ライフサイエンスコーパス: beta-2 receptor

1 es a reversible conformational change of the beta 2 receptor.

2 are supported by experimental studies of the beta 2 receptor.

3 olidine) as a PET agent for nicotine alpha(4)beta(2) receptors.

4 in double KO mice lacking both beta(1)- and beta(2)-receptors.

5 enol was reduced in mice lacking beta(1)- or beta(2)-receptors.

6 osition reduced activity at the beta(1)- and beta(2)-receptors.

7 , IL-23alpha subunit p19 (IL23A), adrenergic beta-2 receptor (ADRB2), oxidized LDL (lectin-like) rece

8 SD) but only weak relaxations to salbutamol (beta(2)-receptor agonist; 13 +/- 3%; P < 0.05) or BRL-37

9 pointing and less effective than long-acting beta(2)-receptor agonists.

10 of IL-6 by salmeterol was dependent upon the beta(2) receptor and could also be induced by cAMP or cA

11 intrinsic activity at either the beta(1) or beta(2) receptor, and significant thermogenesis effects

12 ut were unaffected by ICI-118,551 (selective beta(2)-receptor antagonist) or SR-59,230A (selective be

13 alpha 1B, alpha 2B, and beta 2 receptors are expressed in rat footpads; alpha 1

14 s are expressed in rat footpads; alpha 1 and beta 2 receptors are localized specifically to sweat gla

15 Because the gene coding the adrenergic beta(2) receptor (beta(2)AR) is embedded in the 5-HT(4)R

16 rent consensus on the relative importance of beta(2) receptor blockade in treating glaucoma may have

17 depression and activation slowing of alpha 1 beta 2 receptors, but had little effect on currents from

18 Zn2+ slowed macroscopic gating of alpha 1 beta 2 receptors by inducing a novel slow exponential co

19 These results demonstrate that the beta(2) receptor can be a critical effector of acute str

20 fector of acute stress, and that beta(1) and beta(2) receptors can have quite distinct roles in CNS s

21 nuclear phospho-ERK1/2 than the chimeric V2 beta 2 receptor, consistent with the cytosolic retention

22 Surprisingly, beta(2)-receptors contribute to adrenergic vasodilation

23 alpha 1 and, to a lesser extent, beta 2 receptors decrease during development, whereas al

24 The number of alpha 1 and beta 2 receptors decreases after P21, when the sympathet

25 eptor cross-talk, which in turn could modify beta-2 receptor downregulation and associated tolerance

26 Analysis of CD spectra of purified beta 2 receptor in the detergent micelle indicated that

27 ABA (5 microM)-triggered currents of alpha 1 beta 2 receptors in a concentration-dependent manner (in

28 nses in K-177 cells expressing human alpha 4 beta 2 receptors, in IMR-32 and SH-SY5Y cells expressing

29 In stably transfected HEK-293 cells, the V2 beta 2 receptor increased ERK1/2-mediated, Elk-1-driven

30 In summary, the beta-2 receptor mediates beta-adrenergic stimulation of

31 t, it is not known whether the beta-1 or the beta-2 receptor mediates this effect.

32 polymerase chain reaction analyses show that beta(2)-receptor mRNA is the predominant beta-receptor m

33 lmeterol induced high-affinity states of the beta 2-receptor (pKh 9.6 +/- 0.4 and 10.4 +/- 0.7, respe

34 Binding of (18)F-nifrolidine to alpha(4)beta(2) receptor-rich regions in rats and monkeys indica

35 Nicotine alpha(4)beta(2) receptor subtypes are implicated in the study of

36 ion pattern of nAChR containing alpha(4) and beta(2) receptor subunits (alpha(4)beta(2)*).

37 97), destroyed ligand binding of the alpha(M)beta(2) receptor, suggesting that these function-blockin

38 open and closed conformation of the alpha(M)beta(2) receptor, thereby indirectly affecting alpha(M)b

39 Similar contributions of beta(1)- and beta(2)-receptors to isoproterenol-induced vasorelaxatio

40 Using these mutant alpha(M)beta(2) receptors, we have mapped the epitopes of nine b

41 -fold selectivity over the human beta(1) and beta(2) receptors, which also displays good oral bioavai

42 eptors and enhanced activity at beta(1)- and beta(2)-receptors, while fluorination at the 6-position

43 also biexponential for preactivated alpha 1 beta 2 receptors with current depression more than fourf

44 substitution of the I domain of the alpha(L)beta(2) receptor with that of alpha(M) confers the alpha

45 or with that of alpha(M) confers the alpha(L)beta(2) receptor with the ability to interact with LRP1.