ライフサイエンスコーパス: best-characterized

1 ing debate about how this capacity should be best characterized.

2 ozyme derived from Bacillus anthracis is the best characterized.

3 of which CCCTC-binding factor (CTCF) is the best characterized.

4 ylation has been one of the most studied and best characterized.

5 The best characterized, 4E10 and 2F5, are polyreactive, bind

6 Thus far, the best characterized AA-responsive genes are all transcrip

7 The best-characterized acetylation of newly synthesized hist

8 Villin and fimbrin are the best characterized actin-filament bundling or cross-link

9 in many aspects of the viral life cycle, its best-characterized activity is self-assembly into 240-mo

10 s mRNA is a central component of SGs and the best-characterized activity of vhs is as an endoribonucl

11 ed mutagenesis and are, therefore, among the best characterized AFPs.

12 enic lineage, designated AC70, was among the best characterized against SARS coronavirus infection, s

13 e hippocampus and cerebellum is probably the best characterized, although there are also other brain

14 hole bacterium transmission (WBT), which was best characterized among poultry in the Netherlands.

15 s in two genes, KCNA1 and CACNA1A, cause the best characterized and account for the majority of ident

16 icrobial oxylipins, the fungal oxylipins are best characterized and function as hormone-like signals

17 s on pediatric migraine as this has been the best characterized and studied.

18 , which binds CD20 on B cells, is one of the best-characterized antibodies used in the treatment of B

19 agnosis and name has since become one of the best-characterized arboviral diseases.

20 Of these in vitro aggregates, the best characterized are called protofibrils.

21 Two of the best characterized are CwlO and LytE: cells lacking both

22 The best characterized are the copper deficiency and toxicit

23 The best-characterized are the C/D box and the H/ACA box gui

24 nt and theory show that the rearrangement is best characterized as a [1,2] carbon shift toward an ele

25 The S2 state, best characterized as a pi --> (pi*, aryl) transition, h

26 een the metal fragment and the alkane can be best characterized as a three-center, two-electron inter

27 protein conserved from plants to humans and best characterized as a transcriptional coactivator, is

28 E-cadherin is best characterized as adherens junction protein, which t

29 ological insulators have been proposed to be best characterized as bulk magnetoelectric materials tha

30 also observed activity in Ecl mice that was best characterized as bursty--a pattern of activity simi

31 Wnt glycolipoproteins are best characterized as regulators of embryonic developmen

32 Clozapine represents the best-characterized atypical antipsychotic, although it d

33 The oral microbial community is the best-characterized bacterial ecosystem in the human host

34 n-endocytic trafficking roles are known, the best characterized being the transport of hydrolases fro

35 lanking region of the hetP gene provides the best-characterized binding site for the HetR protein so

36 Hematopoiesis is one of the best characterized biological systems but the connection

37 oach we use bacterial chemotaxis, one of the best characterized biological systems.

38 C-reactive protein (CRP), the best characterized biomarker of inflammation, is also an

39 The best characterized biosynthetic enzyme is GmhA, which ca

40 The best-characterized BMC is the carboxysome, a central par

41 wledge on the microbial composition of the 5 best-characterized body sites (gut, skin, oral, airways,

42 lies in which long-distance interactions are best characterized, but similar phenomena in other virus

43 These findings support a system model best characterized by a cascading network failure--analo

44 carriers had more disrupted sleep, which was best characterized by a fragmented sleep profile.

45 n, transmembrane outer membrane proteins are best characterized by assessing membrane integration and

46 This group was best characterized by chromothripsis and the presence of

47 ti-organ autosomal dominant disorder that is best characterized by neurodevelopmental deficits and th

48 of the glutamate carboxypeptidase II family, best characterized by prostate-specific membrane antigen

49 te that B cell-mediated immune regulation is best characterized by the cytokine polarization profile,

50 Whether dominant humans are best characterized by the lay stereotype or the animal v

51 t follow a single-step binding model but was best characterized by two distinct types of interactions

52 roteins regulate internalization events, the best characterized C-terminal EHD, EHD1, regulates endoc

53 lin-degrading enzyme (IDE, insulysin) is the best characterized catabolic enzyme implicated in proteo

54 However, IV.3, perhaps the best characterized CD32a-blocking mAb, was recently show

55 This review focuses on the three best-characterized cell surface mucins expressed in the

56 Currently, the best-characterized chaperone-histone interaction is that

57 To date, the best characterized choline-oxidizing enzyme is the flavi

58 by nuclear factor of activated T cells, the best characterized CnB substrate.

59 In bacteria, the best characterized co-chaperone is the Escherichia coli

60 The best characterized component of lipofuscin is A2E, a bis

61 take a systematic mutational analysis of the best characterized context of the ARS motif, namely the

62 review, I will discuss the functions of the best-characterized copper-responsive proteins in M. tube

63 One of the best-characterized costimulatory pathways includes the I

64 URB597 is one of the best characterized covalent inhibitors of the endocannab

65 contributions of an additional VMPFC pathway best characterized deletion carriers.

66 with the classic HLA genetic loci being the best-characterized determinants.

67 ngers (ZFs) are one of the most abundant and best characterized DNA-binding domains.

68 S6 kinase is the best-characterized downstream effector of mTORC1.

69 dala modulated the lateral occipital complex best characterized EEV-related activity in noncarriers,

70 S6 kinase 1 (S6K1) is the best characterized effector of mTOR, and its regulation

71 One of the best characterized effects of estrogen receptor-alpha (E

72 he regulation of shoot branching, one of the best-characterized endogenous roles for SLs.

73 tic HLA alleles (DQ2 and DQ8) and one of the best characterized environmental factors (gliadin) for a

74 thylation of genomic cytosines is one of the best characterized epigenetic mechanisms, and investigat

75 ersible acetylation of lysines is one of the best characterized epigenetic modifications.

76 The best-characterized example of amino acid-induced regulat

77 Focusing on the best-characterized example of meiotic silencing, meiotic

78 eferred to as trans-tail regulation, and the best-characterized example of this is the dependence of

79 One of the best-characterized families of E3 ubiquitin ligases faci

80 Type I deiodinase (D1) is the best characterized family member and is an integral memb

81 ere mutated in the dehydratase domain of the best characterized family member, lacticin 481 synthetas

82 The Toll-like receptors (TLRs) are the best-characterized family of PRRs and control the activa

83 Like hepatitis C virus, the best characterized Flaviviridae species known to cause h

84 The tethering mechanism has been best characterized for bovine papillomavirus type 1 (BPV

85 Exhaustion has been best characterized for CD8 T cell responses, and occurs

86 Brain-derived neurotrophic factor (BDNF) is best characterized for critical roles in neuronal surviv

87 e that the Mex67-Mtr2 (TAP-p15) heterodimer, best characterized for its essential role in mRNA nuclea

88 mmatory cells, including eosinophils, and is best characterized for its role during the initiation of

89 Although best characterized for its role in regulating transcript

90 t the necessity for blocking H2R, a receptor best characterized for its role in stomach acid producti

91 and break (DSB) repair pathway that has been best characterized for mycobacteria.

92 Although best characterized for sustaining T cell exhaustion duri

93 stromal cells, a relationship that has been best characterized for the interaction between thymocyte

94 Human DNA polymerases eta and iota are best characterized for their ability to facilitate trans

95 Although best characterized for their ability to traverse a varie

96 Vps proteins are best characterized for their role in endosome and vacuol

97 Toll-like receptors (TLRs) are best characterized for their roles in mediating dorsoven

98 However, these have been best characterized for their roles in mRNA export, leavi

99 rin-Eph signaling system is conserved and is best characterized for their roles in neuroblast migrati

100 The best characterized form of an Fe(V) equivalent described

101 Structural domains, the best characterized form of reuse in proteins, are just o

102 endent long-term depression (eCB-LTD) is the best characterized form of striatal plasticity, but the

103 Necroptosis is one the best-characterized forms of regulated necrosis.

104 Engrailed (En), the best-characterized Ftz/Ftz-F1 downstream target, is not

105 rmation from various synaptic inputs and its best characterized function is the regulation of transla

106 genes are important tumor suppressors whose best-characterized function is repair of damaged nuclear

107 The best-characterized function of SMN is as an assembler of

108 Curli fibrils, the best-characterized functional bacterial amyloids, are an

109 in Arabidopsis thaliana comprise one of the best characterized genetic networks in plants.

110 Among the best-characterized genetic alterations in gliomas is the

111 The two best-characterized gp41-specific cross-reactive neutrali

112 The 5-HT3AB receptor is the best-characterized heteropentameric 5-HT3 receptor.

113 Acetylation is one of the most studied and best characterized histone posttranslational modificatio

114 The erythrocyte is one of the best characterized human cells.

115 osomal ClC-5 and the lysosomal ClC-7 are the best characterized human CLC transporters.

116 Currently, even for the best characterized human septin heterocomplex (SEPT2/SEP

117 MLL1 is the best characterized human SET1 family member, which inclu

118 and occasional pandemics, and is one of the best-characterized human RNA viral pathogens(1).

119 iochemical basis of circadian timekeeping is best characterized in cyanobacteria.

120 Their function has been best characterized in DCs and macrophages, where they ac

121 This has been best characterized in Drosophila, where genes encoding r

122 This phenomenon has been best characterized in laminated structures like the reti

123 ) is a recently described DNA repair pathway best characterized in mycobacteria.

124 Although slamf4 function is best characterized in NK cells, the enhanced humoral aut

125 The impact of LAP to immune regulation is best characterized in professional phagocytes, in partic

126 although immunity to transfused platelets is best characterized in relation to HLA-specific antibodie

127 While modifications are best characterized in short, noncoding RNAs such as tRNA

128 ycoprotein complex, the function of which is best characterized in skeletal muscle in relation to mus

129 PY neurons, NPY expressing neurons have been best characterized in the Arcuate Nucleus of the Hypotha

130 erlying molecular mechanisms are complex and best characterized in the flowering plant Arabidopsis th

131 , glucose-regulated gene expression has been best characterized in the liver, where increased glucose

132 Stress erythropoiesis is best characterized in the mouse, where it is extramedull

133 nctions in many Gram-positive species and is best characterized in the pathogen Staphylococcus aureus

134 This process is best characterized in yeast, where V-ATPases are reversi

135 ular endothelial growth factor (VEGF) is the best-characterized inducer of tumour angiogenesis.

136 The best characterized inhibitors of Hsp90 target its ATP bi

137 Ole1p was chosen because it is one of the best characterized integral membrane desaturase and beca

138 can cause parent-of-origin effects, but the best characterized is parent-of-origin-dependent gene ex

139 also via noncanonical pathways of which the best characterized is the planar polarity pathway.

140 thelin 1 (ET-1) is the most abundant and the best-characterized isoform.

141 Herein, we submit the best-characterized LasR modulators to standardized cell-

142 on-classical MHC molecule T22 represents the best characterized ligand for murine gammadelta T cells,

143 nding protein La, are not used to engage its best-characterized ligand, 3' UUU-OH.

144 stinct mature cell types, and represents the best characterized mammalian adult stem cell system.

145 The best characterized mammalian PITPs are the Class I PITPs

146 The best characterized mammalian sleep/wake regulator is hyp

147 The 4 best-characterized MAP kinase pathways, ERK1/2, JNK, p38

148 The best characterized marker of sleep homeostasis is slow w

149 pid eye movement (NREM) sleep, is one of the best characterized markers of sleep need, because it inc

150 Symmetrical division is the best characterized mechanism of stem cell replacement, b

151 Haploinsufficiency (HI) is the best characterized mechanism through which dominant muta

152 The best-characterized mechanism for endocytosis involves cl

153 degradation of homologous transcripts is the best-characterized mechanism.

154 m acute osmotic downshock and is to date the best characterized mechanosensitive channel.

155 acute osmotic downshock, and is to date the best characterized mechanosensitive channel.

156 (MscL), a bacterial channel, is perhaps the best characterized mechanosensitive protein.

157 VEGF is the best characterized mediator of tumor angiogenesis.

158 Although Stat5 is the best-characterized mediator of PRL signals, PRL also act

159 s and function were independent of MITF, the best-characterized melanocyte lineage-specific transcrip

160 Bcl-2 is the best characterized member of a large family of proteins

161 is) protein from bacteriophage lambda is the best characterized member of a large family of recombina

162 Type I deiodinase is the best characterized member of a small family of selenoenz

163 Polo-like kinase 1 (Plk1), the best characterized member of the mammalian polo-like kin

164 P450cam from Pseudomonas putida is the best characterized member of the vast family of cytochro

165 The best characterized member of this family is ExoU, an eff

166 The best characterized member of this family, PLSCR1, is imp

167 soforms, Pak1 is the most ubiquitous and the best characterized member.

168 Bacteriophage T7 RNA polymerase is the best-characterized member of a widespread family of sing

169 ic elongation factor 2 kinase (eEF2K) is the best-characterized member of the alpha-kinase family.

170 The best-characterized member of the family is RASSF1A, whic

171 Flock house virus (FHV) is the best-characterized member of the Nodaviridae, a family o

172 metallo KDO8PS from Aquifex aeolicus are the best characterized members of each class.

173 NOD2 is one of the best characterized members of the cytosolic NOD-like rec

174 chia coli MalE-MalFGK2 complex is one of the best characterized members of the large and ubiquitous f

175 ATPases are the most frequently observed and best-characterized members of this group of transporters

176 Despite being one of the best characterized memory systems of the brain, the ques

177 The mir-17-92 miRNA is among the best characterized miRNA oncogenes, whose genomic amplif

178 are a requirement for seizures in two of the best characterized models of absence epilepsy, and the s

179 dicate that PROG is beneficial in one of the best-characterized models of stroke, and may warrant fur

180 ned capabilities of three of the largest and best characterized module archives by enabling users to

181 Given that the best characterized MPS-I murine model is an immunocompet

182 ly of translational repressors, arguably the best characterized mTORC1 substrates, is sufficient to r

183 One of the best characterized mutations found in several forms of h

184 It is one of the best characterized myosin-I isoforms and appears to have

185 REMs are the best-characterized nanodomain markers via an uncharacter

186 One of the best-characterized natural RIG-I agonists is the defecti

187 oligodendrocyte progenitor cells-one of the best-characterized neural progenitor cells in the mammal

188 e central melanocortin system is perhaps the best-characterized neuronal pathway involved in the regu

189 ctory projection neurons (PNs) are among the best-characterized neuronal types: different PN classes

190 The best characterized noncanonical Wnt, Wnt5a, has been sug

191 e results identify the SPICE interval as the best characterized ocean anoxic event in the pre-Mesozoi

192 esis of acute myeloid leukemia are among the best characterized of all human malignancies.

193 uper elongation complex (SEC), is by far the best characterized of CDK9, CDK12, and CDK13.

194 n regulatory system of Escherichia coli, the best characterized of the biotin-sensing systems, the bi

195 ]) is economically very important and is the best characterized of the herpesviruses that occur prima

196 ead ribozyme from Schistosoma mansoni is the best characterized of the natural hammerhead ribozymes.

197 Among the best characterized of the transcription factors are the

198 The best characterized of these fibrils are SEVI (semen-deri

199 The best characterized of these fluorophores is A2E, a compo

200 The best characterized of these have been mutations in the c

201 The best characterized of these is c-myc/IgH translocation,

202 The best characterized of these is F(o)F1-ATP synthase, the

203 The best characterized of these is IPEX, resulting from muta

204 The best characterized of these pathways, the ER-associated

205 he radical S-adenosyl-l-methionine HydG, the best characterized of these proteins, is responsible for

206 They are now the best characterized of these rather mysterious enzymes th

207 The best characterized of these related transporters is the

208 The best characterized of these responses involves activatio

209 The best characterized of these RNA-binding proteins is the

210 The best characterized of these signals is the leucine-induc

211 ular genomic integrity in multiple ways, the best characterized of which are as a host defense agains

212 HL gene has multiple reported functions, the best characterized of which is its role as the recogniti

213 ave been found to inhibit Treg activity, the best characterized of which is the glucocorticoid-induce

214 coli Na(+)/H(+) antiporter (Ec-NhaA) is the best-characterized of all pH-regulated Na(+)/H(+) exchan

215 phila melanogaster has emerged as one of the best characterized olfactory systems, which in addition

216 Ontogenetically, the kidney is one of the best-characterized organs, but concepts of the regulated

217 One of the best characterized oxidative DNA lesions is 7,8-dihydro-

218 The best-characterized P. falciparum DBL-EBP is erythrocyte

219 hrocyte-binding antigen 175 (EBA-175) is the best-characterized P. falciparum invasion ligand, report

220 The best-characterized p53 activity in vitro is as a transcr

221 The best-characterized par system contains a centromere-bind

222 The best-characterized Parkinsonian DJ-1 missense mutation,

223 The best characterized pathway for subsequent oxalate degrad

224 The best characterized pathway for the initiation of mRNA de

225 The best-characterized pathway for intrinsic forgetting incl

226 The chaperone/usher system is one of the best characterized pathways for protein secretion and as

227 data demonstrate overlap between two of the best-characterized pathways for recognition of pathogen

228 One of the best-characterized pause sequences is a binding site for

229 In animals, the two best-characterized PcG complexes are PRC1 and PRC2.

230 -ATPase (NKA) residue Ser(936), which is the best characterized phosphorylation site in NKA, targeted

231 The best-characterized piRNAs mediate a conserved pathway th

232 idylinositol (PtdIns)(4,5)P(2) is one of the best characterized PIs; studies in which PtdIns(4,5)P(2)

233 The best-characterized plant gene exhibiting a complex antis

234 The genes encoding some of the best-characterized plant secondary metabolite biosynthet

235 in seedling establishment, and are among the best-characterized plant signaling components.

236 e-binding antigen 175 (EBA175) is one of the best-characterized Plasmodium falciparum merozoite ligan

237 ense-mediated mRNA decay (NMD), which is the best-characterized posttranscriptional quality control m

238 ed myometrium from humans and Eker rats, the best characterized preclinical model of leiomyomata.

239 Currently, the best-characterized premalignant lesions are atypical duc

240 One of the best-characterized prions, [PSI(+)], is governed by a co

241 advances in our understanding of some of the best-characterized proteins required for the membrane fi

242 The best characterized putative cleavage event is at amino a

243 absorption to dose relationships that can be best characterized quantitatively by using power equatio

244 d subsequent calcium (Ca(2+)) fluxes are the best characterized receptor-regulated signaling events.

245 cal applications, focusing mainly on the two best-characterized receptors CTLA4 and PD-1.

246 The best characterized regulator of thiols in proteins is Tr

247 PUF family proteins are among the best-characterized regulatory RNA-binding proteins in no

248 The best-characterized regulatory systems in this organism i

249 This review is a survey of the best-characterized restriction factors capable of inhibi

250 cross-modal impact of a sound for one of the best-characterized rhythms arising from the visual syste

251 Here we focused on examining the role of the best characterized RNA demethylase, FTO (fat mass and ob

252 d that this activation is independent of the best-characterized RNA- and protein-sensing PRRs includi

253 The best-characterized role for ARF is in stabilizing p53 in

254 Its best-characterized role is as part of the destruction co

255 live-attenuated MP-12 vaccine is one of the best-characterized RVF vaccines for safety and efficacy

256 The best-characterized Saccharomyces cerevisiae gene regulat

257 We apply our theory to what is arguably the best-characterized sensing system in biology, the chemot

258 Polo-like kinase 1 (Plk1), the best characterized Ser/Thr kinase, is involved in mitoti

259 tural differences between AAV8 and AAV2 (the best-characterized serotype) are located on the capsid s

260 The best-characterized signaling pathways use STAT1, however

261 We describe a model in which the two best-characterized skin-resident DCs, langerhans cells (

262 The best-characterized SM protein is the synaptic factor Mun

263 lcium (CRAC) channel in T lymphocytes is the best-characterized SOC influx channel and is essential t

264 The best-characterized SOCE channels are the Ca(2+) release-

265 One of the best characterized stress response pathways is the unfol

266 s in CuZn superoxide dismutase (SOD1) is the best characterized subset of familial amyotrophic latera

267 easuring the transcriptional activity of its best characterized substrate, NFAT, was significantly in

268 lity to assemble and secrete antibodies, the best-characterized substrate of BiP, has not been invest

269 The M13 phage Procoat protein is one of the best characterized substrates for the novel YidC pathway

270 Esx-1, the best-characterized system, is required for virulence of

271 sophila antimicrobial response is one of the best characterized systems of pattern recognition recept

272 Fast-folding WW domains are among the best-characterized systems for comparing experiments and

273 respect, peptidic foldamers are perhaps the best-characterized systems, as they populate a number of

274 The best characterized T4SS are the type IVA systems, which

275 The best-characterized tandem BRCT domains to date are from

276 TORC2 does not regulate cell growth via its best-characterized target, AKT.

277 itis C virus (HCV) has emerged as one of the best characterized targets for next-generation HCV thera

278 The best-characterized targets of Nef are major histocompati

279 us laevis egg extract, where the gradient is best characterized, that spindles can assemble in the ab

280 teins, of which ANKRD26 and ANKRD30A are the best characterized; these are more distant homologs of P

281 ought to determine which biological features best characterized those viruses that have achieved sust

282 Hematopoietic stem cells (HSCs) are the best-characterized tissue-specific stem cells, yet exper

283 factors, and human equivalents of the three best-characterized tissue-Treg populations-those operati

284 CSLF proteins are the best characterized to date but relatively little informa

285 NF-kappaB is one of the best-characterized transcription factors, providing the

286 Arguably, the best-characterized transsynaptic interactions are formed

287 culture conversion using solid medium is the best-characterized tuberculosis biomarker, having been e

288 133 epitope of CD133 currently is one of the best-characterized tumor stem cell markers for many intr

289 , an inhibitor of Hedgehog signaling, is the best-characterized tumor suppressor in medulloblastoma.

290 The best-characterized type 1 interferon (IFN) signaling pat

291 Clathrin-mediated endocytosis (CME) is the best-characterized type of endocytosis in eukaryotic cel

292 The two best-characterized types of CD4(+) regulatory T cells (T

293 se inositol-requiring enzyme 1 (IRE1) is the best characterized UPR signal transduction molecule.

294 The best-characterized V. cholerae colonization factor is th

295 Myosin V is the best characterized vesicle transporter in vertebrates, b

296 IVs) are considered multigenic, although the best characterized virulence factor is the hemagglutinin

297 g the three classes of PI3Ks, class I is the best characterized, whereas class II has received increa

298 munomodulatory properties of AhR ligands are best characterized with extensive studies of changes in

299 One of the best-characterized WNK1 targets is the protein kinase OS

300 One of the best characterized ZAS proteins is RsrA from Streptomyce