ライフサイエンスコーパス: beta-chain

1 FGB (rs1800790; rs4220) encoding fibrinogen beta chain.

2 haI domain during activation, exerted by the beta chain.

3 t the interface with the betaI domain of the beta chain.

4 ion and inability to associate with the HexA beta chain.

5 ng with C3-fibrinogen interaction within the beta chain.

6 embrane-proximal N-terminal domain binds the beta-chain.

7 ed ubiquitination of a lysine residue in the beta-chain.

8 of C3b that lies near the C terminus of its beta-chain.

9 tural fluctuations in the heme pocket of the beta-chain.

10 arkedly reduced expression of the IFN-gammaR beta-chain.

11 nked phosphate group and Lys-82 of the trans beta-chain.

12 essing a glutamic acid at position 69 of the beta-chain.

13 t alpha domains, paired with an array of TCR-beta chains.

14 epertoire of T-cell receptor (TCR) alpha and beta chains.

15 CDR3) of the T-cell receptor (TCR) alpha and beta chains.

16 (ogen), it is an arginine, just as occurs in beta chains.

17 in humans), which pairs with an array of TCR beta-chains.

18 naling of PDGF-receptor (R)-alpha- and PDGFR-beta-chains.

19 imurium down-modulates expression of the TCR beta-chain, a molecule that is essential for Ag recognit

20 ations in Lck, ZAP70, and the TCR alpha- and beta-chains abrogate Fas signaling.

21 pression of either preassembled VbetaDJbetaC beta-chain accelerated thymocyte development because of

22 interleukin-3 receptor, IL3Ra and the common beta chain, activated JAK2-V617F as well as STAT5 and ER

23 1.6 mum, only 8-fold weaker than the Met/HGF beta-chain affinity.

24 l receptor but exhibited a partial defect in beta-chain allelic exclusion and increased apoptosis.

25 ally use a conserved docking mode, the NKTcr beta-chain allows these cells to recognise unique aspect

26 between the peptide backbone and the HLA-DP2 beta-chain alpha-helix and containing three glutamic aci

27 C4BP isoforms containing beta-chain (alpha7beta1 and alpha6beta1; C4BP[beta(+)])

28 efined as those that expressed identical TCR beta-chain amino acid sequences and recurred in multiple

29 V-1-specific T-cell receptor (TCR) alpha and beta chains, an approach used successfully in cancer the

30 T-cell receptor variable beta-chain analysis was performed with the immunoSEQ ass

31 KDa for alpha1 and alpha2 chains, 226KDa for beta chain and 338.5KDa for gamma chain, respectively.

32 ic molecule Bcl-2 and interleukin-2 receptor beta chain and diminished IL-15-driven proliferation.

33 monoclonal tumors with a single, unique TCR-beta chain and diverse TCR-alpha chains, pinpointing mal

34 dom genomic integration of the TCR alpha and beta chain and expression from nonendogenous promoters r

35 er of this family, is related to the laminin beta chain and has recently been proposed to play an imp

36 ed elements of the T cell receptor alpha and beta chain and, surprisingly, dramatically affected by t

37 nterface with an antiparallel arrangement of beta chains and a unique tangential association of coile

38 rmed by the NH(2)-terminal regions of fibrin beta chains and revealed that the recombinant dimeric (b

39 ressing one of two different T cell receptor beta chains and various MHC alleles, we show that positi

40 timulating the interaction between the LFA-1 beta-chain and 14-3-3 proteins.

41 The band intensity of beta-chain and alpha-chains increased as the extraction

42 CDR3 variable region of the T cell receptor beta-chain and an algorithm that detected significantly

43 capsular zone where they recombine their TCR beta-chain and gamma-chain gene loci.

44 amino acid residues derived from the HLA-DP2 beta-chain and peptide and showed that the TCR does not

45 the acute phase variant of C4BP lacking the beta-chain and protein S binds plasminogen much stronger

46 tronger than the main isoform containing the beta-chain and protein S.

47 acylglycerolacyl transferase 2, ATP synthase beta chain, and redox state may explain the multiple act

48 of invariant T cells is much higher than the beta-chain, and because the TCR alpha-chain V gene segme

49 ch encodes the interleukin 2 (IL-2) receptor beta-chain, and controlled the responsiveness to IL-15,

50 ing the ankyrin-binding site of the spectrin beta-chain, and covalent perturbation by treatment with

51 nished expression of CD122, the IL-2R/IL-15R beta-chain, and impaired expression of the T-box transcr

52 ocated near the C terminus of the fibrinogen beta-chain, and that the binding causes fibrinogen to ol

53 , CCR3, the IL-3/IL-5/GM-CSF receptor common beta-chain, and the transcription factor GATA-1.

54 presence of a genetic variant in the HLA-DP beta chain appear to increase the risk.

55 onresponsive T-cell receptor variable region beta chain are nonresponsive to SEA in monoculture but d

56 The alpha and beta chains are similar, but are chemically and structur

57 The carbohydrate groups attached to beta chains are unusually prominent, the full sweep of 1

58 class II MHC molecules, where the alpha- and beta-chain are encoded on opposite chromosomes, can also

59 he cis-encoded variants where the alpha- and beta-chain are encoded on the same chromosome.

60 Namely, the iT(reg) TCR alpha-chain and beta-chain are overlaid with the alpha-chain and beta-ch

61 We hypothesized that such beta-chains are advantaged during thymic and/or peripher

62 To determine whether such public beta-chains are advantaged during thymic selection, indi

63 The CDR3 regions of both the alpha- and beta-chains are encoded by either germline or nongermlin

64 rial biases, a small fraction of TCRalpha or beta-chains are shared by most individuals, or public.

65 te that in this cell line the TCR-alpha and -beta chains as well as the CD3gamma, CD3delta, CD3epsilo

66 ctivation pocket of the serine protease-like beta-chain as a "hot spot" for allosteric regulation of

67 292 and 422 at the carboxyl terminus of the beta-chain as the principal sites of fibrinogen nitratio

68 Using both the TCR alpha- and beta-chains as tweezers to surround and grip the glucose

69 report, by sequencing of the TCR alpha- and beta-chain associated with CD4(+) Treg, that the TCR rep

70 inhibiting hepatocyte surface expression of beta-chain ATP synthase, inhibits the removal of HDL-apo

71 es within the amino acid 9-23 peptide of the beta-chain (B:9-23).

72 es into two groups where any alpha-chain and beta-chain belonging to the same group are expected to f

73 e in the C-terminal region of the fibrinogen beta-chain (beta384-393).

74 d amino acid residue at position 57 of their beta chain (beta57); this results in the absence of a sa

75 nding alpha chain (IL-5Ralpha), and a common beta chain, betac.

76 he conserved Cys93 residue of the hemoglobin beta-chain (betaCys93) and, specifically, for S-nitrosat

77 third conserved residue is a Cys within the beta-chain (betaCys93) that has been assigned a role in

78 that has been S-nitrosylated at Cys93 of the beta-chain (betaCys93) transitions from the oxygenated f

79 a glutamic acid at the 69th position of the beta-chain (betaGlu69).

80 glutamic acid residue at position 69 of the beta-chain (betaGlu69).

81 isplayed differential MR1 dependency and TCR beta-chain bias, consistent with possible divergent anti

82 1 hotspot that coincides with the known HGF beta chain binding site on blades 2-3 of the SEMA domain

83 fically by blocking HGF alpha-chain (but not beta-chain) binding to MET.

84 tin-2 that bundles actin fibers and spectrin beta-chain, brain 1 that links the plasma membrane to th

85 On introduction of exogenous TCR-beta chains, but not of TCR-alpha chains, assembly and f

86 ption factors T-bet, the IL-2/IL-15 receptor beta chain CD122, and suppression of eomesodermin expres

87 ir expression of the signaling IL-2 receptor beta-chain CD122, forming with common gamma-chain functi

88 ignalling subunits of the IL-2 receptor, the beta chain (CD122) (mean decrease = 58.0%, SE = 2.8%, ra

89 omes) and the interleukin-2 and -15 receptor beta chain (CD122) and an enhanced ability to rapidly pr

90 n EPO receptor subunit (EPOR) and the common beta-chain (CD131).

91 Additionally, the sequences of several TCR beta-chain CDR3 regions were homologous to TCR beta-chai

92 ncoding the HIV-1-specific TCR alpha and TCR beta chains cloned from a CTL clone specific for an HIV

93 erodimer, the alpha-chain interacts with the beta-chain coded by the same chromosome, while in a tran

94 eported possible limitation in the alpha and beta chain combinations that comprise the T cell reperto

95 ompare the global changes in T cell receptor beta chain complementarity determining region 3 (CDR3bet

96 and germline-encoded residues in the second beta-chain complementarity-determining region (CDR2beta)

97 , several identical T-cell receptor variable beta-chain complementarity-determining region 3 sequence

98 r a heterodimer of EPOR and CD131-the common beta chain component of the GM-CSF, interleukin (IL)-3,

99 ds coated with the patient's own DQalpha- or beta-chain components.

100 Detailed analysis of TCRalpha and -beta chain composition is consistent with positive selec

101 In this study, we demonstrate that TCR beta-chain composition can dramatically influence lipid

102 ally exclusive expression of T cell receptor beta-chain constant domains 1 and 2 (TRBC1 and TRBC2).

103 Both alpha- and beta-chains constituted as major components.

104 TCR beta-chain contacts are mostly through the variable CDR3

105 ch TCR is a heterodimer, and both alpha- and beta-chains contribute to determining TCR antigen specif

106 ites in the constant regions of TCR alpha or beta chains could increase the functional avidity of T c

107 e surface expression of hepatic ATP synthase beta chain, decreases the hepatic holoparticle high-dens

108 n bond with bound O(2) in both the alpha and beta chains (DeltaG(His(E7)H-bond) approximately -8 kJ/m

109 Integrins domain (MET Sema-PSI), and the HGF beta-chain demonstrate that onartuzumab acts specificall

110 ges in clonal composition were TCRalpha- and beta chain-dependent and were directly related to the av

111 heptose II group of the lipooligosaccharide beta-chain did not impact levels of gonococcal (strain F

112 nd that expression of these preassembled TCR beta-chains did not downregulate recombinational accessi

113 subunits of human hemoglobin, the alpha and beta chains, display significantly different kinetics fo

114 These findings indicate that NKT TCR beta-chain diversity results in differential and nonhier

115 uses diverse T-cell receptor (TCR) alpha-and beta-chains, does not recognize alpha-galactosylceramide

116 The TRBV17 beta-chain dominated the interaction and, whereas the co

117 structures, NMR characterization of the TCR beta-chain dynamics reveals significant chemical shift e

118 with extracellular regions of the alpha and beta chains each comprising a V-type domain and a C-type

119 types that use the same alpha chain but have beta chains encoded by other genes.

120 sed and frequently dominated by a public TCR beta-chain encoded by the variable gene segment TRBV4-3.

121 I molecules, prevalent HLA-DP molecules with beta-chains encoding Gly84 (DP(84Gly)) constitutively pr

122 ++) in the natural TCR ligand and that MHCII beta-chain flexibility in the area around the peptide p7

123 defects in surfactant proteins or the common beta chain for the GM-CSF receptor (GM-CSFR) are causal.

124 HLA class II alpha and beta chains form receptors for antigen presentation to C

125 ) and an in vitro selection study on the TCR beta chain (four mutations).

126 Here, we conditionally deleted the MHC-II beta-chain from myelinating Schwann cells in mice and in

127 epertoires based on TCRseq of the alpha- and beta-chains from glioma tissue, nonneoplastic brain tiss

128 detail, raising provocative questions about beta chain function.

129 Assembly of a functional TCR beta-chain gene triggers feedback inhibition of V(beta)-

130 T-cell function, we cloned the TCR alpha and beta chain genes from one effective and two ineffective

131 The TCR alpha- and beta-chain genes from a tumor-infiltrating lymphocyte, w

132 Mice that lack the GM-CSF receptor beta chain (GM-CSFRbeta) developed invasive hyphal growt

133 we have identified that the GM-CSF receptor beta-chain (GMRbeta) interacted with ICAM-1 and Shp2 pho

134 Tyrosine phosphorylation of the beta chain has been studied extensively.

135 mer interface (either solely alpha or solely beta chains) has been corrupted.

136 of the TCR-alpha chain with the MHC class II beta chain helix.

137 in O(2)-binding affinity of the alternative beta-chain hemoglobin isoforms were entirely attributabl

138 n E, (iii) globin Y, and (iv) the alpha- and beta-chain hemoglobins of gnathostomes.

139 10, which bound to the recombinant human HGF beta-chain (HGF beta) and competitively inhibited bindin

140 teric activation of the serine protease-like beta-chain (HGF beta), which binds Met to initiate signa

141 ly identical TCR alpha chain but a different beta chain, highlighting the likely dominance of the con

142 The hydrogen bond (H-bond) between beta-chain His(81) and the peptide backbone at the -1 po

143 le (DR52c) containing one of these alternate beta chains (HLA-DRB3*0301) bound to a self-peptide deri

144 ta-chain CDR3 regions were homologous to TCR beta-chains identified previously in allograft arteriosc

145 Expression of IL3Ra or the common beta chain in BaF3 cells also enhanced the ability of JA

146 served lysine in the cytoplasmic tail of the beta chain in dendritic cells (DCs) and B cells.

147 reduced expression of T cell receptor (TCR) beta chain in DN4 thymocytes.

148 fined native T cells expressing an alpha and beta chain in their TCR can only sense antigen when pres

149 ing the optimal orientation of the alpha and beta chains in the expression cassette; 9/10 TCRs favore

150 tochemistry identified hemoglobin alpha- and beta-chains in both rat and human brains, and hemoglobin

151 Sequencing of the T-cell receptor beta-chains in purified T cells revealed clonal expansio

152 the establishment and maintenance of public beta-chains in the periphery is predominantly controlled

153 mited TCR gene usage for both TCR alpha- and beta-chains in type II NKT cells reflects specific antig

154 within the N-terminal portion of the fibrin beta chains, including amino acid residues (beta15-66).

155 and containing three glutamic acids from the beta-chain, including betaGlu69.

156 However, these cells have diverse TCR beta-chains, including Vbeta8, Vbeta7, and Vbeta2 in mic

157 In mice expressing single, rearranged TCR beta-chains, individual mutation of amino acids in the c

158 inct alpha chain paired with the same public beta chain, interact very differently.

159 nd riboflavin cross-links collagen alpha and beta chains into larger polymers.

160 alpha- and gamma-chain sequences (the native beta chain is blocked).

161 y studied human MHCII isotype, HLA-DR, whose beta chain is encoded by the HLA-DRB1 locus, several oth

162 Diversity of the TCR beta chain is generated in part by a random yet intrinsi

163 ertion of the newly formed N terminus in the beta-chain is critical for activity, here by allosterica

164 We show that the influence of the TCR beta-chain is due to a combination of Vbeta-, Jbeta-, an

165 e alpha-chain of the NKTcr is invariant, the beta-chain is more diverse, but how this diversity enabl

166 one amino acid in each of the two hemoglobin beta chains, leading to the polymerization of hemoglobin

167 Using clonotypic TCR beta-chain length and sequence analysis we confirmed tha

168 6) breakpoint resides at the T-cell receptor beta chain locus, Tcrb.

169 Both TCR alpha-chains and TCR beta-chains made contact with the CD1d molecule with a d

170 ut decreased numbers of NKT (T-cell receptor beta chain + mCD1d tetramer(+)) and CD4(+)FoxP3(+) cells

171 poly-Gly/Ala runs in the CDR3 of alpha- and beta-chains might provide high levels of TCR flexibility

172 ant domains of the T-cell receptor alpha and beta chain mRNAs.

173 or recognition is mediated by binding of MSP beta-chain (MSPbeta) to the RON Sema.

174 kably, the catalytic potency of DM with each beta-chain mutant was equal to or greater than that obse

175 Complement component C1q, beta-chain, nonspecific cytotoxic cell receptor protein

176 oire of transgenic Treg cells expressing the beta chain of an FV-specific TCR was virtually devoid of

177 C3 identified two peptide motifs within the beta chain of fibrinogen (residues 424-433, 435-445) tha

178 hat adhiron A6 binds to similar areas on the beta chain of fibrinogen.

179 We also show that the beta chain of hemoglobin, lacking the homologous tyrosin

180 rring murine hybrid cytokine of IL-7 and the beta chain of hepatocyte growth factor (rIL-7/HGFbeta) t

181 We hypothesize that the 12-20 peptide of the beta chain of insulin is responsible for activation of t

182 We show that the common beta chain of the GM-CSF receptor (betac) is dispensable

183 gen interaction, in which both the alpha and beta chain of the NKT TCR is required for ligation above

184 of antigen-presenting cells and the variable beta chain of the T-cell receptor but also to the dimer

185 pping constant domains between the alpha and beta chains of a therapeutic TCR.

186 The proteases cleaved alpha and beta chains of C3 and work in synergy with host regulato

187 d by a mutation in the gene encoding for the beta chains of hemoglobin.

188 ransfected with mRNAs encoding the alpha and beta chains of the HC/2G-1 TCR recognized renal tumor li

189 ompatibility complex class II and specific V-beta chains of the T-cell receptor, thus forming a terna

190 reover, we demonstrate that the cytoplasmic (beta) chain of LRP1 suffices to limit cholesterol accumu

191 severely reduced or absent expression of the beta-chain of adult hemoglobin (alphabeta;HbA).

192 g the dysfunction to a point mutation in the beta-chain of C3 (c.1180T > C; p.Met(373)Thr).

193 The amino terminal of the beta-chain of HbA is modified by 2-hydroxy, 3-phospho pr

194 Conformational exchange mapping of the beta-chain of HbCO A observed at 21.1 T shows significan

195 e immune cytokine interleukin (IL)-7 and the beta-chain of hepatocyte growth factor (HGF) aggregate t

196 ovel hybrid cytokine containing IL-7 and the beta-chain of hepatocyte growth factor (HGF) in the supe

197 ine consisting of interleukin (IL)-7 and the beta-chain of hepatocyte growth factor (HGF) that had ly

198 binding site within the serine protease-like beta-chain of HGF.

199 alpha-chain of HLA-DQ2 (DQA1*05:01) and the beta-chain of HLA-DQ8 (DQB1*03:02).

200 Using high-throughput sequence data from the beta-chain of human T-cell receptors, we infer factors t

201 -chain are overlaid with the alpha-chain and beta-chain of MHC class II, respectively.

202 on, we showed that the T-cell receptor (TCR) beta-chain of our nTreg model was not only sufficient to

203 these conformers are similar to those in the beta-chain of oxyferrous hemoglobin A (HbA) and oxyferro

204 ts a wedge-like position when binding to the beta-chain of TCR, allowing for an interaction between t

205 egion from a mAb directed against CD79B, the beta-chain of the invariant signal-transducing dimer of

206 ted with decreased sialic acid levels on the beta-chain of the IR and reduction of IR signaling.

207 T cells engineered to express the alpha- and beta-chains of a high functional avidity TCR specific fo

208 ansgenic mouse that expresses the alpha- and beta-chains of a myelin oligodendrocyte glycoprotein (MO

209 ved in balanced expression of the alpha- and beta-chains of MHC class II, whereas rs7192 was predicte

210 sed on the dimeric feature of the alpha- and beta-chains of the human major histocompatibility comple

211 or Hb isoform) and HBB-T2 (which encodes the beta-chains of the minor Hb isoform).

212 in a trans heterodimer it interacts with the beta-chain on the other chromosome.

213 after called C4BP[beta(-)] [C4BP lacking the beta-chain]), overexpressed under acute-phase conditions

214 , the importance of complementary alpha- and beta-chain pairing in determining TCR specificity and T

215 and the in vitro functional TCR-alpha- and -beta-chain-pairing assay suggests that every peptide/MHC

216 Most GIL-specific TCRs utilize alpha/beta chain pairs encoded by the TRAV27/TRBV19 gene combi

217 number of unique combinations of alpha- and beta-chain pairs.

218 ous work has shown that both alpha-chain and beta-chain phosphorylations of CD11a/CD18 and CD11b/CD18

219 he acute-phase C4BP isoform C4BP lacking the beta-chain plays a pivotal role in the modulation of the

220 rum expected for NO bound to the heme in the beta-chain plus that of a thiyl radical.

221 MHC class II molecules, in particular around beta-chain position-57 (beta57), afford susceptibility/r

222 d of its carboxyl-terminal NPXY motifs, LRP1 beta-chain positively regulates the expression of ATP bi

223 ould otherwise be sterically hindered by the beta-chain, primarily mediates this interaction.

224 tic of the R and T states, for both alpha or beta chains, prior to the quaternary R-T and T-R shifts.

225 Three alpha-chain and three beta-chain public TCR sequences were shared between indi

226 pertoires focus solely on an analysis of TCR beta-chains, rather than the combined TCRalphabeta heter

227 ative selection of thymocytes expressing TCR beta-chains reactive against several retroviral superant

228 egration site sequencing and T-cell receptor beta-chain rearrangement sequencing, correlated signific

229 nd murine T cells have shown that public TCR beta-chain rearrangements can dominate the Ag-specific a

230 hese three cytokines signal through a common beta-chain receptor but yet differentially affect protei

231 /macrophage-colony stimulating factor common beta-chain receptor.

232 During infection, T cell beta chain repertoire continues to contract while the di

233 Using immune profiling of the T cell beta-chain repertoire in 16 patients with early-stage br

234 Sequencing of the TCR beta-chain repertoire reveals that the DEJ CD8alphaalpha

235 agnitude of the CD8(+) T cell responses, TCR beta-chain repertoires did not significantly differ amon

236 Two beta-chain residues, located near the proposed Be bindin

237 he two peaks to be hemoglobin (Hb) alpha and beta chains, respectively, with no apparent post-transla

238 uated underneath the TCR alpha-chain and TCR beta-chain, respectively.

239 PSI in complex with hepatocyte growth factor beta-chain reveals the receptor-ligand selectivity deter

240 (fusA [mhp083]) (P = 0.002), RNA polymerase beta chain (rpoC [mhp635]) (P = 0.003), adenylate kinase

241 ndicating that pairing of certain alpha- and beta-chain sequences is key for determining TCR specific

242 Public TCR beta-chain sequences were identified across different re

243 taining and clonotypic T cell receptor (TCR) beta-chain sequencing in multiple anatomic regions isola

244 We applied single-cell TCR alpha- and beta-chain sequencing to peripheral blood GAD65-specific

245 7 Vbeta3 transgenic mice, which have a fixed beta-chain specific for pigeon cytochrome c peptide I-Ek

246 e engineered to express single TCR alpha- or beta-chains specific for the D(b)NP366 or D(b)PA224 epit

247 Chimeric analysis indicates that integrin beta chain-specific impacts on induction are dictated by

248 10 residues of the cleaved N terminus of the beta-chain stimulate Met phosphorylation by pro-HGF to l

249 a-globin paralogs, HBB-T1 (which encodes the beta-chain subunits of the major Hb isoform) and HBB-T2

250 seven identical alpha chains and one unique beta chain synthesized in liver and pancreas.

251 xpanded populations of T cells, we amplified beta-chain TCR transcripts by the nonpalindromic adaptor

252 Multiple identical copies of beta-chain TCR transcripts were identified in these pati

253 ified an allele of the T-cell receptor (TCR) beta-chain, Tcrb-V13S1A1, as a candidate gene.

254 que phenotypic traits of CD8(+) TILs and TCR beta chain (TCRbeta) clonotypic frequency in melanoma tu

255 tional profiling and T-cell antigen receptor beta-chain (TCRbeta) genotyping on sequential genital sk

256 first expressing the T cell antigen receptor beta-chain (TCRbeta).

257 cells bearing receptors made up of alpha and beta chains (TCRs) usually react with peptides bound to

258 inant I-A(k) class II molecules possessing a beta-chain-tethered hen egg lysosome peptide lack the Ia

259 We created mice expressing a transgenic TCR-beta chain that confers high affinity for self-lipid/CD1

260 hese cells express a range of TCR alpha- and beta-chains that show differential recognition of glycol

261 For alpha but not for beta chains, the frequency of the nu(4) porphyrin breath

262 In CD4 thymocytes expressing a fixed Tg TCR beta-chain, the associated TCRalpha sequences in wild-ty

263 le CDR3 region of human CD4+ T-cell receptor beta chains to infer the statistical properties of these

264 re MSPalphabeta (disulfide-linked alpha- and beta-chains) to RON ectodomain modulates receptor dimeri

265 inatorial diversity of human T-cell receptor beta-chain (TRB locus) was measured in peripheral blood.

266 In this study, we examined the TCR beta-chain (TRB) diversity of the CD8(+) T cell response

267 Here, we sequenced T-cell receptor beta-chain (TRB) gene rearrangements from immunodominant

268 the gene encoding the T cell receptor (TCR) beta-chain (Trb, also known as Tcrb) using CDR3 sequence

269 KF11) and identified common usage of the TCR beta-chain TRBV7 in eight of nine HLA B57 subjects exami

270 s likely to be Tcrb-V13, indicating that TCR beta-chain usage is a determinant of susceptibility to a

271 rate here that NKTcrs, which varied in their beta-chain usage, recognised diverse glycolipid antigens

272 buried hydroxymethyl that forms a common TCR beta-chain V region variant.

273 class II molecules and T-cell receptor (TCR) beta-chain variable domains (Vbetas).

274 CTL receptor TCR beta-chain variable gene subfamilies were polyclonal, wi

275 ining region 3 (CDR3) regions containing the beta-chain variable region (Vbeta) demonstrated a more d

276 was found irrespective of the member of the beta-chain variable region (Vbeta) family present in the

277 CR) alpha-chain variable region (Valpha) and beta-chain variable region (Vbeta).

278 expressing the T cell antigen receptor (TCR) beta-chain variable region 11 (TRBV11-2) were 'preferent

279 y one or two clones typically expressing TCR beta-chain variable TRBV-15.

280 tive roles of the CDR loops within the NKTcr beta-chain varied as a function of the antigen.

281 nding to variable domains of T cell receptor beta chains (Vbeta) leads to massive release of inflamma

282 troduction of T-cell receptor (TCR) variable beta-chain (Vbeta) monoclonal antibodies has facilitated

283 -cell receptor (TCR) variable regions of the beta-chain (Vbeta).

284 e T cell repertoire to usage of a single TCR beta-chain, Vbeta11, implying selection by Ag.

285 eage, but we also demonstrated that this TCR beta-chain was able to provide stronger TCR signals.

286 ormalized to vector copy, the vector-encoded beta-chain was expressed at a level approximating normal

287 silonRI alpha-chain with the gamma-chain and beta-chain was markedly reduced.

288 Consistently, in the absence of beta-chains, we found a direct interaction between the c

289 Individual residues within the MAIT TCR beta chain were dispensable for the interaction with MR1

290 pr48-/- mice both adult hemoglobin alpha and beta chains were decreased while embryonic hemoglobin ch

291 the alpha-helices of the HLA-DP2 alpha- and beta-chains were also mutated to alanine.

292 ary DNA for T cell receptor (TCR) alpha- and beta-chains were cloned into a retroviral vector.

293 MAGE-A3-specific TCR alpha- and beta-chains were isolated and cloned into a retroviral v

294 We demonstrate that beta-chains were positively selected with similar effici

295 is composed of two polypeptides (alpha- and beta-chains), which form three plasma oligomers with dif

296 receptors for these cytokines use the common beta chain, which serves as the main signaling unit link

297 ules are composed of one alpha-chain and one beta-chain whose membrane distal interface forms the pep

298 g ligand promiscuity to favor development of beta chains with self-reactivity but is occluded by alph

299 Rhinocetin was shown to comprise alpha and beta chains with the molecular masses of 13.5 and 13 kDa

300 We created chimeras of alpha- and beta-chains with the NR2A and NR2B C termini and evaluat