ライフサイエンスコーパス: beta-alanine

1 ular receptor for the itch-inducing chemical beta-alanine.

2 f AMP serves as an anchor for the binding of beta-alanine.

3 s in the coenzyme A pathway, pantothenate or beta-alanine.

4 d gene E (rMrgE) receptor did not respond to beta-alanine.

5 on of pantothenate from ATP, D-pantoate, and beta-alanine.

6 ctly in the conversion of 3-aminopropanal to beta-alanine.

7 2b has been synthesized beginning with N-Cbz-beta-alanine.

8 tizing GABA(A) receptor agonists taurine and beta-alanine.

9 sine's constituent amino acids histidine and beta-alanine.

10 rs, followed by amino acid compounds, mainly beta-alanine.

11 (PanD) enzyme that converts pantothenate to beta-alanine.

12 all zwitterions, such as glycine betaine and beta-alanine.

13 that these mice exhibit normal responses to beta-alanine.

14 , injection of AOA in C57BL/6 mice placed on beta-alanine (0.1% w/v in drinking water) for 2 weeks le

15 h between the extended binding of the parent beta-alanine 1 (DbaPyPyPy-beta-PyPyPy) and the hairpin b

16 The pan D lines had increased levels of leaf Beta-alanine (1.2- to 4-fold), pantothenate (3.2- to 4.1

17 at alpha4beta2delta (gaboxadol, 10 muM, and beta-alanine, 10 muM-1mM), on surface expression of alph

18 These effects were replicated by beta-alanine (100 microM), but not by SKF 89976A (30 mic

19 We found that the conventional beta-alanine-3,3'-diamino-N-methyldipropylamine (betaDa)

20 -penicillamylglycine (6a) and D-penicillamyl-beta-alanine (6d), at 1/20 the molar concentration of et

21 )-oxoisoquinolin-2-yl ]acetyl]-3(S)- ethynyl-beta-alanine, 6d (L-767,679), is a potent fibrinogen rec

22 Fluoro-beta-alanine, a 5-FU catabolite, was not detected in pla

23 beta-Alanine, a popular supplement for muscle building,

24 the decarboxylation of aspartate to produce beta-alanine, a precursor of Coenzyme A (CoA).

25 ions within the laminar glial network causes beta-alanine accumulation in retinal pigment cells and i

26 The dB/dT values suggest that L-glycine and beta-alanine act as structure-breaker, while L-leucine a

27 netic mechanism that requires the binding of beta-alanine after the release of pyrophosphate from the

28 Beta-alanine (Ala) betaine, an osmoprotectant suitable u

29 BOC-L-alanine alkyl esters and BOC-beta-alanine alkyl esters were tested as guests, and the

30 plied capsaicin and intradermal injection of beta-alanine, an MrgprD agonist, excite vigorously all Q

31 decarboxylation of L -aspartate to generate Beta-alanine and carbon dioxide.

32 oxyphenylalanine decarboxylase (DDC) provide beta-alanine and dopamine used in insect cuticle tanning

33 Abiotic amino acids such as beta-alanine and epsilon-aminocaprioc acid are detected

34 In contrast, buffers such as glycine, beta-alanine and gamma-amino-butyric acid (GABA) produce

35 Calcium imaging reveals that beta-alanine and histamine activate distinct populations

36 haracteristic muscle di-peptides composed of beta-alanine and histidine derivatives such as anserine

37 The important roles of beta-alanine and imidazole for 1:1 binding are discussed

38 e ATP-dependent condensation of pantoate and beta-alanine and is a direct precursor of coenzyme A.

39 is able to resolve sarcosine from alpha- and beta-alanine and is useful for quantifying sarcosine in

40 The densities and viscosities of L-glycine, beta-alanine and L-leucine have been determined in water

41 inose and d-ribose with glycine, alpha-l- or beta-alanine and l-valine in pH 7.0 phosphate buffer at

42 expected enzymes for the biosynthesis of the beta-alanine and pantoic acid moieties required for coen

43 d by FMS1, was found to be rate-limiting for beta-alanine and pantothenic acid biosynthesis.

44 G-protein-coupled receptor, member D ligand beta-alanine and PD123319, but not by the Mas antagonist

45 lipid diacylglyceryl-hydroxymethyl-trimethyl-beta-alanine and phosphatidyldimethylpropanethiol, both

46 HEK cells, reduced the potencies of glycine, beta-alanine and taurine by 9-, 6- and 3-fold respective

47 HDOC and classical glycine receptor agonists beta-alanine and taurine directly activated alpha6beta2d

48 ivated by GABA, 1400 s(-1) when activated by beta-alanine, and 50 s(-1) when activated by P4S.

49 s were 0.13, 0.8, and 2.6 mM for D-pantoate, beta-alanine, and ATP, respectively, and the turnover nu

50 ole, gamma = gamma-aminobutyric acid, beta = beta-alanine, and Dp = dimethylaminopropylamide), reveal

51 here gamma = gamma-aminobutyric acid, beta = beta-alanine, and Dp = dimethylaminopropylamide).

52 partic and glutamic acids, glycine, alanine, beta-alanine, and gamma-amino-n-butyric acid (gamma-ABA)

53 nDhp in complexes with hydantoin, N-carbamyl-beta-alanine, and N-carbamyl-beta-amino isobutyrate as w

54 easuring plasma uracil, urinary alpha-fluoro-beta-alanine, and peripheral-blood mononuclear cell (PBM

55 e complexed with AMP and its last substrate, beta-alanine, and show that the phosphate group of AMP s

56 Only 40% of SCs respond to beta-alanine, and their response is only half that of QC

57 ivated by GABA, 1500 s(-1) when activated by beta-alanine, and too low to be determined when P4S was

58 ve predominantly trityl-protected alpha-iodo-beta-alanines, and hence norlanthionines, as the major p

59 fired a single action potential (AP) before beta-alanine application fired multiple APs during beta-

60 The actions on receptors activated by P4S or beta-alanine are also broadly consistent with this idea.

61 s, the primary sensory neurons responsive to beta-alanine are likely part of a histamine-independent

62 Pantothenic acid and beta-alanine are metabolic intermediates in coenzyme A b

63 hotolabile derivative of beta-alanine, caged beta-alanine, are described.

64 ity, low-capacity transporter of taurine and beta-alanine; ATB(0,+) (SLC6A14) is a Na(+)- and Cl(-)-d

65 spe2Delta, spe3Delta, and spe4Delta are all beta-alanine auxotrophs.

66 Insertion of 6-aminohexanoic acid (X) or beta-alanine (B) residues into oligoarginine R8 decrease

67 = 69).Of the 10 dietary biomarkers analyzed, beta-alanine (beef) (P-raw < 0.001), alkylresorcinols C1

68 uents disrupt DNA binding, (R)-alpha-methoxy-beta-alanine (beta((R)-OMe)) maintains strong binding af

69 hylhydroxypyrrole (Hp) amino acids linked by beta-alanine (beta) bind the minor groove of DNA in 1:1

70 A series of alpha-substituted beta-alanine (beta) linked polyamides (DbaPyPyPy-beta*-P

71 improve our understanding of the effects of beta-alanine (beta) substitution and the number of heter

72 (Im), pyrrole (Py), hydroxypyrrole (Hp), and beta-alanine (beta), are synthetic ligands that form hig

73 beta-Alanine (beta-Ala) betaine is an osmoprotective com

74 ethylproline, proline betaine (stachydrine), beta-alanine betaine, 4-guanidinobutyric acid, trigonell

75 erevisiae, ALD2 and ALD3 are specialized for beta-alanine biosynthesis and are consequently involved

76 AD-containing amine oxidases and its role in beta-alanine biosynthesis suggested that its substrates

77 To identify the gene(s) for beta-alanine biosynthesis, we have established the pathw

78 polyamine pathway in yeast are necessary for beta-alanine biosynthesis; spe1Delta, spe2Delta, spe3Del

79 related gene D (rMrgD) receptor responded to beta-alanine but not L-alanine by elevating intracellula

80 nity, low-capacity transporter which accepts beta-alanine but not taurine.

81 were differentially induced by Spd, DAP, and beta-alanine but showed no apparent response to Put, Cad

82 Metabolism of 3-AP to beta-alanine by aldehyde dehydrogenase was also evaluate

83 Photolysis of 2-methoxy-5-nitrophenyl-beta-alanine by irradiation with a 600-ns laser pulse at

84 racterization of a photolabile derivative of beta-alanine, caged beta-alanine, are described.

85 beta-Alanine can activate the glycine receptor, a major

86 inefficient, by demonstrating that exogenous beta-alanine can be effectively routed toward oxidation.

87 The beta-alanine carrier was characterized functionally in t

88 e encodes the transport protein known as the beta-alanine carrier which, due to its broad substrate s

89 s, the key functional characteristics of the beta-alanine carrier, identified previously in situ in i

90 is the molecular correlate of the intestinal beta-alanine carrier, perhaps the last of the classical

91 beta-Alanine carrier-like function has not been demonstr

92 Oligoglycine and oligo(beta-alanine) chains underwent oligomerization by 1,3-di

93 m; the 2-methoxy-5-nitrophenyl derivative of beta-alanine combined with a laser-pulse photolysis meth

94 The beta-alanine component was prepared using Davies' asymme

95 The intracluster open durations elicited by beta-alanine could be described by the sum of two expone

96 zin-3-one chromogens and their corresponding beta-alanine derivatives were synthesized and evaluated

97 dase activity in bacteria known to hydrolyze beta-alanine derivatized substrates.

98 and that bauABCD are essential for growth on beta-alanine derived from DAP (or Spd) catabolism via th

99 an GABA-T and AGXT2 are able to transaminate beta-alanine efficiently.

100 Here we show that, in mice, beta-alanine elicited itch-associated behavior that requ

101 diacylglycerylhydroxymethyl-N,N,N-trimethyl-beta-alanine, esterified with 13-methyl-tetradecanoic (i

102 These inhibitors are functionalized beta-alanines, exemplified by 2a.

103 lanine application fired multiple APs during beta-alanine exposure.

104 binding conformation differing from both the beta-alanine (extended) or gamma-aminobutyric acid (hair

105 ntoate binding, release of PP(i), binding of beta-alanine, followed by the release of pantothenate an

106 showed an equivalent dependence on exogenous beta-alanine for growth in liquid medium.

107 inactive carcinine through conjugation with beta-alanine for transport.

108 other prokaryotes where the enzyme producing beta-alanine from l-aspartate is a pyruvoyl-containing l

109 inating other known and proposed pathways to beta-alanine from malonate semialdehyde, l-alanine, sper

110 ydrogenase-mediated step is required to make beta-alanine from the precursor aldehyde, 3-aminopropana

111 e of alanine analogues, including d-alanine, beta-alanine, glycine and l-serine, but not d-serine, tr

112 ents with an order of potency (hypotaurine > beta-alanine > GES > GABA) similar to that reported for

113 and the order of agonist potency was GABA > beta-alanine > glycine.

114 ic gamma 2L receptors were also activated by beta-alanine > taurine > glycine, and, like some types o

115 uch architecture, the beta-peptoids (N-alkyl-beta-alanines), has found use in a variety of biological

116 s exclusively innervate the skin, respond to beta-alanine, heat, and mechanical noxious stimuli but d

117 beta-amino acid beta-glycine (also known as beta-alanine); however, the potential of these species t

118 2-Methoxy-5-nitrophenyl-beta-alanine hydrolyzes in aqueous solution at neutral p

119 cysteine sulfinic acid, and cysteic acid to beta-alanine, hypotaurine, and taurine, respectively.

120 on of pantothenate from ATP, D-pantoate, and beta-alanine in bacteria, yeast, and plants.

121 xylation of aspartate was the only source of beta-alanine in cell extracts of M. jannaschii.

122 hich is in turn controlled by degradation of beta-alanine in liver and kidney.

123 This structure confirms that binding of beta-alanine in the active site cavity can occur only af

124 n the lamina, we detected both carcinine and beta-alanine in the fly retina, where they are found in

125 antothenate formation from the adenylate and beta-alanine in the second half reaction could not be me

126 established the pathway for the formation of beta-alanine in this organism after experimentally elimi

127 nthesis via conversion of 3-aminopropanal to beta-alanine in vivo.

128 a-cholesterylamine derivatives bearing fewer beta-alanines in the linker region or N-acyl derivatives

129 thyl]-2-oxopiperidinyl ]acetyl]-3(R)- methyl-beta-alanine) in which the lactam chiral center has been

130 In humans, intradermally injected beta-alanine induced itch but neither wheal nor flare, s

131 We tested TrpC3 null mice for beta-alanine induced itch, and found that these mice exh

132 Here too, beta-alanine-induced activation of endogenous MrgD inhib

133 Finally, we assessed the consequence of beta-alanine-induced activation of MrgD in phasic neuron

134 onstrate that mouse TrpC3 is dispensable for beta-alanine-induced acute itch.

135 se effects, the presence of rMrgE restricted beta-alanine-induced internalization of rMrgD.

136 chanically insensitive C-fibres (C-MIAs) are beta-alanine insensitive but vigorously respond to capsa

137 renal beta-alanine transamination upon oral beta-alanine intake.

138 Reverse isotope exchange of [(14)C]-beta-alanine into pantothenate in the presence of AMP wa

139 cellular level, calcium influx triggered by beta-alanine is also unchanged in cultured DRG neurons f

140 t strong and direct evidence indicating that beta-alanine is an efficient substrate for the mammalian

141 The amino acid beta-alanine is an intermediate in pantothenic acid (vit

142 beta-Alanine is conjugated with dopamine to yield N-beta

143 le of pantothenic acid biosynthesis, and the beta-alanine is derived from methionine via a pathway in

144 The metabolic fate of orally ingested beta-alanine is largely unknown.

145 only a small fraction (3-6%) of the ingested beta-alanine is used for carnosine synthesis.

146 der physiological conditions, the DANP-caged beta-alanine is water-soluble and stable and can be used

147 y of 1 as an enolate synthon of homoglycine (beta-alanine) is illustrated by the efficient synthesis

148 ation but did not impair mechanosensation or beta-alanine itch-stimuli associated with nonpeptidergic

149 uced acidification (using glycylsarcosine or beta-alanine) led to Na(+)-dependent, EIPA-inhibitable p

150 ining glutamic acid, glycine, aspartic acid, beta-alanine, leucine, and phenylalanine residues, maxim

151 eks lead to a 3-fold increase in circulating beta-alanine levels and to significantly higher levels o

152 uscle and heart is controlled by circulating beta-alanine levels, which are suppressed by hepatic and

153 hat AICAR inhibited the activity of pantoate beta-alanine ligase in vitro (PanC, EC 6.3.2.1).

154 Beta-alanine-linked pyrrole-imidazole polyamides bind GA

155 e as the major product (>99%) and (R)-styryl-beta-alanine (<1%).

156 ponents, a tetrahydronaphthyridine moiety, a beta-alanine moiety, and a central imidazolidone moiety.

157 yl radicals and cation radicals derived from beta-alanine N-methylamide, N-acetyl-1,2-diaminoethane,

158 riments demonstrated that neither DANP-caged beta-alanine nor its byproducts inhibit or activate the

159 Neither the 2-methoxy-5-nitrophenyl-beta-alanine nor the 2-methoxy-5-nitrophenol photolysis

160 ferentially on basic dipeptides derived from beta-alanine or gamma-aminobutyrate, PM20D2 also acted a

161 he medium, whereas deletion mutants required beta-alanine or pantothenic acid for growth.

162 The receptors were activated by GABA, beta-alanine or piperidine-4-sulfonic acid (P4S), and th

163 ide surfactant poly(sodium undecyl-L-leucine-beta-alanine) (poly L-SULbetaA).

164 Although beta-alanine-producing activity was not detected in the

165 ue samples were incubated with aspartate, no beta-alanine production was observed.

166 In contrast to bacteria, yeast derive the beta-alanine required for pantothenic acid production vi

167 A conjugate containing a beta-alanine residue at the C terminus of the polyamide

168 A beta-alanine residue was coupled to the main-chain (alph

169 n, whereas an analogous compound lacking the beta-alanine residue was strongly localized in the nucle

170 ariation within the seco-cryptophycin unit C beta-alanine residue, but strict structural requirements

171 ee functionally distinct subpopulations with beta-alanine responsive QC fibres likely corresponding t

172 hat bath application of the ligand for MrgD, beta-alanine, resulted in robust inhibition of KCNQ2/3 a

173 In this report, a combination of beta-alanine scanning mutagenesis and kinetic measuremen

174 leus and enantiospecific substitution on the beta-alanine side chain attached to N4.

175 ess the conformational preferences about the beta-alanine side chain.

176 zinebenzylamine attached with a N,N-dimethyl-beta-alanine side chain.

177 luoro-beta-ureidopropionic acid and a-fluoro-beta-alanine signals in the tissues of mice that receive

178 luoro-beta-ureidopropionic acid and a-fluoro-beta-alanine signals in tumors treated with EU and a dra

179 ermore, the application of the Mrgprd ligand beta-alanine significantly reduced the rheobase and incr

180 PASTSAPG was conjugated to biotin using a di-beta-alanine spacer arm.

181 Taurine, gamma-aminobutyric acid, and beta-alanine (substrates of the SLC6 gamma-aminobutyric

182 Insertion of two beta-alanine subunits between a DNP derivative and 3beta

183 Chronic oral beta-alanine supplementation is a popular ergogenic stra

184 Chronic beta-alanine supplementation is becoming increasingly po

185 The present study can partly explain why the beta-alanine supplementation protocol is so inefficient,

186 beta-Alanine supply for this pathway is independent of e

187 ependent of enzymatic synthesis by Black and beta-alanine synthase Pyd3.

188 ssue protein extracts, its potential role in beta-alanine synthesis cannot be excluded.

189 2; OAT1; Oatp1; mdr 1a and 1b; MRP 1 and 5; beta-alanine, system L and system y+L amino acid carrier

190 y, high-capacity transporter for taurine and beta-alanine; TauT (SLC6A6) is a Na(+)- and Cl(-)-depend

191 ted an amino acid sequence including several beta-alanines that occurred in a repeating alphaalphabet

192 Upon photolysis of DANP-caged beta-alanine, the caging group is released within 5 micr

193 Injection of beta-alanine, the expected product of ADC, into dsTcADC-

194 pecific activity modes, including the use of beta-alanine to achieve increased efficacy with alphabet

195 ERK2 as well as maintaining the capacity of beta-alanine to elevate intracellular [Ca(2+)], which wa

196 ATP-dependent condensation of D-pantoate and beta-alanine to form pantothenate in bacteria, yeast and

197 e ATP-dependent condensation of pantoate and beta-alanine to form pantothenate.

198 visual signal transduction, Ebony conjugates beta-alanine to histamine, forming beta-alanyl-histamine

199 These interactions increased the potency of beta-alanine to phosphorylate ERK1 and ERK2 as well as m

200 investigate the putative contribution of two beta-alanine transamination enzymes, namely 4-aminobutyr

201 s, which are suppressed by hepatic and renal beta-alanine transamination upon oral beta-alanine intak

202 t the pauA3B2 operon and the bauABCD operon (beta-alanine utilization).

203 to target genes in four metabolism pathways: beta-alanine; valine, leucine, iso-leucine; aminoacyl-tR

204 However, when beta-alanine was applied for a sufficient duration to pr

205 ntioselective synthesis of these substituted beta-alanines was also developed.

206 -yl)-1H-pyrazol-1-y l]ethyl}phenyl)carbonyl]-beta-alanine, was discovered by optimization of a previo

207 nd the concentration of the third substrate, beta-alanine, was increased.

208 Sarcosine (N-methylglycine) and beta-alanine were also accepted as substrates, albeit wi

209 logues of gamma-aminobutyric acid (GABA) and beta-alanine were designed as conformationally rigid ana

210 ites, nutrients as taurine, nicotinamide and beta-alanine, were found.

211 metabolites, fluorouracil, and alpha-fluoro-beta-alanine, were not meaningfully altered by coadminis

212 ter linkage to the carboxyl functionality of beta-alanine, which activates the inhibitory glycine rec

213 uscle depends on circulating availability of beta-alanine, which is in turn controlled by degradation

214 aminopropanal is further oxidized to produce beta-alanine, which is necessary for the biosynthesis of

215 with a 600-ns laser pulse at 333 nm releases beta-alanine, which then activates glycine receptor-chan

216 Replacement of one beta alanine with Py to afford PyImPyIm-gamma-PyImbetaIm

217 can transport non-alpha-amino acids such as beta-alanine with low affinity, and has a higher affinit

218 photolyzed by a laser pulse to release free beta-alanine within 3 microseconds and with a product qu