ライフサイエンスコーパス: benzo(a)pyrene

1 HepG2 cells identical to that of the parent benzo(a)pyrene.

2 t induced by DMBA or by the aryl hydrocarbon benzo(a)pyrene.

3 , 8-diol, the proximate carcinogenic form of benzo(a)pyrene.

4 ce was observed for benzo(b)fluoranthene and benzo(a)pyrene.

5 droxyvitamin D(3), and of CYP1A1, induced by benzo(a)pyrene.

6 ylnitrosamino)-I-(3-pyridyl)-1-butanone plus benzo(a)pyrene.

7 hylnitrosamino)-I-(3-pyridyl)-1-butanone and benzo(a)pyrene.

8 the high molecular weight compounds such as benzo(a)pyrene.

9 ically important cross-reactants, pyrene and benzo(a)pyrene.

10 ns such as the tobacco-associated carcinogen benzo(a)pyrene.

11 n important pathway in the detoxification of benzo(a)pyrene.

12 al differences in enzymatic bioactivation of benzo(a)pyrene.

13 diol epoxide (BPDE), a bioactivated form of benzo(a)pyrene.

14 d 1 week after three oral administrations of benzo(a)pyrene (2 mg/20 g of body weight) to female A/J

15 a toward phenanthrene, fluoranthene, pyrene, benzo(a)pyrene, 2,3,7,8-tetrachlorodibenzo-p-dioxin, 1,2

16 ls-solvent, soot, and fuel oil-to which (3)H-benzo(a)pyrene ((3)H-BaP; total BaP concentrations of 1,

17 The Km of the enzyme for (-)-trans benzo(a)pyrene-7, 8-diol and 3-OH-BP was 15.5 and 12.3 m

18 Benzo(a)pyrene-7, 8-diol glucuronidating activity was de

19 glucuronosyltransferase with activity toward benzo(a)pyrene-7, 8-diol, the proximate carcinogenic for

20 The DNA adducts N2-deoxyguanosine-benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (N2-dG-BPDE)

21 0-epoxide (N6-dA-BPDE), and N4-deoxycytidine-benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (N4-dC-BPDE)

22 9,10-epoxide (N2-dG-BPDE); N6-deoxyadenosine-benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (N6-dA-BPDE)

23 odiol (BPD), precursor to the potent mutagen benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide, may be an i

24 increased glucuronidating activities toward benzo(a)pyrene-7,8-diol and other metabolites that occur

25 Here we report the isolation of a benzo(a)pyrene-7,8-diol transferase-encoding cDNA, LC14,

26 The environmental carcinogen benzo(a)pyrene-7,8-diol-9,10-epoxide (BPDE) forms DNA ad

27 ibitors blocked this effect, suggesting that benzo(a)pyrene-7,8-dione (BPQ), a planar PAH o-quinone g

28 tivate the tobacco-associated carcinogen (-)-benzo(a)pyrene-7R-trans-7,8-dihydrodiodiol was determine

29 a1 was inducible in Ahr(+/+) by 3 micromol/L benzo(a)pyrene, a known hydrocarbon inducer, the protein

30 to 7,12-dimethylbenz(a)anthracene (DMBA) or benzo(a)pyrene alone (complete carcinogen) or with 12-O-

31 Benzo(a)pyrene alone failed to induce tumors in either w

32 ated meat, processed meat, HCAs, and the PAH benzo(a)pyrene and the risk of colorectal adenoma in 3,6

33 were treated with two chemical carcinogens, benzo(a)pyrene and urethane, to induce skin tumors and l

34 Hexachlorobenzene, benzo(a)pyrene, and beta-naphthoflavone were effective A

35 he intake of individual heterocyclic amines, benzo(a)pyrene, and heme iron.

36 njugation of bay-region anti-diol epoxide of benzo(a)pyrene (anti-BPDE), which, unlike anti-BGCDE or

37 ycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) are widely distributed environmen

38 hylanthracene (1-MA), phenanthrene (PA), and benzo(a)pyrene (B(a)P) caused significant release of 3H-

39 ion, tobacco smoke, and cooked foods include benzo(a)pyrene [B(a)P] and 2,3,7,8-tetrachlorodibenzo-p-

40 ups and treated with a mixture of 3 micromol benzo(a)pyrene [B(a)P] and 3 micromol 4-(methylnitrosami

41 Benzo(a)pyrene [B(a)P] and N-nitroso-tris-chloroethylure

42 ork, the two compounds were shown to inhibit benzo(a)pyrene [B(a)P]-induced pulmonary adenoma formati

43 ed black raspberry extract fractions inhibit benzo(a)pyrene [B(a)P]-induced transformation of Syrian

44 inistered after a single dose of 20 micromol benzo(a)pyrene [B(a)P].

45 Here, we show that the smoke toxins benzo(a)pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-di

46 The kinetic of a photooxidation reaction of benzo(a)pyrene (BaP) carried out in controlled condition

47 Repeated cycles of vascular injury by benzo(a)pyrene (BaP) increase the onset and progression

48 Benzo(a)pyrene (BaP) is present at less than 1%, and the

49 Intakes of benzo(a)pyrene (BaP), a marker of PAHs, and 2-amino-1-me

50 Benzo(a)pyrene (BaP), a prototype of polycyclic aromatic

51 Evidence is presented here that benzo(a)pyrene (BaP), an environmental hydrocarbon metab

52 Polycyclic aromatic hydrocarbons, such as benzo(a)pyrene (BaP), are known mammary carcinogens in r

53 rganic extracts of black raspberries inhibit benzo(a)pyrene (BaP)-induced cell transformation in vitr

54 6CAT reporter activity in cells treated with benzo(a)pyrene (BaP).

55 mate intake of heterocyclic amines (HCA) and benzo(a)pyrene (BaP).

56 nd polycyclic aromatic hydrocarbons, such as benzo(a)pyrene (BaP).

57 ical carcinogen dimethylbenz(a)anthracene or benzo(a)pyrene (BP) followed by twice weekly application

58 12-Dimethylbenz(a)anthracene (DMBA), but not benzo(a)pyrene (BP), depletes BM hematopoietic cells in

59 Benzo(a)pyrene (BP), which is similarly activated by Cyp

60 blasts (MEF) to the ultimate carcinogen anti-benzo(a)pyrene (BP)-7,8-diol-9,10-epoxide (anti-BPDE) re

61 It was of interest that a benzo(a)pyrene (BP)-like DNA adduct was observed in 36 n

62 ding polycyclic aromatic hydrocarbons suchas benzo(a)pyrene (BP).

63 Degradation of benzo(a)pyrene by both UV and UV/H(2)O(2) exhibited pseu

64 e (GST), and (ii) the metabolic clearance of benzo(a)pyrene by hepatic S9 supernatants.

65 active metabolite of the tobacco carcinogen benzo(a)pyrene, can induce p53 gene mutation, down-regul

66 s an endogenous factor in protection against benzo(a)pyrene carcinogenicity.

67 ncreased sensitivity of NQO2-/- mice skin to benzo(a)pyrene carcinogenicity.

68 tly repressed DNA replication in response to benzo(a)pyrene dihydrodiol epoxide (BPDE), a genotoxin t

69 o/Delta1) cells with the DNA adducting agent benzo(a)pyrene dihydrodriol epoxide resulted in a loss o

70 umin significantly inhibited CYP1A1-mediated benzo(a)pyrene diol bioactivation in both oral SCC cells

71 ed PCR (LMPCR) we have previously shown that benzo(a)pyrene diol epoxide (BPDE) adduct formation alon

72 ytes exposed in vitro to a model carcinogen, benzo(a)pyrene diol epoxide (BPDE) by 32P-postlabeling.

73 al aberrations induced in vitro by activated benzo(a)pyrene diol epoxide (BPDE) in lymphocyte culture

74 he levels of DNA adducts induced in vitro by benzo(a)pyrene diol epoxide (BPDE), a bioactivated form

75 Benzo(a)pyrene diol epoxide (BPDE), an active metabolite

76 e prototype polycyclic aromatic hydrocarbon, benzo(a)pyrene diol epoxide [B(a)PDE], or B(a)PDE plus U

77 gene by a variety of carcinogens, including benzo(a)pyrene diol epoxide, benzo(g)chrysene diol epoxi

78 four dose levels each of gamma-irradiation, benzo(a)pyrene diol epoxide, N-methyl-N-nitro-N-nitrosog

79 Higher tail moments of gamma-radiation and benzo(a)pyrene diol epoxide-induced comets were signific

80 Constitutive DNA damage, benzo(a)pyrene diol epoxide-induced damage, and repair a

81 The median gamma-radiation-induced and benzo(a)pyrene diol epoxide-induced Olive tail moments,

82 porter gene damaged by exposure to 75 microM benzo(a)pyrene diol epoxide.

83 formed by N-acetoxy-2-acetylaminofluorene or benzo(a)pyrene diol epoxide.

84 To test this hypothesis, we evaluated benzo(a)pyrene diol-epoxide (BPDE)-induced mutagen sensi

85 formation of Syrian hamster embryo cells and benzo(a)pyrene diol-epoxide [B(a)PDE]-induced activator

86 ximum tolerated concentrations of (+/-) anti-benzo(a)pyrene diol-epoxide, no induced mitochondrial mu

87 lity of p53 codons 157, 248, 249, and 250 to benzo(a)pyrene-diol-epoxide (BPDE), an active metabolite

88 ment with the carcinogens methylnitrosourea, benzo(a)pyrene-diolepoxide 1, or both for 12 weeks.

89 when compared with the 1,6-, 3,6-, and 6,12-benzo(a)pyrene-diones.

90 e powerful polycyclic hydrocarbon carcinogen benzo(a)pyrene display transversion point mutations in t

91 rongly correlated with levels of total PACs, benzo(a)pyrene equivalent mass, and OPAHs.

92 y two of 92 samples had detectable levels of benzo(a)pyrene-equivalents (a combined measure of carcin

93 Surprisingly, ultraviolet B light or Benzo(a)pyrene exposure of skin shows that SNP309G allel

94 Treatment with benzo(a)pyrene failed to significantly increase p53 and

95 The treatment of NQO2-/- mice skin with benzo(a)pyrene failed to significantly increase tumor su

96 +/+) mice were treated with a single dose of benzo(a)pyrene, followed by twice weekly applications of

97 east tissues treated in vitro with 4 micro M benzo(a)pyrene in 76 cancer cases and 60 noncancer contr

98 under constitutive conditions and induced by benzo(a)pyrene in Ahr(+/+) and Ahr(-/-) VSMCs.

99 to 7,12-dimethylbenz(a)anthracene (DMBA) and benzo(a)pyrene in C3H/HeN mice and resulted in a state o

100 concentrations of phenanthrene, pyrene, and benzo(a)pyrene in the environment.

101 )anthracene, chrysene, benzo(b)fluoranthene, benzo(a)pyrene] in vegetable oils.

102 The dose-response curve obtained with benzo(a)pyrene incubated 24 h at pH 4.7 was different fr

103 were significant predictors of the level of benzo(a)pyrene-induced adducts in the breast tissues.

104 enethyl isothiocyanate (PEITC-NAC) inhibited benzo(a)pyrene-induced lung tumorigenesis in A/J mice, a

105 n increased sensitivity of NQO1-null mice to benzo(a)pyrene-induced skin cancer.

106 nstrate that NQO2 protects against DMBA- and benzo(a)pyrene-induced skin carcinogenesis and suggest t

107 ivity to 7,12-dimethylbenz(a)anthracene- and benzo(a)pyrene-induced skin carcinogenesis.

108 Benzo(a)pyrene is considered a classic DNA-damaging carc

109 d keratinocytes to the chemical stress agent benzo(a)pyrene led to induction of NQO1 and stabilizatio

110 In the present studies, we show that benzo(a)pyrene metabolite benzo(a)pyrene-trans-7,8-dihyd

111 rase UGT1A7 catalyzes the glucuronidation of benzo(a)pyrene metabolites and other bulky aromatic comp

112 ediates conjugation and elimination of toxic benzo(a)pyrene metabolites.

113 The oxidation products of benzo(a)pyrene obtained in different conditions were tes

114 a variety of agents (the chemical carcinogen benzo(a)pyrene, oncogenes c-myc and ZNF217, and/or domin

115 as further exacerbated following exposure to benzo(a)pyrene or 17beta-estradiol.

116 95% CI, 1.01-1.35, respectively) as well as benzo(a)pyrene (OR, 1.18; 95% CI, 1.02-1.35).

117 reaction was observed after incubation with benzo(a)pyrene oxidation products that was attributed to

118 thracene, chrysene, benzo(b)fluoranthene and benzo(a)pyrene (PAH4) that have been chosen as indicator

119 xhibited even higher activity toward certain benzo(a)pyrene phenols, including the major 3- and 9-phe

120 extract, aromatic and polar DEP fractions, a benzo(a)pyrene quinone, and a phenolic antioxidant induc

121 e-trans-7,8-dihydrodiol-9,10-epoxide and not benzo(a)pyrene quinones contributed to increased benzo(a

122 tic Daphnia magna, anthracene, chrysene, and benzo(a)pyrene resulted in no or limited acute toxicity

123 or age and personal measurements of airborne benzo(a)pyrene, the largest reductions in levels of S-GS

124 Although benzo(a)pyrene, the marker used for evaluating the carci

125 The benzo(a)pyrene + TPA also showed increase in tumor incid

126 ransferase (UGT)-mediated glucuronidation of benzo(a)pyrene-trans-7,8-dihydrodiol (BPD), precursor to

127 dies, we show that benzo(a)pyrene metabolite benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide and no

128 pyrene-trans-7S,8S-dihydrodiol [(+)-BPD] and benzo(a)pyrene-trans-7R,8R-dihydrodiol [(-)-BPD] forms o

129 n liver microsomal incubations with purified benzo(a)pyrene-trans-7S,8S-dihydrodiol [(+)-BPD] and ben

130 e reactivity of photodegradation products of benzo(a)pyrene vs. DNA has been assessed using both geno

131 Benzo(a)pyrene was never detected in infusions.

132 o be the ultimate carcinogenic metabolite of benzo(a)pyrene, was about 9-625-fold higher as compared

133 ls, PAH blood content, with the exception of benzo(a)pyrene, was not linked to fugacity.

134 sed the concentration of five PAHs including benzo(a)pyrene, which increased approximately 2-fold.