ライフサイエンスコーパス: beta-endorphin

1 nes, beta-lipotropic hormone (beta LPH), and beta endorphin.

2 an altered cleavage profile for the peptide beta-endorphin.

3 alpha-neoendorphin, but not endomorphins or beta-endorphin.

4 -stimulating hormone, and the opioid peptide beta-endorphin.

5 elanocyte-stimulating hormone (beta-MSH) and beta-endorphin.

6 n of beta-lipotropin to gamma-lipotropin and beta-endorphin.

7 ation in the level of C-terminally processed beta-endorphin.

8 ere used for dual immunocytochemistry of Fos/beta-endorphin.

9 through the post-translational processing of beta-endorphin.

10 n (POMC), or PVN levels of Met-Enkephalin or beta-Endorphin.

11 peptide Y, vasoactive intestinal peptide, or beta-endorphin.

12 amic acid decarboxylase 67 (GAD67), NPY, and beta-endorphin.

13 )O-induced increases in nitrite, nitrate and beta-endorphin.

14 timulate an NO-dependent neuronal release of beta-endorphin.

15 O metabolites nitrite and nitrate as well as beta-endorphin.

16 yzed for their content of NO metabolites and beta-endorphin.

17 tisera against the endogenous opioid peptide beta-endorphin.

18 ient or lacking either pre-pro-enkephalin or beta-endorphin.

19 tobarbital-anesthetized rats pretreated with beta-endorphin (0.5 nmol i.c.v.).

20 a peptidase which converts beta-endorphin to beta-endorphin 1-17 (gamma-endorphin), beta-endorphin 1-

21 in to beta-endorphin 1-17 (gamma-endorphin), beta-endorphin 1-18, and their corresponding C-terminal

22 co-administration of morphine (1 microg) and beta-endorphin (1 microg) into either the amygdala alone

23 Co-administration of beta-endorphin (1 microg) into the amygdala and morphine

24 of morphine (1 microg) into the amygdala and beta-endorphin (1 microg) into the PAG failed to produce

25 he similar effects of intra-DVC injection of beta-endorphin (1 pmol) are inhibited by naloxone and no

26 psilon (epsilon)-opioid-receptor antagonist, beta-endorphin(1-27) prevents these effects of etorphine

27 ethadone (LAAM), morphine, meperidine, DADL, beta-endorphin(1-31), enkephalins, and dynorphin A(1-17)

28 ity to the suppressive actions of Gly-Gln or beta-endorphin-(1-27) injections that modulate voluntary

29 ficacy was shown to be comparable to central beta-endorphin-(1-27) or intraperitoneal (i.p.) naltrexo

30 In contrast, the opioid peptidergic agonist beta-endorphin (10 microgram/kg, i.p.) administered afte

31 Following intrathecal administration, beta-endorphin (10-100 nmol) and GRP (1-10 nmol) dose-de

32 rolysis of fluorogenic peptides based on the beta-endorphin 12-24 sequence, Abz-T-P-L-V-T-L-X(1)-X(2)

33 nto the rostral ventromedial medulla altered beta-endorphin (15 microg) analgesia elicited from the v

34 Both morphine (2.5-5 micrograms) and beta-endorphin (2.5-5 micrograms) microinjected into eit

35 Glycyl-L-glutamine (Gly-Gln; beta-endorphin 30-31) is an endogenous dipeptide that is

36 y, we investigated whether glycyl-glutamine (beta-endorphin(30-31)), an inhibitory dipeptide synthesi

37 ore effective in reducing morphine (60%) and beta-endorphin (79%) analgesia in the amygdala on the ju

38 essed pro-opiomelanocortin, the precursor of beta-endorphin (a known EOP), and constituted the majori

39 d in the DVC, whereas the similar effects of beta-endorphin, a peptide derived from the same precurso

40 egulated by, in part, the endogenous opioid, beta-endorphin, acting on mu-opioid receptors.

41 ted by opioids, leading to the proposal that beta-endorphin acts to provide feedback inhibition.

42 d respiratory depression produced by central beta-endorphin administration.

43 We found that beta-endorphin aggregation and dissociation occur in vit

44 ght carbohydrates exhibit the same effect on beta-endorphin aggregation as phosphate.

45 point as well as more rapid dissociation of beta-endorphin amyloid fibrils at lower pH indicate the

46 In contrast, beta-endorphin amyloid fibrils obtained in the presence

47 l factors on the assembly and disassembly of beta-endorphin amyloids in vitro.

48 ning exercise increases blood levels of both beta-endorphin (an opioid) and anandamide (an endocannab

49 However, the A118G variant receptor binds beta-endorphin, an endogenous opioid that activates the

50 e PAG significantly reduce both morphine and beta-endorphin analgesia elicited from the amygdala.

51 sary for the full expression of morphine and beta-endorphin analgesia elicited from the amygdala.

52 PAG significantly reduced morphine, but not beta-endorphin analgesia in the amygdala on the tail-fli

53 the multiple modulatory mechanisms mediating beta-endorphin analgesia in the PAG, and in terms of whe

54 The opioid mediation of beta-endorphin analgesia in the ventrolateral periaquedu

55 Whereas mecamylamine failed to reduce beta-endorphin analgesia on either measure, scopolamine

56 l (11%) and transient (30 min) reductions in beta-endorphin analgesia on the jump test, MK-801 produc

57 al (9%) and transient (30 min) reductions in beta-endorphin analgesia on the tail-flick test.

58 l (23%) and transient (30 min) reductions in beta-endorphin analgesia on the tail-flick test.

59 Glycosylated beta-endorphin analogues of various amphipathicity were

60 esidues in the helical address region of the beta-endorphin analogues without destroying mu-, delta-,

61 py showed colocalization of cathepsin L with beta-endorphin and alpha-MSH in the intermediate pituita

62 addiction, mediated by the hedonic action of beta-endorphin and anhedonic effects of withdrawal, may

63 these neurons produce the endogenous opioid beta-endorphin and are heavily regulated by opioids.

64 As the opioid peptides beta-endorphin and enkephalin increase splenic NK cell f

65 the measurement of instrumental behavior of beta-endorphin and enkephalin knock-out mice that both o

66 We conclude that both beta-endorphin and enkephalin positively contribute to t

67 y granules yet expresses endogenous opioids (beta-endorphin and Met-enkephalin) and uroguanylin in ap

68 In addition, we have shown that beta-endorphin and mu-opiate receptor are expressed at t

69 The expression of both beta-endorphin and mu-opiate receptor correlated positiv

70 hemistry and immunoelectron microscopy using beta-endorphin and mu-opiate receptor specific antibodie

71 ed the brain-to-blood transport of morphine, beta-endorphin and other opioids.

72 (POMC) neurons release the endogenous opioid beta-endorphin and POMC neuron activity is inhibited by

73 f the infiltration of immunocytes containing beta-endorphin and the consequent decrease of the beta-e

74 y structural differences between melittin or beta-endorphin and their respective synthetic analogs.

75 Moreover, neurons triple-labeled with c-Fos, beta-endorphin and VGLUT3 were noted in this region foll

76 y completely prevented carboxy-shortening of beta-endorphins and greatly diminished conversion of bet

77 of neuroendocrine peptides (dynorphin A-17, beta-endorphin, and alpha- melanocyte-stimulating hormon

78 hormones adrenocorticotropic hormone (ACTH), beta-endorphin, and alpha-melanocyte stimulating hormone

79 e for cathepsin L in the production of ACTH, beta-endorphin, and alpha-MSH peptide hormones in the re

80 ock-out mice showed major decreases in ACTH, beta-endorphin, and alpha-MSH that were reduced to 23, 1

81 mone, alpha-, beta-, and gamma-melanotropin, beta-endorphin, and beta-lipotropin.

82 nadotropin-releasing hormone (GnRH), VP, OT, beta-endorphin, and dopamine neurons, are responsive to

83 proopiomelanocortin (POMC), the precursor to beta-endorphin, and endomorphin 1 and 2 on sectioned rat

84 mu-opioid receptor agonists (e.g., morphine, beta-endorphin, and enkephalin) inhibit luteinizing horm

85 gonadotropin-releasing hormone-I, dopamine, beta-endorphin, and gonadotropin-releasing hormone-II ne

86 analgesic responses induced by morphine and beta-endorphin, and indicate that the latter response is

87 prolactin, corticotropin-releasing hormone, beta-endorphin, and somatotropin release-inhibiting fact

88 tein as well as its derivatives beta LPH and beta-endorphin, and that this process is modulated by TP

89 deprived feeding states but were reduced in beta-endorphin- and enkephalin-deficient mice only when

90 0-100 nmol) dose-dependently attenuates both beta-endorphin- and GRP-elicited robust scratching witho

91 The same pathway produces beta-endorphin, another POMC derivative, which potential

92 selected for three different receptors: anti-beta-endorphin anti-body, streptavidin, and thrombin, an

93 nsulin, growth hormone releasing factor, and beta-endorphin are nearly equivalent substrates for the

94 Enkephalins and beta-endorphin are nonselective endogenous MOR ligands.

95 ide (POMC), and its opioid cleavage product, beta-endorphin, are expressed in the mouse retina.

96 Using a monoclonal antibody (3E-7) against beta-endorphin as a target, we selected a single peptide

97 fferential affinity to the endogenous ligand beta-endorphin as well as alterations in pain sensitivit

98 Wild type IDE cleaved beta-endorphin at Leu(17)-Phe(18) and Phe(18)-Lys(19), w

99 Nardilysin cleaves beta-endorphin at the monobasic site, Phe(17)-Lys(18), w

100 olved in pain modulation-metenkephalin (ME), beta-endorphin (BE), and substance P (SP)-in patients un

101 Within 36 h after TPA stimulation, beta-endorphin became undetectable in cell extracts, coi

102 To enhance beta-endorphin (BEP), the endogenous opioid polypeptide

103 halamic NSCs differentiated these cells into beta-endorphin (BEP)-producing neurons in culture.

104 The endogenous peptides beta-endorphin (beta-END) and neuropeptide Y (NPY) have

105 in-releasing hormone (CRH), urocortin (Ucn), beta-endorphin (beta-END), ACTH, and corticosterone (COR

106 role also exists for the endogenous opiate, beta-endorphin (beta-END).

107 The enzymatic cleavage products of beta-endorphin (beta-endorphin1-27 and Gly-Gln) reduce v

108 The role of beta-endorphin (beta-EP) in ethanol-altered NK cell cyto

109 The mechanism by which ethanol induces beta-endorphin (beta-EP) neuronal death during the devel

110 cAMP system is involved in ethanol-regulated beta-endorphin (beta-EP) release from rat hypothalamic n

111 induced by the mu-sensitive opioid peptide, beta-endorphin (betaEND, 10 microg, i.c.v.) was signific

112 CB1R activation selectively increases beta-endorphin but not alpha-melanocyte-stimulating horm

113 Thus, beta-endorphin cell therapy may offer some therapeutic v

114 A recognized beta-endorphin cleavage product, Gly-Gln, inhibits volun

115 tion of cell bodies containing enkephalin or beta-endorphin, colchicine (90-100 microg/kg) was inject

116 A118G) may have higher receptor binding for beta-endorphin compared with AA homozygotes that may con

117 evels of oxidation products of NO as well as beta-endorphin, compared to levels in fractions collecte

118 fall in arterial pressure elicited by i.c.v. beta-endorphin, consistent with evidence that cyclic dip

119 The results suggest that although beta-endorphin-containing fibres are absent in many part

120 bility, CB(2) immunolabeling was detected on beta-endorphin-containing keratinocytes in stratum granu

121 endorphin and the consequent decrease of the beta-endorphin content in the inflamed tissue.

122 Although conversion of beta-lipotropin to beta-endorphin decreased, the lack of PC2 activity cause

123 Adult male beta-endorphin deficient and wild type mice were subject

124 Overall, the beta-endorphin deficient mice and wild type mice had fai

125 After the conflict, the beta-endorphin deficient mice had higher corticosterone

126 th the aggressive conspecific several of the beta-endorphin deficient mice showed clear signs of coun

127 In this experiment beta-endorphin deficient mice were used to study the rol

128 re returned to baseline levels faster in the beta-endorphin deficient mice.

129 In this study, we used the beta-endorphin deficient mutant mouse line C57BL/6-Pomc1

130 tion in proenkephalin knockout (PENK KO) and beta-endorphin-deficient (BEND KO) mice, and how the bod

131 Herein we demonstrate that morphine and beta-endorphin disrupt this long-range synchrony of gamm

132 ed NO activity and the stimulated release of beta-endorphin during exposure of rats to N(2)O.

133 at mu and kappa opioid receptors as well as beta-endorphin each produce analgesia elicited from the

134 studies have demonstrated that morphine and beta-endorphin employ different anatomical and neurochem

135 f a rat's hindpaw elicits an accumulation of beta-endorphin-(END) containing immune cells.

136 ls and neurons double-labeled with c-Fos and beta-endorphin, enkephalin or VGLUT3 in the ARC were sig

137 however, growth hormone releasing factor and beta-endorphin exhibit a 40-fold higher kcat, but a 10-f

138 ansgenic mice with a selective deficiency of beta-endorphin exhibit normal analgesia in response to m

139 UVB stimulated beta-endorphin expression was higher in D2 than in B6.

140 king beta-endorphin), heterozygous mice (50% beta-endorphin expression) and sibling wildtype mice fro

141 ) receptor activation induces the release of beta-endorphin from keratinocytes and the activation of

142 mutant POMC cDNA produced a mutant beta-MSH/beta-endorphin fusion protein.

143 s with the rank order of etorphine > DAMGO = beta-endorphin > morphine > butorphanol, and the affinit

144 beta-Endorphin had an LOD of 5 nM when detected directly

145 Functional studies showed that beta-endorphin has potent melanogenic, mitogenic, and de

146 imulating hormone; and the endogenous opioid beta-endorphin) have a diverse array of biological activ

147 Homozygous knockout mice (entirely lacking beta-endorphin), heterozygous mice (50% beta-endorphin e

148 that hemorrhage increased Fos expression by beta-endorphin immunoreactive neurons significantly.

149 The proportion of beta-endorphin immunoreactive neurons that expressed Fos

150 e for beta-endorphin immunostaining, whereas beta-endorphin-immunoreactive neurons were absent in ret

151 ell extracts, coinciding with an increase of beta-endorphin-immunoreactive protein in the culture med

152 aused significant increases in POMC mRNA and beta-endorphin immunoreactivity in both ipsilateral and

153 d-expressing amacrine cells was positive for beta-endorphin immunostaining, whereas beta-endorphin-im

154 t with nerve fibers containing enkephalin or beta-endorphin in both the rVLM and vlPAG.

155 A physiological role for beta-endorphin in endogenous pain inhibition was investi

156 gulated secretion of both chromogranin A and beta-endorphin in response to the usual secretagogue, co

157 s and/or dendrites) containing enkephalin or beta-endorphin in specific regions of the brain stem.

158 oid analgesia elicited by either morphine or beta-endorphin in the amygdala could be altered by eithe

159 roopiomelanocortin (POMC) neurons to release beta-endorphin in the arcuate nucleus (ARC) of the hypot

160 exin A, orexin B, and a novel isoform of rat beta-endorphin in the arcuate nucleus.

161 own that enhancement of endogenous levels of beta-endorphin in the hypothalamus via beta-endorphin ne

162 tration of AAS also increased the content of beta-endorphin in the midline thalamus, suggesting a pos

163 est, but decreased the potency of the opioid beta-endorphin in the periaqueductal gray region of the

164 AtT-20 cells resulted in increased ACTH and beta-endorphin in the regulated secretory pathway.

165 let radiation, to date a functional role for beta-endorphin in the regulation of human epidermal mela

166 ta-melanocyte-stimulating hormone (MSH), and beta-endorphin in the regulation of skin pigmentation, a

167 but the data do not support a major role for beta-endorphin in the regulation of sleep or social stre

168 s activates neurons containing enkephalin or beta-endorphin in the rVLM as well as in the periaqueduc

169 -endorphin were used to study the release of beta-endorphin in the urethane anaesthetized rat followi

170 neuronal structures containing enkephalin or beta-endorphin in these regions.

171 oxidation of epidermal ACTH, alpha-MSH, and beta-endorphin in vitiligo owing to oxidation of methion

172 halin, leu-enkephalin, dynorphin A(1-8), and beta-endorphin in vivo.

173 Beta endorphin-induced constriction was enhanced followi

174 tion produced a dose-dependent inhibition of beta-endorphin-induced hypotension, but not bradycardia,

175 beta-endorphin inhibition of tumor progression also invo

176 ere active toward the physiological peptides beta-endorphin, insulin, and amyloid beta peptide 1-40.

177 Co-administration of subthreshold doses of beta-endorphin into both structures also results in a pr

178 hold doses of morphine into both structures, beta-endorphin into both structures, morphine into one s

179 in into the other structure, or morphine and beta-endorphin into one structure.

180 tions of morphine, mu-selective agonists and beta-endorphin into the amygdala.

181 structures, morphine into one structure and beta-endorphin into the other structure, or morphine and

182 Beta-endorphin is an endogenous opioid peptide that is r

183 beta-Endorphin is an opioid peptide cleaved from the pre

184 Furthermore, beta-endorphin is approximately three times more potent

185 The cancer-preventive effect of beta-endorphin is mediated through the suppression of sy

186 hermal stimulus was applied, suggesting that beta-endorphin is necessary for CB(2) receptor-mediated

187 Whereas plasma beta-endorphin is reported to increase after exposure to

188 t an important mechanism of the transport of beta-endorphin is the cerebrospinal fluid.

189 t, in rodents, another POMC-derived peptide, beta-endorphin, is coordinately synthesized in skin, ele

190 eptive and behavioral effects were absent in beta-endorphin knockout mice and in mice lacking p53-med

191 An antibody that selectively recognized beta-endorphin labeled fibers and neurons in the ventral

192 ty caused an increase in beta-lipotropin and beta-endorphin levels in the mutant animals, but no incr

193 beta-endorphin levels increased in the inflamed paw, and

194 ription, and plasma interleukin-1 (IL-1) and beta-endorphin levels measured.

195 fe-threatening episodes implicates increased beta-endorphin levels resulting from acid-mediated esoph

196 Resting plasma beta-endorphin levels were significantly higher in the H

197 r women, dyadic satisfaction correlated with beta-endorphin levels, depression, and perception of ill

198 ' dyadic satisfaction scores correlated with beta-endorphin levels.

199 Moreover, we show that oxidized beta-endorphin loses its function in the promotion of pi

200 Solitary chemosensory cells that coexpress beta-endorphin, Met-enkephalin, uroguanylin, and Trpm5 e

201 In conclusion, the results suggest that beta-endorphin modulates the acute endocrine, thermoregu

202 These data support the hypothesis that beta-endorphin modulates the response to EtOH.

203 e causal links for itch-eliciting effects by beta-endorphin-MOP receptor and GRP-BB2 receptor systems

204 0 microM concentrations of etorphine, DAMGO, beta-endorphin, morphine, and butorphanol, DAMGO-stimula

205 s designed to examine the involvement of the beta-endorphin/mu-opiate receptor system in human epider

206 elanocortin-1 receptor, we conclude that the beta-endorphin/mu-opiate receptor system participates in

207 rmal melanocytes express a fully functioning beta-endorphin/mu-opiate receptor system.

208 ls of beta-endorphin in the hypothalamus via beta-endorphin neuron transplantation suppresses stress

209 0 +/- 2.6%, depending on neuronal location), beta-endorphin neurons (68.3.0 +/- 4.4%), and VP neurons

210 ds to hyperpolarize guinea pig hypothalamic (beta-endorphin) neurons.

211 rast to traditional mu and kappa opioids and beta-endorphin, none of the OFQ/N fragments in the amygd

212 beta LPH and beta-endorphin of keratinocyte origin may thus be involv

213 ls of epinephrine and norepinephrine but not beta-endorphin or cortisol.

214 t rat dynorphin1-13 but not antisera against beta-endorphin or methionine-enkephalin.

215 the cardiorespiratory depression produced by beta-endorphin or morphine.

216 CD+CID can improve the sequence coverage for beta-endorphin over performing ECD alone (i.e., from 72

217 networks) to show that three neuropeptides (beta-endorphin, oxytocin, and dopamine) play particularl

218 Glycopeptides related to beta-endorphin penetrate the blood-brain barrier (BBB) o

219 s (PVN) (P<0.05), but did not have lower PVN beta-endorphin peptide levels (0.05).

220 The opioid peptide beta-endorphin plays a critical role in bringing the str

221 )), an inhibitory dipeptide synthesized from beta-endorphin post-translationally, inhibits IL-1beta a

222 c-rAAV8 expressing the analgesic gene prepro-beta-endorphin (ppbetaEP) led to significant (P < 0.0001

223 role for insulin-degrading enzyme as both a beta-endorphin-processing and -inactivating enzyme is im

224 et of experiments tested the hypothesis that beta-endorphin-producing neurons, that is, proopiomelano

225 utyric acid (GABA), neuropeptide Y (NPY), or beta-endorphin receptor blockade in the ipsilateral hypo

226 rdiovascular reflexes through enkephalin- or beta-endorphin-related opioid receptors in the rostral v

227 emperature, at least in part, by stimulating beta-endorphin release from pro-opiomelanocortin neurons

228 AM1241 stimulated beta-endorphin release from rat skin tissue and from cul

229 The time-integrated beta-endorphin response to CRH was greater in the patien

230 Depolarization-mediated beta-endorphin secretion was greatly enhanced in the GAP

231 tone, sensation, plasma levels of cortisol, beta-endorphin, selected gut neuropeptides, norepinephri

232 ng in keratinocytes, subsequently increasing beta-endorphin signaling at opioid receptors, and produc

233 During this period, beta-endorphin stimulates PRL secretion by regulation of

234 phine (tail-flick: 70-75%; jump: 60-81%) and beta-endorphin (tail-flick: 100%; jump: 93%) analgesia e

235 des alpha-melanocyte-stimulating hormone and beta-endorphin, the glucocorticoids; and the catecholami

236 ting hormone (alpha-Msh) and carboxy-cleaved beta-endorphin, the products of Cpe-dependent processing

237 have shown the distribution of dynorphin and beta-endorphin throughout social behavior circuits withi

238 ell line contains a peptidase which converts beta-endorphin to beta-endorphin 1-17 (gamma-endorphin),

239 cial attachment, binding of the neuropeptide beta-endorphin to mu-opioid receptors in the central ner

240 al tone regulating feeding behavior, whereas beta-endorphin underlies orosensory reward in high need

241 A functional role for beta-endorphin was assessed in epidermal melanocyte cult

242 125I-beta-Endorphin was cross-linked to preparations enriched

243 Little immunoreactive-beta-endorphin was detected in the areas of brain sample

244 Basal secretion of beta-endorphin was first observed at Embryonic Day 13.5

245 vented in rats when naloxone or antiserum to beta-endorphin was injected in the hindpaw where the nox

246 Hindpaw injection of beta-endorphin was sufficient to produce antinociception

247 proximity to fibers containing enkephalin or beta-endorphin, was observed in the rVLM and ventrolater

248 timulate an NO-dependent neuronal release of beta-endorphin, we conducted a ventricular-cisternal per

249 Given the powerful analgesic properties of beta-endorphin, we tested this hypothesis using pain tol

250 n Western blot analysis, POMC, beta LPH, and beta-endorphin were detected in cell extracts under base

251 n the PAG, while no cell bodies labeled with beta-endorphin were identified in either region.

252 Met-Enkephalin and beta-Endorphin were not affected by dietary treatment.

253 ilized antibodies to the carboxy-terminus of beta-endorphin were used to study the release of beta-en

254 is mechanism allows for the local release of beta-endorphin, where CB(2) receptors are present, leadi

255 tially to inflamed sites, where they release beta-endorphin which activates peripheral opioid recepto

256 ion stimulates release from keratinocytes of beta-endorphin, which acts at local neuronal mu-opioid r

257 emia and exercise both induce the release of beta-endorphin, which plays an important role in the mod

258 Unlike beta-endorphin, which produces itch and attenuates infla

259 from keratinocytes of the endogenous opioid beta-endorphin, which then acts at opioid receptors on p

260 There was no correlation of IL-1 or beta-endorphin with any psychosocial or behavioral compl

261 icroscopy studies revealed an association of beta-endorphin with melanosomes.