ライフサイエンスコーパス: beta-Ala

1 aacetic acid (DOTA)-X-BBN[7-14]NH(2) (X = 0, beta-Ala, 5-Ava, 8-Aoc, or 11-Aun) conjugates and their

2 We have recently discovered that [d-Tyr(6),beta-Ala(11),Phe(13),Nle(14)]Bn-(6-14) has high affinity

3 no acids into the prototype ligand [d-Tyr(6),beta-Ala(11),Phe(13),Nle(14)]Bn-(6-14) or its d-Phe(6) a

4 for nuclear access include the presence of a beta-Ala-tail residue and the lack of a cationic alkyl a

5 dministration of hybrid 13a (H-Dmt-d-Arg-Aba-beta-Ala-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2) to mice resulted i

6 in, the opioid pharmacophore H-Dmt-d-Arg-Aba-beta-Ala-NH2 (7) was linked to peptide ligands for the n

7 beta-Alanine (beta-Ala) betaine is an osmoprotective compound accumula

8 at the position of Asn15, N-butylglycine and beta-Ala at Met16, naphthylalanine (Nal) at Trp19, 4-pyr

9 -(Arg(11))CCMSH (1) {c[Arg-Ser-Asp-dTyr-Asp]-beta-Ala-Cys-Cys-Glu-His-dPhe-Arg-Trp-Cys-Arg-Pro-Val-NH

10 One ligand, GXH-32B-c[beta-Ala-His-d-Nal(2')-Arg-Trp-Glu]-Val-Val-Gly-NH(2), t

11 In particular, the mu-agonist c[beta-Ala-d-Pro-Phe-Trp] 9 was shown to elicit potent ant

12 eta-Ala, N-methyl beta-Ala, and N,N-dimethyl beta-Ala as methyl acceptors.

13 eta-Ala, N-methyl beta-Ala, and N,N-dimethyl beta-Ala, respectively.

14 eta-Ala, N-methyl beta-Ala, and N,N-dimethyl beta-Ala.

15 a-Ala via N-methyl beta-Ala and N,N-dimethyl beta-Ala.

16 4), NAD-beta-Ala-(Arg(11))CCMSH (5), and EAD-beta-Ala-(Arg(11))CCMSH (6) peptides were synthesized an

17 expressing phosphoacceptor mutants rat C/EBP beta Ala-105 or mouse C/EBP beta Ala-217.

18 utants rat C/EBP beta Ala-105 or mouse C/EBP beta Ala-217.

19 tor substrates were 5.3, 5.7, and 5.9 mM for beta-Ala, N-methyl beta-Ala, and N,N-dimethyl beta-Ala,

20 e genus that lacks the synthetic pathway for beta-Ala betaine.

21 mino-3-phenylpropionic acid substitution for beta-Ala(11) in the prototype ligand had the highest sel

22 convert the substrate preference of hGS from beta-Ala to Gly.

23 -Val and the three achiral amino acids Gly, beta-Ala, and GABA).

24 -Glu]-Val-Val-Gly-NH(2) [XXX = nothing, Gly, beta-Ala, gamma-Abu, 6-Ahx; YYY = His, His(3-Bom), (S)-c

25 of the torsional flexibility of the main His-beta-Ala chain, while retaining the rigidity conferred b

26 rovide extra space to accommodate the longer beta-Ala moiety of hGSH in comparison to the glycinyl gr

27 unctional S-adenosyl L-methionine (Ado-Met): beta-Ala N-methyltransferase (NMTase).

28 ndent N-methylation of beta-Ala via N-methyl beta-Ala and N,N-dimethyl beta-Ala.

29 t were highly specific to beta-Ala, N-methyl beta-Ala, and N,N-dimethyl beta-Ala as methyl acceptors.

30 5.3, 5.7, and 5.9 mM for beta-Ala, N-methyl beta-Ala, and N,N-dimethyl beta-Ala, respectively.

31 rifunctional, methylating beta-Ala, N-methyl beta-Ala, and N,N-dimethyl beta-Ala.

32 rified NMTase was trifunctional, methylating beta-Ala, N-methyl beta-Ala, and N,N-dimethyl beta-Ala.

33 SH (3), RAD-beta-Ala-(Arg(11))CCMSH (4), NAD-beta-Ala-(Arg(11))CCMSH (5), and EAD-beta-Ala-(Arg(11))C

34 aceae), it is synthesized via methylation of beta-Ala by the action of a trifunctional S-adenosyl L-m

35 osyl-L-methionine-dependent N-methylation of beta-Ala via N-methyl beta-Ala and N,N-dimethyl beta-Ala

36 ) participate in the three N-methylations of beta-Ala.

37 betaine (93-101 micromol g(-1) dry weight of beta-Ala betaine and Gly betaine) than untransformed cel

38 nosinase activity and the ability to grow on beta-Ala and/or L-His were similar in the mutant and the

39 steine followed by a C-terminal Gly, Ser, or beta-Ala residue [poly-(gamma-Glu-Cys)n-Xaa].

40 ine, tri(ethylene glycol), and Tyr-D-Arg-Phe-beta-Ala (YRFA) peptide were synthesized.

41 In the Plumbaginaceae, beta-Ala betaine is synthesized by S-adenosyl-L-methioni

42 Peptide sequences from purified beta-Ala NMTase were used to design primers for reverse

43 SH (2), RVD-beta-Ala-(Arg(11))CCMSH (3), RAD-beta-Ala-(Arg(11))CCMSH (4), NAD-beta-Ala-(Arg(11))CCMSH

44 RSD-beta-Ala-(Arg(11))CCMSH (1) {c[Arg-Ser-Asp-dTyr-Asp]-bet

45 -His-dPhe-Arg-Trp-Cys-Arg-Pro-Val-NH 2}, RTD-beta-Ala-(Arg(11))CCMSH (2), RVD-beta-Ala-(Arg(11))CCMSH

46 -NH 2}, RTD-beta-Ala-(Arg(11))CCMSH (2), RVD-beta-Ala-(Arg(11))CCMSH (3), RAD-beta-Ala-(Arg(11))CCMSH

47 Phylogenetic analyses suggested that beta-Ala NMTase represents a novel family of N-methyltra

48 the substitution of the Lys linker with the beta-Ala could reduce the renal uptake of (99m)Tc-labele

49 Tase activities that were highly specific to beta-Ala, N-methyl beta-Ala, and N,N-dimethyl beta-Ala a

50 bitory concentration of 50% for analogs with beta-Ala, 5-Ava, and 8-Aoc spacers.

51 The substitution of the Lys linker with beta-Ala linker dramatically reduced the renal uptake of