ライフサイエンスコーパス: beta-adrenergic receptor kinase

1 units (C-terminal fragment peptide of bovine beta-adrenergic receptor kinase).

2 s; Rab5 and Gbetagamma heterodimers; and the beta-adrenergic receptor kinase.

3 nd, to a lesser extent, the PH domain of the beta-adrenergic receptor kinase.

4 cking protein kinase A, protein kinase C, or beta-adrenergic receptor kinase.

5 nding peptide derived from the C terminus of beta-adrenergic receptor kinase 1 (50 microM) prevented

6 The beta-adrenergic receptor kinase 1 (beta ARK1) is a membe

7 beta-Adrenergic receptor kinase 1 (beta ARK1) mediates b

8 Expression of the C-terminus domain of beta-adrenergic receptor kinase 1 (beta ARK1), which con

9 beta-Adrenergic receptor kinase 1 (betaARK 1 or GRK2) me

10 Expression of the betagamma-binding agents beta-adrenergic receptor kinase 1 (C-terminus, betaARK1C

11 tigation we demonstrate a novel finding that beta-adrenergic receptor kinase 1 and phosphoinositide 3

12 by the Gbetagamma scavengers transducin and beta-adrenergic receptor kinase 1 carboxyl-terminal frag

13 Overexpression of beta-adrenergic receptor kinase 1 carboxyl-terminal pept

14 lar regarding the roles of phospholamban and beta-adrenergic receptor kinase 1 in mediating the contr

15 beta-adrenergic receptor kinase 1 interacts with phospho

16 binding, which was associated with increased beta-adrenergic receptor kinase 1 levels.

17 ed since the expression of the C terminus of beta-adrenergic receptor kinase 1, a Gbetagamma subunit-

18 blocked by the Gbetagamma-binding region of beta-adrenergic receptor kinase 1, suggesting that fast

19 vented, however, by the C-terminal region of beta-adrenergic receptor kinase 1, which sequesters Gbet

20 ase form a cytosolic complex, which leads to beta-adrenergic receptor kinase 1-mediated translocation

21 and ERK1/2 activation through activation of beta-adrenergic receptor kinase 1.

22 t enhanced by simultaneous overexpression of beta-adrenergic receptor kinase 1.

23 ein-coupled receptor kinases (GRKs) 2 and 3 (beta-adrenergic receptor kinases 1 and 2 (betaARK1 and -

24 vented by betaARK-ct, a peptide inhibitor of beta-adrenergic receptor kinase-1 (betaARK1) as well as

25 Levels of beta-adrenergic receptor kinase-1 C-terminal fragment th

26 verexpressing a carboxyl-terminal peptide of beta-adrenergic receptor kinase-1 that inhibits Gbetagam

27 nuated in transgenic mice overexpressing the beta-adrenergic receptor kinase-1, another member of the

28 -expression of CCR2B in Xenopus oocytes with beta-adrenergic receptor kinase 2 (beta ark2), but not b

29 essing mammalian mu-opioid receptors (MORs), beta-adrenergic receptor kinase 2 (beta-ARK2) [also call

30 Coexpression of beta-adrenergic receptor kinase 2 (beta-ARK2) and beta-a

31 under the same conditions, overexpression of beta-adrenergic receptor kinase 2 and beta-arrestin 2 ac

32 ressed in the same system, overexpression of beta-adrenergic receptor kinase 2 elevated agonist-induc

33 -protein-coupled receptor kinase 3 (GRK3; or beta-adrenergic receptor kinase 2) was not only necessar

34 n an intron of the gene ADRBK2, encoding the beta-adrenergic receptor kinase 2.

35 eceptor density and increases in Galphai and beta-adrenergic receptor kinase activities attenuate the

36 sphate, pertussis toxin, RGS4, a fragment of beta-adrenergic receptor kinase and inhibitors of cAMP-d

37 messenger-regulated protein kinases and from beta-adrenergic receptor kinase and other members of the

38 ologues of pyruvate carboxylase, DNA gyrase, beta-adrenergic receptor kinase, and human hypothetical

39 GFP and the carboxyl-terminal domain of the beta-adrenergic receptor kinase (beta ARKct), which inhi

40 inhibited by expression of the C-terminus of beta-adrenergic receptor kinase (beta ARKct), which spec

41 recently identified binding partner for the beta-adrenergic receptor kinase (betaARK or GRK-2), whic

42 Here, we analyzed the regulation of beta-adrenergic receptor kinase (betaARK) and GRK6 expre

43 ist-mediated receptor phosphorylation by the beta-adrenergic receptor kinase (betaARK) facilitates su

44 Although the beta-adrenergic receptor kinase (betaARK) mediates agoni

45 dues 355-371) of ICL3, and a deletion of the beta-adrenergic receptor kinase (betaARK) phosphorylatio

46 ic receptor (beta2AR) or an inhibitor of the beta-adrenergic receptor kinase (betaARK), an enzyme tha

47 in numerous signaling proteins including the beta-adrenergic receptor kinase (betaARK), was found to

48 ity could be attributed predominately to the beta-adrenergic receptor kinase (betaARK).

49 ta/gamma scavenger, the carboxyl terminus of beta-adrenergic receptor kinase (betaARK-ct), and N17Ras

50 ct of alterations in the level of myocardial beta-adrenergic receptor kinase betaARK1) in two types o

51 s impairment may involve enhanced myocardial beta-adrenergic receptor kinase (betaARK1) activity beca

52 could be enhanced beta-AR desensitization as beta-adrenergic receptor kinase (betaARK1) activity was

53 A potential molecular mechanism is enhanced beta-adrenergic receptor kinase (betaARK1) activity, bec

54 ility and functional consequences of in vivo beta-adrenergic receptor kinase (betaARK1) inhibition in

55 ing increased expression and activity of the beta-adrenergic receptor kinase (betaARK1).

56 cess mediated in part by increased levels of beta-adrenergic receptor kinase (betaARK1).

57 Since beta-adrenergic receptor kinase, betaARK1, activity rema

58 betaARKct) encoding the carboxyl terminus of beta-adrenergic receptor kinase (betaARKct) in a pig mod

59 ng Gbetagamma using the C-terminal domain of beta-adrenergic receptor kinase (cbetaARK) resulted in c

60 l cells that expression of the C terminus of beta-adrenergic receptor kinase (ct-betaARK), an inhibit

61 The structure establishes that the beta-adrenergic receptor kinase extended PH domain has t

62 wo independent scavengers of Gbetagamma, the beta-adrenergic receptor kinase fragment, and a mutated

63 nase 1 (GPRK1), which is most similar to the beta-adrenergic receptor kinases, G protein-coupled rece

64 ly that the membrane association of betaARK (beta-adrenergic receptor kinase) (GRK2) is mediated, in

65 Further, the abundance or activity of beta-adrenergic receptor kinase, GRK5, or Gi did not sig

66 tagamma inhibitor (glutathione S-transferase-beta-adrenergic receptor kinase (GST-BARK)) did not inhi

67 cted rod outer segments by recombinant human beta-adrenergic receptor kinase (hbetaARK1) holoenzyme w

68 rotein kinase C (PKC) phosphorylation of the beta-adrenergic receptor kinase in membrane association

69 ded pleckstrin homology (PH) domain from the beta-adrenergic receptor kinase is obtained by high reso

70 genic mice, and G protein receptor kinase 2 (beta-adrenergic receptor kinase) levels were increased,

71 n contrast, heterologous PH domains from the beta-adrenergic receptor kinase, phospholipase Cgamma, o

72 Moreover, while beta-adrenergic receptor kinase phosphorylation of rhodo

73 While the beta-adrenergic receptor kinase promotes significant arr

74 terestingly, co-expression of high levels of beta-adrenergic receptor kinase restores receptor down-r

75 enylyl cyclase 2, phospholipase C-beta2, and beta-adrenergic receptor kinase revealed the Gbeta resid

76 quence motif found in potassium channels and beta-adrenergic receptor kinases that are regulated by t

77 ion, whereas cotransfection of C-terminal of beta-adrenergic receptor kinase, which abrogates G(betag