ライフサイエンスコーパス: benzenesulfonamide

1 nd developed a series of molecules (thiazole benzenesulfonamides).

2 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide.

3 ising from 3-((9H-purin-6-yl)amino)-N-methyl-benzenesulfonamide (1) is disclosed along with fundament

4 When two molecules of a benzenesulfonamide (1) were bound simultaneously to one

5 hiazol-2-yl)thio)phenyl)-4-(trifluorome thyl)benzenesulfonamide (1, T2384) revealed two orthosteric p

6 1-aryl-3,4-dihydro-1H-isoquinolin-2-carbonyl)benzenesulfonamides (23-33) was designed.

7 th 4-(3,4-dihydro-1H-isoquinoline-2-carbonyl)benzenesulfonamide (3) (PDB code 4Z1J ), a novel series

8 4-(4-fluorophenyl)-5-hydroxy-2H-pyrazol-3-yl]benzenesulfonamide 31 template readily synthesized from

9 ber (4-[125I]iodo-N-[2-(1'-piperidinyl)ethyl]benzenesulfonamide, 4-[125I]IPBS) was accomplished in hi

10 -([1,1'-biphenyl]-3-yl)-9H-purin-2-yl)amino) benzenesulfonamide (73) that exhibited high potency towa

11 -II) analyte and immobilized 4-(2-aminoethyl)benzenesulfonamide (ABS) ligand display a 100-fold (20 d

12 rbonic anhydrase inhibitors, 4-(2-aminoethyl)benzenesulfonamide (AEBS) and 4-aminobenzensulfonamide (

13 single molecule, 4-methyl-N-9H-xanthen-9-yl-benzenesulfonamide (AH-7614), has been described as an F

14 e) and its elaboration by introduction of C4-benzenesulfonamide and C7- and C8-7-deazapurine substitu

15 Benzenesulfonamide and carbonic anhydrase have been chos

16 Benzenesulfonamide and iminodiacetate (IDA)-conjugated C

17 hydrase-II (hCA-II) as the enzyme source and benzenesulfonamide and its derivatives as inhibitors.

18 onic anhydrase and vancomycin to immobilized benzenesulfonamide and N-alpha-Ac-Lys-D-Ala-D-Ala groups

19 4-(Trifluoromethyl)benzenesulfonamide and N-bromosuccinimide were used as t

20 ions of series of ligands containing coupled benzenesulfonamide and oligoethylene glycol moieties (H2

21 rafts reaction of 4-methyl-N-(pent-4-yn-1-yl)benzenesulfonamides and aldehydes in good yields.

22 asses consisting of N-[2-(diethylamino)ethyl]benzenesulfonamides and N-[2-(diethylamino)ethyl]benzene

23 carbonic anhydrase fusion protein that binds benzenesulfonamides and that also includes the RGD pepti

24 d carboxamido substituted 3-(1H-indazol-3-yl)benzenesulfonamides are potent TTK inhibitors.

25 l)-3-(1-methylpiperidin-4-ylamino)-4-methoxy benzenesulfonamide as potent and selective 5-HT(6) recep

26 ies of cyclohexylamine- and piperidine-based benzenesulfonamides as potent and selective Nav1.7 inhib

27 -methyl]-phen yl}-4-nitro-3-trifluoro-methyl-benzenesulfonamide) as the lead agent.

28 scribes novel N-sulfonyl-aminobiaryl (biaryl-benzenesulfonamides) as potent anticancer agents targeti

29 A series of small molecule benzenesulfonamide based CA-IX inhibitors containing nov

30 ion of a 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide-based scaffold.

31 Benzenesulfonamides bearing various substituted (hetero)

32 zenesulfonamide-CAII than that for ortho-NO2-benzenesulfonamide-CAII complex.

33 phase stability for the complex of para-NO2-benzenesulfonamide-CAII than that for ortho-NO2-benzenes

34 the structure-kinetic relationship in hCAII/benzenesulfonamide complexes, depicting a paradigmatic s

35 2-Nitro-N-alkyl-N-(2-oxo-2-phenylethyl)benzenesulfonamide compounds are known to undergo base-m

36 ein we report the synthesis of two series of benzenesulfonamide containing compounds that incorporate

37 The ionized NH(-) group of each benzenesulfonamide coordinates to the active site Zn(2+)

38 se results demonstrate that radiohalogenated benzenesulfonamides could be a potentially useful class

39 Evaluation of various para-substituted benzenesulfonamides defined a substituent effect on bind

40 We found that compound LF3, a 4-thioureido-benzenesulfonamide derivative, robustly inhibited this i

41 We report two series of novel benzenesulfonamide derivatives acting as effective carbo

42 diselenobisbenzoic scaffold, amino acid, and benzenesulfonamide derivatives were prepared and biologi

43 the substituted aminobenzene, benzoate, and benzenesulfonamide disulfide subclasses.

44 -methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)benzenesulfonamide (DMZ), was determined by X-ray crysta

45 potency of L2 is diminished (to the level of benzenesulfonamide) either in the presence of EDTA or up

46 (4'-cyano-3'-fluoro-biphenyl-2-yl)-4-methoxy-benzenesulfonamide] exhibits remarkable antiproliferativ

47 Achmatowicz oxidation of a furyl-substituted benzenesulfonamide followed by a conjugate addition to t

48 L1 and L2, vis-a-vis their parent compound, benzenesulfonamide, for recombinant human carbonic anhyd

49 amino groups of the dendrimer with 4-carboxy-benzenesulfonamide functionalities.

50 gn of short molecular linkers connecting the benzenesulfonamide group and a para-substituted tail gro

51 In solution, the benzenesulfonamide group coordinates as an anion to a Zn

52 vity appears to reside in the inability of a benzenesulfonamide group to bind at the equivalent of th

53 rawing electrons and lowering the pKa of the benzenesulfonamide group.

54 ]indol-8-ylidene)methyl]amino}-N-(2- pyridyl)benzenesulfonamide (GW8510) or the inactive congener iso

55 compound, 4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide, inhibited AKT and its downstream tar

56 isozymes I and II, the binding affinities of benzenesulfonamide inhibitors are invariably higher with

57 carbonic anhydrase II (CAII, EC 4.2.1.1) and benzenesulfonamide inhibitors in the gas phase.

58 non, we have designed and synthesized simple benzenesulfonamide inhibitors substituted at the para po

59 substituted N-methyl-3-(pyrimidin-4-ylamino)benzenesulfonamide inhibitors that display excellent pot

60 and in the case of binding of p-substituted benzenesulfonamide inhibitors to bovine carbonic anhydra

61 ho position of N-(3,4-dimethyl-5-isoxazolyl) benzenesulfonamide led to the identification of the biph

62 in can bind to a monolayer that presents the benzenesulfonamide ligand, thereby positioning the RGD p

63 Monovalent carbonic anhydrase (CA) binds to benzenesulfonamide ligands presented on the surface of t

64 onic anhydrase II (BCA) and para-substituted benzenesulfonamide ligands with chains of 1-5 glycine su

65 against all 48 human nuclear receptors, the benzenesulfonamide liver X receptor (LXR) agonist N-(2,2

66 midoamine) (PAMAM) dendrimers decorated with benzenesulfonamide moieties were prepared by derivatizin

67 Although a benzenesulfonamide (or related arylsulfonamide) group mi

68 analogues possessing a substituted thiazole benzenesulfonamide pharmacophore that are potent human b

69 structure-affinity studies indicate that the benzenesulfonamide portion of the phenylethylamine and p

70 Each inhibitor contains a benzenesulfonamide prong and a cupric iminodiacetate (ID

71 The efficient one-pot conversion of the benzenesulfonamide-protected pyrrolidine 9 to the Cbz-pr

72 para-substituted n-alkyl and hydroxyethylene-benzenesulfonamides, providing a complete reconstruction

73 compound of this series, namely, 4-sulfamido-benzenesulfonamide, revealed the binding of two molecule

74 The in vitro binding affinity of the benzenesulfonamide rhenium complexes yielded IC(50) valu

75 lphenyl)-3-(trifluoromethyl)- H-pyrazol-1-yl]benzenesulfonamide, SC-58635, celecoxib), which is curre

76 (2-(4-substitued piperazin-1-yl)ethyl)ureido)benzenesulfonamides, showed low nanomolar inhibitory act

77 n of 4-(nitroso)-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide (SMX-NO), the reactive metabolite of

78 A benzenesulfonamide substituent at the N-terminus of the

79 1-hydroxy-1-(trifluoromethyl)-eth yl]phenyl]-benzenesulfonamide (T0901317) and 3-[3-[N-(2-chloro-3-tr

80 -1-hydroxy-1-(trifluoromethyl)ethyl ]phenyl]-benzenesulfonamide (T0901317) inhibited transactivation

81 2-(phenylcarbonyl)hydrazino]carbonyl] benzyl]benzenesulfonamide (TCN 201) produced smaller but not st

82 inity of L1 for hCA-I was similar to that of benzenesulfonamide, the binding affinity of L2 was appro

83 ty approached that of fragment sized primary benzenesulfonamides, the classical zinc binding group fo

84 tituted with linkers of varying lengths to p-benzenesulfonamide to yield nondiastereomeric biosensors

85 erted N-alkyl-2-nitro-N-(2-oxo-2-aryl-ethyl)-benzenesulfonamides to 2H-indazoles 1-oxides under mild

86 -1-hydroxy-1-trifluoromethyl-ethyl )-phenyl]-benzenesulfonamide (TO-901317), which is a potent stimul

87 sible N-alkyl-2-nitro-N-(2-oxo-2-aryl-ethyl)-benzenesulfonamides using glycine, 2-nitrobenzenesulfony

88 By attaching IDA-bound Cu(2+) to benzenesulfonamide via different chain length spacers, w

89 attachment of iminodiacetate (IDA)-Cu(2+) to benzenesulfonamide (via a triethylene glycol spacer) enh

90 2,4-Disubsituted benzenesulfonamides were identified as potent inhibitors

91 naphthyl, and various heteroaryl substituted benzenesulfonamides which displayed subnanomolar hCA IX

92 onic anhydrase II (BCA) and para-substituted benzenesulfonamides with chains of oligoglycine, oligosa

93 A series of fluorinated benzenesulfonamides with substituents on the benzene rin