ライフサイエンスコーパス: beta 2-microglobulin

1 lasma cells, plasma cell labeling index, and beta(2) microglobulin).

2 , which does not associate with the L chain (beta(2)-microglobulin).

3 telets, and higher lactate dehydrogenase and beta-2-microglobulin.

4 gnificantly, independent of cytogenetics and beta-2-microglobulin.

5 effect of Cu(II) binding on the structure of beta-2-microglobulin.

6 er small ligands, nor does it associate with beta(2)-microglobulin.

7 association between HLA class I H chain and beta(2)-microglobulin.

8 rrelated positively with serum M protein and beta(2)-microglobulin.

9 and OV-6 but do not stain with antibodies to beta(2)-microglobulin.

10 binase-activating gene-1 (Rag-1), ICAM-1, or beta(2)-microglobulin.

11 y-49D binds H-2D(d) in the presence of mouse beta(2)-microglobulin.

12 ro a heavy-chain homodimer structure lacking beta(2)-microglobulin.

13 ciated with antigen processing, tapasin, and beta(2)-microglobulin.

14 ressing cells exhibit impaired assembly with beta(2)-microglobulin.

15 The amyloid consists of Asp76Asn variant beta(2)-microglobulin.

16 s, i.e., that at 11.75 kD, was identified as beta(2)-microglobulin.

17 successfully with the amyloidogenic protein beta(2)-microglobulin.

18 including MHC class I, mannose receptor, and beta(2)-microglobulin.

19 51, 53% Durie-Salmon stage III, median serum beta-2-microglobulin 3.1 g/L, median C-reactive protein

20 s of amyloid fibrils formed from full-length beta(2)-microglobulin, a 99-residue protein involved in

21 riatal and limbic volumes, and CSF levels of beta(2)-microglobulin, a non-specific and non-excitotoxi

22 h, we then determined the Zn binding site of beta-2-microglobulin, a protein associated with metal-in

23 following independent characteristics: age, beta-2 microglobulin, absolute lymphocyte count, sex, Ra

24 nds of CD8 that are involved in contact with beta(2)-microglobulin affected interaction with the H-2K

25 Previous studies of beta(2)-microglobulin aggregation have not shown such am

26 n all beta-sheet proteins, transthyretin and beta(2)-microglobulin, alpha-pleated sheet structure for

27 ognition of infected targets by CD8+ CTL was beta 2-microglobulin and MHC class I dependent and was n

28 LIR-1 contacts the mostly conserved beta(2)-microglobulin and alpha3 domains of HLA-A2.

29 eation theory (ANT) to amyloid nucleation of beta(2)-microglobulin and amyloid beta(40) allows us to

30 lele and developed NOD mice expressing human beta(2)-microglobulin and HLA-A*1101 or HLA-B*0702, whic

31 n the structure of an amyloidogenic state of beta(2)-microglobulin and how it may corrupt a soluble c

32 synthesized MHC-I-Hc fails to associate with beta(2)-microglobulin and is retrotranslocated to the cy

33 e conformational properties of acid-unfolded beta(2)-microglobulin and its variants at pH 2.5 as meas

34 ombocytopenia, hypercalcemia, elevated serum beta(2)-microglobulin and lactate dehydrogenase levels,

35 System stages II and III, incorporating high beta(2)-microglobulin and low albumin, are considered to

36 le than random coil structures, for example, beta(2)-microglobulin and the SH3 domain.

37 ved before functional loss at P22, including beta-2 microglobulin and Cx3cr1, and during vision loss

38 Western blot analysis of beta-2 microglobulin and myosin light chain was used to

39 Beta-2 microglobulin and TAP1 (transporter associated wi

40 Further, mice lacking beta(2)-microglobulin (and hence deficient in major hist

41 H-2Kb heavy chain, mouse beta 2-microglobulin, and an ER-targeted version of a pe

42 sic, but its glycosylation, association with beta(2)-microglobulin, and antigenicity at the cell surf

43 ell lines lacking MHC class I, MHC class II, beta(2)-microglobulin, and CD1, as well as tumor cell li

44 IFN-induced transmembrane protein 2 (1-8D), beta(2)-microglobulin, and CD69, were also increased in

45 n was largely dependent on the expression of beta(2)-microglobulin, and experiments with congenic rec

46 e homozygous for targeted disruption of HFE, beta(2)-microglobulin, and for a truncating mutation of

47 h a linear composition of antigenic peptide, beta(2)-microglobulin, and H chain connected by flexible

48 from RNA splicing factor SRp20, histone H2A, beta(2)-microglobulin, and MHC class II I-A(k)beta.

49 as transthyretin, islet amyloid polypeptide, beta(2)-microglobulin, and polyglutamine.

50 creatinine, but did not correlate with age, beta-2-microglobulin, and CA.

51 clophilin; the H3 histone family 3A protein; beta(2) microglobulin; and a cleavage and polyadenylatio

52 e, stage, serum lactate dehydrogenase [LDH], beta(2) microglobulin) appeared to influence outcome exc

53 We previously showed that mice lacking beta(2)-microglobulin are highly susceptible to tumors i

54 gh levels of serum lactate dehydrogenase and beta(2)-microglobulin as characteristics associated with

55 Using myoglobin, cytochrome c, and beta-2-microglobulin as model protein systems, we demons

56 ral marrow activity-strongly correlated with beta-2-microglobulin as surrogate imaging markers of tum

57 normal levels of the MHC class I H chain and beta(2)-microglobulin, as well as normal levels of TAP,

58 all of which associate specifically with the beta 2-microglobulin-assembled, open form of the class I

59 K408A was also associated with more folded, beta(2)-microglobulin-assembled HLA-B8 molecules than wi

60 peptide associated with Alzheimer's disease, beta(2)-microglobulin associated with dialysis-related a

61 sid protein presented by Q9, a member of the beta(2) microglobulin-associated Qa-2 family.

62 with a short cytoplasmic tail expressed as a beta(2)-microglobulin-associated 48-kDa glycoprotein and

63 LILRB1 exclusively bound folded beta(2)-microglobulin-associated class I, whereas LILRB2

64 hout concomitant re-expression of endogenous beta(2)-microglobulin-associated class I.

65 For members of the CD1 family of beta(2)-microglobulin-associated lipid-presenting molecu

66 Beta-2-microglobulin-associated heavy chains which are r

67 Mutants of Ly49A, H-2D(d), and beta(2)-microglobulin at intermolecular contacts and the

68 elongation of the 100-residue protein human beta(2)-microglobulin at pH 2.5, commencing from an acid

69 int abnormalities, -13 or 13-q) and with low beta-2-microglobulin at diagnosis.

70 In rats transgenic for human HLA-B27 and beta(2) -microglobulin (B27-transgenic rats), colitis an

71 agnetic nanoparticle (MN) probe that targets beta(2) microglobulin (B2M), a key component of the majo

72 e weight or levels of the housekeeping genes beta-2 microglobulin (B2M) and glyceraldehyde-3-phosphat

73 Disruption of the Beta-2 Microglobulin (B2M) gene eliminates surface expre

74 is of the importance of the plasma levels of beta-2 microglobulin (B2M) in 553 patients with myelodys

75 were duration of standard therapy and a low beta-2 microglobulin (B2M) level before the first autotr

76 r greater, previous nonprotocol therapy, and beta-2 microglobulin (B2M) of 3 mg/dL or greater as prog

77 acking both Hfe and its interacting protein, beta-2 microglobulin (B2m), deposit more tissue iron tha

78 s in two patterns: the most common contained beta-2 microglobulin (B2M, m/z=11,732) plus one or more

79 beta-2-microglobulin (B2M) is the most commonly altered

80 gene encoding the antigen-presenting protein beta-2-microglobulin (B2M) was identified in a third pat

81 deletions or loss of heterozygosity (LOH) in beta-2-microglobulin (B2M), an essential component of MH

82 sociation with cytolytic activity, including beta-2-microglobulin (B2M), HLA-A, -B and -C and Caspase

83 at AAPCs stably expressing HLA-A*0201, human beta(2)-microglobulin, B7.1, intercellular adhesion mole

84 ent complex containing a class I heavy chain-beta 2 microglobulin (beta 2 m) dimer is assembled onto

85 forms of Qa-1b, one strongly associated with beta 2-microglobulin (beta 2m) and the other associated

86 ized MHC class I heavy chains associate with beta 2-microglobulin (beta 2m) and the soluble chaperone

87 beta 2-Microglobulin (beta 2m) has been demonstrated to

88 anism of the loss or decreased expression of beta 2-microglobulin (beta 2m) in several drug-resistant

89 nuated sporozoites (SPZ) protection model in beta 2-microglobulin (beta 2m) knockout (-/-) mice.

90 lexed with human leukocyte antigen (HLA) and beta 2-microglobulin (beta 2M) molecules are presented a

91 y varying the number of gene copies encoding beta 2-microglobulin (beta 2m) or Ld heavy chain.

92 kDa heavy chain and a 12 kDa soluble subunit beta 2-microglobulin (beta 2m), and which bind an 8-10 a

93 class I molecule, CD1, and are deficient in beta 2-microglobulin (beta 2m)-null mice.

94 ed the phenotype imposed by a null allele of beta 2-microglobulin (beta 2m).

95 Beta 2-microglobulin (beta(2)m) is known to form amyloid

96 by incubation of recombinant wild-type human beta(2)-microglobulin (beta(2)M) ab initio in vitro at l

97 Beta(2)-microglobulin (beta(2)m) amyloid deposits are li

98 ultiple myeloma are elevated serum levels of beta(2)-microglobulin (beta(2)M) and activation or inhib

99 MHC class I molecules and beta(2)-microglobulin (beta(2)m) are membrane glycoprote

100 Heterodimers of MHC class I glycoprotein and beta(2)-microglobulin (beta(2)m) bind short peptides in

101 In this study, we examined whether exogenous beta(2)-microglobulin (beta(2)m) can induce apoptosis in

102 Mice deficient in the product of the beta(2)-microglobulin (beta(2)M) class I light chain fai

103 and quality control of CD1 heavy chain (HC).beta(2)-microglobulin (beta(2)m) complexes is unclear.

104 ass I heavy chains (HCs) and peptide-free HC-beta(2)-microglobulin (beta(2)m) dimers from exiting the

105 TG-->ATA) and in codon 31 (TCA-->TGA) of the beta(2)-microglobulin (beta(2)m) gene were identified in

106 a heterodimeric complex of a heavy chain and beta(2)-microglobulin (beta(2)m) in the endoplasmic reti

107 ous assembly of amyloid fibrils of wild-type beta(2)-microglobulin (beta(2)M) in vitro, under acid co

108 myloidosis (DRA) involves the aggregation of beta(2)-microglobulin (beta(2)m) into amyloid fibrils.

109 Beta(2)-Microglobulin (beta(2)m) is one of over 20 prote

110 Beta(2)-microglobulin (beta(2)m) is the major structural

111 ed Rai and Binet stage disease, higher serum beta(2)-microglobulin (beta(2)M) levels, a greater perce

112 heavy chain of FcRn was associated with the beta(2)-microglobulin (beta(2)m) light chain in U937 and

113 Upon self-recognition of beta(2)-microglobulin (beta(2)M) molecules, PIR-B served

114 ining complexes of H chain (alpha-chain) and beta(2)-microglobulin (beta(2)m) or as beta(2)m-free H c

115 of TPKTSVT placental homing in mice lacking beta(2)-microglobulin (beta(2)m) suggests FcRn/beta(2)m

116 They include defects in beta(2)-microglobulin (beta(2)m) synthesis, loss of the

117 er when it is expressed with Chinese hamster beta(2)-microglobulin (beta(2)m) than murine beta(2)m.

118 f a nonclassical MHC class I alpha-chain and beta(2)-microglobulin (beta(2)m) that binds two ligands,

119 e glycoprotein (heavy chain) associated with beta(2)-microglobulin (beta(2)m) that presents lipid ant

120 Once MHC class I heavy chain binds beta(2)-microglobulin (beta(2)m) within the endoplasmic

121 Allergen-induced AHR, however, develops in beta(2)-microglobulin (beta(2)m)(-/-) mice, which lack c

122 n genes but not genes encoding light chains (beta(2)-microglobulin (beta(2)m)), transporter associate

123 composed of a heavy chain, the small subunit beta(2)-microglobulin (beta(2)m), and a peptide.

124 vy chain, a noncovalently associated protein beta(2)-microglobulin (beta(2)m), and a peptide.

125 subunits, the 45-kDa heavy chain, the 12-kDa beta(2)-microglobulin (beta(2)m), and an approximately 8

126 ed of the lumenal domain of the heavy chain, beta(2)-microglobulin (beta(2)m), and peptide.

127 beta(2)-microglobulin (beta(2)m), labeled with a single

128 to amyloid-like fibrils formed in vitro from beta(2)-microglobulin (beta(2)m), the amyloid fibril pro

129 riant of the naturally amyloidogenic protein beta(2)-microglobulin (beta(2)m), to determine the solut

130 heterodimer consisting of a heavy chain and beta(2)-microglobulin (beta(2)m), which is essential for

131 HC class I recognition by alphabeta T cells, beta(2)-microglobulin (beta(2)m)-associated MHC class I

132 ting dissociation of target organ disease in beta(2)-microglobulin (beta(2)m)-deficient MRL-Fas(lpr)

133 entiation 1) heavy chain in association with beta(2)-microglobulin (beta(2)m).

134 like H chain in noncovalent association with beta(2)-microglobulin (beta(2)m).

135 concentrations of mRNA encoding H chain and beta(2)-microglobulin (beta(2)m).

136 th amyloid-like fibrils formed in vitro from beta(2)-microglobulin (beta(2)m).

137 rates of nucleation and elongation of human beta(2)-microglobulin (beta(2)m).

138 eristics associated with CR included age and beta(2)-microglobulin (beta-2M).

139 nic high-flux dialysis, as defined by higher beta-2 microglobulin (beta(2)M) clearance, compared with

140 growth as monitored by serum levels of human beta-2 microglobulin (beta(2)mu) and by prolonged surviv

141 Dialysis-related amyloidosis secondary to beta-2-microglobulin (beta 2m) deposits is a common comp

142 Beta-2-microglobulin (beta(2)m) has been shown to form a

143 ce, while HSC from class I-deficient donors (beta(2)-microglobulin(-/-) (beta(2)m(-/-))) failed to en

144 played greater susceptibility than CD8(-/-), beta(2)-microglobulin(-/-) (beta(2)m(-/-)), or WT mice t

145 anced Rai stage (P < .001), higher levels of beta(2)-microglobulin (beta2-M) (P < .001), and the abse

146 ha2/alpha3 domains of the H2D(d) H chain and beta(2)-microglobulin (beta2m) and is the functional bin

147 orms classical heterotrimeric complexes with beta(2)-microglobulin (beta2m) and peptide and (beta2m f

148 isk untreated patients < 70 years with serum beta-2 microglobulin (beta2M) >/= 4 mg/L.

149 or understanding its unique interaction with beta-2 microglobulin (beta2m) and peptide.

150 In dialysis patients, beta-2 microglobulin (beta2m) can aggregate and eventual

151 Beta-2 microglobulin (beta2m) is a small globular protei

152 Beta-2 Microglobulin (beta2m) is a small, globular prote

153 beta-2 microglobulin (beta2m) is an amyloidogenic protei

154 egaly, hepatomegaly, hemoglobin (Hgb) level, beta-2 microglobulin (beta2M) level in the serum, number

155 ions to compare the native state dynamics of Beta-2 microglobulin (beta2m), whose aggregation is asso

156 ctures of ThT with two alternative states of beta-2 microglobulin (beta2m); one monomeric, the other

157 Using beta-2-microglobulin (beta2m) as a model amyloid-forming

158 The deposition of beta-2-microglobulin (beta2m) as amyloid fibers results

159 s-related amyloidosis is the accumulation of beta-2-microglobulin (beta2m) as amyloid fibrils in the

160 long-term hemodialysis is the deposition of beta-2-microglobulin (beta2m) as amyloid plaques in the

161 Beta-2-microglobulin (beta2m) deposits as amyloid fibril

162 ly of amyloid-like fibrils formed from human beta-2-microglobulin (beta2m) in vitro.

163 Beta-2-microglobulin (beta2m) self-associates into fibri

164 /=60, elevated lactic dehydrogenase (LDH) or beta-2-microglobulin (beta2M), advanced stage, and bone

165 in both native and unfolded conformations of beta-2-microglobulin (beta2m).

166 growth as monitored by serum levels of human beta-2-microglobulin (beta2mu; P < .01), and prolonged s

167 those known to be produced by keratinocytes (beta-2 microglobulin, betaIG-H3, calgranulin A, cathepsi

168 o inhibit the expression of the light chain, beta(2)-microglobulin, block the dislocation of Class I

169 Pattern 2 lacked beta-2 microglobulin but contained several degradation p

170 phy, was positively linked to high levels of beta-2-microglobulin, C-reactive protein, and lactate de

171 x consisting of the MHC class I heavy chain, beta(2)-microglobulin, calreticulin, tapasin, Erp57 (ER6

172 a full-strength primary response depends on beta(2)-microglobulin (class I major histocompatibility

173 Beta 2 microglobulin clearance of F80B was < 5.0 ml/min

174 Beta 2 microglobulin clearance of T220L dialyzers was <

175 Urea, creatinine, and beta 2 microglobulin clearances were measured at blood f

176 ibility complex (MHC) class I, MHC class II, beta(2)-microglobulin, clusterin, interleukin-13 recepto

177 ither the FcRn H chain alone or FcRn H chain-beta(2)-microglobulin complex and appeared to be maintai

178 g of the free MHC-I-Hc, and not the MHC-I-Hc-beta(2)-microglobulin complex, by p12(I) represents a no

179 asmic reticulum, the class I heavy (H) chain-beta(2)-microglobulin complexes are detected in associat

180 Pretreatment plasma beta(2)-microglobulin concentrations decreased with time

181 Four markers (albumin, beta-2-microglobulin, cystatin C, and osteopontin) were

182 -beta 1-/- mice in the genetic background of beta 2-microglobulin deficiency (beta 2M-/-).

183 red onto a combined class I-deficient mouse (beta-2 microglobulin deficient; beta2m(0)) and class II-

184 idual CD8+ cells present in the periphery of beta 2-microglobulin-deficient (beta 2m-/-) mice are unk

185 no IL-4 or IgE responses to anti-IgD Ab and beta 2-microglobulin-deficient mice make large in vivo I

186 We now find that the failure of beta 2-microglobulin-deficient mice to make an IgE respo

187 to induce an IL-4-dependent IgE response in beta 2-microglobulin-deficient mice, which lack CD1; and

188 NK cells from beta(2)-microglobulin-deficient (B2m(-/-)) and wild-type

189 herpesvirus 68 (gammaHV68) infection of BALB beta(2)-microglobulin-deficient (BALB beta(2)m(-/-)) mic

190 ferentiate into IFN-gamma-producing cells in beta(2)-microglobulin-deficient (beta(2)m(-/-)) B6 recip

191 we also generated K14-OVA Tg chimeras using beta(2)-microglobulin-deficient (beta(2)m) congenic dono

192 conditioned B6 mice rejected both BALB/c and beta(2)-microglobulin-deficient BMCs.

193 BALB/c--> B6 chimeras rejected a low dose of beta(2)-microglobulin-deficient bone marrow cells (BMC)

194 terial burden compared with that of infected beta(2)-microglobulin-deficient mice that lack MHC class

195 erved that engraftment of CD34(+) cells in a beta(2)-microglobulin-deficient nonobese diabetic/severe

196 Cytoxicity was beta-2-microglobulin dependent and largely TAP dependent

197 Thus, CD1-responsive T cells and other beta 2-microglobulin-dependent T cells are not required

198 studies clearly indicate the importance of a beta(2)-microglobulin-dependent but CD8 T-cell- and iNK

199 ys demonstrated induction of a population of beta(2)-microglobulin-dependent, MHC class Ib-restricted

200 abeta does not contact the MHCI alpha(2)- or beta(2)-microglobulin domains.

201 ic value of PCLI response was independent of beta(2)-microglobulin, elevated creatinine, serum M-spik

202 ins was markedly decreased in the absence of beta 2 microglobulin expression and that calreticulin as

203 We report here on the critical importance of beta(2)-microglobulin expression during murine K. pneumo

204 e (human and monkey) MHC class I H chain and beta(2)-microglobulin failed to associate to form the no

205 e amyloid-forming proteins human insulin and beta(2)-microglobulin for segments that form fibrils.

206 in if patients with spondylarthritis express beta(2)-microglobulin-free HLA-B27 heavy chains in the f

207 xon (MuMT; B cell and antibody deficient) or beta 2 microglobulin gene (beta 2-/-; CD8 deficient) was

208 Unlike the results from the beta-2 microglobulin gene deletion experiments, our appr

209 I-deficient due to targeted mutation in the beta-2-microglobulin gene (SJL/J B2m (-/-) mice).

210 ed in mice deficient in micro heavy chain or beta-2 microglobulin genes, slightly extended in mice de

211 6), Thr(238), Arg(239), and Asp(241); and in beta(2)-microglobulin, Gln(29) and Lys(58)) of the Ly49A

212 Multivariate analysis identified beta(2)-microglobulin >/= 3 mg/L (P < .001) and age >/=

213 antation greater than 1 year from diagnosis; beta-2 microglobulin > 2.5 at transplant; female patient

214 T3b, age >/=65 years, male gender, levels of beta-2-microglobulin >5.5 mg/L, and multiple myeloma rel

215 Two partially folded intermediates of beta(2)-microglobulin have been identified experimentall

216 Male rats transgenic for HLA-B27 and human beta(2) -microglobulin (hbeta(2) m) spontaneously develo

217 spondylarthritis that develops in B27/human beta(2)-microglobulin (Hubeta(2)m)-transgenic rats.

218 monstrated for a simultaneous immunoassay of beta(2)-microglobulin, IgG, bovine serum albumin, and C-

219 t, vascular endothelial growth factor, Ptx3, beta(2)-microglobulin, IL-1alpha, Mcp-1 and -3, RANTES (

220 res assembly of MHC class I with peptide and beta 2-microglobulin in the endoplasmic reticulum.

221 ere was no significant binding of m4/gp34 to beta(2)-microglobulin in the absence of class I H chain,

222 a as inclusion bodies and refolded them with beta(2)-microglobulin in the presence or absence of a ra

223 families bound HLA-B27 in both classical and beta(2) microglobulin-independent forms.

224 lin-associated 48-kDa glycoprotein and novel beta(2)-microglobulin-independent 37-kDa nonglycosylated

225 Furthermore, tumor recognition was beta(2)-microglobulin-independent.

226 The self-assembly of beta(2)-microglobulin into fibrils leads to dialysis-rel

227 veal any differences in the association with beta(2)-microglobulin, invariant chain of class II MHC,

228 In multivariate analysis, however, beta(2)-microglobulin is the most important prognostic f

229 beta -2 microglobulin knockout (KO) mice were protected

230 beta 2 microglobulin knockout (beta2M-/-) mice lack CD8+

231 ese diabetic-severe combined immunodeficient-beta(2) microglobulin knockout (NOD/SCID/beta(2)m(-/-))

232 model of psychological stress and OVA-loaded beta(2)-microglobulin knockout "donor" cells that cannot

233 minished in mice deficient in CTL, including beta(2)-microglobulin knockout (KO), CD8 KO, and SCID mi

234 beta(2)-Microglobulin knockout animals controlled infect

235 Beta(2)-microglobulin knockout mice displayed significan

236 As beta(2)-microglobulin knockout mice lack both CD8(+) T c

237 account for the increased mortality noted in beta(2)-microglobulin knockout mice.

238 placed orthotopically in eyes of C57BL/6 and beta-2 microglobulin knockout mice (deficient in CD8(+)

239 beta-2 Microglobulin knockout mice showed rejection of c

240 ing early, acute rejection, yet T cells from beta-2 microglobulin knockout recipients of corneal allo

241 Using beta(2)-microglobulin-knockout, IFN-gamma-knockout, and

242 ted by the results in CD8+ T cell deficient, beta 2 microglobulin KO mice.

243 type mice, active disease was more severe in beta(2)-microglobulin KO mice.

244 ysis, factors predicting for longer FFS were beta(2)-microglobulin less than 3 mg/L (P =.01) and ATT

245 bsence of t(4;14), del(17p), and 1q gain and beta(2)-microglobulin less than 5.5 mg/L.

246 ating CD20 levels correlated positively with beta(2)-microglobulin level (p =.006) and percentage of

247 High serum beta(2)-microglobulin level and International Staging Sy

248 ient subgroups, including those based on the beta(2)-microglobulin level, cytogenetic profile, and re

249 ctive of survival include the patient's age, beta(2)-microglobulin level, monoclonal protein level, h

250 cyte count and serum neopterin levels, serum beta 2-microglobulin levels, and thrush or fever.

251 ush) or fever; serum neopterin levels; serum beta 2-microglobulin levels; number and percentage of CD

252 abnormal karyotype (P =.002) and high serum beta(2)-microglobulin levels (P =.0005), were most preva

253 CD8(+) T cells was measured, as were plasma beta(2)-microglobulin levels.

254 t stratum more frequently had elevated serum beta-2 microglobulin levels, high-risk Rai stage, and we

255 Low beta-2-microglobulin levels less than 2 mg/L were indepe

256 me 13 (triangle up13) abnormalities and with beta-2-microglobulin </= 2.5 mg/L, C-reactive protein </

257 Transthyretin, beta(2)-microglobulin, lysozyme, and the prion protein a

258 severe combined immunodeficiency (NOD/SCID) beta(2) microglobulin(-/-) mice, engrafted with human CD

259 Immunization and challenge studies with beta(2)-microglobulin(-/-) mice indicated that the reduc

260 CMV infection as compared with K(b-/-)D(b-/-)beta(2)-microglobulin(-/-) mice that lack expression of

261 th MIP-1 alpha was significantly impaired in beta(2)-microglobulin(-/-) mice.

262 An optimal ratio of three beta-2 microglobulin molecules per single HLA heavy chai

263 Irradiated beta(2)-microglobulin mutant mice or mice with mutations

264 In contrast, mouse H chains associated with beta(2)-microglobulin normally and bound peptide at leas

265 with normal CG, PCLI of less than 0.5%, and beta(2)-microglobulin of 3 mg/L.

266 In multivariate analysis, beta-2-microglobulin of more than 3.5 microg/mL at diagn

267 gnificant differences in the actual level of beta 2-microglobulin or in residual renal function betwe

268 e characteristics (prior treatment, elevated beta(2)-microglobulin or lactate dehydrogenase, or Rai s

269 due to deletion of the genes encoding either beta(2)-microglobulin or the TCR element J alpha 281.

270 he absence of accessory cells, MHC class II, beta 2-microglobulin, or TAP-1, suggesting that Ag prese

271 (BMPC%; P =.0004), increased levels of serum beta(2)-microglobulin (P =.04), and dominant cardiac amy

272 m levels of soluble IL-2R alpha and/or human beta-2-microglobulin (P <.05, t test) and by survival of

273 with HC10, but not with a mAb to folded B27-beta(2)-microglobulin-peptide complexes.

274 The HLA-B *1502/peptide/beta(2)-microglobulin protein complex showed binding aff

275 on and is stoichiometrically associated with beta(2)-microglobulin, similar to class I molecules.

276 is an increase in the levels of lactoferrin, beta(2)-microglobulin, sodium, lysozyme C, and cystatin

277 rs consisting of an antigenic peptide-spacer-beta(2)-microglobulin-spacer H chain.

278 P), lysozyme, myoglobin, alpha-synuclein and beta(2)-microglobulin, suggesting that common structural

279 inated when immune complex-loaded DCs lacked beta(2) microglobulin, TAP, or MHC class II, demonstrati

280 ion of MHC class I and related genes such as beta(2)-microglobulin, Tap1, or Lmp2, but did not affect

281 MHC class I antigen presentation, including beta-2 microglobulin, (TAP1), and TAP2.

282 ined high plasma concentrations of wild-type beta(2)-microglobulin, the affected members of this kind

283 Although m4/gp34 requires beta(2)-microglobulin to bind class I, there was no sign

284 ed endocytosis of both FITC-albumin and FITC-beta(2)-microglobulin to similar extents but without alt

285 onse (UPR) in macrophages from HLA-B27/human beta(2)-microglobulin-transgenic (B27-transgenic) rats.

286 normal renal function and normal circulating beta(2)-microglobulin values.

287 The Asp76Asn beta(2)-microglobulin variant was thermodynamically unst

288 ehensive biophysical characterization of the beta(2)-microglobulin variant, including its 1.40-A, thr

289 nts with ALK-positive and ALK-negative ALCL, beta(2)-microglobulin was >/= 3 mg/L in 12% and 33% (P =

290 However, if beta(2)-microglobulin was incorporated into the analysis

291 m lactate dehydrogenase was high in 35%, and beta-2 microglobulin was more than 3.0 mg/L in 35% of pa

292 Patients' plasma levels of HIV-1 RNA and beta 2-microglobulin were measured in stored plasma.

293 rium loss for fully deuterated ubiquitin and beta(2)-microglobulin were observed after 10 min of back

294 P53 aberration, advanced Rai stage, and high beta-2 microglobulin were independently associated with

295 ine) and middle molecular weight substances (beta 2 microglobulin) were compared during dialysis with

296 0 peptides (three from insulin and five from beta(2)-microglobulin) were identified as amyloid-like.

297 inhibitor of metalloproteinase [TIMP]-1, and beta-2-microglobulin) were higher in rAKI versus nAKI (P

298 dy, LTRs had lower baseline plasma levels of beta-2-microglobulin, were more likely to have trisomy 1

299 Recombinant sG1 associated with beta(2)-microglobulin, whereas rsG2 did not.

300 mers accumulate in the absence of tapasin or beta(2)-microglobulin, whereas W6/32-reactive dimers are