ライフサイエンスコーパス: beauty

1 silk protein fibers that embody strength and beauty.

2 itude increases linearly with the feeling of beauty.

3 and then judged whether they had experienced beauty.

4 evolutionary advantages and often with great beauty.

5 tand a simple cell in all its complexity and beauty.

6 total synthesis of molecules of unimaginable beauty and diversity such as the four discussed in this

7 ever, I question his ensuing arguments about beauty and goodness, and thereby the practical value of

8 bert Burns Woodward's publications exhibit a beauty and majesty infrequently seen in the scientific l

9 ermline transposition frequency for Sleeping Beauty and piggyBac was approximately 10% or about one n

10 ompare them with the preferences of Sleeping Beauty and piggyBac, showing that each superfamily has a

11 The distraction greatly reduces the beauty and pleasure experienced from stimuli that otherw

12 ies in providing ecosystem services, natural beauty and pleasure, and sustaining human lives is a mes

13 Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annu

14 e results provide a visceral reminder of the beauty and the complexity of living systems.

15 analysis of 23,417 piggyBac, 30,303 Sleeping Beauty, and 27,985 TcBuster integrations in HEK-293 cell

16 Truth may be beauty, and beauty truth, in more than a metaphorical se

17 wo transposon systems, PiggyBac and Sleeping Beauty, and give guidance on the use of different engine

18 al role in visual art, it is often linked to beauty, and observers can detect it efficiently in the l

19 d by their geometrical perfection, intrinsic beauty, and particular properties of polyhedranes, a ser

20 e attention due to their symmetry, aesthetic beauty, and potential applications in catalysis, plasmon

21 s challenges that arise, relating to art and beauty, and provide ideas for a way forward.

22 tion by trace element analysis in edible and beauty argan oil is a method that can be generalised.

23 ere assessed by ICP-AES in virgin edible and beauty argan oil samples prepared from four remote locat

24 ons of human ICC, we electroporated Sleeping Beauty-based oncogenic transposon plasmids into the left

25 BEAUTY (BLAST Enhanced Alignment Utility) is an enhanced

26 ransposon biology and indicate that Sleeping Beauty can be readily improved for enhanced genetic rese

27 clinical neurology and, even more often, in beauty clinics.

28 , practitioners will encounter more and more beauty-conscious teenagers using these products for prev

29 s, and when it does, there is no place for a beauty contest.

30 ue that such sites potentially devolve into "beauty contests" where patients in need are evaluated on

31 c toxicity at smelters, mercury in paint and beauty creams, dioxin in waste oil in Missouri, polychlo

32 Neuroanatomically, when contemplating beauty, curvilinear contour activated the anterior cingu

33 on sense and philosophy suggest that feeling beauty differs from sensuous pleasures such as eating or

34 ained by non-viral gene transfer of Sleeping Beauty DNA plasmids and selectively expanded ex vivo usi

35 n delivered into the genome via the Sleeping Beauty DNA transposon, suggesting that the observed meth

36 colorectal cancer (CRC) in several Sleeping Beauty DNA transposon-based forward genetic screens in m

37 cer susceptibility gene in multiple Sleeping Beauty DNA transposon-based forward genetic screens in m

38 ied derivatives of the piggyBac and Sleeping Beauty DNA transposons.

39 Transposition of Sleeping Beauty elements has been observed in cultured cells, hep

40 one of the most amazing displays of mineral beauty ever created in nature.

41 PiggyBac and Sleeping Beauty have different integration preferences.

42 sted a functional transposon called Sleeping Beauty in the one-cell mouse embryo.

43 investigators who seek reinvigoration in the beauty in their craft.

44 accelerates tumorigenesis following Sleeping Beauty insertional mutagenesis in a mouse model of melan

45 Sleeping Beauty insertional mutagenesis in this model led to acce

46 Sleeping Beauty is a new tool for unbiased, forward genetic scree

47 The experience of beauty is a pleasure, but common sense and philosophy su

48 Sleeping Beauty is a synthetic "cut-and-paste" transposon of the

49 Sleeping Beauty is an active DNA-transposon system from vertebrat

50 That is, to some significant degree, beauty is in the "eye of the beholder." Here, we investi

51 through hydrodynamic injection and sleeping beauty-mediated somatic integration.

52 namic injection in combination with Sleeping Beauty-mediated somatic integration.

53 A forward genetic screen utilizing Sleeping Beauty mutagenesis in mice previously identified potenti

54 Beyond the spectacular beauty of such minute structures lie surfaces evolutiona

55 An understanding of the complexities and beauty of the biological process of hearing itself is un

56 Moreover, the beauty of the cascade process is further underscored by

57 cular biology while experiencing the natural beauty of the Pacific Coast.

58 able position of being able to share the raw beauty of the world around us-and in the case of neurosc

59 The beauty of this idea lies in its simplicity and testabili

60 e point during his or her education, and the beauty of this process has led many of us to go deeper a

61 n: either consensus judgments about physical beauty (paracingulate cortex) or individualized preferen

62 ling goal of providing a judgment of liking, beauty, perfection, or similar.

63 preserved TSCM potential using the Sleeping Beauty platform.

64 BEAUTY Post-Processing of submitted search results is av

65 his favoritism is not sufficient to create a beauty premium in competitive settings.

66 An account of the "beauty premium" based only on mating motivations overloo

67 There is believed to be a 'beauty premium' in key life outcomes: it is thought that

68 te-based and stereotype explanations for the beauty premium, have too many confounding effects, and l

69 dable, but mating motives do not explain the beauty premium.

70 ate the experimental and field evidence of a beauty premium.

71 dividual by highlighting the type of hygiene/beauty products the person uses, diet, medical status, a

72 Three recent improvements to the BEAUTY program described here make the enhanced output (

73 ols, including BLAST, FASTA, Smith-Waterman, BEAUTY, PROSITE, and BLOCKS searches.

74 ample of such a transition is the decay of a beauty quark into a strange quark.

75 -accounted for nearly 60% of the variance in beauty ratings.

76 ferent types of visual stimuli covaried with beauty ratings.

77 load in the presence of the Flp and Sleeping Beauty recombinases.

78 at only the pleasure associated with feeling beauty requires thought and disprove his claim that sens

79 manuel Kant [1, 2] claimed that experiencing beauty requires thought but that sensuous pleasure can b

80 encing and bioinformatics pipeline, Sleeping Beauty (SB) capture hybridization sequencing (SBCapSeq),

81 es the DNA damage introduced during Sleeping Beauty (SB) element excision and reinsertion in mammalia

82 he chromosomal transposition of the Sleeping Beauty (SB) element in mouse embryonic stem cells, provi

83 mariner family transposable element Sleeping Beauty (SB) for transgenesis and long-term expression st

84 enesis strategy based on a two-step Sleeping Beauty (SB) forward genetic screen to identify and valid

85 conducted a mutagenic screen using Sleeping Beauty (SB) in mice to identify new candidate cancer gen

86 A Sleeping Beauty (SB) in science refers to a paper whose importanc

87 Sleeping Beauty (SB) is the most active Tc1/mariner-type transpos

88 ively suppresses tumorigenesis in a Sleeping Beauty (SB) mouse model of cancer.

89 vanced DNA vectors derived from the Sleeping Beauty (SB) system to avoid the expense and manufacturin

90 rmits conditional mobilization of a Sleeping Beauty (SB) transposase allele by Cre recombinase to ind

91 The N-terminal domain of the Sleeping Beauty (SB) transposase mediates transposon DNA binding,

92 The Sleeping Beauty (SB) transposon (Tn) system is a nonviral gene de

93 a novel nonviral vector system, the Sleeping Beauty (SB) transposon (Tn) to insert a wild-type beta-g

94 Sleeping Beauty (SB) transposon is a natural nonviral gene transf

95 The Sleeping Beauty (SB) transposon is a nonviral method of gene deli

96 The Sleeping Beauty (SB) transposon is a promising gene transfer vect

97 The Sleeping Beauty (SB) transposon is a Tc1/mariner family transposo

98 The Sleeping Beauty (SB) transposon is an emerging tool for transgene

99 The Sleeping Beauty (SB) transposon is an integrative nonviral plasmi

100 The Sleeping Beauty (SB) transposon mutagenesis screen is a powerful

101 cer (CRC) progression, we performed Sleeping Beauty (SB) transposon mutagenesis screens in mice carry

102 The Sleeping Beauty (SB) transposon mutagenesis system is a powerful

103 We used Sleeping Beauty (SB) transposon mutagenesis to identify events th

104 leukemia, we targeted cre-dependent Sleeping Beauty (SB) transposon mutagenesis to the blood-forming

105 The Sleeping Beauty (SB) transposon represents an important vehicle f

106 The Sleeping Beauty (SB) transposon system can integrate foreign sequ

107 The Sleeping Beauty (SB) transposon system combines the advantages of

108 Over the past decade, the Sleeping Beauty (SB) transposon system has been developed as the

109 The Sleeping Beauty (SB) transposon system has been used as a somatic

110 The Sleeping Beauty (SB) transposon system has been used as an insert

111 The Sleeping Beauty (SB) transposon system is a nonviral DNA delivery

112 The Sleeping Beauty (SB) transposon system provides the first random

113 sly described an approach using the Sleeping Beauty (SB) transposon system to model hematopoietic mal

114 his study we utilized the non-viral Sleeping Beauty (SB) transposon system using the SB100X hyperacti

115 Recently, the Sleeping Beauty (SB) transposon system was shown to be useful for

116 The Sleeping Beauty (SB) transposon system was used to elucidate cand

117 nt non-viral approach combining the Sleeping Beauty (SB) Transposon System with selective proliferati

118 ene expression in pigs by using the Sleeping Beauty (SB) transposon system.

119 expression in rabbits by using the Sleeping Beauty (SB) transposon system.

120 The latest generation of Sleeping Beauty (SB) transposon vectors fulfills these requiremen

121 We used the Sleeping Beauty (SB) transposon, delivered as naked plasmid DNA b

122 ment and metastasis, we performed a Sleeping Beauty (SB) transposon-based forward genetic screen in m

123 ecently, two groups have shown that sleeping beauty (SB) transposon-based insertional mutagenesis can

124 s of MPNST development, we used the Sleeping Beauty (SB) transposon-based somatic mutagenesis system

125 Here we use Sleeping Beauty (SB) transposon-mediated insertional mutagenesis

126 Here we show that Sleeping Beauty (SB) transposon-mediated mutagenesis drives melan

127 tant allele of Apc (Apc(Min)) using Sleeping Beauty (SB) transposon-mediated mutagenesis.

128 were genetically modified using the Sleeping Beauty (SB) transposon/transposase system to express a C

129 ling of the piggyBac (PB), Tol2 and Sleeping Beauty (SB) transposons and the murine leukemia virus (M

130 preferential integration sites for Sleeping Beauty (SB) transposons into a particular 100 bp region

131 Mice harboring mutagenic Sleeping Beauty (SB) transposons were crossed with mice expressin

132 Here we show that Sleeping Beauty (SB), a member of the Tc1/mariner class of transp

133 However, since the resurrection of Sleeping Beauty (SB), the possibility of performing forward genet

134 ssion, through a human IDO-encoding Sleeping Beauty (SB)-based nonviral gene-integrating approach, ha

135 Forward genetic screens using Sleeping Beauty (SB)-mobilized T2/Onc transposons have been used

136 es in the IR/DR subgroup, including Sleeping Beauty (SB).

137 ficiencies of piggyBac, hyperactive Sleeping Beauty (SB11), Tol2, and Mos1 in four mammalian cell lin

138 BEAUTY searches of the NCBI and EMBL non-redundant prote

139 cells genetically modified with the Sleeping Beauty system to express D-CAR stably were propagated se

140 We used electrotransfer of Sleeping Beauty system to introduce a CAR transposon and selectiv

141 ed T cells were generated using the Sleeping Beauty system to stably introduce the CD19-specific CAR

142 ercome this constraint, we used the Sleeping Beauty transposable element to achieve chromosomal integ

143 e transcription unit expressing the Sleeping Beauty transposase (SB) and another expressing human uri

144 The Sleeping Beauty transposase (SB) was constructed on the basis of

145 PiggyBac or Sleeping Beauty transposase bigenic rats bred with wild-type albi

146 Sleeping Beauty transposase binds to the inverted repeats of salm

147 We show that the Sleeping Beauty transposase can efficiently insert transposon DNA

148 in-deleted canine FVIII in cis with Sleeping Beauty transposase in hyaluronan nanocapsules and inject

149 uitously express either piggyBac or Sleeping Beauty transposase were generated by standard zygote inj

150 coexpress the Etv6-RUNX1 fusion and Sleeping Beauty transposase.

151 tructed by ligating the CMV-driven "Sleeping Beauty" transposase gene downstream to the Tc1-like tran

152 sposition but were inactive against Sleeping Beauty transposition and long interspersed nucleotide el

153 For example, the Sleeping Beauty transposon (SB) can transform a wide range of ver

154 Sleeping Beauty transposon (SB-Tn) has emerged as an important no

155 -CA) with mice in which a mutagenic Sleeping Beauty transposon (T2/Onc) was mobilized only in B cells

156 ng these mice with those carrying a Sleeping Beauty transposon array.

157 Using the Sleeping Beauty transposon as a delivery system, we introduced an

158 l of this approach, we encapsulated Sleeping Beauty transposon expressing the B domain-deleted canine

159 For example, the Sleeping Beauty transposon has become highly instrumental to indu

160 Mobilizing the Sleeping Beauty transposon in cerebellar neural progenitor cells

161 ted this hypothesis by performing a Sleeping Beauty transposon mutagenesis screen in which common ins

162 We used it to perform a Sleeping Beauty transposon mutagenesis screen to identify genes t

163 A new study uses Sleeping Beauty transposon mutagenesis to drive osteosarcomagenes

164 An unbiased Sleeping Beauty transposon screen revealed MyoD as a putative med

165 dentified in previous retroviral or Sleeping Beauty transposon screens, including Spic, which encodes

166 y shows for the first time that the Sleeping Beauty transposon system can be used to identify candida

167 uced pluripotent stem cells using a Sleeping Beauty transposon system carrying the micro-utrophin gen

168 d insertional mutagenesis using the Sleeping Beauty transposon system in mice carrying germline or so

169 tional mutagenesis screen using the Sleeping Beauty transposon system in mice with mammary-specific i

170 sorders have shown efficacy for the Sleeping Beauty transposon system in the treatment of hemophilia,

171 factor in prostate cancer, and the Sleeping Beauty transposon system is a useful tool for identifyin

172 ional mutagenesis indicate that the Sleeping Beauty transposon system may be a safer alternative than

173 in Nature, Sun et al. (2014) used a sleeping beauty transposon system to demonstrate that natural hem

174 the mouse and the rat, by using the Sleeping Beauty transposon system.

175 Thus, Sleeping Beauty transposon targeted to liver sinusoidal endotheli

176 Here we report the ability of the Sleeping Beauty transposon to act as a somatic insertional mutage

177 rodynamically codelivered using the Sleeping Beauty transposon to initiate liver tumorigenesis.

178 ation of a single-copy inactivating Sleeping Beauty transposon to Pten disruption within the same gen

179 liary tract was accomplished by the Sleeping Beauty transposon transfection system with transduction

180 A Sleeping Beauty transposon, engineered to elicit loss-of-function

181 g the local hopping activity of the Sleeping Beauty transposon, the lacZ reporter gene was dispersed

182 e identified such mutations using a Sleeping Beauty transposon, which caused rapid-onset AML in 80% o

183 A hybrid piggyBac/Sleeping Beauty transposon-based insertional mutagenesis system t

184 In this study, we conducted a Sleeping Beauty transposon-mediated insertional mutagenesis scree

185 a novel tyrosinase minigene-tagged Sleeping Beauty transposon-mediated mutagenesis, which allows for

186 netic screen in Emu-TCL1 mice using Sleeping Beauty transposon-mediated mutagenesis.

187 ed human PAX7+ satellite cells with Sleeping Beauty transposon-mediated nonviral gene transfer, highl

188 ted throughout the genome using the Sleeping Beauty transposon.

189 expressed in p53fl/fl mice using a sleeping beauty transposon.

190 using ex vivo mutagenesis with the Sleeping Beauty transposon.

191 hMet and mutant-beta-catenin using sleeping beauty transposon/transposase leads to hepatocellular ca

192 , introducing DNA plasmids from the Sleeping Beauty transposon/transposase system to directly express

193 MA148 was genetically modified by "Sleeping Beauty" transposon-mediated delivery of DsRed2 fluoresce

194 Sleeping Beauty transposons have the potential for use as chromos

195 ce and forward genetic screens with Sleeping Beauty transposons implicate additional signaling cascad

196 Mobilization of Sleeping Beauty transposons in NSCs induced the immortalization o

197 nts, which were further deployed by Sleeping Beauty transposons throughout the genome of human bone e

198 have also been developed to deliver Sleeping Beauty transposons to the lung, liver and tumors for tre

199 Truth may be beauty, and beauty truth, in more than a metaphorical sense, and fal

200 These results support the use of Sleeping Beauty vectors in carrying an insulated IHK-beta-globin

201 o construct a synthetic transposon, Sleeping Beauty, which could be identical or equivalent to an anc