ライフサイエンスコーパス: beta-arrestin 1

1 n the Arg(363)-Arg(393) region in the bovine beta-arrestin 1.

2 eceptor selectivity for beta-arrestin 2 over beta-arrestin 1.

3 rectal cancer cells expressing WT and mutant beta-arrestin 1.

4 ansfection with the scaffold/adapter protein beta-arrestin 1.

5 appaB, IkappaBalpha, as a binding partner of beta-arrestin 1.

6 Gbetagamma and c-Src, and possibly involves beta-arrestin 1.

7 ctivation was enhanced by over-expression of beta-arrestin 1.

8 a-arrestin 2 to be 100-fold more potent than beta-arrestin 1.

9 cadaverine, a mutant dynamin I, and a mutant beta-arrestin 1.

10 llowing the overexpression of either GRK2 or beta-arrestin 1.

11 or kinases (GRKs) 2, 3, 5, and 6, as well as beta-arrestin 1.

12 were equally effective at coupling to Gi and beta-arrestin-1.

13 e rescued by ectopic expression of wild-type beta-arrestin-1.

14 esponding to the antibody-binding epitope on beta-arrestin-1.

15 rt, caused by activatory signals mediated by beta-arrestin-1.

16 licated in maintaining the inactive state of beta-arrestin-1.

17 hosphorylated vasopressin-2 receptor tail to beta-arrestin-1.

18 o functionally and conformationally activate beta-arrestin-1.

19 gnizes the phosphopeptide-activated state of beta-arrestin-1.

20 as being critical to nuclear localization of beta-arrestin-1.

21 by LC tandem MS, 71 proteins interacted with beta-arrestin 1, 164 interacted with beta-arrestin 2, an

22 oprecipitation of the PAFR and clathrin with beta-arrestin-1, 2) fluorescent resonance energy transfe

23 In contrast, beta-arrestin 1/2 double knockout cells showed greatly e

24 type, beta-arrestin 1, beta-arrestin 2, and beta-arrestin 1/2 knock-out mice.

25 could indeed be detected in IL-8-stimulated beta-arrestin 1/2 knockout cells, and cytoplasmic Rac wa

26 FLAG epitope-tagged beta-arrestin 2 into the beta-arrestin 1/2 null background restored EGF receptor-

27 ed transcriptional responses observed in the beta-arrestin 1/2 null background were lost.

28 In the beta-arrestin 1/2 null background, 1 h of exposure to LP

29 acid did not stimulate TGR5 association with beta-arrestin 1/2 or G protein-coupled receptor kinase (

30 al-regulated kinase 1 and 2 phosphorylation, beta-arrestin 1/2 recruitment, and MOP trafficking, and

31 eric G proteins and the scaffolding proteins beta-arrestin 1/2.

32 minant-negative form of the beta-arrestin 1, beta-arrestin 1 (319-418), blocked agonist-mediated inte

33 ulated inositol phosphate production by 48% (beta-arrestin-1), 71% (beta-arrestin-2), and 84% (beta-a

34 both G-protein-coupled receptor-kinase 2 and beta-arrestin-1, a G-protein-coupled receptor adaptor pr

35 We found that beta-arrestin 1 acted as a scaffold for PHLPP2 and Akt1,

36 carcinoma cells, the increased expression of beta-arrestin-1 after glucocorticoid treatment impairs G

37 ated that Galpha(i), betagamma subunits, and beta-arrestin-1 all play a critical role in IGF-I mitoge

38 Here we report the crystal structure of beta-arrestin-1 (also called arrestin-2) in complex with

39 oexpressed isoforms of beta-arrestin (termed beta arrestin 1 and 2) are highly similar in amino acid

40 -2 and show, in vitro, that these domains in beta-arrestin 1 and 2 interact equally well with AP-2 in

41 Both beta-arrestin 1 and 2 interact with IkappaBalpha in tran

42 Besides their role in desensitization, beta-arrestin 1 and 2 promote the formation of signaling

43 incubated with progastrin or Bmp2; levels of beta-arrestin 1 and 2 were knocked down using small inte

44 To better define differences in the roles of beta-arrestin 1 and 2, we prepared mouse embryonic fibro

45 mice and cultured human cells via CCK2R- and beta-arrestin 1 and 2-dependent suppression of Bmp2 sign

46 rimeric G proteins and the scaffold proteins beta-arrestin 1 and 2.

47 hway that required CCK2R and was mediated by beta-arrestin 1 and 2.

48 activate RhoA, the concurrent recruitment of beta-arrestin 1 and activation of G(alphaq/11) leads to

49 raction of the phosphorylated receptors with beta-arrestin 1 and beta-arrestin 2.

50 alling complex was made by docking activated beta-arrestin 1 and beta2AR crystal structures into the

51 The interaction of beta-arrestin 1 and c-Src is critical for the regulation

52 /11) in response to ET-1 stimulation, and 2) beta-arrestin 1 and Src kinase form a molecular complex

53 onse involved formation of a complex between beta-arrestin 1 and the Akt phosphatase PHLPP2, and acti

54 beta-Arrestin-1 and -2 can mediate activatory signals by

55 and 3) rapid and transient redistribution of beta-arrestin-1 and -2 from the cytosol to the plasma me

56 immunoreactive Galphaq/11, GRK-2 and -3, and beta-arrestin-1 and -2 in a subpopulation of neurons.

57 tion of NK1-R, Galphaq/11, GRK-2 and -3, and beta-arrestin-1 and -2 in cultured myenteric neurons.

58 ne, followed by a striking redistribution of beta-arrestin-1 and -2 to endosomes containing the NK1-R

59 TSH stimulated translocation of beta-arrestin-1 and -2 to TSHR, whereas C2 failed to tra

60 ons that may be mediated by GRK-2 and -3 and beta-arrestin-1 and -2.

61 erize the cellular localization of wild type beta-arrestin-1 and a series of N domain mutants to dete

62 that glucocorticoids differentially regulate beta-arrestin-1 and beta-arrestin-2 gene expression in m

63 Alterations in the cellular complement of beta-arrestin-1 and beta-arrestin-2 occur in many human

64 luding stimulation of Ca(2)(+) mobilization, beta-arrestin-1 and beta-arrestin-2 recruitment, and ext

65 The nonvisual arrestins, beta-arrestin-1 and beta-arrestin-2, are multifunctional

66 dicated that E2 increased the recruitment of beta-arrestin-1 and c-Src to ERalpha.

67 Furthermore, there was significantly more beta-arrestin-1 and E2F1 associated with these promoters

68 with nicotine led to enhanced recruitment of beta-arrestin-1 and E2F1 on vimentin, fibronectin, and Z

69 mulation to ERK activation and lipolysis; 3) beta-arrestin-1 and G alpha(q/11) can mediate TNFalpha-i

70 uitin content of IRS-1, suggesting that both beta-arrestin-1 and IRS-1 competitively bind to Mdm2.

71 -P1 peptide to block the interaction between beta-arrestin-1 and PLCgamma abolishes TRV120027-induced

72 -arrestin-1 content due to ubiquitination of beta-arrestin-1 and proteosome-mediated degradation.

73 gation requires CME and causes engagement of beta-arrestin-1 and recruitment of a p38 MAPK signalosom

74 oid receptor (GR) to induce the synthesis of beta-arrestin-1 and repress the expression of beta-arres

75 can be enhanced by the presence of GRK2 and beta-arrestin-1 and show that these molecules have multi

76 ons, and normalized expression of glomerular beta-arrestin-1 and Snail.

77 H receptors in fibroblasts from mice lacking beta-arrestin-1 and/or beta-arrestin-2.

78 beta-arrestins (1 and 2) are widely expressed cytosolic

79 beta-Arrestins 1 and 2 are multifunctional adaptor prote

80 ciprocal effects of down-regulated levels of beta-arrestins 1 and 2 are primarily due to differences

81 Upon their discovery, beta-arrestins 1 and 2 were named for their capacity to

82 Coexpression of beta-arrestins 1 and 2, regulators of G-protein signalin

83 functional adaptor and transducer molecules, beta-arrestins 1 and 2.

84 ctive than palmitate or oleate in recruiting beta-arrestins 1 and 2.

85 arrestin-1), 71% (beta-arrestin-2), and 84% (beta-arrestins-1 and -2).

86 rminal peptide competed for association with beta-arrestin 1, and phosphorylated central or distal C-

87 uitination of TRPV4, a process that requires beta-arrestin 1, and subsequently to internalization and

88 ansfer-positive interactions among the PAFR, beta-arrestin-1, and clathrin, 3) recruitment and activa

89 eptor (IGF-IR) endocytosis is facilitated by beta-arrestin-1, and internalization is necessary for IG

90 yclase signaling, to a strong recruitment of beta-arrestin-1, and to a positive cross talk of D1R and

91 Microinjection of beta-arrestin 1 antibody inhibited ET-1- but not insulin

92 Microinjection of anti-beta-arrestin-1 antibody specifically inhibited IGF-I mi

93 2 on beta-arrestin and the amino terminus of beta-arrestin-1 are required for this effect of beta-arr

94 In mice and in human cell lines, beta-arrestin-1 (ARRB1), activated via beta(2)-adrenorec

95 ve state of visual arrestin (arrestin 1) and beta-arrestin 1 (arrestin 2) have been resolved.

96 re, our data implicate a functional role for beta-arrestin 1 as a mediator of cellular migration and

97 R signaling, and highlight the importance of beta-arrestin-1 as a target molecule for this desensitiz

98 munoprecipitation experiments, we found that beta-arrestin 1 associated with the ETA receptor in an a

99 hosphorylation coincided with an increase in beta-arrestin 1-associated PGES3 and an arrestin-depende

100 p85 within the pseudopodia, suggesting that beta-arrestin-1 association with PI3K may spatially rest

101 This was associated with a decrease in beta-arrestin-1 association with the beta2-AR as well as

102 eumococci-induced colocalization of PAFr and beta-arrestin 1 at the plasma membrane of endothelial ce

103 Arenas et al (2014) describe a novel role of beta-arrestin-1 at the IS periphery: endocytosis of TCRs

104 generated different fragmentation of bovine beta-arrestin 1, at Pro(276).

105 Overexpression of wild-type (WT) beta-arrestin-1 attenuated insulin-induced degradation o

106 ryonic fibroblast (MEF) cells lacking either beta-arrestin 1 (beta arr1(-/-)) or beta-arrestin 2 (bet

107 ac macromolecular complex involving VDCC and beta-arrestin 1 (beta-Arr1) into clathrin-coated vesicle

108 a novel bypass mechanism through which ETAR/beta-arrestin-1 (beta-arr1, ARRB1) links Wnt signaling t

109 However, a dominant-negative form of the beta-arrestin 1, beta-arrestin 1 (319-418), blocked agon

110 Our data reveal beta-arrestin 1, beta-arrestin 2, and AT1R as key regula

111 -dependent myofilament Ca(2+) sensitivity in beta-arrestin 1, beta-arrestin 2, and AT1R knockout mice

112 ing fibroblast lines derived from wild type, beta-arrestin 1, beta-arrestin 2, and beta-arrestin 1/2

113 ive hemodynamics, we found that mice lacking beta-arrestin 1, beta-arrestin 2, or AT1R were unable to

114 Co-expression of PAR1 with beta-arrestin 1 (betaarr1) in COS-7 cells resulted in a

115 ular loop (V2R(DeltaICL3)) can interact with beta-arrestin 1 (betaarr1) only through the phosphorylat

116 We investigated whether adrenal beta-arrestin 1 (betaarr1)-mediated aldosterone producti

117 beta-Arrestin-1 (betaArr1) plays a major role in the des

118 beta-Arrestin-1 (betaArr1), a scaffolding protein critic

119 dependent aldosterone production mediated by beta-arrestin-1 (betaarr1), a universal heptahelical rec

120 we show that in NCM460 cells exposed to NT, beta-arrestin-1 (betaARR1), and beta-arrestin-2 (betaARR

121 Here we reveal that TRV120027, a beta-arrestin-1-biased agonist of the angiotensin II rec

122 ion of the LH/CG R, and that the trigger for beta-arrestin-1 binding to the LH/CG R appears to be R a

123 ASK1/p38 MAPK heterodimer is recruited to a beta-arrestin-1 bound MKK3.

124 t receptor exhibits reduced association with beta-arrestin 1 but continues to exhibit association wit

125 A mutants of CXCR2 exhibit normal binding to beta-arrestin 1 but exhibit decreased binding to adaptin

126 Conversely, suppression of beta-arrestin 1, but not beta-arrestin 2, expression by

127 ablate tight junctions consistent with EMT; beta-arrestin-1, but not beta-arrestin-2, was required f

128 by depletion of cellular beta-arrestin 2 and beta-arrestin 1 by small interfering RNA.

129 Down-regulation of beta-arrestin-1 by siRNA inhibited TSH-stimulated phosph

130 Edman degradation analysis of a beta-arrestin 1 C-terminal fragment fused to enhanced gr

131 These results show that the prostaglandin E/beta-arrestin 1/c-Src signaling complex is a crucial ste

132 association of a prostaglandin E receptor 4/beta-arrestin 1/c-Src signaling complex resulting in the

133 a clearly show that both visual arrestin and beta-arrestin 1 can bind to monomeric rhodopsin and stab

134 In summary, we have found the following: (i) beta-arrestin-1 can alter insulin signaling by inhibitin

135 molecules in the TNFalpha action cascade; 2) beta-arrestin-1 can couple TNFalpha stimulation to ERK a

136 beta-arrestin-dependent mechanism, and that beta-arrestin-1 can directly associate with and inhibit

137 ponent G alpha(q/11) and the adapter protein beta-arrestin-1 can function as signaling molecules in t

138 vity blocks PAR-2-stimulated chemotaxis, and beta-arrestin-1 colocalizes with p85 within the pseudopo

139 x shows marked conformational differences in beta-arrestin-1 compared to its inactive conformation.

140 ing and purifying a functional human beta2AR-beta-arrestin-1 complex that allowed us to visualize its

141 phospho-barcodes are translated to specific beta-arrestin-1 conformations and direct selective signa

142 hrin recognizes and stabilizes GRK2-specific beta-arrestin-1 conformations.

143 es an approximately 50% decrease in cellular beta-arrestin-1 content due to ubiquitination of beta-ar

144 This insulin-induced decrease in beta-arrestin-1 content was blocked by inhibition of pho

145 duced proteasomal degradation of IRS-1; (ii) beta-arrestin-1 decreases the rate of ubiquitination of

146 n and enhanced IL-10 and IL-22 production in beta-arrestin-1-deficient mice likely lead to attenuated

147 Chronic insulin treatment leads to enhanced beta-arrestin-1 degradation.

148 inositol phosphate signaling while enhancing beta-arrestin-1-dependent stimulation of the MAPK pathwa

149 Cotransfection with beta-arrestin 1 did not increase the rate or extent of a

150 In insulin-treated, beta-arrestin-1-downregulated cells, there was complete

151 dentify the interaction kinetics of CB1R and beta-arrestin 1 during their endocytic trafficking as di

152 Exogenous expression of wild type beta-arrestin-1 enhanced the transcriptional activity of

153 lays important roles in the nucleus, but how beta-arrestin-1 enters the nucleus remains unclear becau

154 podocytes and hyperplastic lesion formation; beta-arrestin-1 expression increased in visceral podocyt

155 igration via ET(A)R activation and increased beta-arrestin-1 expression.

156 lasma membrane that also contained Rab5a and beta-arrestin 1, followed by rapid recycling of the NK1R

157 strate that ERK1/2 activation is mediated by beta-arrestin 1 from receptors localized exclusively at

158 rticoid response elements in intron-1 of the beta-arrestin-1 gene and intron-11 of the beta-arrestin-

159 in insulin-treated cells in which endogenous beta-arrestin-1 had been downregulated rescued IGF-I- an

160 physical association between the GLP-1 R and beta-arrestin-1 in cultured INS-1 pancreatic beta cells.

161 Our goal was to investigate the role of beta-arrestin-1 in IBD using mouse models of colitis.

162 els, have demonstrated an important role for beta-arrestin-1 in inflammation.

163 Ectopic expression of wild-type beta-arrestin-1 in insulin-treated cells in which endoge

164 oimmunoprecipitated with follicular membrane beta-arrestin-1 in response to LH/CG R activation compar

165 ether, these studies reveal a novel role for beta-arrestin-1 in the growth and metastasis of NSCLC.

166 However, the role of beta-arrestin-1 in the pathogenesis of inflammatory bowe

167 Neutralization of beta-arrestin-1 inhibited all of these cellular events,

168 Knockdown of beta-arrestin-1 inhibited TSH-stimulated up-regulation o

169 btypes differentially regulate ASM GPCRs and beta-arrestin-1 inhibition represents a novel approach t

170 Small interfering RNA-mediated knockdown of beta-arrestin-1 inhibits TNFalpha-induced tyrosine phosp

171 beta-Arrestin 1 interacts with, and acts as an adaptor f

172 beta-Arrestin 1 is required for internalization and mito

173 We now show that beta-arrestin 1 is required to activate the small GTPase

174 beta-arrestin-1 is an adaptor protein that mediates agon

175 (ii) This downregulation of endogenous beta-arrestin-1 is associated with decreased IGF-I-, LPA

176 We found that beta-arrestin-1 is associated with TRAF2 (TNF receptor-a

177 In the present study, we determined whether beta-arrestin-1 is involved in insulin-induced insulin r

178 we demonstrate that the scaffolding protein beta-arrestin-1 is necessary for nicotine-mediated induc

179 work, we found that beta-arrestin 2, but not beta-arrestin 1, is required for LPA-induced NF-kappaB a

180 imulates lipolysis in 3T3-L1 adipocytes, and beta-arrestin-1 knockdown blocks the effects of TNFalpha

181 beta-Arrestin-1 knockdown broadly attenuated GLP-1 signa

182 However, beta-arrestin-1 knockdown did not affect GLP-1 R surface

183 rotein-1 and matrix metalloproteinase 3, and beta-arrestin-1 knockdown inhibited both of these effect

184 beta-arrestin-1 knockdown or KO had no effect on signali

185 To this end, we subjected wild-type (WT) and beta-arrestin-1 knockout (beta-arr-1(-/-)) mice to colit

186 on IRS-1 degradation; and (iv) inhibition of beta-arrestin-1 leads to enhanced IRS-1 degradation and

187 ic insulin treatment down-regulates cellular beta-arrestin 1 levels, leading to a marked impairment i

188 h these promoters in human NSCLC tumors, and beta-arrestin-1 levels correlated with vimentin and fibr

189 Increased beta-arrestin-1 levels in podocytes retrieved from cresc

190 Recent evidence indicates that beta-arrestin 1 may act as an important mediator in G pr

191 etromer complex as a gatekeeper, terminating beta-arrestin 1-mediated ERK phosphorylation.

192 Arg323 and Lys409 residues were required for beta-arrestin-1-mediated sustained ERK phosphorylation a

193 th phosphoinositide (PI) hydrolysis and with beta-arrestin-1-mediated sustained extracellular signal-

194 -induced signaling mechanism for CB1 wherein beta-arrestin 1 mediates short term signaling to ERK1/2

195 beta-Arrestin-1 mediates agonist-dependent desensitizati

196 -1 action, showing that the scaffold protein beta-arrestin-1 mediates the effects of GLP-1 to stimula

197 Addition of recombinant purified beta-arrestin-1 mimicked human chorionic gonadotrophin t

198 e of Cell, Kang et al. provide evidence that beta-arrestin 1 moves to the nucleus in response to GPCR

199 Expression of a phosphorylation-independent beta-arrestin 1 mutant (R169E) significantly rescued the

200 We also show a beta-arrestin 1 mutant, which engages coated structures

201 beta-Arrestin 1 mutants, impaired either in c-Src bindin

202 Whereas neither beta-arrestin 1 nor G(alphaq/11) activation alone is suf

203 hese results demonstrate a critical role for beta-arrestin-1 nuclear localization in scaffolding and

204 Mutation of the NLS led to a loss of beta-arrestin-1 nuclear localization in transfected cell

205 Loss of beta-arrestin-1 nuclear localization was accompanied by

206 uctural basis and functional implications of beta-arrestin-1 nuclear localization.

207 Second, overexpression of arrestin 2 or 3 (beta-arrestin 1 or 2) abolished the V2 receptor-mediated

208 beta-Arrestin 1 or beta-arrestin 2 depletion prevented t

209 Overexpression of either beta-arrestin 1 or beta-arrestin 2 led to marked inhibit

210 s and murine airways/whole animal subject to beta-arrestin-1 or -2 knockdown or knockout (KO).

211 gnals via beta-arrestin, and in mice lacking beta-arrestin-1 or -2, KP-triggered GnRH secretion is si

212 inin B2 receptor (B2R) complexes with either beta-arrestin-1 or -2.

213 We sought to determine the effect of beta-arrestin-1 or beta-arrestin-2 inhibition or gene ab

214 In select experiments, beta-arrestin-1 or dynamin-2 were neutralized by intrace

215 DNA constructs that encode dominant negative beta-arrestin-1 or dynamin.

216 ing RNA approach for selectively suppressing beta-arrestins 1 or 2 expression by up to 95%.

217 However, upon coexpression of arrestin-2 (beta-arrestin-1) or arrestin-3 (beta-arrestin-2), intern

218 These results suggest that endogenous beta-arrestin-1 participates in agonist-dependent desens

219 in membrane-associated beta-arrestin-1, that beta-arrestin-1 participates in agonist-dependent desens

220 rat beta-arrestin-2 (PET(178)P), but not rat beta-arrestin-1 (PER(177)P).

221 a(i)-associated pathway; and (iii) increased beta-arrestin 1 phosphorylation at Ser-412.

222 Taken together, these studies indicate that beta-arrestin-1 plays a role in GLP-1 signaling leading

223 A mounting body of evidence suggests that beta-arrestin-1 plays important roles in the nucleus, bu

224 Silencing of beta-arrestin-1 prevented podocyte phenotypic changes an

225 beta-Arrestin-1 promoted the expression of the mesenchym

226 G protein-coupled receptor kinase 3 (GRK3), beta-arrestin-1, Pyk2, and focal adhesion kinase (FAK).

227 With its phosphate-binding concave surface, beta-arrestin-1 'reads' the message in the receptor phos

228 ptor in an agonist-dependent manner and that beta-arrestin 1 recruited Src kinase to a molecular comp

229 hermore, D1R or D3R antagonists counteracted beta-arrestin-1 recruitment and MAPK activation induced

230 We conclude that PAF signaling requires CME, beta-arrestin-1 recruitment of a p38 MAPK signalosome, a

231 xpression of a dominant negative fragment of beta-arrestin-1 reduces PAR-2-stimulated internalization

232 beta-Arrestin 1 selectively binds to the SNARE-binding r

233 Adult mice lacking beta-arrestin 1 selectively in hepatocytes did not show

234 Whether beta-arrestin 1 serves a functional role in these events

235 A549-luciferase cells lacking beta-arrestin-1 showed a significantly reduced capacity

236 cific phospholipase C (PLCgamma) to the AT1R-beta-arrestin-1 signalling complex.

237 In contrast, beta-arrestin 1 siRNA had no effect.

238 Transfection of neurons with beta-arrestin-1 small interfering RNA prevented E2-induc

239 restin-1 was knocked down by transfection of beta-arrestin-1 small interfering RNA, insulin-induced I

240 n with the beta2-AR as well as a decrease in beta-arrestin-1-Src and Src-beta2-AR association.

241 rough mGlu1a receptors require expression of beta-arrestin-1, suggesting a possible role for receptor

242 Finally, GRK2 and beta-arrestin-1 synergistically enhanced both the rate a

243 atterns induce distinct structural states of beta-arrestin-1 that are coupled to distinct arrestin fu

244 varian follicles contain membrane-associated beta-arrestin-1, that beta-arrestin-1 participates in ag

245 follicular membranes unexpectedly contained beta-arrestin-1, the role of arrestins in desensitizatio

246 ategy to retrieve AT(1)R-engaged isoforms of beta-arrestin 1 to confirm direct interaction of fragmen

247 10 nM) induced translocation of the NK1R and beta-arrestin 1 to perinuclear sorting endosomes contain

248 al reconstructions reveal bimodal binding of beta-arrestin 1 to the beta2AR, involving two separate s

249 iotensin stimulation leads to recruitment of beta-arrestin 1 to this complex.

250 Activated ET(A)R recruited beta-arrestin-1 to form a trimeric complex with Src lead

251 protein-coupled receptor kinase-2 (GRK2) and beta-arrestin-1 to regulate the phosphorylation state an

252 Within this paradigm, M3D-arr recruited beta-arrestin-1 to the plasma membrane, and promoted pho

253 tion of CB1-GFP with red fluorescent protein-beta-arrestin 1 upon ORG27569 treatment using confocal m

254 cterize the interactions between beta2AR and beta-arrestin 1 using hydrogen-deuterium exchange mass s

255 The structure of the beta-arrestin-1-V2Rpp-Fab30 complex shows marked conform

256 The overexpression of either the beta-arrestin 1-V53D dominant negative inhibitor of beta

257 beta-Arrestin-1 was associated with the receptors for IG

258 When endogenous beta-arrestin-1 was knocked down by transfection of beta

259 ased dynamics in both the N and C domains of beta-arrestin 1 when coupled to the beta2AR.

260 ynergistically enhanced by cotransfection of beta-arrestin-1, which had no effect on m2 mAChR functio

261 iation was inhibited to overexpression of WT beta-arrestin-1, which led by decreased ubiquitin conten

262 ues suggest engagement of the finger loop of beta-arrestin 1 with the seven-transmembrane core of the

263 Replacing the C-terminal region of beta-arrestin-1 with its counterpart on beta-arrestin-2

264 ound a marked decrease in the association of beta-arrestin-1 with the IGF-IR and a 55% inhibition of

265 en CFP-iNOS and beta-arrestin 2-YFP (but not beta-arrestin 1-YFP) that increased 3-fold after B1R sti