ライフサイエンスコーパス: bench

1 evaluated using waterborne simazine as test bench.

2 es have been performed at a real engine test bench.

3 insisting on reserving their own time at the bench.

4 have little or no time left for work at the bench.

5 an identify further models to examine at the bench.

6 young researchers to not stay away from the bench.

7 But can cell biologists think outside the bench?

8 rified each of the L1RAD events by using wet-bench analyses.

9 while catalyzing new hypotheses both at the bench and at the bedside.

10 s investigators move from the bedside to the bench and back again.

11 e lung injury (TRALI) through the bedside to bench and back to the bedside model.

12 robably bridge the translational gap between bench and bedside in the near future.

13 of risk factors to AF pathogenesis from both bench and bedside studies.

14 studies between DNIC and CPM, gauged between bench and bedside, are key for the development of analge

15 science, focusing on transitions between the bench and bedside.

16 es of fastidious anaerobes inoculated on the bench and held at ambient or refrigerator temperature fo

17 with high viability, can be performed on the bench and is applicable to virtually all genetic and non

18 ng the crosstalk between the bedside and the bench and leading to improved patient management paradig

19 ence communication and outline an agenda for bench and social scientists--driven by current social-sc

20 approaches to neuroendocrinology both at the bench and the bedside.

21 entions as they traverse the gap between the bench and the bedside.

22 onments, researchers often need to leave the bench and venture into the field.

23 ameworks for bringing molecular imaging from benches and small-animal laboratories to large-animal su

24 y that requires functional validation at the bench, and point towards a more complete understanding o

25 s validated by experimental data from both a bench- and a large-scale MDC system.

26 onella and mycobacteria across a transect of bench- and pilot-scale hot water experiments carried out

27 treatment, exemplifying a successful bed-to-bench-and-back approach.

28 Third, at the bench, antibody-dependent and antibody-independent mecha

29 al practice using a specimen-based, bench-by-bench approach.

30 FICANCE STATEMENT We have used a "bedside-to-bench" approach to investigate the functional regulation

31 se pharmacology, also called the "bedside to bench" approach, that deals with new uses for a well kno

32 lipoprotein metabolism through classical wet bench approaches.

33 n combined fine-mapping, bioinformatics, and bench-based approaches to functionally characterize all

34 h experience in clinical, translational, and bench-based research in fibrotic lung diseases was conve

35 ues, the understanding of which will aid the bench biologist in analysing omics data.

36 features that can be accessed and updated by bench biologists and bioinformaticians in ways that are

37 The tools are intended for use by bench biologists as well as bioinformaticists.

38 This leaves bench biologists with the complex and unscalable task of

39 onal resources are increasingly available to bench biologists, tailored ongoing education is necessar

40 gene expression compendia into the hands of bench biologists.

41 Second, the Drupal Bioinformatic Software Bench (biosoftware_bench) allows for a rapid and secure

42 e in actual practice using a specimen-based, bench-by-bench approach.

43 eneration of causal research conducted using bench, clinical, and population strategies.

44 Our first bench comparison of susceptibility of different stent de

45 This bedside-to-bench concept has not been explicated in psychiatry, alt

46 Noting the paucity of wet-bench data regarding combinatorial effects of ABA and in

47 This wide gap between bench discoveries and clinical applications is mainly be

48 oRNAs targets, how one goes from the initial bench discovery to actually developing a therapeutically

49 Using a bench dynamometer, the emissions from the following mixt

50 imental methods, which are not only prone to bench effects and artifacts but are also time-consuming,

51 In "Bedside to Bench", Eric Nestler discusses two trials of individuals

52 unct to the time consuming and expensive wet bench experiments necessary to discover new drug therapi

53 o-gene influences and subsequently to design bench experiments to confirm these network predictions.

54 study, we combined mathematical models with bench experiments to identify a core regulatory circuit

55 nge of in silico functional analyses and wet bench experiments, our findings highlight new biological

56 oration to advanced analysis of results from bench experiments.

57 translation: the initial studies translating bench findings to the first patients (T1) are connected

58 h in situ borehole measurements collected on Bench Glacier, Alaska, reveal numerous water-filled basa

59 However, to date, the "genomic bench" has not worked itself to the clinical thrombosis

60 ides as an example where improvements at the bench have been inspired and validated using single-mole

61 It works on a laboratory bench, in air, in the terrestrial magnetic field and amp

62 o) conditions identical to the catalyst test bench including the presence of water vapor.

63 Interventions: The Friendship Bench intervention comprised 6 sessions of individual pr

64 barriers to moving lead candidates from the bench into developmental programmes before clinical test

65 nt of N2 (delta(15)N2) was monitored via gas bench isotope ratio mass spectrometry (GB-IRMS) for 21 d

66 In Bedside to Bench, Maria Kleppe and Ross L. Levine look at recent cl

67 ostdischarge mortality was 50%, a prognostic bench mark for hospice referral.

68 ying capacity of the cornea, and a potential bench mark for validating theoretical modelling of stres

69 monic NPs under physiological conditions, as bench-marked against the well-established PEG ligands.

70 Rate theory modeling, bench-marked against this data, suggests a crucial role

71 Computed and optical-bench-measured point spread function (PSF) and glare sou

72 s to the bedside requires more study in both bench models and patients.

73 Bench models of coronary bifurcation lesions demonstrate

74 the population can also be translated to the benches of laboratory science.

75 form for titrations either on the laboratory bench or for in situ measurements in environmental or di

76 ated manufacturing techniques, and extensive bench, pre-clinical, and clinical testing, lead failure

77 ee sets of 12 repetitions of four exercises: bench press, dumbbell curl, dumbbell squat, and standing

78 A bench prototype system based on this scheme was previous

79 In 'Bedside to Bench,' Rachel Larder and Stephen O'Rahilly peruse a hum

80 Effective treatments indicate areas for bench research on the mechanisms of the disorder.

81 critical appraisal, or based on physiology, bench research, or first principles-National Health Serv

82 boratories, it is a significant task for the bench researcher to routinely identify available dataset

83 uinone (DBBQ), were treated using a modified bench scale collimated beam device, mimicking UV treatme

84 At bench scale, waters were exposed to lignite or bituminou

85 With modeling, and experiments at both bench-scale and field-scale, we demonstrate that reducin

86 of experiments were conducted with parallel bench-scale AS reactors treating municipal wastewater wi

87 In bench-scale batch and column experiments, anion exchange

88 as subsequently obtained by cultivation in a bench-scale bioreactor.

89 Bench-scale coagulation/flocculation/sedimentation simul

90 We report a three-stage bench-scale column extraction process to selectively ext

91 developed and validated using data from the bench-scale DCMD treatment of synthetic wastewaters.

92 water collected from Long Island Sound in a bench-scale direct contact MD system to investigate the

93 Bench-scale experiments and physiochemical property pred

94 This outcome emphasizes the importance of bench-scale experiments in realistic water matrices.

95 Bench-scale experiments were carried out for 24 h using

96 Bench-scale experiments were performed to evaluate virus

97 The approach integrated bench-scale experiments, an in situ spectroscopic techni

98 The sludge was then incinerated on a bench-scale fluidized bed reactor in a series of experim

99 Subsequently, a bench-scale fluidized-bed reactor was developed, applyin

100 We used a bench-scale flume to study the fate of 19 parent pharmac

101 Quantifying the performance of the bench-scale gas recovery system in terms of its ability

102 was validated with mesocosm experiments, and bench-scale hydroponic measurements were performed to de

103 Bench-scale jar tests demonstrated that both MeI-treated

104 Bench-scale jar tests using three different source water

105 ication conditions were identified following bench-scale liquid hot water pretreatment.

106 Bench-scale MB prototypes were constructed from commerci

107 We use a bench-scale prototype machine to synthesize graphene on

108 The integrated continuous bench-scale reactor system produced 18 g/L of C16-C18 tr

109 omparison, we studied biofilm formation in a bench-scale reverse osmosis (RO) system using the same f

110 Using kinetic modeling and bench-scale RO experiments, we demonstrate that the low

111 A was thermochemically treated with PVC in a bench-scale rotary furnace in order to remove heavy meta

112 ng a continuous stirred reactor coupled to a bench-scale sequencing batch reactor, we observed sustai

113 This bench-scale study evaluated the influence of dissolved m

114 In this bench-scale study, arsenic mobilization from arsenopyrit

115 identify biocake proteins on membranes in a bench-scale submerged membrane bioreactor (MBR).

116 el processes that govern solvent behavior to bench-scale testing, through process engineering and pro

117 conditioning (HVAC) systems were measured in bench-scale tests using 10 and 17 cm(2) coupons over 24

118 This report describes results of a bench-scale treatability study to evaluate the efficacy

119 st two taxa of marine phytoplankton grown in bench-scale, batch cultures: the diatom, Pseudonitzshia

120 eductant has been extensively studied at the bench-scale, but due to technical challenges it has only

121 bioinformatician doing gene prediction or a bench scientist designing primers for PCR.

122 not only serve as an excellent reference to bench scientists testing for new interactions but also t

123 ines in CpG, CHG and CHH context and enables bench scientists to visualize and interpret their methyl

124 It is widely used by bench scientists, bioinformaticians, computer scientists

125 s for further verification and validation by bench scientists.

126 laboratory medicine specialists, nurses, and bench scientists.

127 lows, challenging its adoption by nonexpert, bench scientists.

128 ally available data by both 'in silico' and 'bench' scientists.

129 ogenetic protein-2 (rhBMP-2) in a laboratory bench setting and air-dried induce relevant bone formati

130 web portal has been developed that provides bench-side biologists easy access to the server-side com

131 In 'Bedside to Bench', Simone Hettmer and Amy J. Wagers examine the imp

132 In the bench simulation of concrete processing, only 0.4-0.5% o

133 of particular benefit to laboratories where bench space is at a premium.

134 ot, two-step neopentylglycolborylation, this bench stable and inexpensive Ni(II)-based catalyst can b

135 e, thienyl di-MIDA boronate esters represent bench stable and low toxicity alternatives to highly tox

136 ed phosphine 1 with K(2)PtCl(4) afforded the bench stable complex 3 which upon treatment with Ag[CB(1

137 ed by electrophilic C-H borylation producing bench stable crystalline solids in good yield and excell

138 se of benzimidazolium hydrogen carbonates as bench stable solid precursors for the preparation of NHC

139 formation developed herein utilizes entirely bench stable starting materials, including organotrifluo

140 t, and efficient method for the synthesis of bench-stable 3-isoquinolone MIDA boronates.

141 Alkyl oxalates are new bench-stable alcohol-activating groups for radical gener

142 of aldehydes and amines through the use of a bench-stable allyldioxaborolane.

143 alyzed generation of aryl electrophiles from bench-stable amides with potential applications for a br

144 ducts is possible with TMS(2)MIDA, to afford bench-stable and easily isolable MIDA-boronates in moder

145 The transformations utilize the inexpensive, bench-stable catalyst NiCl(2)(PCy(3))(2) to furnish biar

146 ethyl)phenyl)boronic acid as a highly active bench-stable catalyst.

147 romides as well as allylated indoles using a bench-stable Co(III) catalyst.

148 nation of nitriles to primary amines using a bench-stable cobalt precatalyst under 4 atm of H2 is rep

149 A modular and bench-stable diazaphospholane ligand enables highly enan

150 cially available aluminum hydride DIBAL-H or bench-stable Et3 AlDABCO as the catalyst and H-Bpin as b

151 The optimal method, using the bench-stable ferroceniumboronic acid salt 1 in hexafluor

152 us methods for this transformation have used bench-stable fluorine atom sources; however, many still

153 The bench-stable fluoroborate salts of all catalysts (1F-4F)

154 on to nitriles and isolated as corresponding bench-stable hydrochloride salts.

155 In this reaction, a bench-stable hydroxylamine derivative is used as the ami

156 Using the recently reported bench-stable imidazole-1-sulfonyl azide as diazotransfer

157 This approach yields bench-stable intermediates and avoids many of the functi

158 nes has been developed using a highly active bench-stable iron(II) precatalyst to give alpha-aryl car

159 Here, we demonstrate the use of bench-stable N-H and N-alkyl oxaziridines derived from r

160 as condensed with Ellman's reagent to form a bench-stable N-tert-butanesulfinyl imine 6, which served

161 At room temperature a readily accessible bench-stable Ni(II) precatalyst is highly active and can

162 A representative number of bench-stable nonsymmetric diarylcarbenium tetrafluorobor

163 rifluoroborate salts, providing a variety of bench-stable organoboron building blocks for downstream

164 thiane, heteroaryl, and aryl derivatives) as bench-stable organometallics that can be readily utilize

165 nprotected thienylsulfonamides from air- and bench-stable organotrifluoroborates in the absence of a

166 A bench-stable potassium trifluoroborate enol ether reagen

167 earth metal BINOLate complexes that serve as bench-stable precatalysts for Shibasaki's REMB catalysts

168 In addition, it utilizes bench-stable reagents, is operationally simple, shows hi

169 Readily prepared and bench-stable rhodium complexes containing methylene brid

170 The crystalline, bench-stable siloxane transfer agent (1) is easily prepa

171 DMMN is a commercially available, bench-stable solid.

172 These azulene sulfonium salts are bench-stable species that may be employed as pseudohalid

173 We now describe the preparation of bench-stable splice modulators by adapting carbohydrate

174 The optimized process uses a bench-stable succinimide-based Pd precatalyst (FurCat) t

175 (trimethylsilyl)toluenes reagents, which are bench-stable surrogates of benzyl anions and alpha-silyl

176 oromethyl N-tert-butanesulfinyl hemiaminals, bench-stable surrogates of trifluoromethyl ketoimines, p

177 rom the use of readily available alkynes and bench-stable tosylhydrazones, which are easily prepared

178 adium system is inexpensive, easy to handle, bench-stable, and effective in catalysis in the presence

179 This report introduces readily available, bench-stable, cheap, and benign N-acylsaccharins as aryl

180 This 'portable desaturase' (Tz(o)Cl) is a bench-stable, commercial entity (Aldrich, catalogue numb

181 ng alkyl tosylate coupling partners that are bench-stable, crystalline solids that can be prepared fr

182 A bench-stable, hydroxy-bridged alpha-diimine-Pd dimer can

183 ul sp(3)-sp(3) coupling technology that uses bench-stable, native organic functional groups, without

184 d these reagents lead to a variety of useful bench-stable, synthetic intermediates.

185 The computational and wet-bench strategies can be applied to the reference genome

186 , allowing the seamless incorporation of wet-bench structural information from chemical probes and/or

187 al dysfunction and arrhythmia as reported in bench studies.

188 neys can be considered suitable grafts after bench surgery to remove the tumor.

189 Real-time monitoring in the bench system indicated that high temperature and moistur

190 murine model allows researchers to actually bench test and evaluate, in preclinical studies, the eff

191 We bench-tested APP2 on ~700 3D microscopic images and foun

192 The platform bench tests involved OFETs integrating phospholipids and

193 a durable, solar-powered air monitoring park bench that measures real-time ozone, PM2.5, and meteorol

194 latacept, have made the progression from the bench, through nonhuman primate studies and into the cli

195 It takes <12 h of bench time over a 4-d time period, and it generates up t

196 he time required, this protocol takes 20.5 h bench time to complete.

197 )]PF6 in >1 g quantities in less than 5 h of bench time.

198 rspective on the transition from life at the bench to an editorial career.

199 al disorders are beginning to translate from bench to bedside along the paths of neuroprotection, gen

200 over the whole translational spectrum (from 'bench to bedside and back again') with recognition that

201 gineering, very few products have moved from bench to bedside and effective therapy remains lacking.

202 ilitating the development of treatments from bench to bedside are included.

203 on of targeted molecular imaging agents from bench to bedside is currently a slow process, with a cle

204 Translation of novel therapies from bench to bedside is hampered by profound disparities bet

205 Thus, no new treatment has made it from bench to bedside since tissue plasminogen activator was

206 re of a clinical reality through the ongoing bench to bedside transition, research in this field must

207 ress disorder that have been developed via a bench to bedside translational model.

208 An interdisciplinary, bench to bedside translational research approach is cruc

209 research is typically used to refer both to "bench to bedside" research, in which preclinical researc

210 In "Bench to Bedside", Jennifer Warner-Schmidt peruses recen

211 In 'Bench to Bedside', Joel R. Chamberlain and Jeffrey S. Ch

212 e extended to the clinical research setting (bench to bedside) and then to clinical practice and even

213 o has become a prototype for transition from bench to bedside, culminating in the development and cli

214 In Bench to Bedside, Kornelia Polyak peruses studies that u

215 nslation of new liposomal nanomedicines from bench to bedside, new cost-effective and scalable produc

216 To view this Bench to Bedside, open or download the PDF.

217 In 'Bench to Bedside,' Keval Chandarana and Rachel Batterham

218 arkable speed with which these can move from bench to bedside.

219 or, which allowed moving this biomarker from bench to bedside.

220 tate the application of this technology from bench to bedside.

221 in the transition of stem cell therapy from bench to bedside.

222 rn which therapeutics can be translated from bench to bedside.

223 -TB agents may decrease time and effort from bench to bedside.

224 ailures to translate disease treatments from bench to bedside.

225 these candidate therapeutics has moved from bench to bedside.

226 poietic cell therapies from human PSCs from "bench to bedside."

227 torical perspective on CRT's evolution from "bench to bedside." We also comment on the task faced by

228 ety for Nutrition hosted the symposium "From bench to bedside: novel therapeutic advances through the

229 oad areas: translation of new knowledge from bench to bedside; design and conduct of clinical trials;

230 determInantS of cardiovascular disease: from bench to beyond-Premature Acute Coronary SYndrome), a pr

231 gents and pesticides has progressed from the bench to clinical trial.

232 ion of new best practice advice from science bench to field, and ideas for future work and directions

233 t different development stages, from the lab bench to phase III clinical trials to clinical practice.

234 strategies for tolerance induction from the bench to the bedside and discuss the mechanisms by which

235 s, genomic medicine has been moving from the bench to the bedside throughout all medical disciplines

236 Research in critical care extends from the bench to the bedside, involving multiple departments, sp

237 n order to rapidly move translation from the bench to the bedside, we believe that cooperative resear

238 isease (aGVHD) have been translated from the bench to the bedside.

239 me of the major obstacles to moving from the bench to the bedside.

240 at novel agents use, as they evolve from the bench to the bedside.

241 acial tissue engineering from the laboratory bench to the chair side.

242 challenges in translating findings from the bench to the clinic.

243 ng with efforts to move geroscience from the bench to the clinic.

244 w of products from the producer's laboratory bench to the end users, and what can be done about it?

245 g products have already stepped from the lab-bench to the market.

246 tion of L-NVs, favouring their step from the bench to the market.

247 ent of neurotherapies must continue from the bench to their ultimate place at the bedside.

248 d biomarkers exist for either, which impedes bench-to-bedside approaches.

249 In this article, we review the bench-to-bedside journey of natalizumab, along with the

250 are in preclinical testing for FXS; however, bench-to-bedside plans for the clinic are severely limit

251 e potential of systems biology to facilitate bench-to-bedside research and create novel strategies to

252 e, pioneers of this new drug class provide a bench-to-bedside review on preclinical validation of IDO

253 Here, we discuss how the tried and true bench-to-bedside strategies resulted in some spectacular

254 human health and disease, exemplified by the bench-to-bedside success of Jak inhibitors ('jakinibs')

255 yeloma (MM) is a remarkable example of rapid bench-to-bedside translation in new drug development.

256 Successful bench-to-bedside translation of nanomedicine relies heav

257 Challenges exist in bench-to-bedside translation, but they are not insurmoun

258 ivo and represents a promising candidate for bench-to-bedside translation.

259 inical grade CAR(+) T cells is an example of bench-to-bedside translational science that has been acc

260 e most critical bottlenecks in translational bench-to-bedside tumor biology research.

261 The translation of these "bench-to-bedside" findings into new therapeutic strategi

262 Through an iterative bench-to-bedside-and-back process, methods to efficientl

263 This direction is called bench-to-bedside.

264 now given at several universities about the bench-to-newsroom career path.

265 A bench-to-patient approach, mostly descriptive and "looki

266 ression pattern with the one observed on the bench top or to display expression patterns of interest

267 the last decade as it has transitioned from bench top science to applied technology.

268 Here we present the use of high-resolution bench top-based infrared microspectroscopy to investigat

269 coffee authenticity using low-field (60MHz) bench-top (1)H NMR spectroscopy.

270 atial mapping of molecular orientation using bench-top apparatus, enabling a rational approach toward

271 essing equipment and can be performed on the bench-top as a clean-room environment is not required.

272 ns for optimization of biological processes, bench-top characterization of these extended structural

273 enough to replace their bulky and expensive bench-top counterparts.

274 In bench-top experiments using an external illumination int

275 Animal studies, bench-top experiments, and computational modeling were i

276 Compared to the bench-top implementations, the integrated Pound-Drever-H

277 LEBS signals were recorded through a bench-top instrument.

278 e is equal to that obtained with traditional bench-top instrumentation.

279 Next, we present LOC counterparts for those bench-top instrumentations.

280 Current bench-top interferometers operate in the near field with

281 ental results, when compared to conventional bench-top manual assays, reagent consumption was signifi

282 Bench-top methane production tests of shale core and pro

283 First, we review the essential bench-top neuroscience instrumentation as per their func

284 itivity and specificity potentially rivaling bench-top optical systems.

285 us, the Genisys4 provides a small, efficient bench-top preclinical PET alternative for quantitatively

286 The Genisys4 is a small bench-top preclinical PET scanner designed to enable ima

287 f the Negishi coupling), including a one-pot bench-top protocol using an air- and moisture-stable bis

288 In our era of bench-top sequencers and unprecedented computational pow

289 orphology with resolution similar to that of bench-top SHG microscopy.

290 phone spectrometer is comparable to existing bench-top spectrometers in terms of stability and wavele

291 The immunoassay was performed on a bench-top system that fulfilled all the necessary charac

292 in challenge in the transition from previous bench-top systems to a preclinical scanner are phase art

293 The key advantages of using this bench-top, rapid, process development tool are the flexi

294 ials were discouraging, requiring bedside-to-bench translation and functional reevaluation of the dru

295 n also be performed at the molecular biology bench using typical reagents and procedures.

296 el bioinformatics approach combined with wet bench validation to identify gene networks associated wi

297 pretrial and posttrial relief rulings, and 1 bench verdict.

298 These consisted of bench, virtual reality, and cadaveric models.

299 The entire system is assembled on the lab bench, without the need for cleanroom facilities.

300 ed here, which involves approximately 4 d of bench work, is optimized for the study of mammalian cell