ライフサイエンスコーパス: bell-shaped

1 rrent-voltage (I-V) relationship for ICa was bell shaped.

2 se curve of GRP-stimulated DNA synthesis was bell shaped.

3 3-O-[(R)-3-hydroxymyristoyl]-GlcNAc are both bell-shaped.

4 d probability of having African ancestry was bell-shaped.

5 The V/K(ne) pH profile is bell-shaped.

6 permine, the k(cat)/K(amine)-pH profiles are bell-shaped.

7 second-order rate constants of inhibition is bell-shaped.

8 tes it at low concentrations, resulting in a bell-shaped activation profile.

9 HIV RNase H with Mn2+ or Co2+ ions generated bell-shaped activity dose-response curves.

10 c-Jun exhibits a bell-shaped activity on androgen receptor-mediated trans

11 H253A, K227A, H253A/K227A, and D234N remain bell-shaped, although their significantly lower activiti

12 ociation constant (k(lim)/K(d)) versus pH is bell-shaped and characterized by two macroscopic pK(a) v

13 tion of free enzyme with free cytochrome) is bell-shaped and closely resembles that of kox/Kd(cyt c),

14 he matrix metalloproteinase (MMP) family are bell-shaped and exhibit neutral pH optima.

15 (cat)/K(m) for URI from Escherichia coli are bell-shaped and indicate that one group must be unproton

16 ting with the l(o) phase, the OTP profile is bell-shaped and lies above that in the pure ESM membrane

17 ce of the fast central release component was bell-shaped and similar to that of I(Ca) in both cell gr

18 The pH profile of H224Q sHS is bell-shaped and similar to those reported for other MMPs

19 voltage dependence of the Ca2+ transient was bell-shaped and the maximum was centered at approximatel

20 nd the two components of central release was bell shaped, and the magnitude of each release component

21 citive component as a function of voltage is bell-shaped, and decreases with frequency.

22 Plots of activity versus log [metal ion] are bell-shaped, and the inhibitory phases of the profiles h

23 al evolution of Ca(2+) spark frequencies was bell-shaped, and the maximal spark frequency was reached

24 the data show that the size distribution is bell-shaped, and there is an approximately 40-A differen

25 en to separate the approximately symmetrical bell-shaped areas (negatives) from the skewed tails (pos

26 oM) concentration-response curve for LTP was bell shaped as no enhancement was seen with 30 microM se

27 s for the Y82F enzyme-catalysed reaction was bell-shaped as for the wild-type protein.

28 r PAD in response to 0.1-100 microM 5-HT was bell-shaped but in the capsaicin pre-treated group, a no

29 mutations shifted the peak of the InsP(3)R1 bell-shaped Ca(2+) dependence from 0.2 micro M to 1.5 mi

30 In [3H]ryanodine binding measurements, bell-shaped Ca2+ activation/inactivation curves were obt

31 all three mammalian InsP3R isoforms display bell-shaped Ca2+ dependence in physiological range of Ca

32 y InsP3 without shifting the peak of InsP3R1 bell-shaped Ca2+ dependence.

33 The bell-shaped Ca2+-dependence curve of type I InsP3R is id

34 Ca2+ for all three InsP3R1 isoforms; 3) the bell-shaped Ca2+-dependence is wider for the InsP3R1-SII

35 pS) than the InsP3R1-SII(+) (81 pS); 2) the bell-shaped Ca2+-dependence peaks at 200-300 nM Ca2+ for

36 Bell-shaped cell spreading curves encompassing all subst

37 do not respond to RANTES with the classical bell-shaped chemotactic response curve, suggesting that

38 lution structure reveals an asymmetric, dumb-bell-shaped complex with 4-fold symmetry, a length of 14

39 With these constructs, the bell-shaped concentration dependence of leukocyte migrat

40 tokines like IL-8, and also has the familiar bell-shaped concentration dependence seen for CXC cytoki

41 st-noncompetitive antagonist hybrids produce bell-shaped concentration-response curves, whereas the a

42 response at higher concentrations, producing bell-shaped concentration-response curves.

43 ar Ca2+ and [3H]noradrenaline release with a bell-shaped concentration-response profile; maximum enha

44 The k(cat)/K(m) value for the peptide is bell-shaped, consistent with a requirement that the nitr

45 e-channel Ca2+ current (iCa) rather than the bell-shaped current-voltage (I-V) relation of macroscopi

46 onditions, Hg(II) bioavailability followed a bell shaped curve as DOM concentrations increased, both

47 a coli and Aquifex aeolicus LpxC displayed a bell-shaped curve (EcLpxC yields apparent pKa values of

48 We calculate the bell-shaped curve and show that, if materials can be eng

49 te constant versus pH profiles were fit to a bell-shaped curve for all adducts.

50 PtNHase was found to exhibit a bell-shaped curve for plots of relative activity versus

51 CtNHase was found to exhibit a bell-shaped curve for plots of relative activity vs pH o

52 The acidic pK(a) in the bell-shaped curve is due to the phenolic hydroxyl of Tyr

53 We show that a bell-shaped curve of cleavage activation is obtained as

54 Analysis at different pH values produced a bell-shaped curve of the WT enzyme, but D387G exhibited

55 esulted in mitotic arrest with a symmetrical bell-shaped curve over time.

56 -direction the dependence of kcat of pH is a bell-shaped curve that is described by pKaS of 6.4 and 1

57 distinguishable from the second phase of the bell-shaped curve that was obtained in the absence of ha

58 nectin concentrations tested and shifted the bell-shaped curve upwards.

59 In general, a bell-shaped curve was obtained for each of the MT-MMPs i

60 ergent concentration dependent, exhibiting a bell-shaped curve with its maximum activity near the cri

61 nase (MMP) catalysis is described by a broad bell-shaped curve, indicating the involvement of two uns

62 ct of heparin with all FXa derivatives was a bell-shaped curve, which disappeared if the ionic streng

63 The ANG pH-rate profile is a classic bell-shaped curve, with pK(1) = 5.0 and pK(2) = 7.0.

64 of log k(cat)/K(m) versus pH is a distorted bell-shaped curve, with slopes of +1 on the acid side an

65 at n = 3, and then declines: the result is a bell-shaped curve.

66 cose with a response profile that followed a bell-shaped curve.

67 ing channels as a function of log10(Ca) is a bell-shaped curve.

68 was dosage dependent on the inducer, with a bell-shaped curve.

69 The 'bell-shaped' curve relating cytosolic Ca(2+) concentrati

70 the trough concentrations obtained from the bell-shaped curves are comparable to normal plasma level

71 Apparently corresponding bell-shaped curves displaying the pro-oxidant effect of

72 th log k cat/ K m and log k cat conformed to bell-shaped curves for which an inverse solvent kinetic

73 he mutants as a function of pH display broad bell-shaped curves that are similar to the wild-type enz

74 the pH-dependence of V(max) and V/K describe bell-shaped curves, consistent with the hypothesis that

75 trations (10(-1) to 10(5) units/ml) produced bell-shaped curves, demonstrating that inhibition occurs

76 Instead of the expected narrow bell-shaped cytoplasmic free Ca2+ concentration ([Ca2+]i

77 we show that in contrast to IL-8, where the bell-shaped dependence arises from the effects of CXCR1/

78 rmediate at 505 nm is affected by pH, with a bell-shaped dependence for the forward rate constant, k(

79 Unlike interfering with the bell-shaped dependence of InsP(3)Rs to [Ca(2+)](i), CT9

80 wever, these synthetic lipids give rise to a bell-shaped dependence of membrane permeability on [Chol

81 two p K a values previously observed by the bell-shaped dependence of the LpxC-catalyzed reaction.

82 arcus theory of electron transfer predicts a bell-shaped dependence of the reaction rate on the react

83 ude of the caged ADP tension transient had a bell-shaped dependence on Ca(2+), reaching a maximum at

84 open probabilities for PC-2 and S812A show a bell-shaped dependence on cytoplasmic Ca(2+) but there i

85 centration, whereas the type I isoform has a bell-shaped dependence on cytoplasmic Ca2+.

86 e constants did not exhibit a characteristic bell-shaped dependence on heparin concentration.

87 currents, the membrane capacitance showed a bell-shaped dependence on membrane potential with a peak

88 ve previously shown that MshB activity has a bell-shaped dependence on pH with pK(a) values of approx

89 d to Zn(2+)-LpxC; both metalloenzymes have a bell-shaped dependence on pH with similar pK(a) values,

90 In particular, movement amplitude showed a bell-shaped dependence on stimulus frequency, with a pea

91 tion kinetics, and the noise has a predicted bell-shaped dependence on the activation states of the e

92 er, the rate of charge recombination shows a bell-shaped dependence on the inverse temperature, first

93 2+)](i) transient amplitudes and I(Ca) had a bell-shaped dependence on V(m), but [Ca(2+)](i) reached

94 reasonably well the experimentally observed bell-shaped dependencies of bovine serum albumin or gela

95 y blocked by cobalt, and exhibited a similar bell-shaped dependency on voltage with a peak response a

96 The pH dependence of the activity was bell-shaped, depending on the ionization state of two gr

97 The pH-activity profile was bell-shaped, depending on the ionization state of two gr

98 The pH profile was bell-shaped, depending on the ionization state of two io

99 ially after lavage and were sigmoidal with a bell-shaped derivative function.

100 eric species built from the association of a bell-shaped dimer, a process we characterized by electro

101 ind the Dorsal gradient maintains a constant bell-shaped distribution during embryogenesis.

102 ns exhibit a 60% incidence of diabetes and a bell-shaped distribution of insulin levels as related to

103 f subjects to clopidogrel followed a normal, bell-shaped distribution, with a mean and standard devia

104 doses of 0.1, 0.3 and 1.0 mg/kg, produced a bell-shaped dose response effect on DA efflux in the mPF

105 fic IgE and challenged with Pen a 1 showed a bell-shaped dose response for secretion, with optimal Pe

106 The ORL-1 antagonist also eliminated the bell-shaped dose-response curve for buprenorphine-induce

107 Thus, Cas exhibits an unusual bell-shaped dose-response curve in response to EGF stimu

108 and high concentrations, reminiscent of the bell-shaped dose-response curve obtained for TBS-induced

109 ) versus 5-HT(7) receptors, may underlie the bell-shaped dose-response curve via a mechanism of 'cros

110 he presence of tetrodotoxin, NMDA produced a bell-shaped dose-response curve with stimulation of phos

111 ed the GTPase activity following an inverted bell-shaped dose-response curve, whereas when EF-2 and r

112 uced pMF was dose dependent, but exhibited a bell-shaped dose-response curve.

113 ions in both pMHC affinity and dose produced bell-shaped dose-response curves and different optimal p

114 In addition, two narrow bell-shaped dose-response curves were identified with ma

115 rease in its inhibitory effect, resulting in bell-shaped dose-response curves.

116 tly increased cell proliferation albeit with bell-shaped dose-response kinetics.

117 mber of these analogues were found to have a bell-shaped dose-response profile in the alpha1 beta2 ga

118 tment increased the PKCalpha activity with a bell-shaped dose-response relationship peaking at 10 nM,

119 d each affected the rotational behavior in a bell-shaped dose-response relationship producing increas

120 s 3-5 each affected rotational behavior in a bell-shaped dose-response relationship producing maximal

121 ents but to a lesser extent, indicative of a bell-shaped dose-response relationship.

122 PKCalpha-PLC-phospholipase D (PLD)-mTOR in a bell-shaped, dose-dependent manner requiring the Ca2+ se

123 with the 5' flanking region of Tac1 showed a bell-shaped effect of SDF-1alpha on luciferase activity

124 nct binding sites for halides comes from the bell-shaped effects observed when the second-order rate

125 Extreme values of Psi0 lead to asymmetric, bell-shaped extension-rotation profiles with sharp maxim

126 ed by circular dichroism exhibit reversible, bell-shaped folding and unfolding transitions, implying

127 rofiles for both k(cat) and k(cat)/K(m) were bell-shaped for all of the HDAC isozymes, with pH optima

128 (M)-pH profiles with N(1)-acetylspermine are bell-shaped for all the mutants; the similarity to the p

129 t)/K(m)(L-OSHS) versus pH profile of eCGS is bell-shaped for both reactions.

130 The resistive component is bell-shaped for both voltage and frequency.

131 erating effects on heparin concentration was bell-shaped for ZPI reactions with both factors Xa and X

132 f STIM1, CRAC current was a highly nonlinear bell-shaped function of Orai1 expression and the minimum

133 ies or nonrecombining chromosome region is a bell-shaped function of the mutation rate: at some point

134 ma distribution, which is in contrast to the bell-shaped Gamma distribution when the gene effects wer

135 speed tuning curves of MT neurons should be bell-shaped (Gaussian) as a function of the logarithm of

136 Saturating HCII dependences and bell-shaped heparin dependences of the fluorescence chan

137 In computational models, such a bell-shaped "hill of activity" is commonly assumed to be

138 (R2N)PPn(+*) further show that the symmetric bell-shaped hole distribution distorts and shifts toward

139 merizes via the FAD-binding domain to form a bell-shaped homodimer in solution with a maximal dimensi

140 endence of phasic contraction which was more bell-shaped (i.e. more similar to that of ICa,L) than th

141 Cyclosporine treatment caused bell-shaped improvements in cardiac output, stroke volum

142 The voltage-contraction relationship was bell-shaped in Na+-free solutions (to eliminate the Na+

143 tate concentration-response curves that were bell-shaped in response to either glutamate or AMPA.

144 tionship between contraction and voltage was bell-shaped in the absence of Na-Ca exchange.

145 The time course of D was bell-shaped, indicating it was an intermediate.

146 me modest effects, the shapes of neither the bell-shaped k(cat)/S(0.5)-pH (and related functions) plo

147 The bell-shaped logarithmic GAG dependences fit an obligator

148 rge of the membrane motor is manifested as a bell-shaped membrane potential dependence of the membran

149 trong plasmonic coupling effect, and (iii) a bell-shaped nanostructure that can effectively amplify t

150 ctural units (dialkyammonium groups) in dumb-bell-shaped organic molecules template the assembly of e

151 ore fatty acid synthesis enzymes displayed a bell-shaped pattern of expression between 5 and 13 days

152 males), and, respectively, showed a U- and a bell-shaped pattern with age.

153 rmal eyes and optic nerve crush alone showed bell-shaped patterns of change: approximately 50% below

154 is qualitatively different from the largely bell-shaped patterns typical of EMG activity associated

155 the chemical shift analysis, nonuniform and bell-shaped peak intensity profiles, and limited proteol

156 The concept of bell-shaped persistent neural activity represents a corn

157 ssociated with a rate constant that showed a bell-shaped pH dependence indicative of participation of

158 Furthermore, we conclude that the simple bell-shaped pH dependence of k(cat) and k(cat)/K(m) for

159 The bell-shaped pH dependence of permeability suggests that,

160 Furthermore, the wild-type hydratase shows a bell-shaped pH dependence of the kcat/Km with pKa values

161 o-step mechanism is also consistent with the bell-shaped pH dependence of the reaction rate.

162 In addition, normal bell-shaped pH dependence on the reaction catalyzed by M

163 The bell-shaped pH dependence upon pK(app)'s of 7.1 and 9.1

164 -)(CoA), and V/K(homoserine) all exhibited a bell-shaped pH dependence with apparent pK's of 6.6 and

165 (kcat/Km)app and kred/Kd exhibit comparable bell-shaped pH dependence with pKa values of 6.4 +/- 0.2

166 lated cytochrome c(3+) reduction displayed a bell-shaped pH dependence with the protonation of a grou

167 ecovery to the colored ground state showed a bell-shaped pH dependence, controlled by two pKa values

168 Formation of this complex exhibits bell-shaped pH dependence, with pKa values of 6.5 and 7.

169 ameter klim/Kd for the fast phase exhibits a bell-shaped pH dependence, with two pKa values of 9.3 +/

170 A bell-shaped pH profile and salt concentration dependence

171 s ranging from minutes to hours, exhibited a bell-shaped pH profile for k(bkdn), typical of the pH-ra

172 The simulation data reveal a bell-shaped pH profile for the total helix content, in a

173 he k(cat)/K(M) value for spermine exhibits a bell-shaped pH profile, with an average pK(a) value of 8

174 The k(cat)/K(m) value for BESPM exhibits a bell-shaped pH profile, with pK(a) values of 9.8 and 10.

175 Both bell-shaped pH profiles are quantitatively accounted for

176 pKa values range from 7.0 to 8.7) exhibited bell-shaped pH profiles whose maxima were distinct for e

177 strated that the mutant proteases maintained bell-shaped pH profiles, as well as suicide-inhibitor su

178 finity of MKP3 for oxyanion, and restore the bell-shaped pH rate profile for the MKP3-catalyzed react

179 ysis of bulky polycyclic substrates exhibits bell-shaped pH rate profiles in the absence of ERK2.

180 from RNase A and serve to generate a similar bell-shaped pH versus k(cat)/K(M) profile for RNA cleava

181 Bell-shaped pH versus rate profiles were observed for V(

182 These measurements show bell-shaped pH-rate curves for each enzyme in the presen

183 A bell-shaped pH-rate profile for k(cat) and k(cat)/K(m) i

184 yl phosphate (4NPP), the reaction exhibits a bell-shaped pH-rate profile for kcat/KM indicative of ca

185 bstrate Cdk2-pTpY/CycA, however, did yield a bell-shaped pH-rate profile with a pK(a) of 6.1 for the

186 stingly, Cdc25B does not exhibit the typical bell-shaped pH-rate profile with small molecule substrat

187 gnificant shift in pK(1) to higher pH in the bell-shaped pH-rate profiles (k(cat)/K(m)) for several p

188 Both YopH and Cdc25A exhibit bell-shaped pH-rate profiles for the hydrolysis of mNBP,

189 The existence of bell-shaped pH-rate profiles for the K73A variant sugges

190 ypoxanthine and 1,N(6)-ethenoadenine follows bell-shaped pH-rate profiles, indicating that AAG-cataly

191 a 1 gamma 2S delta constructs resulted in a 'bell-shaped' pH titration relationship.

192 MAD2 complex is cell cycle regulated with a "Bell" shaped profile and peaks at prometaphase.

193 A bell-shaped profile of the observed rate constant for an

194 diates was measured and exhibited an unusual bell-shaped profile over the pH range of 5.0-9.5 with a

195 ate of assembly depends on the pH level in a bell-shaped profile, and two pK(a) values that are in go

196 for isoleucyl 4-cyanothiazolidide yielded a bell-shaped profile, with pK(a)=5.0 and pK(b)=7.6.

197 he pH dependence of the IMPDH reaction shows bell-shaped profiles for kcat and the kcat/Km values for

198 The broad and bell-shaped profiles representing the diversity of the V

199 Bell-shaped profiles were observed for k(cat) and k(cat)

200 Bell-shaped profiles were observed for kcat and kcat/Km

201 en expression for the urease reaction with a bell-shaped rate-pH dependence.

202 Among all nelfinavir-treated patients, a bell-shaped relationship between adherence and the risk

203 The standard view postulates a bell-shaped relationship between adherence to therapy an

204 atients with detectable viremia, there was a bell-shaped relationship between Gag-specific CD4+ T cel

205 A distinct bell-shaped relationship between lung volume and carbon

206 These characteristics produce a bell-shaped relationship between the apparent dissociati

207 ch case, superoxide production had a similar bell-shaped relationship to the reduction state of cytoc

208 A bell-shaped relationship was also observed for the proba

209 tatic conditions, cell migration speed had a bell-shaped relationship with fibronectin concentration.

210 unctional conductance (G(j)), which showed a bell-shaped relationship with junctional potential (V(j)

211 nt of shortening blocked by nifedipine had a bell-shaped relationship with voltage, whereas the "nife

212 We observe an asymmetric, approximately bell-shaped, relationship between the average intracellu

213 Bell-shaped relationships between adherence and resistan

214 te but produced an increase (potassium) or a bell-shaped response (rubidium) with a supercoiled templ

215 nocytes, neutrophils, and macrophages with a bell-shaped response curve in a pertussis toxin-sensitiv

216 e.g. dihydrorhodamine) previously revealed a bell-shaped response to co-generated (*)NO and O(2) flux

217 The activity of the enzyme exhibited a bell-shaped response to divalent cations and pH.

218 Similar bell-shaped results were found when the GRT analysis was

219 at which superoxide oxidation ensued yielded bell-shaped ring currents.

220 elationship in 200 microM cadmium (Cd2+) was bell-shaped, supporting a role of ICa,L rather than VDCR

221 xhibit distinct pH dependence (the former is bell-shaped, the latter sigmoidal), again consistent wit

222 These data generate classic bell-shaped time-constant-potential curves.

223 nd C(20):C(20:3Delta11,14,17)PE, an inverted bell-shaped Tm profile was detected in the plot of Tm ag

224 have shown that the information conveyed by bell-shaped tuning curves increases as their width decre

225 Numerosity-selective neurons showed bell-shaped tuning curves with one of the presented nume

226 ivities of large populations of neurons with bell-shaped tuning curves.

227 of episodes, each consisting of a distinct, bell-shaped velocity profile (submovement) that rarely o

228 pear to be consistent with the arm-referent, bell-shaped, visual target tuning curves and target sele

229 A bell-shaped voltage dependence and modest sensitivities

230 hannel current (I(Ca)), and it shifted their bell-shaped voltage dependence leftward by approximately

231 -cAMP, membrane-permeable form of cAMP), the bell-shaped voltage dependence of cytosolic Ca2+ transie

232 ISO dramatically broadened the bell-shaped voltage dependence of intracellular Ca(2+) t

233 Confocal imaging revealed that the bell-shaped voltage dependence of SR Ca(2+) release is a

234 ials and the I-V relationship maintained its bell-shaped voltage dependence.

235 nd total amount of released Ca2+ exhibited a bell-shaped voltage dependence.

236 mplitude of the Ca2+ transient also showed a bell-shaped voltage dependence.

237 plitude of the Ca2+ transient again showed a bell-shaped voltage dependence.

238 ntraction in physiological [Na+] and a broad bell-shaped voltage-contraction relationship was observe

239 K(+)-based, Na(+)-free solution exhibited a 'bell-shaped' voltage dependence of the L-type Ca2+ chann

240 in's voltage sensor imparts a characteristic bell-shaped, voltage-dependent nonlinear capacitance (NL

241 tinociception display ceiling effects or are bell shaped, which have been attributed to the partial a

242 The V profile is bell shaped with slopes of 1 and -1, giving pKa values o

243 voltage dependence of phasic contraction was bell-shaped with 0 Na+, became much loss bell-shaped wit

244 was bell-shaped with 0 Na+, became much loss bell-shaped with 10 mM Na+ and with 20 mM Na+ the phasic

245 We found that the distribution is nearly bell-shaped with a peak at 50 base pairs (bp) upstream o

246 The (catR)/ versus pH profile of ytCBS is bell-shaped with a pH optimum of 8.3, and the pK(a) valu

247 The pH-k(cat) profile is bell-shaped with a pK(a) of 6.4 +/- 0.1 for the ascendin

248 he pH dependence of k(cat)/K(m,phosphite) is bell-shaped with a pK(a) of 6.8 for the acidic limb and

249 ip (assessed 45 min after DPAT injection) is bell-shaped with an ED50 approximately 1 mg/kg on the as

250 The pH dependence of V/K was bell-shaped with apparent pKs of 6.5 and 8.3.

251 By contrast, the doxorubicin response was bell-shaped with high doses failing to increase H2AX pho

252 The activity dependence on pH was bell-shaped with highest activity between pH 6.8 and pH

253 ate 2b, which lacks a 6-carboxyl group, were bell-shaped with limiting slopes of unity on both sides

254 dase activity and beta-lactam acylation were bell-shaped with maximal activity at pH 8.0-8.5.

255 tionship predicted by the CICR hypothesis is bell-shaped with no contraction at ECa.

256 profile of V/K for L-ribulose 5-phosphate is bell-shaped with pK values of 5.94 and 8.24.

257 the substrate Abz-LPETG-Dap(Dnp)-NH(2) were bell-shaped with pK(a) values of 6.3 +/- 0.2 and 9.4 +/-

258 versus pH profiles with and without CaM were bell-shaped with the ionization of a group at pK(a) of 7

259 ons in LiCl with and without MgCl2 were both bell-shaped with the pH optima in the neutral range.

260 or the observed first-order rate constant is bell-shaped with two ionizable groups of pK(a) 4.9 and 5

261 aF/F versus voltage curve, from sigmoidal to bell-shaped, with a maximum at approximately +30 mV.

262 taining a pro-alpha factor cleavage site was bell-shaped, with a maximum near pH 4.0.

263 (III) as a function of SCN- concentration is bell-shaped, with a trough comparable with normal SCN- p

264 pH dependence of kcat/Km for L-kynurenine is bell-shaped, with apparent pKa's of 6.25 +/- 0.05 on the

265 e of kcat/Km for 3-hydroxykynurenine is also bell-shaped, with apparent pKa's of 6.49 +/- 0.07 and 8.

266 rves for these T-cell activation markers are bell-shaped, with different maxima and midpoints, depend

267 The plot of log k(cat)/K(m) versus pH is bell-shaped, with fitted pK(a) values of 6.76 +/- 0.09 a

268 The k(cat)/K(sarc) pH profile is bell-shaped, with pK(a) values of 8.8 and about 10; the

269 against Ac2-l-Lys-D-Ala-d-Ala (kcat/Km) was bell-shaped, with pKa values at 6.9 and 10.1.