ライフサイエンスコーパス: beta

1 ngly, more active transforming growth factor beta.

2 hat mediate stellate cell activation via TGF-beta.

3 structures increase in cells exposed to IFN-beta.

4 nted significantly higher disposition index (beta = 0.056, SE = 0.026; p = 0.035).

5 0 msec, P = .031), and shorter QRS duration (beta = 0.16 msec/10 msec, P = .049).

6 ted through later poverty at age 7-14 years (beta = -0.01, 95% confidence interval: -0.04, 0.01) and

7 ater LTL attrition (3 herpesviruses vs none, beta = -0.07 and P = .02; 4 infections vs none, beta = -

8 ion at age 7-14 years (i.e., joint mediators beta = -0.07, 95% confidence interval: -0.12, -0.02) tha

9 medial (beta = -0.22, P = .03) and lateral (beta = -0.08, P = .03) temporal regions, subcortical whi

10 temporal regions, subcortical white matter (beta = -0.13, P = .02), and occipital regions (beta = -0

11 a = -0.07 and P = .02; 4 infections vs none, beta = -0.14 and P < .001).

12 ta = -0.13, P = .02), and occipital regions (beta = -0.15, P = .03) in the whole sample and the occip

13 subgroup and meta-regression analyses (slope beta = -0.16; 95% CI, -0.29 to -0.03; P = .02).

14 the whole sample and the occipital regions (beta = -0.21, P = .01) in the CN subsample statistically

15 ver, APOE epsilon4 rendered only the medial (beta = -0.22, P = .03) and lateral (beta = -0.08, P = .0

16 nder and histological brain tumor diagnosis (beta = -0.253, p < 0.001).

17 th Panic and Agoraphobia scale (PAS) scores (beta=0.005, SE=0.002, p=0.021, n=131) among cases in the

18 etween exposure to p,p'-DDE and BMI z-score (beta=0.13 BMI z-score (95% CI: 0.01, 0.25) per log incre

19 line severity and treatment was significant (beta=0.22, 95% CI 0.05-0.39; p=0.013).

20 in blood was negatively associated with age (beta=-0.03/10 y; r(2)=0.07; P=1.6x10(-7)) but not with c

21 n those without (29.6pg/ml, IQR = 20.9-41.8; beta = 1.461, p = 0.005 and beta = 1.902, p = 0.002, res

22 IQR = 20.9-41.8; beta = 1.461, p = 0.005 and beta = 1.902, p = 0.002, respectively).

23 ore was associated with both binocular 24-2 (beta = 1.95; 95% CI, 0.47-3.43; P = .01) and 10-2 (beta

24 Notably, two domains harbored by beta-1,3 galactosyltransferase, an essential enzyme in f

25 of defence related enzymes, i.e. chitinase, beta-1,3-glucanase and PAL, and higher content of epicat

26 monstration that an SRRP is required to bind beta-1,4-linked galactose and the first time that one of

27 and positron emission tomography for amyloid-beta ((11) C-PiB or (18) F-florbetapir) and tau ((18) F-

28 ociated with lower QRS Sokolow-Lyon voltage (beta = 15.1 microV/10 msec, P = .004), lower QRS Cornell

29 mg every 24 weeks or subcutaneous interferon beta-1a at a dose of 44 mug three times weekly for 96 we

30 and in 2.9% of those treated with interferon beta-1a.

31 al comparing early versus delayed interferon beta-1b treatment in 465 patients with a CIS.

32 1.95; 95% CI, 0.47-3.43; P = .01) and 10-2 (beta = 2.57; 95% CI, 1.12-4.01; P = .001) sensitivities,

33 ation of 18 compounds (mixture of anabolics, beta-2 agonists, diuretics, stimulants, narcotics, and b

34 msec, P = .004), lower QRS Cornell voltage (beta = 9.2 microV/10 msec, P = .031), and shorter QRS du

35 idogenic cleavage of APP and produce amyloid beta (Abeta) at the expense of sAPPalpha and other non-a

36 It is not known exactly where amyloid-beta (Abeta) fibrils begin to accumulate in individuals

37 of Alzheimer's disease (AD) include amyloid-beta (Abeta) plaques, neurofibrillary tangles, and react

38 eurologically normal elderly without amyloid-beta accumulation (normal ageing, n = 13), and neurologi

39 gically normal elderly with cortical amyloid-beta accumulation (pathological ageing, n = 15).

40 ormone (TH) and TH receptors (TRs) alpha and beta act by binding to TH response elements (TREs) in re

41 Importantly, beta activity is not continuously elevated, but fluctuat

42 showed that the fast reaction corresponds to beta-adduct formation (the kinetic product), while the s

43 beta-adrenergic receptor antagonism after experimental s

44 tially reflecting down-regulation of cardiac beta-adrenergic receptor function in chronic hypoxia.

45 Activation of beta-adrenergic receptors (betaARs) enhances both the in

46 r environments could control beta-synuclein (betaS) aggregation via altering its charge distribution,

47 ded for five different photoredox reactions (beta-alkylation, beta-aminoalkylation, dehalogenation, a

48 high levels of diastereocontrol, leading to beta-amino ketones in high yields.

49 erent photoredox reactions (beta-alkylation, beta-aminoalkylation, dehalogenation, amine arylation, a

50 roliferation in a mouse model of Alzheimer's beta-amyloidosis was increased threefold.

51 diversity index), with secondary outcomes of beta and gamma Simpson's and Shannon's diversities.

52 d to determine the mechanism of action of ER-beta and its ligands.

53 AMPK activity also failed to up-regulate IFN-beta and TNF-alpha after treatment with DMXAA or the nat

54 ted, demonstrating both collision frequency (beta) and background particle concentration (B) to be in

55 by these mRNAs include Wnt/beta-catenin, TGF-beta, and stem cell signaling.

56 or, proliferation-transforming growth factor beta, and Wnt-catenin beta1.

57 was markedly disordered, suggesting that the beta-annulus had been disrupted and that this could dest

58 In conclusion, activin and TGF-beta are strongly connected signaling pathways that are

59 Type I interferons (IFNalpha/beta) are critical mediators of any anti-viral immune re

60 rminal peptide competed for association with beta-arrestin 1, and phosphorylated central or distal C-

61 Both in G protein-mediated pathways and in beta-arrestin 2 recruitment, no ligand-independent activ

62 minal peptides competed for association with beta-arrestin 2.

63 Results from controlled expression of either beta-arrestin isoform demonstrate that beta-arrestin2 ac

64 Recent evidence recognizes the beta-arrestin system as a key regulator of not only GPCR

65 locarpine on endogenous M3R is biased toward beta-arrestin.

66 beta-arrestin2 acts in an opposite manner to beta-arrestin1 by promoting degradation of an unstimulat

67 iated regulatory protein complex composed of beta-Arrestin1, ARHGAP21 and Cdc42.

68 ither beta-arrestin isoform demonstrate that beta-arrestin2 acts in an opposite manner to beta-arrest

69 nosine 5'-3-O-(thio)triphosphate binding and beta-arrestin2 recruitment.

70 ral beta-hydroxylated, beta-fluorinated, and beta-arylated carboxylic acids.

71 d suppression, and target reappearances with beta-band enhancement.

72 ctive hypothesis, which posits that top-down beta-band influences directly modulate bottom-up gamma b

73 ces of a salient target were associated with beta-band suppression, and target reappearances with bet

74 The beta-barrel assembly machinery (BAM) is a conserved mult

75 in complex responsible for the biogenesis of beta-barrel outer membrane proteins (OMPs) in Gram-negat

76 The Bam complex assembles beta-barrel proteins into the outer membrane (OM) of Gra

77 erized by a major capsid protein bearing two beta-barrels.

78 tin prescriptions included male sex, filling beta-blocker and antiplatelet agent prescriptions, and a

79 Although beta-blockers increase survival in patients with heart f

80 nists, diuretics, stimulants, narcotics, and beta-blockers) spiked in human urine and plasma samples.

81 statins, renin-angiotensin system blockers, beta-blockers, dual antiplatelet therapy, and long-term

82 0%, type of surgery, and preoperative use of beta-blockers, intra-aortic balloon pump, or catecholami

83 The chiral beta-borylated amides are useful synthons for the synthe

84 ontinuously elevated, but fluctuates to give beta bursts.

85 The enzymatic beta-C-H hydroxylation of the feedstock chemical isobuty

86 ns with a beta-hGly residue instead of a (S)-beta-Caa(l) constituent.

87 The tetrahydro-beta-carboline of strictosidine aglycone is converted in

88 Here, using human beta-cardiac myosin-S1, we combine published data from t

89 cessibility of phenolics, flavonoids, rutin, beta-carotene and lutein and changes in antioxidant acti

90 Fat types affected beta-carotene differently.

91 s a major site for the conversion of dietary beta-carotene to retinaldehyde by the enzyme BCO1.

92 ctions between ORF2 and a complex containing beta-catenin and HMGA1 have functional significance.

93 ssion levels were negatively correlated with beta-catenin and PKM2 levels in breast cancer tissues.

94 observations are consistent with the role of beta-catenin and SNAIL in epidermal stem cell maintenanc

95 beta-catenin and Snail1 expression was generally high in

96 Overexpression of KCNQ1 trapped beta-catenin at the plasma membrane, induced a patent lu

97 , followed by phosphorylation of and loss of beta-catenin from the nucleus, thereby reducing expressi

98 triggers the mechanosensitive activation of beta-catenin in adjacent epidermal cells, initiating the

99 atenin levels and define PKC as an important beta-catenin interaction partner and signaling opponent

100 identified a novel pathway for regulation of beta-catenin levels and define PKC as an important beta-

101 nt of the destruction complex that regulates beta-catenin levels.

102 S2 overexpression in ACC cells inhibited Wnt/beta-catenin pathway activity by promoting beta-catenin

103 Mutations of the beta-catenin pathway change the phenotype of a common ne

104 while esculetin significantly inhibited Wnt/beta-catenin pathway in vitro and in vivo.

105 t/beta-catenin pathway activity by promoting beta-catenin phosphorylation and degradation, it also in

106 These tumors lack deregulation of APC/beta-catenin signaling components, which are crucial gat

107 y, we investigated the molecular role of Wnt/beta-catenin signaling pathway in reparative dentinogene

108 dentified LGR4 as a master controller of Wnt/beta-catenin signaling-mediated breast cancer tumorigene

109 d-forward mechanism to achieve sustained Wnt/beta-catenin signaling.

110 LMNA cardiomyopathy, suggested decreased WNT/beta-catenin signalling.

111 In contrast, a slight activation of beta-catenin significantly increased bone formation and

112 -beta-catenin tumors showed up-regulation of beta-catenin targets like glutamine synthetase (GS), leu

113 K-Ras-beta-catenin tumors showed up-regulation of beta-catenin

114 of the culture system, IWP2 decreased total beta-catenin while CHIR99021 increased it in nuclear loc

115 imultaneously coordinates the attenuation of beta-catenin, both of which are required to execute the

116 es downstream of LRP6, including JNK and WNT/beta-catenin, inhibited the biologic activity of domain

117 umors with common CRC mutations such as APC, beta-catenin, or RNF43.

118 in estrogen receptor, progesterone receptor, beta-catenin, or vimentin expression between placebo and

119 hways represented by these mRNAs include Wnt/beta-catenin, TGF-beta, and stem cell signaling.

120 egulation may promote beta-oxidation through beta-catenin, whereas hypertrophy was dependent on mamma

121 y enhanced the ability of HMGA1 to stimulate beta-catenin-dependent transcription, suggesting that in

122 po1), an extracellular protein that enhances beta-catenin-dependent Wnt signaling and has previously

123 ppress GC growth through a novel SOCE/Ca(2+)/beta-catenin-mediated anti-proliferation of GC cells, wh

124 hways, as well as increased total and active beta-catenin.

125 family kinase (SFK) FYN as well as Tyr142 in beta-catenin.

126 Here we report a beta-cyclodextrin (beta-CD)-based polymer network with higher affinity for

127 ted water and demonstrate the versatility of beta-CD-based adsorbents.

128 Since beta cell dysfunction occurs during diabetes development

129 ining of the expression of genes involved in beta cell function, but also continual repression of clo

130 ll, indicating that acquiring and sustaining beta cell identity and function requires not only active

131 er, a high-glucose intake alone did increase beta cell mass and insulin secretion moderately.

132 Although beta cell mass was preserved 8 days post-injection, tota

133 monstrates the highly volatile nature of the beta cell, indicating that acquiring and sustaining beta

134 rough reduction in STARD10 expression in the beta cell.

135 dening our understanding of cytokine-induced beta-cell apoptosis in early T1D.

136 ess, explaining why SRp55 depletion triggers beta-cell apoptosis.

137 2 proteins DP5 and PUMA and consequent human beta-cell apoptosis.

138 The introduction of beta-cell autoantigens via the gut through Lactococcus l

139 Spry2 deletion in the adult mouse beta-cell caused hyperglycemia and hypoinsulinemia.

140 Islet beta-cell dysfunction and aggressive macrophage activity

141 al role of inflammation in cytokine-mediated beta-cell dysfunction and death in type 1 diabetes melli

142 oreover, chronically elevated glucose causes beta-cell dysfunction, but little is known about how cel

143 n mediating the effect of leptin to modulate beta-cell electrical activity by promoting AMP-activated

144 While mitophagy is critical to pancreatic beta-cell function, the posttranslational signals govern

145 ferences in markers of insulin secretion and beta-cell function.

146 cAMP Epac pathways in the effects of ANP on beta-cell function; the latter seems to prevail.

147 We report on East-Asian alpha- and beta-cell gene signatures and substantiate several genes

148 either to beta-cell tumours (insulinomas) or beta-cell hyperplasia.

149 ion, the posttranslational signals governing beta-cell mitochondrial turnover are unknown.

150 strongly suggest that an early deficiency in beta-cell number in infants with CF may contribute to th

151 ession has recently been described as highly beta-cell selective in the human pancreas and constitute

152 es of hypoglycaemia and can be due either to beta-cell tumours (insulinomas) or beta-cell hyperplasia

153 served sequences that control pancreatic and beta-cell type-specific transcription, which are found w

154 landscape of insulinomas relative to normal beta cells.

155 ated PLIN2 expression and ER stress in their beta cells.

156 1 is cytoprotective to rat, mouse, and human beta-cells exposed to cytokines or thapsigargin-induced

157 Inhibition of KCC2 activity in clonal MIN6 beta-cells increases basal and glucose-stimulated insuli

158 At later stages, younger beta-cells join the islet following differentiation from

159 apoptotic Bcl-2 proteins in human pancreatic beta-cells, broadening our understanding of cytokine-ind

160 In pancreatic beta-cells, mitochondrial bioenergetics control glucose-

161 deleterious downstream effects in pancreatic beta-cells.

162 novel approaches to regenerating pancreatic beta-cells.

163 e experiments showed that alpha-cellular and beta-cellular clocks are oscillating with distinct phase

164 s regulating BACE1 distribution in axons and beta cleavage of APP at synapses remain largely unknown.

165 iated APP mutation, shifted the preferential beta-cleavage site of BACE1 in APP from the Glu(11) site

166 ive interface exchange between the TCR alpha/beta constant domain pair and the IgG1 CH3 homodimer was

167 Together these data demonstrate that pol beta contains a specific NLS sequence in the N-terminal

168 Here we report a beta-cyclodextrin (beta-CD)-based polymer network with h

169 d-glucosaminyl)-1,2,3-triazoles as well as C-beta-d-glucosaminyl 1,2,4-triazoles and imidazoles were

170 Aryl substituted 1-(beta-d-glucosaminyl)-1,2,3-triazoles as well as C-beta-d

171 somes from receptor solubilized in n-dodecyl-beta-d-maltoside analogs.

172 ween arylazides N3 Ar with a bulky copper(I) beta-diketiminate.

173 ow that the same as for genes SPAD follows a beta distribution, which provides a good description of

174 ughout the signaling duration and across Tgf-beta doses, and significantly increased the information

175 beta-endorphin levels increased in the inflamed paw, and

176 route in six steps; however, both alpha and beta epimers could be obtained by a nonstereoselective a

177 neous type 2 airway inflammation in juvenile beta-epithelial Na(+) channel (Scnn1b)-transgenic (Tg) m

178 alyses and expressed as odds ratios (ORs) or beta-estimates with 95% confidence interval (CI).

179 docyte injury, fibronectin accumulation, TGF-beta expression, and, most notably, age-related impairme

180 nd that actin, Arp2/3, vinculin and integrin-beta first accumulated at the cell's leading edge.

181 r the synthesis of chiral beta-hydroxylated, beta-fluorinated, and beta-arylated carboxylic acids.

182 e coherence (ITPC) measure for the theta and beta frequency bands.

183 Importantly, endo-beta-galactosidase coupled with MALDI-MS allowed these t

184 on-invasive imaging of Hmox1 expression, and beta-galactosidase for high-resolution mapping of expres

185 on MnO2 with different morphologies (alpha, beta, gamma and delta) was investigated using flow tube

186 cyclic sulfamidate imines with a variety of beta,gamma-unsaturated alpha-ketocarbonyls in neat condi

187 The resistivity of our beta-GeSe crystals measured in-plane is on the order of

188 s could be obtained by removal of a terminal beta-GlcNAc moiety by treatment with beta-N-acetylglucos

189 We also noted that PUL1,6-beta-glucan is syntenic to many PULs from other Bacteroi

190 tilization of yeast and fungal cell wall 1,6-beta-glucans is a widespread adaptation within the human

191 mino)-1-(3-pyridyl)-1-butanol (NNAL), NNAL-N-beta-glucuronide, and NNAL-O-beta-glucuronide.

192 (NNAL), NNAL-N-beta-glucuronide, and NNAL-O-beta-glucuronide.

193 prodomain, apply force, and release the TGF-beta growth factor.

194 rees C is a far lower temperature than usual beta --> alpha phase transformations in SiC.

195 For example, beta-H elimination of (Phebox)Ir(OAc)(n-octyl) (2-Oc) pr

196 ns, including a sevenfold enhancement of the beta-hairpin formed by residues 27-31 and 33-38.

197 timate helix, the extended Omega-loop, and a beta-hairpin turn of the Phy-specific domain.

198 ties of At2g44920 as a representative of the beta-helix family to determine if it had exceptional glo

199 was observed when the sequence begins with a beta-hGly residue instead of a (S)-beta-Caa(l) constitue

200 wenty H-atoms available for either alpha- or beta-hydride elimination.

201 d branching due to significant reductions in beta-hydrogen elimination.

202 Alpha-beta Hydrolase Domain Containing 5 (ABHD5) is a key regu

203 Alpha-beta hydrolase domain-containing 5 (ABHD5), the defectiv

204 useful synthons for the synthesis of chiral beta-hydroxylated, beta-fluorinated, and beta-arylated c

205 ai virus infection efficiency, decreased IFN-beta, IFN-lambda1, and interferon-stimulated chemokine g

206 utation in the actin-binding domain (ABD) of beta-III-spectrin causes high-affinity actin binding and

207 ukin-6 (IL-6) expression after interleukin-1 beta (IL-1beta) stimulation.

208 ndidate therapeutic targets to lower amyloid-beta in a preventive mode, i.e., gamma- and beta-secreta

209 ibution, thus opening new possible roles for betaS in Parkinson's and other neurodegenerative disease

210 w in alpha) and is highly selective (high in beta) in forming the probe-protein adducts.

211 OPTN and NDP52), thereby alleviating amyloid-beta-induced loss of synapses and cognitive decline in A

212 associated decrease in tumor necrosis factor-beta, interferon-gamma, and monocyte chemoattractant pro

213 factor (GF) domain in each monomer, pro-TGF-beta is secreted and stored in latent complexes.

214 factor, transforming growth factor beta (TGF-beta), is thought to play a pivotal role.

215 chiral N-tert-butanesulfinyl aldimines with beta-keto acids under basic conditions at room temperatu

216 lf) and a dihydrodipyrrin substituted with a beta-ketoester (BC half) forms a propenone bearing the t

217 malononitriles, providing a diverse array of beta-ketonitriles.

218 ary regarding the effectiveness of prolonged beta-lactam infusion.

219 uberculosis (Mtb) expresses a broad-spectrum beta-lactamase (BlaC) that mediates resistance to one of

220 e boronic acid synergy test, and the metallo-beta-lactamase Etest, had specificities of >90% for dete

221 ay was performed on all isolates to identify beta-lactamase-encoding genes.

222 ersus short-term infusion of antipseudomonal beta-lactams in patients with sepsis.

223 oxamates facilitated syntheses of monocyclic beta-lactams suitable for incorporation of a thiomethyl

224 one of the highly effective antibacterials, beta-lactams.

225 rturbed evolved prior to the clinical use of beta-lactams.

226 ioselective synthesis of N-heterocycle-fused-beta-lactones from N-linked ketoacids is described.

227 markers useful for in vivo dose responses of beta-lapachone treatment in humans, avoiding toxic side

228 The polymer chain is terminated by a beta-linked Kdo (3-deoxy-d-manno-oct-2-ulosonic acid) re

229 pecies and other proteins related to amyloid-beta metabolism or Alzheimer's disease were quantified b

230 beta-methylamino-L-alanine (BMAA) has been linked to sev

231 take was highest on delta-MnO2 but lowest on beta-MnO2, with a geometric uptake coefficient (gammaobs

232 , for subsequent use by RAM2 to produce 16:0 beta-monoacylglycerol.

233 ned the same overall structure of native TGF-beta monomers and bound TbetaRII in an identical manner.

234 ocholic acid and decrease of tauro-alpha and beta-muricholic acid in Tgr5(-/-) mice.

235 icity to OGA in O-GlcNAc regulation.O-linked beta-N-acetyl glucosamine (O-GlcNAc) is an important pro

236 ification of nucleocytoplasmic proteins with beta-N-acetylglucosamine (GlcNAc) and regulates numerous

237 erminal beta-GlcNAc moiety by treatment with beta-N-acetylglucosaminidase and selective extension of

238 (BuSn)12 (OH)3 (O)9 (OCH3 )12 (Sn(H2 O)2 )] (beta-NaSn13 ).

239 Deprotonated compounds with only beta-O-4 linkages, or both 5-5 and beta-O-4 linkages, sh

240 with only beta-O-4 linkages, or both 5-5 and beta-O-4 linkages, showed major 1,2-eliminations of neut

241 d to neuronal dysfunction induced by amyloid-beta oligomers (AbetaOs).

242 Smad transcription factors activated by TGF-beta or by BMP receptors form trimeric complexes with Sm

243 gonist-induced activation of phospholipase C beta or with a rapamycin-inducible system in which vario

244 Brief epochs of beta oscillations have been implicated in sensorimotor c

245 t farther from a movement onset state during beta oscillations that were neurofeedback-induced or nat

246 utants by screening for inefficient seedling beta-oxidation phenotypes.

247 PTEN down-regulation may promote beta-oxidation through beta-catenin, whereas hypertrophy

248 purine and pyrimidine metabolism, fatty acid beta-oxidation, phospholipid catabolism, arachidonic aci

249 on of lipase 3 and enzymes for mitochondrial beta-oxidation.

250 rocyclization of alpha-(N-hydroxy/aryl)imino-beta-oxodithioesters with in situ generated Cu-carbenoid

251 of some species with prunasin, tyramine and beta-p-arbutin, may be limited in food applications.

252 The aggregation of the amyloid beta peptide (Abeta) into amyloid fibrils is a defining

253 nic peptides, such as the well-known amyloid-beta peptide involved in Alzheimer's disease.

254 d before or during the formation of SOA from beta-pinene.

255 CyRPA has a six-bladed beta-propeller fold, and we identify the region that int

256 This revealed four beta propellers, in an assembly markedly similar to thos

257 the relative contribution of endogenous TGF-beta proteins to the negative regulation of muscle mass

258 A combination of alpha and beta provides a tiered system for quantitatively assessi

259 ecule that mediates IL-37 binding to the TGF-beta receptor complex.

260 Beta-receptor blockade does not alter the tachycardia ph

261 in levels of fibrosis signaling mediator TGF-beta remained the same and the second messenger, Smad2/3

262 dditional liquor store or convenience store (beta [SE], -0.004 [0.002]; P = .02).

263 -beta in a preventive mode, i.e., gamma- and beta-secretase; the rationale behind these two targets;

264 An ER-beta-selective ligand increased markers of tricarboxylic

265 Using T-cell receptor-beta sequencing and tumour reactivity assays, we predict

266 The beta-sheet self-assembles to form long fibrils with the

267 l acidic region of Ng peptide pries open the beta-sheet structure between the Ca(2+) binding loops pa

268 cm(-1)), H-bonded parallel- and antiparallel-beta-sheets (1690cm(-1)) and H-bonded beta-turns (1664cm

269 beta-SiC, preferred for nuclear applications, is metasta

270 1-mediated cell death via the RIG-I-MAVS-IFN-beta signaling axis.

271 s and attenuated the upregulation of the TGF-beta signaling pathway and alpha1-antitrypsin protein (a

272 t a pharmacological compound that abates TGF-beta signalling and enhances ERK5 signalling may be usef

273 te tensile strength (UTS) for two engineered beta-solenoid protein mutant fibril structures (spruce b

274 To this end, the amounts of amyloid-beta species and other proteins related to amyloid-beta

275 resulting in a shortening of the C-terminal beta-strand.

276 31 of Escherichia coli RNA polymerase (RNAP) beta subunit is a part of RNA binding domain in transcri

277 s the protein into a large membrane-anchored beta subunit that noncovalently associates with the smal

278 sed by activation and thiol deprotonation of beta-subunit cysteines.

279 pha1A subunit with auxiliary alpha2delta and beta subunits.

280 e actin flow with their cytoskeleton-binding beta-subunits tilted by applied force.

281 of receptors for a distinct class of the TGF-beta superfamily ligands.

282 ifferent cellular environments could control beta-synuclein (betaS) aggregation via altering its char

283 ture was slower (P < 0.05) than that of pure beta-TBECH.

284 ic growth factor, transforming growth factor beta (TGF-beta), is thought to play a pivotal role.

285 was activated by transforming growth factor beta (TGFbeta)-activated kinase 1 (TAK1; MAP3K7), which

286 beta-Thalassemia is associated with several abnormalitie

287 Vector carrying shRNA against TGF-beta, though did not inhibit HBV replication alone, enha

288 ic induction with transforming growth factor beta to set up a dual-compartment culture.

289 owing: i) increased Gsk3beta activation, ii) beta-transducin repeat containing E3 ubiquitin protein l

290 Here, we show that beta-TrCP, the substrate recognition component of an E3

291 relevance of thymic function, measured by sj/beta-TREC ratio, in HIV disease progression by analyzing

292 omain-containing adapter-inducing interferon-beta (TRIF) and Z-DNA-binding protein 1 (ZBP1)/DNA-depen

293 ther the mutation resided within the Tubb4a (beta-tubulin 4A) gene, because mutations in the TUBB4A g

294 ted that these compounds bind efficiently to beta-tubulin at the colchicine binding site.

295 of approximately 200 kDa that also contained beta-tubulin.

296 rallel-beta-sheets (1690cm(-1)) and H-bonded beta-turns (1664cm(-1)).

297 rns, which are highly reminiscent of peptide beta-turns.

298 ion of this approach also afforded (Z)-alpha,beta-unsaturated amino esters in moderate to good yields

299 for the construction of (hetero)cyclic alpha,beta-unsaturated carboxylic acids from 1,6- and 1,7-enye

300 induces pro-angiogenic responses through TGF-beta, which may act as the bridging molecule that mediat

301 rban form on NO2 is larger for small cities (beta x IQR = -0.46 for cities < approximately 300000 peo