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1 Modeling the complete actin.myosin ATPase cycle has always been limited by the lack of experimental data concerning key
2 However, its implementation in nanophotonics has so far been limited by the coarse resolution of conventional inkjet-
3 lication of more than a single molecular contrast agent has been limited by MRI's ability to only dynamically measure a s
4 Clinical application of immunotherapeutic approaches has been limited by a lack of target antigens that discriminate m
5 widespread application of this technology in catalysis has been limited by the relatively poor chemical reactivity of no
6 Research into the pathophysiology of these conditions has been limited by the availability of animal and human model sy
7 inhibitors of MBLs are currently unavailable as design has been limited by the incomplete knowledge of their mechanism.
8 the experimental study of cotranscriptional RNA folding has been limited by the lack of easily approachable methods that
10 r potential use as targets for therapeutic intervention has been limited by the lack of tool compounds that can specifica
11 nal physiology, cell biology, and other investigations, has been limited by lack of a robust gene knockout or knock-down
12 LT3 inhibitors in patients with acute myeloid leukaemia has been limited by rapid generation of resistance mutations, par
13 he direct and comprehensive analysis of oxidized lipids has been limited by available analytical methods.
14 mental understanding of the electrodeposition mechanism has been limited by its complexity and is often gained only throu
16 n high surface area oxide supported metal nanoparticles has been limited by less than atomic resolution typically achieve
17 loss of noradrenergic neurons by means of neuroimaging has been limited by the lack of radioligands that are selective f
18 ding of the mechanism of action of CARM1 in oncogenesis has been limited by a lack of selective tool compounds, particula
19 cy virus (HIV) intrahost evolution in AIDS pathogenesis has been limited by the need for longitudinally sampled viral seq
20 Implementation of precision oncology for these patients has been limited by incomplete understanding of the molecular alt
21 driven tool to study culture and society, but its power has been limited by the use of data from books and simple analyti
22 rocedure; however, its integration in clinical practice has been limited by a lack of consensus on how to measure it.
23 ing heat at high temperatures, but liquid-metal pumping has been limited by the corrosion of metal infrastructures.
24 y of solid tumors using antibody-targeted radionuclides has been limited by low therapeutic indices (TIs).
25 or protein, and, by inference, of functional receptors, has been limited by a lack of reliable immunohistochemical eviden
26 been applied in research studies, but its clinical role has been limited by its lack of reproducibility, its lack of a cl
27 Eradication of systemic tuberculosis (TB) has been limited by neglected populations and the HIV pandemic.
29 RA wild-type GIST, including mutant BRAF-driven tumors, has been limited by a lack of model systems.
30 tudinal characterization of early brain growth in-utero has been limited by a number of challenges in fetal imaging, the
31 yme-free, template-directed synthesis of nucleic acids have been limited by 'strand inhibition', whereby transferring inf
32 Current immunotherapeutic approaches have been limited by poor clearance of a core AD lesion, cerebral
33 to understand the initial stages of nanoscale bending have been limited by experimental resolution.
34 generate olefins with high E-selectivity (>99% E) but have been limited by low to moderate yields.
35 strain imaging in patients with ischemic heart disease have been limited by sample size and design.
36 e specialized function, genetic analyses of the family have been limited by the scarcity of loss-of-function phenotypes [
37 neity in patterns of brain development, but frequently have been limited by small samples and analytics that do not evalu
38 Subset analysis suggests that prior studies may have been limited by confounding variables or the technique of ide
39 efits to intracellular drug delivery from nanomedicine have been limited by biological barriers and to some extent by tar
40 characterize sequence-intrinsic activity of promoters have been limited by relatively low throughput and the length of t
41 amination reactions, but the yields of these reactions have been limited by low chemoselectivity for the amination of C-H
42 However, their performance, reliability and stability have been limited by the chemical treatment steps required for the
44 lue of wound outcomes, and culture-independent studies have been limited by cross-sectional design and small cohort size.
45 ever, clinical application of phototriggerable systems have been limited by concerns over phototoxicity of lasers and lim
47 been few controlled studies of these therapies, which have been limited by their small sample sizes; most studies have b
48 Quantifying that response has, however, been limited by the typically coarse temporal resolution (mon
49 al analyses of stem cell-derived cardiomyocytes has largely been limited by biologically undefined factors including 3D n
50 Traditionally, the utility of methyl NMR has often been limited by the difficulty in assigning the methyl resona
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