ライフサイエンスコーパス: beta structure

1 iented orthogonal to the fibril axis ("cross beta" structure).

2 Second, Hsp104 unfolds cross-beta structure.

3 ambda Cro sequence strongly favors the alpha+beta structure.

4 y protected by systematically H-bonded cross-beta structure.

5 must be modular, compact, and adopt a cross-beta structure.

6 pha-helix and that the 1-123 region may have beta structure.

7 the misfolding of Abeta42 into pathological beta structure.

8 s thermally stable and has a high content of beta structure.

9 th high fidelity into a double-layered cross-beta structure.

10 diffraction patterns consistent with a cross-beta structure.

11 pecially applicable to the de novo design of beta structure.

12 m of polypeptide configuration, termed cross-beta structure.

13 of 4.7 A, oriented appropriately for a cross-beta structure.

14 ed helical bridge joining a two-domain alpha/beta structure.

15 er transform-infrared spectrum indicative of beta structure.

16 pact, highly soluble, monomeric form rich in beta structure.

17 rientations in the beta subunit of the alpha beta structure.

18 acked the single-stranded DNA, and assumed a beta structure.

19 ide or protein aggregates containing a cross-beta structure.

20 find detailed evidence for an extended cross-beta structure.

21 nd extended conformation that can form cross-beta structure.

22 L9 (NTL9), a model protein with mixed alpha/beta structure.

23 harged surface of the fibrillar amylin cross-beta structure.

24 prions immediately C-terminal to their cross-beta structure.

25 n the region found to undergo a refolding to beta-structure.

26 , and propensities to form alpha-helices and beta-structure.

27 ent of residues within this region in stable beta-structure.

28 glycine), in equilibrium predominantly with beta-structure.

29 alpha-helical PrP(C) into aggregates rich in beta-structure.

30 protofibril, consistent with a superpleated beta-structure.

31 d PrPSc containing additional intermolecular beta-structure.

32 pha-helical secondary structure with a minor beta-structure.

33 de features, indicating a "loosening" of the beta-structure.

34 These intermediates were high in beta-structure.

35 es in alpha-helical conformation and <10% in beta-structure.

36 omain, domain C, which forms an antiparallel beta-structure.

37 hroism spectral properties characteristic of beta-structure.

38 ain with three helices and a small amount of beta-structure.

39 There is no evidence for any increase in beta-structure.

40 embrane-inserted peptide from alpha-helix to beta-structure.

41 C to PrPSc by template-assisted formation of beta-structure.

42 trinsic property of these peptides to form a beta-structure.

43 exhibits a reversible temperature-dependent beta-structure.

44 fibrils probably have a parallel in-register beta-structure.

45 ichroism measurements, this peptide adopts a beta-structure.

46 e aggregates, doing so by a slow increase in beta-structure.

47 t, and CD spectra that are characteristic of beta-structure.

48 are inconsistent with the formation of cross-beta-structure.

49 reflect two different architectures of cross-beta-structure.

50 iates, the earliest of which appears to lack beta-structure.

51 gument for the dynamic nature of their cross-beta-structure.

52 form a globular domain containingalpha- and beta-structure.

53 tional equilibrium in Abeta42 shifts towards beta-structure.

54 II helix that is closely packed to the core beta-structure.

55 ing pattern and strand twist, when designing beta structures.

56 the formation of the highly stable extended beta structures.

57 nd P-loop NTP hydrolase) are all mixed alpha-beta structures.

58 isting of both random coil and heterogeneous beta structures.

59 0 oligomers are rich in beta-sheet and cross-beta structures.

60 tially improve remote homology detection for beta structures.

61 nvolving transient populations of non-native beta-structures.

62 PSIIFILAYSLKKKS) retained a tendency to form beta-structures.

63 Circular dichroism shows primarily beta-structures.

64 2 promotes formation of more benign parallel beta-structures.

65 ls consist of conformationally uniform cross-beta-structures.

66 isease, where it forms interdigitating cross-beta-structures.

67 duli were 378 MPa for alpha- and 460 MPa for beta-structures.

68 P-2 had 3-fold less alpha-helix, 7-fold more beta-structure, 6-fold more reactive C terminus to carbo

69 ngements of the peptide satisfied the "cross-beta-structure", a hallmark of amyloid fibrils.

70 e inhibitors bind to and stabilize the early beta-structured Abeta oligomers and thus delay aggregati

71 tures of this complex reveal an unusual, all-beta structure adopted by the TCP domain and explain how

72 amorphous aggregates (protofibrils) rich in beta-structure after the lag phase but prior to the deve

73 due to nearly random allocation of alpha and beta structure along wild-type sequences.

74 In the former, an infinite, open beta-structure along one crystal axis results, while in

75 promoting increases in both alpha-helix and beta-structure, although they differ in binding affinity

76 Protein misfolding and formation of cross-beta structured amyloid fibrils are linked to many neuro

77 ns is essential for effective attenuation of beta-structured amyloid oligomeric species often associa

78 l N-terminal domain and a central open alpha/beta structure, an active site consisting of a SAM bindi

79 ling constants indicate the presence of some beta structure and a short helix, but the intervening lo

80 ry amino acid sequence, share a common cross-beta structure and bind the histochemical dye Congo Red

81 provide a new route for accessing the cross-beta structure and expanding the scope of protein design

82 NTL9 has a mixed alpha-beta structure and folds via a two-state mechanism.

83 a LC secreted by both cell lines contained a beta structure and formed amyloid fibrils.

84 Comparisons, made to pol beta structure and motions in the presence of a correct

85 s for molecular assembly of an amyloid cross-beta structure and provide insights into mechanistic asp

86 ined models of proteins with mixed alpha and beta structure and the analysis of the structural databa

87 the transcriptome is enriched in mixed alpha-beta structures and depleted in membrane proteins relati

88 of enzymatic degradation of Abeta with cross-beta structures and show the series of steps involved in

89 at VP5* forms the body and base primarily in beta-structure and alpha-helical conformations, respecti

90 500-A-long secreted protein that is rich in beta-structure and contains two regions, R1 and R2, of t

91 Smaller quantities of beta-structure and poly(l-proline) II (PPII) helix were

92 e indicated the presence of small amounts of beta-structure and substantial amounts (>50%) of alpha-h

93 r alanine, leads to increased propensity for beta-structure and the formation of amyloid-like fibrils

94 tions of the NHA hydroxyl with active center beta-structure and the heme ring polarize and distort th

95 xistence of fibril-like parallel in-register beta-structures and strongly suggest an antiparallel bet

96 ared data suggest that unique alpha-helical, beta structures, and side chain rearrangements are assoc

97 in a coiled coil motif, with no evidence of beta structures, and this was confirmed by circular dich

98 otein is monomeric in solution, has residual beta-structure, and is in a premolten globule state that

99 bule-like states cluster in the alpha-helix, beta-structure, and PPII-helix regions of the Ramachandr

100 udies of synthetic sPLA2 showed alpha-helix, beta-structure, and random coil contents consistent with

101 associated with turns, bends, alpha-helices, beta-structures, and random coils for inactivated viruse

102 al residues that are disordered in the alpha beta structure are fully resolved in our structure.

103 exists in a region where short stretches of beta-structure are found at analogous positions in GM-CS

104 ese changes concerned mainly glutenins since beta-structures are characteristic for them.

105 al structure, and the transverse axes of any beta structure, are preferentially oriented parallel to

106 show evidence of changes in alpha-helix and beta-structures as well as signals consistent with Arg,

107 ection at (0.47 nm)(-1), indicative of cross-beta structure, as predicted.

108 Globular heads folded in an unusual Beta-structure associate to form molecular dimers, and e

109 s work contributes to our understanding of A beta structure associated with aggregation and toxicity

110 mine at near residue level, the changes in A beta structure associated with aggregation to a fibril f

111 te that elastin has more turns and distorted beta-structure at higher temperatures.

112 bilayer and an increased propensity to form beta-structures at the membrane surface.

113 ble with higher distribution in the extended beta structure basin, but not a coil.

114 vent reveal that the CTFs adopt a metastable beta-structure: beta-hairpin for Abeta(x-42) (x=29-31) a

115 ys2 and Cys99 stabilizes a long and parallel beta-structure between strand A (residues 3-12) and stra

116 Arg(28) to Lys(181) and consists of an alpha/beta structure built from a six-stranded parallel beta-s

117 circular dichroism, it possesses no alpha or beta structure but has some organized structure associat

118 circular dichroism, they possess no alpha or beta structure but have some organized structure associa

119 Recombinant Hwp1 lacks alpha and beta structures by circular dichroism and likely exists

120 d of globules and short rods, show primarily beta-structure by circular dichroism (CD), enhance the f

121 d thioflavin T fluorescence and were rich in beta-structure by circular dichroism.

122 als how both parallel and antiparallel cross-beta structures can be constructed from similar peptide

123 Whereas beta structures can now be predicted with the new proced

124 idin distinguishes it from alpha-helical and beta-structured cationic peptides, because five of indol

125 l structure; the beta-solenoid has the cross-beta structure characteristic of all amyloids, but is in

126 The protein has a typical two-domain alpha/beta structure, characteristic of periplasmic extracytop

127 We show that the fractions of beta structure computed in our simulations and measured

128 The beta-structure condenses about beta(3-4), while alpha1 a

129 nding to DNA the disordered peptides adopt a beta-structure conformation.

130 oes an immediate conversion to a predominant beta-structured conformation in 2 mM SDS which does not

131 observed in the gluten structure concerning beta-structures, conformation of disulphide bridges, and

132 The catalytic domain is an alpha/beta structure contained within the first 92 amino acids

133 a folding topology in which three primarily beta-structure-containing domains meet to form a shallow

134 as accompanied by a dramatic increase in the beta-structure content and a characteristic increase in

135 e change involved an increase in predominant beta-structure content and in fluorescence with thioflav

136 ut no substantial population of alpha(L)- or beta-structures, despite sampling alpha(L)- and beta-str

137 better alignment in the turn region and the beta-structure domain.

138 The minimal beta-structure element is the beta-hairpin, which is als

139 was completely inhibited due to formation of beta-structure-enriched oligomers with high concentratio

140 results suggest that a parallel in-register beta structure exists at these spin-labeled positions.

141 family members, giving rise to a novel alpha/beta structure for the serotonin binding slot.

142 thods may be applicable to recognizing other beta structures for which strand topology and profiles o

143 and Arg66 accessible on the same face of the beta-structure for interaction with RNA.

144 he critical part of the parallel in-register beta-structure for the studied [PSI(+)] prion variant li

145 nilino-1-napthalenesulfonic acid binding and beta-structure formation inhibits FN multimerization and

146 f a simplified amino acid alphabet to design beta-structure forming L2 peptides with improved RecA-li

147 rgetically unfavorable in the extended cross-beta structure found in amyloid.

148 ADP-ribosylating toxins that have a similar beta-structure framework.

149 In contrast, the mechanism of formation of beta structures has not been studied experimentally.

150 of the structure, whereas the addition of a beta-structure has less effect.

151 s of wild-type proteins with mixed alpha and beta structure have symmetric distribution of alpha and

152 ing by Hsp104 then resolves N-terminal cross-beta structure in a stepwise manner.

153 sistent with an important role for a compact beta structure in mutant huntingtin-induced cell toxicit

154 u, are consistent with an important role for beta structure in PHF formation, and may also help expla

155 rm infrared (FTIR) spectra characteristic of beta structure in solution, binds to lipid bilayer vesic

156 his segment of the peptide are involved in a beta structure in the fibril.

157 o N- and C-terminal regions within the rigid beta structure in the repeat region of Tau(3RD).

158 y, this change involves the formation of new beta structure in which interstrand hydrogen bonds orien

159 ulated the formation of ordered amyloid-like beta structures in a system formed by 18 polyvaline chai

160 Electron diffraction confirmed cross-beta structures in both fibrils.

161 gnetic resonance techniques to contain cross-beta structures in which the beta-sheets have an in-regi

162 s showed that when the FLIVI sequence adopts beta-structure in aqueous solution, it associates into a

163 ocess, with the association process inducing beta-structure in otherwise non-beta-monomers.

164 d Arg38 is caused by a disruption of regular beta-structure in strand C opposite the beta-bulge in st

165 This leads to an increased population of beta-structure in the CHC.

166 ibril, the hinge loop that forms an extended beta-structure in the dimer remains protected, consisten

167 The beta-structure in the DNA pairing peptides can be induce

168 loid nucleation without measurably enhancing beta-structure in the monomer ensemble.

169 n monomers and oligomers is the formation of beta-structure in the oligomers occurring together with

170 epeat domain, which partially adopts a cross-beta-structure in the resulting amyloid-like fibrils.

171 f such side-chain interactions but it lacked beta-structure in two of the three denatured ensembles:

172 ost entirely helical, the Abeta analogs were beta-structured in the resulting vesicle dispersions.

173 s, the domain is partially converted to form beta-structures in lipid bilayers.

174 a-structures, despite sampling alpha(L)- and beta-structures in our MC simulations.

175 vent models predict that PHF6 forms extended beta-structures in solution, a finding consistent with t

176 suggesting conformational non-equivalence of beta-structures in the disease-associated Y145Stop varia

177 that M2-10, M2-14, M2-18, and M2-30 assumed beta-structures in this environment.

178 shares with mature amyloid fibrils the cross-beta structure, in which adjacent beta-sheets adhere by

179 s have shown that RRMs adopt a compact alpha/beta structure, in which four antiparallel beta-strands

180 ernative packing arrangements of native-like beta-structure, in which proline isomerism is important

181 self-associate in a specific manner to form beta-structured inclusions.

182 helix (helix A, or helix C) and the central beta structure involving the residues in the sixth, seve

183 The fucose alpha(1-->2) galactose beta structure is expressed by uterine epithelial cells

184 s predominantly alpha-helical, although some beta structure is likely to be present.

185 A CD spectrum indicative of beta structure is observed within 1 min of the solvent s

186 The alpha/beta structure is strikingly similar to the globular dom

187 detected with FTIR, indicating that a final beta-structure is attained.

188 al change of the peptide from random coil to beta-structure is important in binding ss- and dsDNA.

189 The resulting beta-structure is relatively planar and loose in the maj

190 ive folding in beta-hairpins and other small beta-structures is driven by cooperative strand-strand a

191 By analogy with the rat pol beta structure, it is suggested that each of these HhH m

192 more exposed and has a higher propensity to beta structure may accelerate the rate of fibril formati

193 stinction can be explained by a superpleated beta-structure model for PolyQKd-33 and a model with two

194 A beta-structure model for the loop L2 of RecA protein whe

195 s process leads to co-aggregates featuring a beta-structure motif that is characteristic for mature a

196 Both CCP and LmP have an extended section of beta structure near Trp(191) and Trp(208), respectively,

197 he 4.7 A spacing characteristic of the cross-beta structure of amyloids.

198 The alpha+beta structure of the protein reveals an SH3-like topolo

199 Through comparative analysis of the cross-beta structures of fibril-forming peptides, we identifie

200 novo approach for predicting both alpha and beta structures of proteins are described.

201 onserved loop that links predicted alpha and beta structures of this RNA binding motif lack who funct

202 As a result, the beta-structure of Abeta42 is more stable than that of Ab

203 no acids crucial to G(34) recognition by the beta-structure of the anticodon-binding domain of Thermu

204 linked macrocyclic beta-sheets 6 bind to the beta-structured oligomers more strongly, because N-termi

205 can bind to the N-terminal-based core of the beta-structured oligomers, while the C-terminal-derived

206 , we report an analysis of the effect of TGF-beta structure on its binding to TbetaRII by using TGF-b

207 This motif, with beta-structure on the outside and alpha-helix on the ins

208 nstructured polypeptide that adopts an alpha-beta structure only in the presence of the protease.

209 erminus of NEDD8 locking it into an extended beta-structure optimal for catalysis.

210 agments Sup35 prions without unfolding cross-beta structure or releasing soluble Sup35.

211 ed conformational change to either primarily beta-structure or helical structure, depending, among ot

212 of the C-terminal helix followed by loss of beta-structure or the opposite.

213 regates progressed to soluble fibers rich in beta-structure over a roughly 2 day period.

214 minal region, on the other hand, retains its beta-structure over the pH range 1-11, whereas more alka

215 erstanding of how arsenic binding influences beta-structure, pairs of cysteines were introduced into

216 variation in the amino-acid sequences of the beta-structures presents a challenge to developing a mod

217 When interacting with beta-structure promoting substances, such as surfactants

218 OPLS-AA reveals moderate beta-structure propensity coupled with extensive, but we

219 domains in the tau protein; all contain high beta-structure propensity in their R2, R3, and R4 repeat

220 echanism to form energetically-favored cross-beta structures, regardless of their precise sequences.

221 2.2-A resolution, revealing a compact alpha/beta structure related to the START domain present in th

222 lution, it can form aggregates rich in cross-beta structure, relatively long helical segments when bo

223 bow (with the active site nucleophile)-alpha-beta structure, residues 131-175 of the synthase.

224 ficiency, highlighting the importance of the beta-structure-rich regions for tau aggregation.

225 hese aggregates contain intermolecular cross-beta structure similar to that found in amyloid diseases

226 e, we observe the formation of two different beta-structured states with similar but distinct spectro

227 ty packing tends to occur toward the ends of beta-structure strands where hydrogen bonds are more lik

228 he aromatic side chains does not occur until beta-structure sufficient to bind thioflavin T has devel

229 nd C453 is populated by both random coil and beta-structure, suggesting that the cooperative structur

230 ectroscopy of StAR in PC membranes show more beta-structure than in aqueous buffers, and the presence

231 fined secondary structure that contains more beta-structure than the native state.

232 including a conserved beta alpha beta alpha beta structure that comprises the phosphoesterase motif.

233 GAR-syn adopts an alpha/beta structure that consists of four domains labeled N,

234 nstrate that curli fibrils possess the cross-beta structure that distinguishes protein amyloid.

235 Therefore, the extended D2 beta-structure that connects D1 to membrane-bound D4 app

236 s) fold at cell surfaces, adopting alpha- or beta-structure that enable their intracellular transport

237 prion protein-like conformation enriched in beta-structure that is in good agreement with available

238 can form soluble aggregates with predominant beta-structures that differ in stability and morphology.

239 Due to universality of the amyloid beta structure, the anisotropic mechanical dissociation

240 For the beta portions of alpha/beta structures, the C(alpha) rmsd's are less than 6.0 A

241 i, which isomerizes to form the active alpha beta structure; the structure of the enzyme has been det

242 her with selected beta-O-4, beta-5, and beta-beta structures, these compounds provide a detailed unde

243 use of the higher flexibility and entropy of beta structures, they could be preferred under the influ

244 nverted the all-alpha structure to the alpha+beta structure through sequences that could adopt both f

245 mbles: beta(3-4) was the only portion of the beta-structure to contain significant residual structure

246 om coil at low surfactant concentration, via beta-structure to the fully formed alpha-helical state a

247 n conformation, by causing an alpha-helix to beta-structures transition in both proteins.

248 As minimalist versions of beta-structure, two-stranded beta-hairpins are commonly

249 ore, the P protein folds to its native alpha/beta structure upon addition of various small molecule a

250 that mutant huntingtin polyglutamine adopts beta structure upon conversion to a toxic form.

251 an aqueous buffer and adopts a more ordered beta-structure upon binding to negatively charged membra

252 he structurally disordered N-terminus adopts beta-structure upon conversion to PrP(Sc) at low pH.

253 ajor refolding to a parallel and in-register beta-structure upon conversion.

254 lly soluble but that fragments or designs of beta structure usually aggregate suggests that natural b

255 sidual native helical structure, whereas the beta-structure was completely disrupted.

256 The beta-structure was oriented along the bilayer normal.

257 Consistent with their defining cross-beta structure, we find that in this series the amyloid

258 pair homologous DNAs by forming filamentous beta-structures, we propose how the information from the

259 beta-strand propagation and the promotion of beta-structure when an Arg is introduced adjacent to the

260 omprising an alpha-helix, a 3(10) helix, and beta-structure when bound to cyclin A-Cdk2.

261 e data suggest that the pro-peptide adopts a beta-structure when in contact with the protein, but it

262 dSP-C is fully recoverable from the amyloid beta-structure when the pH is once again lowered.

263 bles of proteins with significant amounts of beta-structure, where the specific entropy costs of cont

264 hat the N-terminal half was likely to form a beta-structure whereas the C-terminal half was likely to

265 hroism of the complex revealed a mixed alpha/beta structure, whereas Aga2p alone had no periodic seco

266 structure that is followed by conversion to beta-structure, whereas EtOH only unfolds the protein.

267 MeOH result in the formation of a non-native beta-structure, whereas subsequent additions of TFE indu

268 o an (alpha/beta)8 barrel with an associated beta-structure, whereas the attached CBM35 displays a je

269 e-2,6-bisphosphatase domain has a core alpha/beta structure which consists of six stacked beta-strand

270 The enzyme has an open (alpha, beta) structure which differs from the classical dinucle

271 ists of three domains: domain 1 has an alpha/beta structure; while domain 2 and domain 3 are beta-bar

272 nter-chain disulfides, and their presence in beta-structures with dense backbone hydrogen bonds creat

273 delicately balanced between alpha and alpha/beta structures, with different functions encoded with o

274 lical domains accompanied by the increase of beta structures within the PrP molecule.

275 s no evidence for significant enhancement of beta-structure within the monomer ensemble.