102 Our results suggest that LPD/pAAVaspa
is well tolerated in human subjects and is associated wi
103 First-generation nanotherapies
are well tolerated in humans and evidence shows that the
104 ical trials have indicated that GPx mimetics
are well tolerated in humans, this study may have import
105 It is expected to
be well tolerated in humans and is available for clinica
106 hieved with peak blood levels of TQ known to
be well tolerated in humans, a clinical trial in patient
107 losures from clinical trials confirm that it
is well tolerated in humans and elevates cGMP in cerebra
108 YF17D
is well tolerated in humans and vaccination induces robu
109 Since PK11195
is well tolerated in humans as a single agent, its furth
110 nation with a proteosome-based adjuvant that
is well tolerated in humans plus glatiramer acetate, an
111 FK506 crosses the blood brain barrier,
is well tolerated in humans, and is active in neurons an
112 ials have indicated that the M40403 molecule
is well tolerated in humans, this study may have importa
113 Clopidogrel
is well tolerated in infants and young children at this
114 Although rA2cp248/404/1030 Delta SH
was well tolerated in infants, only 44% of infants who r
115 In this study, we observed that IDA
was well tolerated in LF-endemic populations.
116 Oral and inhaled RBV appear to
be well tolerated in LTRs, and our data support the use
117 PFT inhibitors (PFTIs)
are well tolerated in man, but are highly cytotoxic to P
118 inistration of phenylbutyrate, at doses that
are well tolerated in man, exerts significant neuroprote
119 results demonstrate that SSPN overexpression
is well tolerated in mdx mice and improves sarcolemma de
120 explain why prolonged hypercapnia appears to
be well tolerated in mechanically ventilated patients.
121 Moreover, CDDO-Im and TRAIL
are well tolerated in mice and the combination of CDDO-I
122 dies indicate that these candidate compounds
are well tolerated in mice without any significant side
123 it proliferation of mammalian cell lines and
are well tolerated in mice.
124 rties of the analogue and established that 3
is well tolerated in mice, displays substantial PK impro
125 tumor endothelial cells and tumor cells, and
is well tolerated in mice.
126 le genetic knockout (KO) of LRRK2 expression
is well-tolerated in mice and rats, a unique age-depende
127 proteasome or growth of mammalian cells, and
is well-tolerated in mice.
128 Hyperpolarized, double-labeled aspirin
was well tolerated in mice and could be observed by both
129 In vivo, DMF10.167.4 antibody
was well tolerated in mice and did not detectably bind t
130 Cambinol
was well tolerated in mice and inhibited growth of Burki
131 EGF-SubA
was well tolerated in mice and led to a significant tumo
132 frontrunner compound (5h) from these studies
was well tolerated in mice.
133 8 displayed excellent brain penetration and
was well-tolerated in mice.
134 s in lymphoma xenografted mice at doses that
were well tolerated in mice, rats, and monkeys.
135 Thus, PG
is well tolerated in most tissues, but the eventual accu
136 Treatment
was well tolerated in most however serious AEs can occur
137 Although the drug
was well tolerated in most patients, a previously unreco
138 Treatment
was well tolerated in most patients, though 10 withdrew
139 Mavacamten, a novel myosin inhibitor,
was well tolerated in most subjects with symptomatic nHC
140 soluble, has favorable pharmacokinetics, and
is well tolerated in murine systems.
141 LMB-2
was well tolerated in nine patients at the maximum-toler
142 f allogeneic, bone marrow-derived human MSCs
was well tolerated in nine patients with moderate to sev
143 Although OGG1 depletion
is well tolerated in non-transformed cells, we report he
144 In contrast, type II
is well-tolerated in normal monkeys and shows both acute
145 p38 MAPK inhibition with oral losmapimod
was well tolerated in NSTEMI patients and might improve
146 Initial clinical studies showed it to
be well-tolerated in older patients with relapsed/refrac
147 Herpes zoster vaccine
is well tolerated in older, immunocompetent adults.
148 ed in patients younger than 70, and 200 mg/d
was well tolerated in older patients.
149 TPE appears to be a promising treatment that
was well tolerated in our elderly patients.
150 ISA
was well tolerated in our ill patient population.
151 DNA methyltransferase inhibitors
are well tolerated in outpatient settings, with azacitid
152 Such aneuploidy
is well tolerated in papillae, as it does not significan
153 IB092, at doses of up to 2100 mg, appears to
be well tolerated in participants with progressive supra
154 Riociguat
was well tolerated in PATENT-2.
155 plications, but also minimize bleeding risk,
are well tolerated in patients with organ dysfunction, a
156 In particular, these contrast media
are well tolerated in patients with renal insufficiency
157 splatin (ITP) was previously demonstrated to
be well tolerated in patients with advanced transitional
158 dministration of Ad(GV)VEGF121.10 appears to
be well tolerated in patients with clinically significan
159 gh in this study oral alendronate appears to
be well tolerated in patients with PBC, larger studies a
160 olymerized bovine hemoglobin and has already
been well tolerated in patients undergoing cardiopulmona
161 several reverse transcriptase inhibitors has
been well tolerated in patients with AIDS-related malign
162 The formulation
is well tolerated in patients over the age of 1 year for
163 Short-term treatment with rhIL-11
is well tolerated in patients with active Crohn's diseas
164 sured by objective response rate and PFS and
is well tolerated in patients with advanced pancreatic N
165 We conclude that GSNO
is well tolerated in patients with CF and improves oxyge
166 UDCA
is well tolerated in patients with CHF.
167 ive beta- and alpha-blockade with carvedilol
is well tolerated in patients with COPD who do not have
168 Ensartinib has activity and
is well tolerated in patients with crizotinib-refractory
169 We conclude that ATRA
is well tolerated in patients with emphysema, and trials
170 without an abbreviated course of prednisone
is well tolerated in patients with myelofibrosis and act
171 reduces eosinophilic airway inflammation and
is well tolerated in patients with persistent moderate-t
172 TEC has significant antitumor activity and
is well tolerated in patients with progressive androgen-
173 CONCLUSION:Vorinostat monotherapy
is well tolerated in patients with recurrent GBM and has
174 In summary, daratumumab
is well tolerated in patients with relapsed AL amyloidos
175 CytoFab
is well tolerated in patients with severe sepsis, effect
176 r HbA1c reduction than does glimepiride, and
is well tolerated in patients with type 2 diabetes recei
177 or report we demonstrated that this approach
is well tolerated in patients with underlying immunodefi
178 ant and concomitant EV with high-dose 3D-CRT
is well tolerated in patients with unfavorable-risk pros
179 INTERPRETATION: Eltrombopag
is well-tolerated in patients with lower-risk myelodyspl
180 y of life and C-reactive protein levels, and
was well tolerated in patients with active Crohn's disea
181 Sorafenib plus dacarbazine
was well tolerated in patients with advanced melanoma an
182 Single-agent R115777
was well tolerated in patients with advanced NSCLC, but
183 Alectinib showed clinical activity and
was well tolerated in patients with ALK-positive NSCLC w
184 Idelalisib treatment
was well tolerated in patients with allergic rhinitis an
185 Although postprocedural AR>/=grade 2
was well tolerated in patients with AR>/=grade 2 at base
186 d overall survival compared with placebo and
was well tolerated in patients with castration-resistant
187 , or ineligible and intolerant patients, and
was well tolerated in patients with HCV genotype 1b infe
188 data reported in registrational studies, and
was well tolerated in patients with HCV genotype 5 or 6
189 tions compared with placebo or ezetimibe and
was well tolerated in patients with hypercholesterolemia
190 Intravenous glyburide
was well tolerated in patients with large hemispheric st
191 PTX
was well tolerated in patients with NASH.
192 Dacetuzumab monotherapy
was well tolerated in patients with NHL in doses up to 8
193 The integrated treatment
was well tolerated in patients with predominantly prior
194 ons, inhibited radiographic progression, and
was well tolerated in patients with PsA.
195 Long-term treatment with tadalafil
was well tolerated in patients with pulmonary arterial h
196 nd point of the study was not met, riociguat
was well tolerated in patients with pulmonary hypertensi
197 The combination of ibrutinib plus venetoclax
was well tolerated in patients with relapsed or refracto
198 Subcutaneous administration of DARA-MD
was well tolerated in patients with relapsed or refracto
199 Thalidomide at a dose of 400 mg/d
was well tolerated in patients younger than 70, and 200
200 BAT product
was well tolerated in patients.
201 G-CSF therapy
was well-tolerated in patients with active RA, and was n
202 Repeated subconjunctival sirolimus
was well-tolerated in patients with GA, although no posi
203 used in combination with standard treatments
was well-tolerated in patients with WG.
204 Both doses of atorvastatin
were well tolerated in patients with CKD.
205 Conclusion Perindopril and bisoprolol
were well tolerated in patients with HER2-positive early
206 Sixteen-week sildenafil monotherapy
is well tolerated in pediatric pulmonary arterial hypert
207 uzumab, a potent lymphocyte-depleting agent,
is well tolerated in pediatric renal transplantation.
208 Conclusion ATO consolidation cycles
were well tolerated in pediatric patients with APL and a
209 6n-2 was found to
be well-tolerated in phase 1 clinical studies and repres
210 stimulates angiogenesis in animal models and
was well tolerated in Phase I clinical trials.
211 as effectively converted recent-onset AF and
was well tolerated in placebo-controlled studies.
212 late-dependent reaction, i.e. that 5-CHO-THF
is well tolerated in plants.
213 This chemoradiotherapy regimen
is well tolerated in poor-risk patients and yields a med
214 search suggests that a higher PCO2 level may
be well tolerated in premature infants.
215 Whether anti-VEGF treatment
is well tolerated in preterm infants, however, has to be
216 Importantly, drug conjugates of 3A5
were well tolerated in primates at levels in excess of t
217 r of two large recombinant Hip1 polypeptides
was well tolerated in Ptch1+/- mice, induced B and T cel
218 that a 50muL suprachoroidal injection of TA
was well tolerated in rabbit eyes and demonstrated excel
219 ADx-001
was well tolerated in rats and monkeys and exhibited the
220 Toxicity studies showed that cKK-E12
was well tolerated in rats at a dose of 1 mg/kg (over 10
221 VKA
were well tolerated in real-life, and the influences of
222 Temsirolimus
is well tolerated in recurrent GBM patients.
223 The combination of erlotinib and bevacizumab
is well tolerated in recurrent or metastatic squamous-ce
224 ZD1839 has single-agent activity and
is well tolerated in refractory SCCHN.
225 ibition/angiotensin-receptor blocker therapy
is well tolerated in renal allograft recipients with chr
226 ed as an oil-in-water emulsion, was found to
be well-tolerated in rodents (mice, hamsters, rats) foll
227 ith a >100 mg/kg concentration of this agent
is well tolerated in rodents, without any hematotoxicity
228 Compound 13a
was well tolerated in rodents (in mice, LD50 = 2326 mg/k
229 Spiroindane 42
was well tolerated in rodents in vivo, demonstrated effi
230 Toxicologic analysis showed that rBD1
was well tolerated in rodents with LD50 values of 40 mg/
231 tric embolization is feasible and appears to
be well tolerated in severely obese patients.
232 Conclusion Bariatric embolization
is well tolerated in severely obese adults, inducing app
233 lizumab or sequentially after olaparib might
be well tolerated in single patients.
234 l ischemia at plasma concentrations known to
be well tolerated in stroke patients.
235 nsive suppression of ventricular growth that
was well tolerated in terms of both clinical outcome and
236 f hypercapnia and associated severe acidosis
are well tolerated in the absence of contraindications (
237 ring and following treatment, these regimens
are well tolerated in the AYA population.
238 Thus, 2'-F-modified nucleotides
are well tolerated in the guide (antisense) and passenge
239 g aroyl units including heterocyclic systems
are well tolerated in the present domino reaction protoc
240 Although the replacements
are well tolerated in the wild type, the mutations sever
241 cebo-controlled study, inhaled NO appears to
be well tolerated in the population of ARDS patients stu
242 The WIT appears to
be well tolerated in the rabbit eye, with no evidence of
243 acid (RNA) which showed the modification to
be well tolerated in the sequence contexts examined.
244 LAIV appears to
be well tolerated in the vast majority of children with
245 e that the lifetime absence of ADAR1-editing
is well tolerated in the absence of MDA5.
246 Endoscopist-directed propofol sedation
is well tolerated in the appropriately selected patient.
247 hich is a major risk for acute liver injury,
is well tolerated in the context of chronic DDC-mediated
248 er found that loss of either component alone
is well tolerated in the developing brain, in contrast t
249 mouse transthyretin (TTR) indicated that GNA
is well tolerated in the seed region of both strands in
250 Bevacizumab with modified FOLFOX6
is well tolerated in the surgical adjuvant setting in th
251 We maintain that aneuploidy
is well tolerated in the wild strains of S. cerevisiae t
252 osteric substitution of sulfur for 4'-oxygen
was well tolerated in the catalytic site of HIV-1 revers
253 The WIT
was well tolerated in the eye and no overt signs of toxi
254 Ranpirnase
was well tolerated in the majority of patients, and ther
255 External-beam radiation therapy
was well tolerated in the posttransplantation setting in
256 All of the monomers
were well tolerated in the DNA duplexes and induced only
257 ding mRNA targets showed that 2'-5' linkages
were well tolerated in the sense strand, but only at a f
258 Microneedle patches
were well tolerated in the skin, with mild erythema, min
259 ous compared with placebo and etanercept and
were well tolerated in the treatment of patients with mo
260 Dual mRNAs
are well-tolerated in these studies with no adverse find
261 y, markedly lowers LDL-C levels and seems to
be well tolerated in these patients.
262 ce-weekly alendronate improves bone mass and
is well tolerated in these patients, but there is a conc
263 was significantly increased; AVP antagonism
was well tolerated in these patients.
264 eutic doses of bioengineered miR-34a prodrug
were well tolerated in these animals.
265 Subconjunctival sirolimus appears to
be well tolerated in this pilot trial and shows promise
266 exercise tolerance or lung function, despite
being well-tolerated in this COPD population.
267 ncy suggests definitive endoscopic treatment
is well tolerated in this patient population.
268 combination of high-dose IFNalpha2b and GMK
is well tolerated in this patient population.
269 Meropenem
was well tolerated in this cohort of critically ill infa
270 retinal injection with pars plana vitrectomy
was well tolerated in this cohort.
271 Simvastatin
was well tolerated in this elderly and multimorbid patie
272 Bevacizumab
was well tolerated in this heavily pretreated patient po
273 Therapy
was well tolerated in this patient population but myelos
274 Rituximab
was well tolerated in this patient population, with most
275 Overall FCM
was well tolerated in this pediatric population and appe
276 Rituximab
was well tolerated in this predominantly older adult pat
277 Natalizumab
was well tolerated in this study.
278 Lumacaftor/ivacaftor
was well tolerated in this young population; no new safe
279 Overall, MDMA
was well-tolerated in this sample.
280 However, both doses of ITI-007
were well tolerated in this patient population, as evide
281 Subsequently, 8 mg/m(2)/d
was well tolerated in three patients.
282 The results indicate that the modifications
are well tolerated in various positions of the passenger
283 LDK
is well tolerated in vertebrates and induces long-term r
284 in this case, which suggests that cilium can
be well tolerated in vitreous cavity for as long as 40 y
285 piperazine, piperidine, but not sulfonamide)
were well tolerated in vitro, and the hydrophilic linker
286 ve been widely used to study TG2 biology and
are well tolerated in vivo, but these compounds have onl
287 ngiogenic therapy, and that beta1 inhibition
is well tolerated in vivo as a tractable strategy to dis
288 Debio-1452-NH3
is well tolerated in vivo, reduces bacterial burden in m
289 Deficiency of the Pim kinase genes
is well tolerated in vivo, suggesting that PIM1 inhibiti
290 al nontumor-bearing mice indicated that T115
is well-tolerated in vivo (maximum total tolerated dose,
291 rate that pharmacological inhibition of CREB
is well-tolerated in vivo and indicate that such inhibit
292 fective than single-frequency ultrasound and
is well-tolerated in vivo.
293 diet to C57BL/6 mice, 2500 mg/kg/day OGT2378
was well tolerated in vivo and biologically active, depl
294 It
was well tolerated in vivo with no sign of acute toxicit
295 Under conditions where it
was well tolerated in vivo, this FOXO4 peptide neutraliz
296 ntravitreal delivery of LiGluR and MAG0(460)
was well tolerated in vivo.
297 Roscovitine and PIK-90, in combination,
were well tolerated in vivo and acted in a synthetic-let
298 CVD 908-htrA and CVD 906-htrA
were well tolerated in volunteers; mild diarrhea in 3 of
299 Live attenuated influenza vaccine
was well tolerated in young children in Senegal, but did
300 Quininib
is well tolerated in zebrafish, human cell lines, and mu