ライフサイエンスコーパス: begin to

1 n exactly where amyloid-beta (Abeta) fibrils begin to accumulate in individuals with Alzheimer's dise

2 the field is to move beyond correlations and begin to address causation, an effective system is neede

3 factors of bacterial pathogens is one way to begin to address the issue of resistance.

4 To begin to address the mechanism of peripheral CGRP action

5 l for a chlorin to resemble chlorophyll?" To begin to address the structure-spectrum relationship, >

6 To begin to address these issues, ASCO convened two complem

7 To begin to address these issues, we sought to identify T r

8 To begin to address this challenge, we have developed a com

9 To begin to address this gap, we identified GPER/GPR30, a G

10 To begin to address this question, we designed strains of L

11 To begin to address this question, we investigated the mech

12 o engage, with the differences observed here beginning to address how the TAM can be more effective t

13 In this review, we discuss how studies are beginning to address the nature of these niches as well

14 ers build on this early foundation, they are beginning to advance the field towards more fine-grained

15 Recently, various studies have begun to approach this question by comparing brain respo

16 cades ago, when the pioneers of cell culture began to ask questions we still ask today: How does orga

17 We have begun to ask questions about how these cells can be regu

18 e climate science and policy communities are beginning to assess the feasibility and potential benefi

19 "really, really smart." Also at age 6, girls begin to avoid activities said to be for children who ar

20 h Foxp3 and other Treg cell signature genes, began to be activated in Treg precursor cells.

21 ot be easily found without ML, but ML cannot begin to be effective until a sufficient number of insta

22 ologous phenotypes and cell types, which are beginning to be addressed by emerging technologies.

23 in intercellular communication, exosomes are beginning to be appreciated as agents of immunoregulatio

24 nosing the associated outcomes, its value is beginning to be appreciated, and the genomics revolution

25 n capabilities, in therapeutic resistance is beginning to be better understood, the significance of e

26 s of invertebrate tricellular junctions, are beginning to be characterized, many questions remain.

27 High zinc homeostasis mechanisms are beginning to be defined in animals, but low zinc homeost

28 sms that govern glia-mediated regulation are beginning to be discovered, but much remains unknown abo

29 the complexities of its regulation are only beginning to be discovered.

30 cular mechanisms of shell formation are only beginning to be elucidated in Mollusca.

31 Their function in retinal cells is just beginning to be elucidated, and a few have been found to

32 amically regulated in these contexts is just beginning to be elucidated.

33 etabolites in epigenetic regulation are just beginning to be elucidated.

34 ly studied, the role of the thalamus is just beginning to be elucidated.

35 ent of specific viral determinants, are just beginning to be elucidated.

36 glycans influence brain function is only now beginning to be elucidated.

37 psychiatric symptoms and suicidality is only beginning to be explored.

38 ds, scaffolds, and biological activities are beginning to be globally explored, beyond individual app

39 ents underlying this rapid communication are beginning to be identified, such as the ROS producing NA

40 ating immune cell functions in vivo are just beginning to be identified.

41 ologies, and microbiome-based approaches are beginning to be implemented in the clinic for diagnostic

42 hase anion binding applications is only just beginning to be realized in simple acyclic systems.

43 es of human physiology and behaviour is only beginning to be recognised in the field of public health

44 ed, the functional roles of lncRNAs are only beginning to be recognized and the molecular mechanism o

45 t of particulate matter (PM) on the brain is beginning to be recognized.

46 uences of individual m(6)A modifications are beginning to be revealed, but the effects of m(5)C and P

47 an dynamically modulate their shape are just beginning to be revealed.

48 sms responsible for this patterning are just beginning to be revealed.

49 ell and natural killer cell biology are just beginning to be uncovered, accumulating data support the

50 radiation and cytotoxic chemotherapy is just beginning to be understood as a major barrier to therape

51 stimated by fatigued individuals and is only beginning to be understood by scientists.

52 any aspects of optic pathway development are beginning to be understood, the mechanisms promoting the

53 lular bases for cholinergic actions are just beginning to be understood.

54 netic architecture of quantitative traits is beginning to be understood.

55 intracellular proteins in ways that are only beginning to be understood.

56 t their underlying brain mechanisms are only beginning to be understood.

57 ndary structure and RNA conformation is only beginning to be understood.

58 effects of silicone oil on the RPE are only beginning to be understood.

59 munity in the tumor microenvironment is just beginning to be understood.

60 onse to ambient temperature changes are only beginning to be understood.

61 seq) technology is hitting its stride and is beginning to be widely adopted.

62 etween these distinct signal types have only begun to be characterized, and their dynamics during dec

63 However, its role has recently begun to be elucidated.

64 However, this potential has only begun to be explored in pioneering work harnessing DNA s

65 trong spin-orbit coupling have only recently begun to be explored.

66 chano-protective roles of caveolae have only begun to be explored.

67 he possible effects of AbetaOs on astrocytes begun to be investigated.

68 c targets in mammals, nuclear receptors have begun to be studied in parasitic worms, where they are w

69 Dihydrexidine has begun to be tested in patients with schizophrenia or sch

70 the underlying mechanisms have only recently begun to be uncovered.

71 These findings begin to build a picture of the cellular actions underly

72 Sea-level rise is beginning to cause increased inundation of many low-lyin

73 To begin to characterize the B. burgdorferi transcriptome d

74 Here, we begin to characterize the microbiome associated with str

75 Previous work has begun to characterize the conformational and electrostat

76 961, the National Institutes of Health (NIH) began to circulate biological preprints in a forgotten e

77 We have begun to clarify the cellular and molecular mechanisms t

78 ancial burden in 2011, when the coverage gap began to close.

79 netics through Meta Analysis) consortium are beginning to collect data in large quantity and to condu

80 and metastatic outgrowth of cancer cells are beginning to come into view.

81 at the importance of these modifications has begun to come into focus.

82 The year at which AGMT began to consistently exceed that critical temperature w

83 ylserine, the Kd values of all four proteins began to converge.

84 activity-dependent modes of myelination are beginning to crystallize in a model of myelin plasticity

85 erging next-generation sequencing studies to begin to decipher the nature of the heritable contributi

86 1990-2001, atherosclerotic CVD and CAD rates began to decline more rapidly during the 2002-2011 perio

87 oportion of pneumonia caused by pneumococcus began to decline.

88 m tracer levels on Line P and that they will begin to decline in 2017-2018.

89 Abeta40 in the ISF are relatively stable and begin to decline within minutes of blocking Abeta produc

90 The lactulose began to decompose above 180 degrees C.

91 the core body temperature and blood pressure began to decrease as the animals were near death.

92 However, rates began to decrease with the 1960 to 1969 birth cohorts.

93 Together, the findings begin to define molecular checkpoints during development

94 These findings begin to define the selectivity of POMGNT2 and suggest t

95 Clinical studies are beginning to define these factors as immune profiles tha

96 Physiological investigation has begun to define disease subtypes, clarifying heterogenei

97 Molecular analyses have begun to define fetal and adult hematopoiesis, while cel

98 gate systems and biochemistry, the field has begun to define the toolkit Wolbachia use for host manip

99 We begin to delineate the possible role of an increased rat

100 m to a proinflammatory phenotype, and we are beginning to delineate the reciprocal influence of obesi

101 biology are still unclear, recent data have begun to delineate the specialized roles of Tfr cells in

102 Recently, researchers have begun to delve in an idea born decades ago: the desalina

103 Studies have begun to describe the impact of a few pathogenic mutatio

104 and in 2011 after the condition of the boat began to deteriorate.

105 t remain unclear, diseased RP photoreceptors begin to deteriorate, eventually leading to cell death a

106 as MAIT cells are primed by SAgs, they also begin to develop a molecular signature consistent with e

107 n is a highly complex process by which seeds begin to develop and establish themselves as viable orga

108 ice, retinal vascular and astrocyte networks begin to develop at birth, expanding radially from the o

109 In the mid-1990s, my research group began to devise a method to establish endothelial cell c

110 phagocytes, intravascular myeloid precursors began to differentiate into macrophages and dendritic ce

111 pulations become geographically isolated and begin to differentiate genetically.

112 ulations, each of which will be isolated and begin to differentiate genetically.

113 -cell immunoglobulin mucin-3, and CD123 have begun to differentiate MDS HSPCs from healthy counterpar

114 e in hair or feather bud development, we are beginning to discover that multiple mechanisms may, in a

115 To begin to disentangle motor from conceptual contributions

116 However, recent sequencing efforts have begun to dissect the complex genomic landscape of MIBC,

117 d three distinct mitochondrial lineages that began to diverge 1.0-2.0 million years ago (Ma).

118 ST382 appeared to be an emerging clone that began to diverge from its ancestor approximately 32 year

119 However, the BMI curves begun to diverge already at 17.8 years before expected s

120 and humoral hallmarks of type-2 immunity and begin to elucidate a novel mechanism by which it regulat

121 Here we begin to elucidate the mechanisms by which post-traumati

122 osition of dorsal-horn networks, studies are beginning to elucidate the intricate computational logic

123 iRNA biogenesis and modes of action, and are beginning to elucidate the mechanisms of miRNA degradati

124 ing clinical and molecular-based techniques, begins to elucidate the FH heterogeneity and the mutatio

125 Rodent studies have begun to elucidate a role of Cav1.3 L-type Ca(2+) channe

126 wave of quantitative single-cell studies has begun to elucidate how signaling dynamics determine cell

127 Animal models have begun to elucidate how skin barrier defects can lead to

128 Studies of a CHN1 mouse model have begun to elucidate mechanisms of selective vulnerability

129 ut omics profiling, and genome editing, have begun to elucidate plant terpene metabolism, and such in

130 metabolic syndrome, and recent efforts have begun to elucidate the contribution of PGE2 in these eve

131 plant to the fungus and several studies have begun to elucidate the mechanisms that control the plant

132 Studies on the biology of CTCs have begun to elucidate the molecular mechanisms of CTC gener

133 nit activity and stronger gamma oscillations began to emerge.

134 F2 genes, molecularly targeted therapies are beginning to emerge, as a result of a deeper understandi

135 n is still lacking, but important themes are beginning to emerge, primarily in budding yeast.

136 Although the role of 5-LO in tumor cells is beginning to emerge, with the notion that tumor-promotin

137 o cell cycle and environmental cues are only beginning to emerge.

138 esponses and transplant outcomes is only now beginning to emerge.

139 chaeal virus diversity and structure is just beginning to emerge.

140 h high permeability and high selectivity are beginning to emerge.

141 gh resolution structural information is only beginning to emerge.

142 however, applications in nephrology are just beginning to emerge.

143 sequences of such changes for ecosystems are beginning to emerge.

144 ar basis of their mutual regulation has only begun to emerge in plants.

145 However, resistance to these compounds has begun to emerge often months to years after their initia

146 al catalysts to address this deficiency have begun to emerge.

147 distinct instances of necroptosis have just begun to emerge.

148 e general principles of metastasis that have begun to emerge.

149 t picture of their activation mechanisms has begun to emerge.

150 s through each time series sequentially from beginning to end, thus enabling real-time online estimat

151 st that, by the Late Pleistocene, humans had begun to engage in activities that have led to alteratio

152 tacles, novel LRAs are under development and beginning to enter combination testing with viral cleara

153 ticles from the peer-reviewed literature, is beginning to erode the trust of both the scientific comm

154 We found that GFP-expressing newborn cells began to establish a DGC-like morphology at approximatel

155 To begin to evaluate the mechanistic basis for nanI express

156 Therefore, we have begun to evaluate novel AD diagnostic agents that can be

157 Although human infants begin to exhibit disparity-specific responses between 3

158 These populations began to expand in neonatal mice and, upon malignant tra

159 threaten the financial relief patients have begun to experience under closure of the coverage gap in

160 To begin to experimentally address this knowledge gap, we a

161 en we try to influence others, these results begin to explain the biological mechanisms that shape in

162 crophages in the pathogenesis of SIV/HIV and begin to explain why infants are more prone to rapid dis

163 Recent work has begun to explore the function of autophagy in cancer met

164 Recently, researchers have begun to explore the relationship between peripheral BDN

165 isease, only recently have studies of PABPN1 begun to explore the role of this protein in skeletal mu

166 ide into an inner and outer compartment that began to express markers of smooth muscle precursors and

167 ultured TIMP1-activated human and mouse HSCs began to express stromal-derived factor-1, which induced

168 7.06 per 100,000 population in 2008 and then began to fall slightly.

169 Vasopressin levels begin to fall within minutes of water consumption, even

170 To begin to fill this knowledge gap, we assessed the reprod

171 e available with polio funding in Africa and begin to find ways to keep some of the talented staff, i

172 ioned by these experiences, dopamine neurons begin to fire upon the earliest presentation of a cue, a

173 spective on the ways in which this field has begun to flourish.

174 cent years, a growing amount of research has begun to focus on the oral microbiome due to its links w

175 ence that at least some beta-barrel proteins begin to fold before they interact with the Bam complex,

176 Proteins begin to fold in the ribosome, and misfolding has pathol

177 It is here that the nascent chain begins to fold.

178 the most massive structures in the Universe began to form shortly after the Big Bang, in regions cor

179 In 2013 England and Wales began to fund a live attenuated influenza vaccine progra

180 the past seven decades; however, we are only beginning to gain a molecular understanding of the key s

181 A deluge of whole-genome sequencing has begun to give insights into the patterns and processes o

182 dramatically broadened, and researchers have begun to harness new approaches to explore how rodents a

183 clude genetic variation in the pathogen have begun to highlight a potential need to rethink how the f

184 Studies in model organisms are beginning to identify the genes and pathways important f

185 ells are becoming better defined as research begins to identify potential interactions between previo

186 Molecular studies have begun to identify candidate loci, but much of the underl

187 Recent advances in tumor profiling have begun to identify novel genomic features that may influe

188 n to generate pattern, we have only recently begun to identify the biological elements that operate a

189 l concepts of receptor pharmacology and have begun to illuminate the distinct mechanisms by which str

190 y of complementary discovery approaches have begun to illuminate this microbial "dark matter," which

191 These studies begin to illustrate how the complex efferent system of t

192 s, as well as public and private payers, are beginning to implement alternative delivery and payment

193 As a small number of dietary guidelines are beginning to incorporate more general environmental conc

194 flection point (in hours) when complications began to increase was used to define early and delayed s

195 concentrations were observed when discharge began to increase.

196 drome virus (PRRSV) crosses the placenta and begins to infect fetuses.

197 s a revolution in diagnosis, and has already begun to inform increasingly targeted and individualised

198 amp up routine immunization (RI) activities, began to intensify activities to strengthen RI.

199 These results begin to interrogate the functions of NoV proteins durin

200 These considerations have begun to intersect with the decreasing costs and availab

201 ers to study acute social stress, and we are beginning to investigate the genetic mechanisms subservi

202 ollinosis and airborne pollen monitoring has begun to investigate as a causative agent since 1986.

203 Several recent reports have begun to investigate the feasibility of coupling chromat

204 ce and time, but new multiscale knowledge is beginning to link these relationships.

205 roteins that are enriched at the synapse has begun to link autophagy to synapses and synaptic dysfunc

206 ers and interactions in the PAR network have begun to merge with biophysical, theoretical and computa

207 dy sizes, the body size at which individuals begin to migrate, and the seasonal timing of migration a

208 ablish a solid biochemical basis on which to begin to model its actions in cells and animals, we deve

209 s, collection digitization, and imaging have begun to more fully harness the power that such large da

210 In particular, warming begins to negatively impact plant growth at cooler tempe

211 New studies in mice are now beginning to obtain mechanistic insight into how high-fa

212 This research has only begun to parse out contributions of the many neural, end

213 More diverse target audiences began to participate, and mobile components were added t

214 icle articulates what happened when the GPEI began to pay more attention to the dynamics of human and

215 apeutics, but recent chemistry advances have begun to penetrate this evolutionary armor.

216 mation at pH 4.5 largely starts with rA7 and begins to plateau with rA8; another proposed a so-called

217 Nanotechnology has begun to play a remarkable role in various fields of sci

218 cludes mesodermal progenitor cells that have begun to precociously differentiate into cartilage cells

219 ive cultural evolution, and new research has begun to probe the key psychological attributes that may

220 Other studies are beginning to provide insight into how neuronal diversity

221 human synovial fibroblast preparations have begun to provide important new insights into the interpl

222 Imaging genetics and genomics research has begun to provide insight into the molecular and genetic

223 t exploratory and theory-driven methods have begun to pursue these opportunities.

224 ), crown groups Chlorophyta and Streptophyta began to radiate early in the Neoproterozoic (1,000-542

225 However, these methods have now begun to reach their limits.

226 t fusion protein and establish a system that begins to reconstitute mammalian cell fusion.

227 years, northeastern US fish populations have begun to recover in lakes that were historically incapab

228 he direct functionalization of C-H bonds are beginning to reshape the field of retrosynthetic analysi

229 lating data in humans and animal models have begun to reveal aberrant epigenetic modifications in bra

230 complexes with their antiviral function has begun to reveal common principles of critical interactio

231 Recent work has begun to reveal how the viral capsid interacts with spec

232 igations of its functional connectivity have begun to reveal significant differences from other corti

233 experimental and computational studies have begun to reveal the detailed reaction mechanisms and kin

234 These studies have begun to reveal the promising ways in which PARPs may be

235 cently have sophisticated imaging techniques begun to reveal their ubiquity in nature.

236 ly computational nature of social science is beginning to reverse this traditional bias against predi

237 With learning, dopamine concentration began to rise increasingly earlier in the execution of t

238 els, have shown remarkable progress and have begun to rival human performance in some challenging tas

239 EAC cells incubated with ERBB inhibitors began to secrete ligands for the TGFbeta receptor and un

240 Thus, we begin to see how regulatory information encoded at indiv

241 lar design, these calculations have recently begun to see widespread applications in early-stage drug

242 ade, the homologues of a 4-mum-long bivalent begin to separate.

243 structures of nine flagellar filaments, and begin to shed light on the molecular basis of filament s

244 The Journal of Cell Biology and Science have begun to shed light on the mechanism of centriole elimin

245 nt of drugs that are specific to LMS and has begun to shed light on the similarities and possible uni

246 Work conducted in recent years has begun to shed light on the various posttranscriptional c

247 Rising temperatures have begun to shift flowering time, but it is unclear whether

248 The study of the intestinal microbiota has begun to shift from cataloging individual members of the

249 In 2013, the virus began to spread across other parts of Oceania and in 201

250 pparent during "doming," when the blastoderm begins to spread over the yolk sac, a process involving

251 It has been inferred that the AMOC began to strengthen mid-YDS, producing a bipartite struc

252 day (E) 12.5, the mesenchymal precursor pool began to subdivide into an inner and outer compartment t

253 These oscillations begin to subside soon before anaphase onset.

254 oscale devices and bioprinted 3D tissues are beginning to supplant traditional 2D cell cultures and p

255 Therefore, in this work, we have begun to tackle the challenges of EM by introducing addi

256 The US government began to take systematic interest in such misconduct in

257 of these different chemical modifications is beginning to take shape, but it's clear that in both cod

258 in recent years, the catalysis community has begun to take advantage of these features, drawing inspi

259 alth and Welfare of Japanese Governments has begun to take preventive measures against JC pollinosis

260 n recognized for some time, we are only just beginning to test whether WGD affects community context.

261 tu synchrotron diffraction patterns from the beginning to the end of the reaction process.

262 Diagnostic reversals of COPD from the beginning to the end of the study period occurred in 12.

263 juices exhibited strong differences from the beginning to the last step of pressing cycle for numerou

264 ists in providing high-resolution insight is beginning to transform drug discovery efforts, and there

265 New tools, practices, and partnerships are beginning to transform local fisheries, biodiversity con

266 tific output from these efforts has not only begun to transform our understanding of the genetic arch

267 ve therapies for mitochondrial disorders are beginning to translate from bench to bedside along the p

268 oups and genome-wide association studies are beginning to uncover the complex genetic architecture of

269 Research has begun to uncover common mechanisms underlying transmissi

270 However, recent studies have begun to uncover dynamic, active roles for BMs in many d

271 Here we discuss recent findings that have begun to uncover how different parts of the secretory pa

272 Here we have begun to uncover the effects of cytochrome P450 (CYP) 4A

273 years, genome-wide profiling approaches have begun to uncover the molecular programs that drive devel

274 ses on describing examples in which we might begin to understand GxEs on the molecular, cellular, cir

275 To begin to understand how neuronal iron handling might be

276 nto the drivers of population cycles, we can begin to understand the causes of cycle gain and loss, h

277 ared origins of mental disorders and help us begin to understand the mechanisms through which the 'p

278 Therefore, to begin to understand the role of P. stomatis in periodont

279 uman Genome Project, it has been possible to begin to understand the underlying genetics and to use t

280 iological and economic interest, we are only beginning to understand how plants connect and reconnect

281 and super-resolution imaging studies, we are beginning to understand how the ULK1 and PI3KC3-C1 compl

282 chinery within each compartment, we are only beginning to understand how these compartments are struc

283 but after 10 years of investigation, we are beginning to understand how they are organized in the ME

284 We are just beginning to understand how translational control affect

285 We are beginning to understand the connections between QS and b

286 We are only beginning to understand the environmental cues that cont

287 We are now beginning to understand the microbiota-host co-regulated

288 We are also beginning to understand the processes that lead to acqui

289 s is a key cellular process that we are only beginning to understand, mediated by the beta-barrel ass

290 Simultaneously, we have begun to understand the vital importance of splicing in

291 mid and late 1980s, when the chaperone story began to unfold.

292 s viral counterparts, their early history is beginning to unfold.

293 les induced by microbial interactions, as we begin to unravel the complexity of microbial interaction

294 for palate development, recent studies have begun to unravel the extensive cross-regulation of multi

295 vances in preclinical work and genetics have begun to unravel the molecular architecture linking dopa

296 Thus, we have begun to unravel the molecular consequences of the 759G>

297 Nonetheless, translational studies have begun to unravel these distinct pathologies, identifying

298 Recent discoveries, however, are beginning to unveil new components of the inflammasome m

299 To address this problem, we have begun to use an unbiased mass spectrometry-based approac

300 indicate that catalyst reduction capability begins to wane after 5-6 years, 3 times faster than is o