ライフサイエンスコーパス: beta-integrin

1 cident with an increase in filopodial L1 and beta-integrin.

2 y of molecules including ECM protein-binding beta integrins.

3 serine/threonine kinase that interacts with beta integrins.

4 educed aa sequences were compared with other beta integrins.

5 ial binding of the nonphosphorylated form of beta-integrins.

6 nt of neutrophil PECAM-1 activates leukocyte beta-integrins.

7 ltimately mediating activation of neutrophil beta integrins, (3) regulation of endothelial calcium in

8 quence with shared similarity to other known beta integrins (44.6-61.5%).

9 partially inhibited by the inclusion of anti-beta integrin Ab or tissue inhibitor of metalloproteinas

10 -linked kinase (ILK) directly interacts with beta integrins and phosphorylates Akt in a phosphatidyli

11 thereby preventing lysosomal degradation of beta integrins and their associated a subunits.

12 sminogen activator, and interactions between beta integrins and tissue vitronectin.

13 sis of the hemocyte glycoproteins identified beta-integrin and dominin as CvGal1 "self"-ligands.

14 stributed late in development, at which time beta-integrin and Enabled specifically associate with ac

15 e signaling proteins, Lena (leech Ena/Vasp), beta-integrin and paxillin, but not beta-catenin, phenoc

16 cted intercalated disk fragments even though beta-integrin and vinculin have been completely removed

17 llular environment through interactions with beta-integrins and actin.

18 d proteins that bind the cytoplasmic tail of beta-integrins and localize to adhesions that anchor str

19 ICAP-1 and the cytoplasmic domains of other beta integrins, and requires a conserved and functionall

20 NA-binding partners: the cytoplasmic tail of beta-integrin, and FilGAP.

21 ple defects in blood cells involving various beta integrins (beta(1), beta(2), and beta(3)) occur sim

22 munoprecipitates with at least two different beta integrins, beta 1 integrins in 293T cells and beta

23 ith structural predictions, strain increases beta-integrin binding to FLNA, whereas it causes FilGAP

24 affinity to the talin head domain and blocks beta-integrin binding to talin.

25 hesized that integrin-linked kinase (ILK), a beta-integrin-binding scaffolding protein and serine/thr

26 Single gene mutations in beta integrins can account for functional defects of ind

27 the direct recruitment of proteins onto the beta integrin chain cytoplasmic domain.

28 es the rapid recruitment of alpha-actinin to beta-integrin complexes at the membrane, and that the re

29 naling and motility events when localized to beta-integrin-containing focal contact sites via interac

30 d an activation-independent association with beta integrin cytoplasm domain.

31 s but lacked the region proposed to bind the beta integrin cytoplasmic domain and the tyrosine kinase

32 s of amino acids conserved between different beta integrin cytoplasmic domains, we identified the try

33 rily conserved tyrosine motifs (NPxY) in the beta integrin cytoplasmic tail to phosphotyrosine-bindin

34 nside-out signaling, a process requiring the beta integrin cytoplasmic tail, we examined the effect o

35 The cytoplasmic protein, talin, binds to beta integrin cytoplasmic tails and actin filaments, hen

36 7 bound to the membrane distal NPXY motif in beta integrin cytoplasmic tails, thereby preventing lyso

37 nd the membrane-proximal region (MPR) in the beta-integrin cytoplasmic domain.

38 domain to membrane-proximal sequences in the beta-integrin cytoplasmic domain.

39 3 forms a ternary complex with the Talin and beta-integrin cytoplasmic tails.

40 A phylogenetic analysis of beta integrins did not clearly resolve whether vertebrat

41 Pactolus is similar to the beta integrins, except it lacks a functional metal ion-d

42 Scanning is critically dependent on T cell beta-integrin function, as well as myosin light chain ki

43 s did not clearly resolve whether vertebrate beta integrin genes duplicated prior to the origin of ve

44 mining loops" (SDLs) in the I-like domain of beta integrin in regulating ligand binding.

45 To delineate the role of specific members of beta integrins in stress erythropoiesis in the adult, we

46 UNC-95 is active downstream of PAT-3/beta-integrin in the assembly pathways of the muscle den

47 alpha-actinin interacts with syndecan-4 in a beta-integrin-independent manner.

48 oval or blocking of Thy-1, or blocking Thy-1-beta integrin interactions, decreased mEV uptake and pre

49 herin or alpha-catenin, and muscle-expressed beta-integrin is non-autonomously required for this loca

50 The binding of talin to beta-integrin is strengthened by PtdIns(4,5)P(2), sugges

51 and associated with the cytoplasmic tail of beta-integrin, is a complex of many proteins, including

52 al antibody (MS13) that binds to a domain of beta-integrin known to be a ligand-binding site for cell

53 key modulatory role of a binding site within beta integrins, known as the ADMIDAS domain, in controll

54 oduct shared >/=55.6% aa similarity to other beta integrin LBDs.

55 Murine Pactolus is a beta-integrin-like molecule expressed exclusively on the

56 facilitates CvGal1-mediated cross-linking to beta-integrin, located on the hemocyte surface, leading

57 Increased expression of CD11b, the beta-integrin marker of microglia, represents microglial

58 and is required for actin reorganization and beta-integrin-mediated adhesion after TCR crosslinking.

59 a suggest that the interaction of Thy-1 with beta integrins mediates mEV uptake by lung fibroblasts,

60 on of cell adhesion molecules, including the beta-integrin myospheroid (mys), accompany this developm

61 on-blocking antibodies against other alpha(v)beta integrins or suppression of beta(8) integrin expres

62 h either Mab13 or Cytochalasin-D, to inhibit beta-integrin or actin polymerization, respectively, sig

63 egans mutant strains that do not make either beta-integrin or vinculin, we were able to determine tha

64 mutant for myospheroid, the major Drosophila beta-integrin, or doubly mutant for multiple edematous w

65 ption process and the specific role of alpha/beta integrins, osteopontin, and related extracellular m

66 ve evolved in coordinated fashion with their beta integrin partners.

67 les, the UNC-97 protein colocalizes with the beta-integrin PAT-3 to the focal adhesion-like attachmen

68 The cytoplasmic tail of beta-integrin (PAT-3) is associated with a conserved fou

69 and prevented their association of ILK with beta-integrins, paxillin, and vinculin.

70 egrin focal adhesion (FA) complex components beta-integrin, PINCH, and integrin-linked kinase (ILK) c

71 s phenotype, and localization of myospheroid beta-integrin protein is disrupted in tendrils mutant te

72 The linkage of heterodimeric (alpha/beta) integrin receptors with their extracellular matrix

73 on of Rap1 (CtsK-Rap1), which promotes talin/beta integrin recognition, yields similar osteopetrotic

74 or cell adhesion but also by double-stranded beta-integrin RNA.

75 ere used to amplify from Bge cDNA, a partial beta integrin sequence of 2285 bp that contained a 1971

76 general, the phylogeny of neither alpha nor beta integrins showed a close correspondence with patter

77 ts known, in other circumstances, to mediate beta integrin signaling.

78 oplasmic tyrosine motif as a key mediator of beta-integrin signals and a potential target for new the

79 disorganization of the costameric orthologs beta-integrin, Spectrin, Talin, and Vinculin, and we pre

80 hogenic signaling circuit to operate through beta-integrin stimulation, we further show how Cdc42 is

81 The beta integrin subunit cytoplasmic domain is essential fo

82 ding of talin to the cytoplasmic tail of the beta integrin subunit.

83 ndent on the context of the remainder of the beta integrin subunit.

84 Mutations in Dlar and the common beta-integrin subunit mys cause a failure in oocyte elon

85 al movement of cells and localization of the beta-integrin subunit, Myospheroid, which is also requir

86 to the ligand binding domain (LBD) of known beta integrin subunits and Bge cDNA.

87 Leu262 is highly conserved among beta integrin subunits and lies within an intrachain loo

88 Several changes in the coding sequence of beta integrin subunits have now been described in human

89 opmental switching between alphav-associated beta integrin subunits to sequentially express alphavbet

90 lation sites are found in the 18 alpha and 8 beta integrin subunits.

91 on-binding sites are found in both alpha and beta integrin subunits.

92 lex interacts with the cytoplasmic domain of beta-integrin subunits and is critical for integrin sign

93 Transcription of alpha- and beta-integrin subunits is also altered in crol and EcR m

94 flexible cytoplasmic tails of the alpha- and beta-integrin subunits.

95 e of talin bound to an authentic full-length beta integrin tail.

96 he cytoskeletal protein talin, an actin- and beta-integrin tail-binding protein, plays an important r

97 to SNX17, SNX31 but not SNX27 binds several beta integrin tails in early endosomes in a PI3 (phospha

98 Surprisingly, unligated integrin or beta integrin tails recruit caspase-8 to the membrane, w

99 a FERM domain, which may enable them to bind beta integrin tails.

100 Talin interacts with beta-integrin tails and actin to control integrin activa

101 ellular and intracellular environments, with beta-integrin tails connecting to the actin cytoskeleton

102 s with acidic membrane phospholipids as well beta-integrin tails contribute to the ability of kindlin

103 Although F3 contains the binding site for beta-integrin tails, F0 and F1 are also required for act

104 disease, completely disrupted its binding to beta-integrin tails.

105 for talin binding between PIPKIgamma661 and beta-integrin that may regulate dynamic FA turnover.

106 e formation of a complex involving the alpha/beta integrin transmembrane helix dimer, the head domain

107 Activation of heterodimeric (alpha/beta) integrin transmembrane receptors by the 270 kDa cy

108 PAT-3 (beta-integrin), UNC-112 (kindlin), and PAT-4 (integrin-l

109 peptide mimicking the cytoplasmic domain of beta-integrin when compared with FAK of interphase cells

110 rate that SNX31 is an endosomal regulator of beta integrins with a restricted expression pattern.