1 ilure, and the need for additional treatment
became clear.
2 iation and orchestration of this process has
become clear.
3 of electricity in animal and plant life has
become clear.
4 heir potential importance have only recently
become clear.
5 al virulence factors in vivo is beginning to
become clear.
6 innate immune system against foreign RNA has
become clear.
7 unction to specify cell fate is beginning to
become clear.
8 g changes, as the significance of a stimulus
becomes clear.
9 attitudinal change set toward public health
becomes clear.
10 d-sparing agents to manage frequent relapses
becomes clear.
11 tionary origins of these cells are only just
becoming clear.
12 disorders of the central nervous system, is
becoming clear.
13 an animal model for multiple sclerosis, are
becoming clear.
14 es a limited number of sulfation patterns is
becoming clear.
15 nstruct eye-specific circuit development are
becoming clear.
16 Its functions in these parasites are
becoming clear.
17 for osteopontin in B-cell differentiation is
becoming clear.
18 up, a large proportion of the infections had
become cleared (
34-100%), or the pathogen load reduced,
19 a characteristic nonspherical cap shape, has
become clear again, with a water drop sitting on an oil
20 ocesses between pathogen and mutualist fungi
become clear,
although the outcomes are often opposite i
21 lational implications of these advances have
become clear,
and have begun to impact significantly on
22 athogenesis of kidney disorders is gradually
becoming clear,
and the need for disease models that rec
23 The importance of this heterogeneity will
become clear as we learn more about the role of NK cells
24 The need for such assays is
becoming clear,
as in some patients, HLA-specific memory
25 y aspects of synaptic regulation by eCBs are
becoming clear,
details of the subcellular organization
26 It has
become clear from occurrence studies that different fold
27 It
becomes clear from this systematic review that while mos
28 We show that CUP expression
becomes cleared from boundary subdomains between petal p
29 It is
becoming clear from genomic and physiological investigat
30 It has
become clear,
however, that both cytokines can have dire
31 It has also
become clear,
however, that CDK4/6 effectively counter c
32 It is
becoming clear,
however, that the location of fat deposi
33 A few key issues are
becoming clear,
however.
34 t functional unit of a GPCR is a monomer, it
became clear in the past decades that the vast majority
35 It has
become clear in recent years that periodontitis is an in
36 However, it has
become clear in recent years that these DExH/D RNA helic
37 However, it has
become clear in recent years that they play an equally i
38 metabolic events linked to productivity have
become clear in the past 2-3 years.
39 tual principles governing plant immunity are
becoming clear,
its systems-level organization and the e
40 As will
become clear,
much remains to be learned about the bioch
41 cells, apical membranes are established and
become cleared of cell-cell junctions, thereby allowing
42 Frequently, the role of the supra-domain
becomes clear only once the three-dimensional structure
43 It has
become clear over recent years that isotype choice is vi
44 nication in CNS homeostasis and function has
become clear over that last two decades.
45 It has
become clear over the past decade that inhibition of PAR
46 It has
become clear recently that PTEN (phosphatase and tensin
47 the neural implementation of which has only
become clear recently.
48 erived CD4+CD25+ regulatory T (TR) cells, it
became clear that a variety of additional peripherally i
49 Since it
became clear that all cancer cells express tumor-specifi
50 In the intervening years it
became clear that both viruses were widespread in the hu
51 It
became clear that by utilizing imaging some patients cou
52 Yet, recently it
became clear that cells with identical genomes exposed t
53 It
became clear that children with attention deficit disord
54 Thus, it
became clear that debilitated COPD patients would need i
55 In recent years, it
became clear that in addition to their immune-suppressiv
56 It
became clear that intra-acinar trypsinogen activation co
57 mice or cancer patients, in recent years, it
became clear that MDSCs play a critical role in the regu
58 in a semi-arid region of south-east Spain it
became clear that most of these cells had a high lipid c
59 Recently, it
became clear that patients may develop an obstructive (b
60 Europhosphatase meeting (Turku, Finland), it
became clear that phosphatases can no longer be ignored
61 nal channels incorporated, but after 1980 it
became clear that processes other than ion channel gatin
62 tality were measured in the same neurons, it
became clear that synuclein accumulation preceded and st
63 ransforming growth factor-beta (TGFbeta), it
became clear that Th17 cell development overlapped that
64 th the native synthetic human RLF (hRLF), it
became clear that the cross-linked analogue largely reta
65 As it
became clear that the essential building block of tissue
66 Soon, it
became clear that the mutations identified impaired the
67 In the early 1990s, it
became clear that the outer membrane permeability barrie
68 ned by the type of TCR they express, it soon
became clear that the TCR type per se does not play a de
69 -13-producing cell is an NK T (NKT) cell, it
became clear that this cell does not express invariant N
70 Nearly 80 years elapsed before it
became clear that visceral afferent neurons could themse
71 e of the cyberinfrastructure development, it
became clear that we were also building an integrated sa
72 Recently, it has
become clear that a charge density wave (CDW) phase exis
73 ing diverse strategies, only recently has it
become clear that a growing number involve electron tran
74 Over the years it has
become clear that a neuron's health is subject to dynami
75 organisms to different environments, it has
become clear that a substantial portion is generated by
76 At the same time, it has
become clear that Abeta peptides derived from amyloid pr
77 ntify the volume and activity of BAT, it has
become clear that activated BAT combusts fatty acids rat
78 Recently, it has also
become clear that ACTN4 can function in the nucleus.
79 recombinant proteins, in recent years it has
become clear that affinity tags can have a positive impa
80 It has recently
become clear that alarmins play important roles as initi
81 In recent years, it has
become clear that all of the organisms on the Earth are
82 During the past decade or so, it has
become clear that alterations in intracellular Ca(2+) ha
83 It has also
become clear that anti-IgE (Omalizumab), the first monoc
84 However, it has also
become clear that antibody recognition of the region is
85 Recently, it has
become clear that apoE binding to its receptors plays a
86 However, during the past decade it has
become clear that apoptotic cells can produce diverse si
87 Over the past decade, it has
become clear that aqueous chemical processes occurring i
88 In the past few decades, it has
become clear that asymmetric catalysis is one of the mos
89 Moreover, it has
become clear that autophagy and autophagy-related proces
90 Within the past decade, it has
become clear that autophagy has not only retained its ev
91 More recently, however, it has
become clear that avoidance of damage to the host is als
92 Moreover, it has
become clear that BAT plays an important role in insulin
93 It has
become clear that BKCa channels often form complexes wit
94 Meanwhile, it had also
become clear that calcium is an ambivalent messenger.
95 ng to the linear non-threshold model, it has
become clear that cellular responses can be very differe
96 It has now
become clear that chronic intermittent low doses of phen
97 Therefore, it has
become clear that comparative studies designed to elucid
98 It has recently
become clear that components of the proteasome are recru
99 G activation in vertebrates, it has recently
become clear that core components of the cGAS-STING path
100 Nonetheless, it has
become clear that CRT is a multicompartmental protein th
101 It has recently
become clear that deficiencies of these processes are as
102 Using genomics methods, it has
become clear that developmental control genes are a dist
103 However, it has
become clear that disease is a complex outcome which can
104 Although it has
become clear that distinct HSC subsets exist that are st
105 In recent years, it has
become clear that early diagnosis and timely reduction i
106 Instead, it has
become clear that elevated levels of Ras activity are cr
107 It has
become clear that enhancer blocking elements should not
108 Recently it has
become clear that epigenetic changes play a role in this
109 e during host-bacterial interactions, it has
become clear that epithelia are being utilized by the ho
110 und a central substrate-binding site, it has
become clear that even the most simplistic transporters
111 Since their discovery 30 years ago, it has
become clear that exosomes contribute to many aspects of
112 However, it has also
become clear that false positives caused by off-target e
113 Indeed, it has
become clear that G4 structures can pose prominent barri
114 In recent years, however, it has
become clear that gp120 glycosylation can also be includ
115 Recently, it has
become clear that growing tissues show specific and high
116 From these studies, it has
become clear that H2A and H2B ubiquitination play critic
117 Recently, it has
become clear that herpesviruses are unique among pathoge
118 It has
become clear that hypoxia shapes and induces specific ma
119 Yet, it has
become clear that IFN-gamma also has a strong impact on
120 Although it has recently
become clear that IgA also mediates other immunological
121 Interestingly, in recent years, it has
become clear that immune cells express a non-neuronal ch
122 In recent years, it has
become clear that in many proteins, significant regions
123 It has
become clear that in Saccharomyces cerevisiae the transc
124 It has also
become clear that iNKT cells can rapidly mature dendriti
125 In recent years, it has
become clear that innate immune cells termed neutrophils
126 or the study of integrin biology, and it has
become clear that integrin outside-in signaling is highl
127 However, it has
become clear that intermediate states, rather than matur
128 f immune effector genes, but recently it has
become clear that key IFN-gamma functions are mediated b
129 n tumorigenesis remain to be defined, it has
become clear that maintaining redox balance is critical
130 Only relatively recently has it
become clear that mammalian genomes encode tens of thous
131 Only more recently has it
become clear that many eusocial species also regularly r
132 In recent years, it has
become clear that mechanical cues play an integral role
133 It has
become clear that microRNA (miRNA) can affect tumorigene
134 However, in recent years it has
become clear that most septic patients do not die from a
135 Recently, it has
become clear that motile cilia play a central role in in
136 It has
become clear that multiple genes can encode one enzymati
137 Over the last 5 years, it has
become clear that mutations of POLG are a major cause of
138 More recently, it has
become clear that NF-kappaB signalling also has a critic
139 s of Titan by the Cassini spacecraft, it has
become clear that no such oceans exist.
140 pic of investigation for a long time, it has
become clear that noncoding RNAs also play key roles in
141 More recently, it has
become clear that not only does an individual's environm
142 It has
become clear that one of the major therapeutic targets i
143 Over the past few years, it has
become clear that oscillatory dynamics of cortical netwo
144 Over the past few years it has
become clear that over half of the mammalian heart deriv
145 It has
become clear that particular microRNAs (miRNAs) function
146 It has
become clear that pelvic floor disorders rarely occur in
147 It has recently
become clear that plant biosynthetic pathway-encoding ge
148 Recently, it has
become clear that plants harbor more complex gene regula
149 In recent years, it has
become clear that platelets also act as modulators of in
150 More recently, it has
become clear that prophylactic therapy with AZI actually
151 ase MDM2 is widely accepted, it has recently
become clear that regulation of p53 translation also con
152 Lately, it has
become clear that regulatory T cells (Tregs) play a majo
153 It has recently
become clear that researchers interested in understandin
154 However, in the past three years it has
become clear that roughly 1% of predicted genes in anima
155 It has recently
become clear that several factors must coincide for the
156 It has recently
become clear that several pathogenic DNA viruses express
157 In recent years, it has
become clear that skin plays an essential role in modula
158 ogenase (SDH) in paraganglioma (PGL), it has
become clear that some cells and tissues are not only ab
159 usceptibility to cutaneous pathogens, it has
become clear that some innate immune defects might promo
160 , Tregs are functionally diverse, and it has
become clear that some of this diversity segregates with
161 Recently, it has
become clear that some protein complexes are dynamic in
162 mary role in substrate translocation, it has
become clear that some transporters have acquired a seco
163 It has
become clear that STAT family proteins play a major role
164 Since then, it has
become clear that subcellular targeting of mRNAs is prev
165 the anatomical and functional levels, it has
become clear that subtle structural differences exist be
166 hes into tumor and germline analyses, it has
become clear that the ability to achieve high-throughput
167 Over the last decade, it has
become clear that the accumulation of misfolded proteins
168 Over the past few decades it has
become clear that the activity or the oncogenic potentia
169 ton have been firmly established, but it has
become clear that the bacterial actins form a wide varie
170 Recently, it has
become clear that the characteristic phenotype of BRCA1
171 However, it has also
become clear that the clinical benefit associated with t
172 aging and neurodegenerative disease, it has
become clear that the crosstalk between these systems ca
173 cause of RA is currently unresolved, it has
become clear that the damaging effects are a result of t
174 Recently, it has
become clear that the frequency of regulatory T cells (T
175 Recently, it has
become clear that the mammalian heart is not a post-mito
176 During the last decade, it has
become clear that the mammalian immune system is able to
177 Most recently, it has
become clear that the melanopsins are only distantly rel
178 Although it has
become clear that the morbidities associated with IUGR a
179 Over time, it has
become clear that the mucosal immune system in general a
180 It has
become clear that the outcome of this interaction is inf
181 Furthermore, it has
become clear that the performance of PCR-based assays in
182 Since that time, however, it has
become clear that the period shifts seen in the early ex
183 In recent times it has
become clear that the pharmacology of these receptors is
184 It has
become clear that the phosphatidylinositol 3-kinase (PI3
185 It has also
become clear that the physiological role of the cuticle
186 It has also
become clear that the preimmune repertoire contains func
187 It has
become clear that the prognosis for infants/children wit
188 Over the past 25 years, it has
become clear that the proteins forming the deposits are
189 Over the past several years, it has
become clear that the Rho family of GTPases and related
190 pathogenesis at the molecular level, it has
become clear that the Rim101 pathway, and pH responses i
191 tructure along the longitudinal axis, it has
become clear that the rodent hippocampus can be anatomic
192 It has
become clear that the role of PKC in tumorigenesis is ce
193 Since this initial finding, it has
become clear that the role of PKC-theta in T cells is co
194 While it has
become clear that the structure of cyt c changes, the ex
195 ith the advent of cellular therapies, it has
become clear that the success of future therapies in pro
196 It has
become clear that the surface levels of inhibitory GABA(
197 More recently, it has
become clear that the surfaces of two-stranded coiled co
198 It has recently
become clear that the transcriptional output of the huma
199 Recently, it has
become clear that the two most common mutations in the H
200 During the last 10 years it has
become clear that the UPS plays a prominent regulatory r
201 In recent years, it has
become clear that the wound inflammatory response may be
202 subsets has become much broader, and it has
become clear that there are multiple dimensions by which
203 It has
become clear that there are substantial interindividual
204 Over the past decade, it has
become clear that there is an important subset of memory
205 s an important public health problem, it has
become clear that there is an unmet need in regard to tr
206 Importantly, it has
become clear that there is significant diversity in the
207 However, it has
become clear that these enzymes are also important regul
208 However, it has
become clear that these same brain systems are also vuln
209 can be studied in isolation in vitro, it has
become clear that these steps are intimately connected w
210 Recently, however, it has
become clear that these three processes are not the only
211 Einstein relation, in the past decade it has
become clear that they can be independently altered by m
212 are a similar structure and function, it has
become clear that they differ with respect to their role
213 Since then, it has
become clear that this structure is the site of B cell c
214 It has
become clear that to address the complex and interrelate
215 e studies of regulated transcription, it has
become clear that traditional definitions of enhancers a
216 It has
become clear that ultraviolet A (UVA) radiation from the
217 It has recently
become clear that various aspects of nucleic acid metabo
218 to its potent effects on vasculature, it has
become clear that vascular endothelial growth factor (VE
219 Recently, it has
become clear that when the regulation of the storage and
220 rily affect appearance and fertility, it has
become clear that women with this syndrome may also pote
221 It has
become clear that WT1 can act as an oncogene in many tum
222 Over the past few years, it has
become clear that, at the pathophysiological level, cere
223 In recent years, it has
become clear that, in addition to conventional anterogra
224 gher-resolution information, however, it has
become clear that, on the molecular level, amyloids comp
225 In this context, it
becomes clear that any rational designs of MALDI matrice
226 d structures of macromolecular complexes, it
becomes clear that the interactions that involve protein
227 It also
becomes clear that the orientation of the ball is not in
228 However, it quickly
becomes clear that the sequence flexibility allowed a gi
229 equencing data in a phylogenetic context, it
becomes clear that there is extensive variation througho
230 It is
becoming clear that a radical change of cell identity of
231 Remarkably, it is now
becoming clear that adult beta cells retain plasticity a
232 It is
becoming clear that astrocytes are active participants i
233 It is, however,
becoming clear that autophagy may play a key role in reg
234 acilitating immune cell responses, it is now
becoming clear that cellular metabolism has direct roles
235 Although details remain unknown, it is
becoming clear that chromatin is polymorphic depending o
236 It is
becoming clear that complex interactions of environment,
237 ntinued use of traditional approaches, it is
becoming clear that conditioned fear involves much more
238 However, it is also
becoming clear that continued differentiation and specia
239 It is
becoming clear that diet, exercise, and other lifestyle
240 e temporal regulation of this pathway, it is
becoming clear that disruption of local signalling may l
241 It is
becoming clear that epigenetic changes are involved in h
242 lly defined by acute stroke risk, it is also
becoming clear that far more subclinical events are occu
243 ions are an increasing population, and it is
becoming clear that genetic mutations that cause develop
244 However, it is also
becoming clear that germline BRCA1/2 mutations are neith
245 However, it is
becoming clear that in order to accurately measure genet
246 might function solely as antioxidants, it is
becoming clear that many of the beneficial chemicals in
247 It is
becoming clear that microRNAs, a new class of small regu
248 ome sequencing projects are completed, it is
becoming clear that multipartite genomes comprised of mo
249 It is
becoming clear that nervous system development and adult
250 It is
becoming clear that OA absorbs light substantially (henc
251 tion of PA needed for mTOR activation, it is
becoming clear that PA generated via the LPAAT and DGK p
252 orically seen as a benign disease, it is now
becoming clear that Plasmodium vivax can cause significa
253 Therefore, it is
becoming clear that PLZF has a broad impact on the immun
254 PTMs truly constitute a strict "code," it is
becoming clear that PTMs on histone proteins function in
255 It is
becoming clear that retinal glia should not be studied i
256 Although recently discovered, it is
becoming clear that rhomboids control many important cel
257 It is
becoming clear that risk assessments in the future will
258 portance of small peptide signals, but it is
becoming clear that secreted peptide signals are importa
259 It is
becoming clear that sex differences are not simply refle
260 It is, however,
becoming clear that significant pathology, such as micro
261 It is nevertheless
becoming clear that silk properties are a consequence of
262 nisms in central excitability, but it is now
becoming clear that spinal hyperexcitability can be regu
263 It is
becoming clear that structural-maintenance-of-chromosome
264 of gamma-secretase enzymatic activity, it is
becoming clear that substrate dimerization and/or the al
265 It is
becoming clear that such gradients are not always simple
266 On the basis of recent reports, it is
becoming clear that T cell exhaustion also plays a cruci
267 the current era of complex treatments, it is
becoming clear that the "bar" needs to be set higher, wi
268 selection for metabolic synergies and it is
becoming clear that the ability of communities to extrac
269 It is
becoming clear that the bone morphogenetic protein (BMP)
270 It is
becoming clear that the brain is an important reservoir
271 It is
becoming clear that the cohesin and condensin complexes
272 It is
becoming clear that the composition of the individual fa
273 asic science of the overactive bladder it is
becoming clear that the control of bladder functioning i
274 n membrane fusion-and-fission, but it is now
becoming clear that the dynamic lipid environment, where
275 It is now
becoming clear that the ER chaperones have critical func
276 Second, it is now
becoming clear that the human intestinal microbiome is i
277 However, it is
becoming clear that the immune system and/or innate immu
278 It is
becoming clear that the peculiar structures of repeat-co
279 This is timely because it is
becoming clear that the prevalence of the spondyloarthri
280 It is now
becoming clear that the subcellular localization and int
281 As these studies progress, it is
becoming clear that the transporters form complexes both
282 Moreover, it is
becoming clear that the virome is part of a dynamic netw
283 s of CSU that need to be resolved, but it is
becoming clear that there are at least 2 distinct pathwa
284 signals that drive chemotaxis in vivo, it is
becoming clear that there is a complex interplay of chem
285 It is
becoming clear that there is an enormous diversity of CD
286 It is
becoming clear that these novel RNAs perform critical fu
287 g the mechanism of biofilm dispersion, it is
becoming clear that this process coincides with alterati
288 It is
becoming clear that upregulated protein kinase C (PKC) s
289 It is
becoming clear that, although spines experience voltages
290 It is
becoming clear that, in addition to gene gain, the loss
291 Postoperatively, the cornea
became clear,
the filtering bleb functioned well, and IO
292 riving forces in SpA pathophysiology are now
becoming clear;
these data may lead to the development o
293 n era in which the need to control costs has
become clear,
this situation is undesirable.
294 ellular pathways whose collective effect may
become clear through the organized structure of molecula
295 the behavior of individual actin regulators
becomes clear,
we must address why cells require multipl
296 The dependence on alpha7-nAChRs
becomes clear when comparing wild-type (WT) mice with mi
297 The importance of this scaling
becomes clear when phloem transport is modelled using tu
298 thesis of aryl, vinyl, and alkyl halides, it
becomes clear which methods have surfaced as most favore
299 ificance of oligomerization of this receptor
became clear with the recent observation that a missplic
300 y, the mechanism of this class of enzymes is
becoming clear with evidence from multiple recent studie