ライフサイエンスコーパス: become clear

1 ilure, and the need for additional treatment became clear.

2 innate immune system against foreign RNA has become clear.

3 unction to specify cell fate is beginning to become clear.

4 s assembly and function are only starting to become clear.

5 iation and orchestration of this process has become clear.

6 ed to elucidate additional architectures has become clear.

7 attitudinal change set toward public health becomes clear.

8 d-sparing agents to manage frequent relapses becomes clear.

9 g changes, as the significance of a stimulus becomes clear.

10 Its functions in these parasites are becoming clear.

11 for osteopontin in B-cell differentiation is becoming clear.

12 disorders of the central nervous system, is becoming clear.

13 an animal model for multiple sclerosis, are becoming clear.

14 es a limited number of sulfation patterns is becoming clear.

15 tionary origins of these cells are only just becoming clear.

16 up, a large proportion of the infections had become cleared (34-100%), or the pathogen load reduced,

17 a characteristic nonspherical cap shape, has become clear again, with a water drop sitting on an oil

18 ocesses between pathogen and mutualist fungi become clear, although the outcomes are often opposite i

19 lational implications of these advances have become clear, and have begun to impact significantly on

20 athogenesis of kidney disorders is gradually becoming clear, and the need for disease models that rec

21 The importance of this heterogeneity will become clear as we learn more about the role of NK cells

22 The need for such assays is becoming clear, as in some patients, HLA-specific memory

23 nical importance of these integrins has also become clear, because aberrant integrin expression and/o

24 y aspects of synaptic regulation by eCBs are becoming clear, details of the subcellular organization

25 It becomes clear from this systematic review that while mos

26 We show that CUP expression becomes cleared from boundary subdomains between petal p

27 It is becoming clear from genomic and physiological investigat

28 It is also becoming clear how these mechanisms are modulated by gen

29 It has become clear, however, that both cytokines can have dire

30 It has also become clear, however, that CDK4/6 effectively counter c

31 A few key issues are becoming clear, however.

32 t functional unit of a GPCR is a monomer, it became clear in the past decades that the vast majority

33 It has become clear in recent years that periodontitis is an in

34 However, it has become clear in recent years that they play an equally i

35 metabolic events linked to productivity have become clear in the past 2-3 years.

36 tual principles governing plant immunity are becoming clear, its systems-level organization and the e

37 As will become clear, much remains to be learned about the bioch

38 cells, apical membranes are established and become cleared of cell-cell junctions, thereby allowing

39 xtracellular cysteine-rich domain of FZD has become clear only very recently.

40 It has become clear over recent years that isotype choice is vi

41 nication in CNS homeostasis and function has become clear over that last two decades.

42 It has become clear over the past decade that inhibition of PAR

43 It has also become clear over time that rather than being a single s

44 It has become clear recently that PTEN (phosphatase and tensin

45 the neural implementation of which has only become clear recently.

46 nsight into solute-solvent interactions have become clear relatively recently.

47 Since it became clear that all cancer cells express tumor-specifi

48 In the intervening years it became clear that both viruses were widespread in the hu

49 It became clear that by utilizing imaging some patients cou

50 Yet, recently it became clear that cells with identical genomes exposed t

51 It became clear that children with attention deficit disord

52 Thus, it became clear that debilitated COPD patients would need i

53 In recent years, it became clear that in addition to their immune-suppressiv

54 It became clear that intra-acinar trypsinogen activation co

55 mice or cancer patients, in recent years, it became clear that MDSCs play a critical role in the regu

56 in a semi-arid region of south-east Spain it became clear that most of these cells had a high lipid c

57 Recently, it became clear that patients may develop an obstructive (b

58 Europhosphatase meeting (Turku, Finland), it became clear that phosphatases can no longer be ignored

59 nal channels incorporated, but after 1980 it became clear that processes other than ion channel gatin

60 It became clear that stearates and sodium dodecyl sulfates

61 tality were measured in the same neurons, it became clear that synuclein accumulation preceded and st

62 ransforming growth factor-beta (TGFbeta), it became clear that Th17 cell development overlapped that

63 th the native synthetic human RLF (hRLF), it became clear that the cross-linked analogue largely reta

64 Soon, it became clear that the mutations identified impaired the

65 In the early 1990s, it became clear that the outer membrane permeability barrie

66 quilibria among these LIB components, and it became clear that the state-of-the-art electrolyte syste

67 ned by the type of TCR they express, it soon became clear that the TCR type per se does not play a de

68 damage signaling kinases were identified, it became clear that they directly regulate a wide range of

69 Over time, it became clear that this method leads to variation in the

70 Nearly 80 years elapsed before it became clear that visceral afferent neurons could themse

71 e of the cyberinfrastructure development, it became clear that we were also building an integrated sa

72 It soon became clear that, with larger and larger GWAS on more a

73 Recently, it has become clear that a charge density wave (CDW) phase exis

74 Over the years it has become clear that a neuron's health is subject to dynami

75 organisms to different environments, it has become clear that a substantial portion is generated by

76 ntify the volume and activity of BAT, it has become clear that activated BAT combusts fatty acids rat

77 Recently, it has also become clear that ACTN4 can function in the nucleus.

78 It has recently become clear that alarmins play important roles as initi

79 In recent years, it has become clear that all of the organisms on the Earth are

80 During the past decade or so, it has become clear that alterations in intracellular Ca(2+) ha

81 atory settings, or via introspection, it has become clear that animals can exhibit exquisite graded s

82 It has also become clear that anti-IgE (Omalizumab), the first monoc

83 However, it has also become clear that antibody recognition of the region is

84 However, during the past decade it has become clear that apoptotic cells can produce diverse si

85 However, it has also become clear that appropriate use of the BAT necessitate

86 Over the past decade, it has become clear that aqueous chemical processes occurring i

87 Furthermore, it has become clear that ARV therapy does not fully restore hea

88 In the past few decades, it has become clear that asymmetric catalysis is one of the mos

89 Moreover, it has become clear that autophagy and autophagy-related proces

90 Within the past decade, it has become clear that autophagy has not only retained its ev

91 Moreover, it has become clear that BAT plays an important role in insulin

92 It has become clear that BKCa channels often form complexes wit

93 Meanwhile, it had also become clear that calcium is an ambivalent messenger.

94 ng to the linear non-threshold model, it has become clear that cellular responses can be very differe

95 It has recently become clear that components of the proteasome are recru

96 In the last decade, it has become clear that connexin hemichannels also provide a p

97 G activation in vertebrates, it has recently become clear that core components of the cGAS-STING path

98 Nonetheless, it has become clear that CRT is a multicompartmental protein th

99 Using genomics methods, it has become clear that developmental control genes are a dist

100 However, it has become clear that disease is a complex outcome which can

101 Although it has become clear that distinct HSC subsets exist that are st

102 In recent years, it has become clear that early diagnosis and timely reduction i

103 Instead, it has become clear that elevated levels of Ras activity are cr

104 Recently it has become clear that epigenetic changes play a role in this

105 und a central substrate-binding site, it has become clear that even the most simplistic transporters

106 Since their discovery 30 years ago, it has become clear that exosomes contribute to many aspects of

107 However, it has also become clear that false positives caused by off-target e

108 Recently it has become clear that Fiu also represents a liability for E.

109 Indeed, it has become clear that G4 structures can pose prominent barri

110 In recent years, however, it has become clear that gp120 glycosylation can also be includ

111 Recently, it has become clear that growing tissues show specific and high

112 From these studies, it has become clear that H2A and H2B ubiquitination play critic

113 Recently, it has become clear that herpesviruses are unique among pathoge

114 Over the last several years it has become clear that higher order assemblies on membranes,

115 It has become clear that hypoxia shapes and induces specific ma

116 Yet, it has become clear that IFN-gamma also has a strong impact on

117 Although it has recently become clear that IgA also mediates other immunological

118 Interestingly, in recent years, it has become clear that immune cells express a non-neuronal ch

119 In recent years, it has become clear that innate immune cells termed neutrophils

120 or the study of integrin biology, and it has become clear that integrin outside-in signaling is highl

121 It has now become clear that interferons also induce an 'interferon

122 However, it has become clear that intermediate states, rather than matur

123 f immune effector genes, but recently it has become clear that key IFN-gamma functions are mediated b

124 n tumorigenesis remain to be defined, it has become clear that maintaining redox balance is critical

125 Only relatively recently has it become clear that mammalian genomes encode tens of thous

126 More recently, it has become clear that mammalian genomes encode thousands mor

127 Only more recently has it become clear that many eusocial species also regularly r

128 In recent years, it has become clear that mechanical cues play an integral role

129 It has become clear that microRNA (miRNA) can affect tumorigene

130 However, in recent years it has become clear that most septic patients do not die from a

131 It has become clear that multiple genes can encode one enzymati

132 s of Titan by the Cassini spacecraft, it has become clear that no such oceans exist.

133 pic of investigation for a long time, it has become clear that noncoding RNAs also play key roles in

134 More recently, it has become clear that not only does an individual's environm

135 More recently, it has become clear that not only intrachromosomal interactions

136 Over the past few years it has become clear that over half of the mammalian heart deriv

137 It has become clear that pelvic floor disorders rarely occur in

138 It has recently become clear that plant biosynthetic pathway-encoding ge

139 Recently, it has become clear that plants harbor more complex gene regula

140 In recent years, it has become clear that platelets also act as modulators of in

141 More recently, it has become clear that prophylactic therapy with AZI actually

142 Lately, it has become clear that regulatory T cells (Tregs) play a majo

143 It has recently become clear that researchers interested in understandin

144 Over the last decade, it has become clear that respiratory and intestinal tract micro

145 ogenase (SDH) in paraganglioma (PGL), it has become clear that some cells and tissues are not only ab

146 usceptibility to cutaneous pathogens, it has become clear that some innate immune defects might promo

147 , Tregs are functionally diverse, and it has become clear that some of this diversity segregates with

148 Recently, it has become clear that some protein complexes are dynamic in

149 mary role in substrate translocation, it has become clear that some transporters have acquired a seco

150 these stresses and over recent years it has become clear that sphingolipids are a key player in thes

151 It has become clear that STAT family proteins play a major role

152 Since then, it has become clear that subcellular targeting of mRNAs is prev

153 the anatomical and functional levels, it has become clear that subtle structural differences exist be

154 It has recently become clear that T cells from MM patients are able to r

155 It has also become clear that targeting these pathways does not erad

156 hes into tumor and germline analyses, it has become clear that the ability to achieve high-throughput

157 Over the past few decades it has become clear that the activity or the oncogenic potentia

158 ton have been firmly established, but it has become clear that the bacterial actins form a wide varie

159 However, it has also become clear that the clinical benefit associated with t

160 aging and neurodegenerative disease, it has become clear that the crosstalk between these systems ca

161 cause of RA is currently unresolved, it has become clear that the damaging effects are a result of t

162 Recently, it has become clear that the frequency of regulatory T cells (T

163 Over the past decade, however, it has become clear that the functions of IL-17 are far more nu

164 ids and sphingolipid metabolites, and it has become clear that the intracellular sphingolipid composi

165 Recently, it has become clear that the mammalian heart is not a post-mito

166 During the last decade, it has become clear that the mammalian immune system is able to

167 Although it has become clear that the morbidities associated with IUGR a

168 Over time, it has become clear that the mucosal immune system in general a

169 It has recently become clear that the pathogenesis of periodontitis is a

170 While it has become clear that the percentage of rhythmic genes varie

171 Furthermore, it has become clear that the performance of PCR-based assays in

172 Since that time, however, it has become clear that the period shifts seen in the early ex

173 In recent times it has become clear that the pharmacology of these receptors is

174 It has become clear that the phosphatidylinositol 3-kinase (PI3

175 It has also become clear that the physiological role of the cuticle

176 advent of superresolution techniques, it has become clear that the plasma membrane is compartmentaliz

177 It has also become clear that the preimmune repertoire contains func

178 It has become clear that the prognosis for infants/children wit

179 pathogenesis at the molecular level, it has become clear that the Rim101 pathway, and pH responses i

180 tructure along the longitudinal axis, it has become clear that the rodent hippocampus can be anatomic

181 Since this initial finding, it has become clear that the role of PKC-theta in T cells is co

182 Recently, it has become clear that the structure and dynamics of clathrin

183 While it has become clear that the structure of cyt c changes, the ex

184 ith the advent of cellular therapies, it has become clear that the success of future therapies in pro

185 More recently, it has become clear that the surfaces of two-stranded coiled co

186 It has become clear that the TME has diminished innate sensing

187 It has recently become clear that the transcriptional output of the huma

188 During the last 10 years it has become clear that the UPS plays a prominent regulatory r

189 y for use in ecological applications, it has become clear that their results differ in significant wa

190 subsets has become much broader, and it has become clear that there are multiple dimensions by which

191 It has become clear that there are substantial interindividual

192 Over the past decade, it has become clear that there is an important subset of memory

193 s an important public health problem, it has become clear that there is an unmet need in regard to tr

194 Importantly, it has become clear that there is significant diversity in the

195 However, it has become clear that these enzymes are also important regul

196 However, it has become clear that these same brain systems are also vuln

197 can be studied in isolation in vitro, it has become clear that these steps are intimately connected w

198 Recently, however, it has become clear that these three processes are not the only

199 dramatically in the past decade as it is has become clear that they are ubiquitous and have a much br

200 Einstein relation, in the past decade it has become clear that they can be independently altered by m

201 Since then, it has become clear that this structure is the site of B cell c

202 It has become clear that to address the complex and interrelate

203 e studies of regulated transcription, it has become clear that traditional definitions of enhancers a

204 It has become clear that WT1 can act as an oncogene in many tum

205 Over the past few years, it has become clear that, at the pathophysiological level, cere

206 In recent years, it has become clear that, in addition to conventional anterogra

207 Over the past 15 years, it has become clear that, like other developmental pathways (e.

208 gher-resolution information, however, it has become clear that, on the molecular level, amyloids comp

209 oncogenic driver mutations is expanding, it becomes clear that alterations in a given gene might hav

210 In this context, it becomes clear that any rational designs of MALDI matrice

211 It now becomes clear that cell metabolism is an integral part o

212 esearch, face precisely this challenge as it becomes clear that practices such as community engagemen

213 easurements with fluorescence microscopy, it becomes clear that SPD tends to align DNA orientation, w

214 It becomes clear that the increase in the density of marker

215 orts from many prominent research groups, it becomes clear that the instability of superoxide in the

216 d structures of macromolecular complexes, it becomes clear that the interactions that involve protein

217 However, it quickly becomes clear that the sequence flexibility allowed a gi

218 equencing data in a phylogenetic context, it becomes clear that there is extensive variation througho

219 It is becoming clear that a radical change of cell identity of

220 Remarkably, it is now becoming clear that adult beta cells retain plasticity a

221 It is becoming clear that alterations to HEV network density a

222 iversity present within the human CNS, it is becoming clear that an understanding of this diversity w

223 It is becoming clear that astrocytes are active participants i

224 It is, however, becoming clear that autophagy may play a key role in reg

225 It is becoming clear that both innate and adaptive immune resp

226 acilitating immune cell responses, it is now becoming clear that cellular metabolism has direct roles

227 ing data become more widely available; it is becoming clear that certain tumors share evolutionary ch

228 Although details remain unknown, it is becoming clear that chromatin is polymorphic depending o

229 It is becoming clear that complex interactions of environment,

230 ntinued use of traditional approaches, it is becoming clear that conditioned fear involves much more

231 However, it is also becoming clear that continued differentiation and specia

232 It is becoming clear that diet, exercise, and other lifestyle

233 e temporal regulation of this pathway, it is becoming clear that disruption of local signalling may l

234 It is becoming clear that epigenetic changes are involved in h

235 lly defined by acute stroke risk, it is also becoming clear that far more subclinical events are occu

236 ions are an increasing population, and it is becoming clear that genetic mutations that cause develop

237 However, it is also becoming clear that germline BRCA1/2 mutations are neith

238 It is now becoming clear that in addition to T cells, B cells can

239 At the same time, it is becoming clear that in many of these data sets in which

240 However, it is becoming clear that in order to accurately measure genet

241 It is becoming clear that many of the existing culture models

242 It is becoming clear that microRNAs, a new class of small regu

243 ophagy has boomed in recent years, and it is becoming clear that mitophagy is a complex and multi-fac

244 It is becoming clear that nervous system development and adult

245 It is becoming clear that OA absorbs light substantially (henc

246 tion of PA needed for mTOR activation, it is becoming clear that PA generated via the LPAAT and DGK p

247 orically seen as a benign disease, it is now becoming clear that Plasmodium vivax can cause significa

248 Therefore, it is becoming clear that PLZF has a broad impact on the immun

249 In conclusion, it is becoming clear that PRS have value in disease risk predi

250 PTMs truly constitute a strict "code," it is becoming clear that PTMs on histone proteins function in

251 It is becoming clear that resilience involves active and uniqu

252 It is becoming clear that retinal glia should not be studied i

253 Although recently discovered, it is becoming clear that rhomboids control many important cel

254 It is becoming clear that risk assessments in the future will

255 g new molecular and imaging approaches it is becoming clear that RNA should be considered an integral

256 portance of small peptide signals, but it is becoming clear that secreted peptide signals are importa

257 It is becoming clear that several human pathologies are caused

258 It is becoming clear that sex differences are not simply refle

259 It is, however, becoming clear that significant pathology, such as micro

260 It is nevertheless becoming clear that silk properties are a consequence of

261 It is becoming clear that specific, well-motivated hierarchica

262 nisms in central excitability, but it is now becoming clear that spinal hyperexcitability can be regu

263 It is becoming clear that structural-maintenance-of-chromosome

264 of gamma-secretase enzymatic activity, it is becoming clear that substrate dimerization and/or the al

265 On the basis of recent reports, it is becoming clear that T cell exhaustion also plays a cruci

266 the current era of complex treatments, it is becoming clear that the "bar" needs to be set higher, wi

267 selection for metabolic synergies and it is becoming clear that the ability of communities to extrac

268 However, it is becoming clear that the biology of glucagon is much more

269 It is becoming clear that the bone morphogenetic protein (BMP)

270 It is becoming clear that the cardiologist needs both to consi

271 It is becoming clear that the cohesin and condensin complexes

272 It is becoming clear that the composition of the individual fa

273 n membrane fusion-and-fission, but it is now becoming clear that the dynamic lipid environment, where

274 It is now becoming clear that the ER chaperones have critical func

275 Second, it is now becoming clear that the human intestinal microbiome is i

276 However, it is becoming clear that the immune system and/or innate immu

277 This is timely because it is becoming clear that the prevalence of the spondyloarthri

278 Moreover, it is becoming clear that the virome is part of a dynamic netw

279 Rather than being used in isolation, it is becoming clear that their value is maximized when they a

280 s of CSU that need to be resolved, but it is becoming clear that there are at least 2 distinct pathwa

281 signals that drive chemotaxis in vivo, it is becoming clear that there is a complex interplay of chem

282 It is becoming clear that there is an enormous diversity of CD

283 However, it is becoming clear that these central programs are further s

284 RNAs previously considered noncoding, it is becoming clear that these initial assumptions are incorr

285 ignificance of DUB-E3 interactions and it is becoming clear that they play important but complicated

286 their function in cell elongation, but it is becoming clear that they play major roles in plant growt

287 g the mechanism of biofilm dispersion, it is becoming clear that this process coincides with alterati

288 ent of long-term parasite elimination, it is becoming clear that transmission models are most useful

289 It is becoming clear that, although spines experience voltages

290 It is becoming clear that, in addition to gene gain, the loss

291 Postoperatively, the cornea became clear, the filtering bleb functioned well, and IO

292 riving forces in SpA pathophysiology are now becoming clear; these data may lead to the development o

293 n era in which the need to control costs has become clear, this situation is undesirable.

294 ple molecular mechanisms for these phenomena become clear through advances in both methods and unders

295 ellular pathways whose collective effect may become clear through the organized structure of molecula

296 the behavior of individual actin regulators becomes clear, we must address why cells require multipl

297 The dependence on alpha7-nAChRs becomes clear when comparing wild-type (WT) mice with mi

298 The importance of this scaling becomes clear when phloem transport is modelled using tu

299 thesis of aryl, vinyl, and alkyl halides, it becomes clear which methods have surfaced as most favore

300 y, the mechanism of this class of enzymes is becoming clear with evidence from multiple recent studie