ライフサイエンスコーパス: beta-interferon

1 ines such as interleukin-6 (IL-6), IL-8, and beta interferon.

2 he expression of type I interferons, such as beta interferon.

3 contributes to HCMV-triggered expression of beta interferon.

4 -12) p40, IL-6, IL-10, cyclooxygenase-2, and beta interferon.

5 dary production of gamma interferon or alpha/beta interferon.

6 uding the induction of and response to alpha/beta interferon.

7 h increased cell death or induction of alpha/beta interferons.

8 at are known to be strongly induced by alpha/beta interferons.

9 robust antiviral response when provided with beta interferon, a molecule that strongly stimulates inn

10 CRV), all NPs tested inhibited activation of beta interferon and interferon regulatory factor 3 (IRF-

11 and induces production of cytokines, such as beta interferon and interleukin 6.

12 tion because of their impaired expression of beta interferon and the induction of immunity-related GT

13 ic antiviral protection mediated by an alpha/beta interferon and, later, a specific immune response.

14 n of attack frequency (primarily with type-1 beta interferons and glatiramer acetate).

15 s currently under study or consideration are beta-interferon and synthetic anabolic hormones.

16 In contrast to beta-interferons and glatiramer acetate, the first-gener

17 alovirus (HCMV) gene expression on cytokine (beta interferon) and chemokine (RANTES, MIG, MCP-2, MIP-

18 levels of TMEV, tumor necrosis factor alpha, beta interferon, and interleukin-6 were consistently hig

19 ssion, including production of type I (alpha/beta) interferons, and are thus very susceptible to vira

20 tory tract and have suggested that alpha and beta interferons are the first cytokines recruited to co

21 okines with direct antiviral activity, alpha/beta interferons, are only minimally induced.

22 Induction of high levels of beta interferon by all viruses possessing truncations in

23 response, including the production of alpha/beta interferon, cytokines, and other proteins that rest

24 in HeLa cells after 13 passages in the alpha/beta interferon-deficient human glial cell line U118 MG.

25 ver noncytopathically within 24 h in a alpha/beta interferon-dependent manner.

26 V strains, the sensitivities to murine alpha/beta interferon did not differ appreciably between these

27 d growth in Vero cells pretreated with alpha/beta interferon, displaying an interferon-resistant phen

28 Using this model, no association between beta-interferon exposure and the hazard of disability pr

29 a (Long-Term Benefits and Adverse Effects of Beta-Interferon for Multiple Sclerosis (BeAMS) Study, 19

30 cers of transforming growth factor beta (TGF-beta), interferon gamma (IFN-gamma), and interleukin 10

31 efore and after treatment with interleukin-1 beta, interferon gamma, and tumor necrosis factor a, cyt

32 lammatory mediators (IL-12/IL-23, interferon beta, interferon gamma, CD40L) and platelet markers.

33 naling, including transforming growth factor beta, interferon gamma, insulin-like growth factor I rec

34 associated decrease in tumor necrosis factor-beta, interferon-gamma, and monocyte chemoattractant pro

35 g production of cytokines such as interferon-beta, interferon-gamma, and stimulating dendritic cells

36 ted cells that includes transcription of the beta interferon gene via activation of interferon regula

37 r 3 (IRF3), a transcription factor for alpha/beta interferon genes, and promotes its proteasomal degr

38 y a critical role in the activation of alpha/beta interferon (IFN) genes, HHV-8 has evolved a mechani

39 ARS-CoV-WT infection, induced high levels of beta interferon (IFN) mRNA accumulation and high titers

40 to how coronaviruses affect the type I alpha/beta interferon (IFN) system.

41 the autocrine and paracrine actions of alpha/beta interferon (IFN-alpha/beta) (type I), IFN-gamma (ty

42 V3000, we examined the involvement of alpha/beta interferon (IFN-alpha/beta) activity in VEE pathoge

43 hepatic induction of cytokines such as alpha/beta interferon (IFN-alpha/beta) and gamma interferon (I

44 We have previously shown that alpha/beta interferon (IFN-alpha/beta) and gamma interferon (I

45 We have previously shown that alpha/beta interferon (IFN-alpha/beta) and IFN-gamma inhibit h

46 Our results demonstrate that alpha/beta interferon (IFN-alpha/beta) and IFN-gamma receptors

47 h host innate immunity by inactivating alpha/beta interferon (IFN-alpha/beta) and IFN-gamma signaling

48 (MARV) VP40 matrix protein antagonizes alpha/beta interferon (IFN-alpha/beta) and IFN-gamma signaling

49 inhibited in a noncytopathic manner by alpha/beta interferon (IFN-alpha/beta) and IFN-gamma.

50 nfection blocks cellular production of alpha/beta interferon (IFN-alpha/beta) and the ability of cell

51 a A virus NS1 protein, a virus-encoded alpha/beta interferon (IFN-alpha/beta) antagonist, appears to

52 l protein NS1 of influenza virus is an alpha/beta interferon (IFN-alpha/beta) antagonist, both in vit

53 le disease virus (NDV) functions as an alpha/beta interferon (IFN-alpha/beta) antagonist.

54 The secreted cytokine alpha/beta interferon (IFN-alpha/beta) binds its receptor to a

55 anism by which viruses may inhibit the alpha/beta interferon (IFN-alpha/beta) cascade.

56 ponse genes such as those encoding the alpha/beta interferon (IFN-alpha/beta) cytokines.

57 tein is the inhibition of synthesis of alpha/beta interferon (IFN-alpha/beta) during viral infection.

58 I, initiating downstream signaling and alpha/beta interferon (IFN-alpha/beta) expression that establi

59 n factor critical for the induction of alpha/beta interferon (IFN-alpha/beta) expression.

60 NSs protein occurred in cells lacking alpha/beta interferon (IFN-alpha/beta) genes, indicating that

61 (NS1 and NS2) inhibit the induction of alpha/beta interferon (IFN-alpha/beta) in A549 cells and human

62 r involved in the activation of type I alpha/beta interferon (IFN-alpha/beta) in response to viral in

63 A role for alpha/beta interferon (IFN-alpha/beta) in the IFN-gamma antivi

64 transgenic mice by stimuli that induce alpha/beta interferon (IFN-alpha/beta) in the liver.

65 dames strain inhibits the induction of alpha/beta interferon (IFN-alpha/beta) in vivo and in vitro an

66 The antiviral state induced by alpha/beta interferon (IFN-alpha/beta) is a powerful selective

67 Innate cytokine responses, such as alpha/beta interferon (IFN-alpha/beta) or IFN-gamma, can have

68 y during infection correlated with the alpha/beta interferon (IFN-alpha/beta) peak, and the IFN induc

69 Alpha/beta interferon (IFN-alpha/beta) produces antiviral effe

70 NDV is a potent inducer of both alpha/beta interferon (IFN-alpha/beta) production and dendriti

71 ver, in the cells having no defects in alpha/beta interferon (IFN-alpha/beta) production and signalin

72 id dendritic cells (pDCs) triggers pDC alpha/beta interferon (IFN-alpha/beta) production in a Toll-li

73 le-stranded RNA (dsRNA), inhibits host alpha/beta interferon (IFN-alpha/beta) production, and is an e

74 lock RIG-I-like receptor signaling and alpha/beta interferon (IFN-alpha/beta) production.

75 ystem (CNS), little is known about how alpha/beta interferon (IFN-alpha/beta) protects against periph

76 Alpha/beta interferon (IFN-alpha/beta) protects the host from

77 virus infection and signal through the alpha/beta interferon (IFN-alpha/beta) receptor (IFNAR) to ind

78 Surprisingly, in alpha/beta interferon (IFN-alpha/beta) receptor knockout mice,

79 n leukocyte antigens (HLA) lacking the alpha/beta interferon (IFN-alpha/beta) receptor to study respo

80 ependent on signals through the type I alpha/beta interferon (IFN-alpha/beta) receptor.

81 mice and immune-deficient mice lacking alpha/beta interferon (IFN-alpha/beta) receptors (IFNAR(-)/(-)

82 The alpha/beta interferon (IFN-alpha/beta) response is critical fo

83 hways and/or inhibited or dysregulated alpha/beta interferon (IFN-alpha/beta) response pathways.

84 rotein antagonizes the early antiviral alpha/beta interferon (IFN-alpha/beta) response.

85 interaction of coronaviruses with the alpha/beta interferon (IFN-alpha/beta) response.

86 tein that inhibits RIG-I signaling and alpha/beta interferon (IFN-alpha/beta) responses by both dsRNA

87 Alpha/beta interferon (IFN-alpha/beta) responses did not media

88 is an inhibitor of RIG-I signaling and alpha/beta interferon (IFN-alpha/beta) responses, has been imp

89 tion route, dependent upon functioning alpha/beta interferon (IFN-alpha/beta) responses.

90 onses, especially those related to the alpha/beta interferon (IFN-alpha/beta) signaling pathways and

91 degradation of STAT1 and the block in alpha/beta interferon (IFN-alpha/beta) signaling that occurs a

92 The alpha/beta interferon (IFN-alpha/beta) system is the first lin

93 The alpha/beta interferon (IFN-alpha/beta) system represents one o

94 immune response, and in particular the alpha/beta interferon (IFN-alpha/beta) system, plays a critica

95 ine BMDCs by microarray suggested that alpha/beta interferon (IFN-alpha/beta) transcripts and numerou

96 Alpha/beta interferon (IFN-alpha/beta) triggers antiviral and

97 (IL-12), nitric oxide, NADPH oxidase, alpha/beta interferon (IFN-alpha/beta), and IFN-gamma.

98 te immune response elements, including alpha/beta interferon (IFN-alpha/beta), immunoglobulin M, gamm

99 s (cpBVDV) results in the induction of alpha/beta interferon (IFN-alpha/beta), whereas noncytopathoge

100 was previously demonstrated to inhibit alpha/beta interferon (IFN-alpha/beta)- and IFN-gamma-induced

101 The alpha/beta interferon (IFN-alpha/beta)-induced STAT signal tra

102 largely determined by the efficacy of alpha/beta interferon (IFN-alpha/beta)-mediated antiviral resp

103 e responses to infection by inhibiting alpha/beta interferon (IFN-alpha/beta)-mediated JAK-STAT signa

104 compared the genetic, pathogenic, and alpha/beta interferon (IFN-alpha/beta)-regulatory properties o

105 critical for the biological actions of alpha/beta interferon (IFN-alpha/beta).

106 responses, including the expression of alpha/beta interferon (IFN-alpha/beta).

107 sensitive to the antiviral actions of alpha/beta interferon (IFN-alpha/beta).

108 in SCID mice; prominent among these is alpha/beta interferon (IFN-alpha/beta).

109 of tuberculosis, leads to secretion of alpha/beta interferon (IFN-alpha/beta).

110 se virus (FMDV) is highly sensitive to alpha/beta interferon (IFN-alpha/beta).

111 is associated with the suppression of alpha/beta interferon (IFN-alpha/beta).

112 was found to be due, in large part, to alpha/beta interferon (IFN-alpha/beta).

113 ibroblasts or primary astrocytes, with alpha/beta interferon (IFN-alpha/beta).

114 (moDCs), with the notable exception of alpha/beta interferon (IFN-alpha/beta).

115 (wild-type [WT]) mice and mice deficient in beta interferon (IFN-beta) (BKO), antibody (muMT), IFN-g

116 receptor domain-containing adaptor-inducing beta interferon (IFN-beta) (TRIF) is critical in inducin

117 orted that HCMV attenuates the expression of beta interferon (IFN-beta) and a number of proinflammato

118 express LAT or AL gene products (dLAT2903), beta interferon (IFN-beta) and IFN-alpha RNA expression

119 ned that the extent of reovirus induction of beta interferon (IFN-beta) and IFN-beta-mediated protect

120 cells by restricting the early induction of beta interferon (IFN-beta) and interferon-stimulated gen

121 HCV infection significantly increased beta interferon (IFN-beta) and interleukin-6 (IL-6) secr

122 ytokines involved in innate immunity such as beta interferon (IFN-beta) and interleukin-6 (IL-6).

123 nal domains have similar effects on both the beta interferon (IFN-beta) and LMP1 promoters in BJAB an

124 onstrated that WNV induced the expression of beta interferon (IFN-beta) and several IFN-stimulated ge

125 The addition of antibodies to beta interferon (IFN-beta) blocked interferon-directed M

126 A neutralizing antibody against beta interferon (IFN-beta) blunted Ser(727) phosphorylat

127 CD95-mediated nonapoptotic signaling induced beta interferon (IFN-beta) expression and correlatively

128 Moreover, Cal WT inhibited beta interferon (IFN-beta) expression and replicated mor

129 n hepatoma cells inhibited poly(I.C)-induced beta interferon (IFN-beta) expression and that the HEV o

130 e viral gene 5 product, NSP1, can antagonize beta interferon (IFN-beta) expression by inducing the de

131 In contrast, RSV-induced beta interferon (IFN-beta) expression is not influenced

132 Beta interferon (IFN-beta) expression is triggered by do

133 an cytomegalovirus (HCMV) gene expression on beta interferon (IFN-beta) expression was examined.

134 as reduced by NSC95397 in favor of increased beta interferon (IFN-beta) expression, and NSC95397 was

135 on regulatory factor 3 (IRF3) activation and beta interferon (IFN-beta) expression.

136 immortalized human hepatocytes (IHH) induces beta interferon (IFN-beta) expression.

137 VISA, or Cardif), and inhibits MAVS-mediated beta interferon (IFN-beta) expression.

138 Beta interferon (IFN-beta) gene expression in response t

139 ivate transcription factors needed to induce beta interferon (IFN-beta) gene transcription.

140 s L is a multifunctional protein that blocks beta interferon (IFN-beta) gene transcription.

141 e that mediates virus induction of the human beta interferon (IFN-beta) gene.

142 Beta interferon (IFN-beta) has been used in the treatmen

143 also secreted the immunomodulatory cytokine beta interferon (IFN-beta) in a largely MyD88-independen

144 ys a key role in preventing the induction of beta interferon (IFN-beta) in virus-infected cells.

145 IG-I, KSHV transcription is increased, while beta interferon (IFN-beta) induction is attenuated.

146 r sensor of RNA virus infection resulting in beta interferon (IFN-beta) induction.

147 Autocrine or paracrine signaling by beta interferon (IFN-beta) is essential for many of the

148 Nod2(-/-) mice have reduced beta interferon (IFN-beta) levels and fewer activated de

149 C to the virus and show a rapid induction of beta interferon (IFN-beta) mRNA but not IFN-alpha mRNA.

150 Beta interferon (IFN-beta) mRNA was induced in HRV1a-inf

151 pre-mRNAs, thereby inhibiting production of beta interferon (IFN-beta) mRNA.

152 processing of cellular pre-mRNAs, including beta interferon (IFN-beta) pre-mRNA.

153 s difference was greater under conditions of beta interferon (IFN-beta) pretreatment.

154 izing antibodies, we further determined that beta interferon (IFN-beta) production and secretion are

155 I West Nile virus (WNV) strain Eg101 induced beta interferon (IFN-beta) production as early as 12 h a

156 the host innate defense by interfering with beta interferon (IFN-beta) production in response to dif

157 ave strong to moderate inhibitory effects on beta interferon (IFN-beta) promoter activation.

158 ee distinct mechanisms: it directly inhibits beta interferon (IFN-beta) promoter activity, it promote

159 latory factor 3 (IRF3), or IRF7 to stimulate beta interferon (IFN-beta) promoter activity.

160 proteins also block virus activation of the beta interferon (IFN-beta) promoter and the IFN regulato

161 n was found to inhibit the activation of the beta interferon (IFN-beta) promoter induced by viral inf

162 om the simian virus 40 promoter and from the beta interferon (IFN-beta) promoter, while M proteins of

163 NSs protein inhibited the activation of the beta interferon (IFN-beta) promoter.

164 nger, are necessary for inhibiting the human beta interferon (IFN-beta) promoter.

165 While there is 1 beta interferon (IFN-beta) protein, there are 12 differe

166 , but not ANDV, was found to induce a robust beta interferon (IFN-beta) response early after infectio

167 virus infection that regulates the cellular beta interferon (IFN-beta) response.

168 reading frame [P(C-)], resulting in a potent beta interferon (IFN-beta) response.

169 es, vesicular stomatitis virus evoked robust beta interferon (IFN-beta) responses.

170 gue virus regulation of early, but not late, beta interferon (IFN-beta) responses.

171 navirus infection induces expression of both beta interferon (IFN-beta) RNA and protein in the infect

172 ian rhesus rotavirus (RRV) robustly triggers beta interferon (IFN-beta) secretion, resulting in an IF

173 levels of the downstream antiviral cytokine beta interferon (IFN-beta) than does wild-type virus des

174 3, an important transcriptional regulator in beta interferon (IFN-beta) transcription, fails to effec

175 reduced inhibition of activation of IRF3 and beta interferon (IFN-beta) transcription.

176 Beta interferon (IFN-beta) transcripts were induced earl

177 at the two cell types respond differently to beta interferon (IFN-beta) treatment.

178 In contrast, epithelial production of beta interferon (IFN-beta) was not inhibited.

179 All three proteins inhibit the expression of beta interferon (IFN-beta), and further examination reve

180 Poly(I.C) pretreatment upregulated beta interferon (IFN-beta), IFN-gamma, IL-1beta, and tum

181 Consistent with this finding, RSV-induced beta interferon (IFN-beta), interferon-inducible protein

182 aE3L mutant virus triggers the production of beta interferon (IFN-beta), interleukin-6 (IL-6), CCL4,

183 3alpha), and the MyD88-independent molecules beta interferon (IFN-beta), nitric oxide, and IFN-gamma-

184 tory transcription factors (IRF-3 or IRF-7), beta interferon (IFN-beta), or the receptor for type I I

185 production of type I interferons, including beta interferon (IFN-beta), which, surprisingly, promote

186 ed following L. monocytogenes infection in a beta interferon (IFN-beta)-dependent fashion.

187 nfection can overcome the establishment of a beta interferon (IFN-beta)-induced antiviral state in pr

188 response characterized by the expression of beta interferon (IFN-beta).

189 e synthesis of proinflammatory cytokines and beta interferon (IFN-beta).

190 hantaviruses inhibit the early induction of beta interferon (IFN-beta).

191 terleukin 1beta (IL-1beta), IL-6, IL-10, and beta interferon (IFN-beta).

192 dia infection, resulting in the synthesis of beta interferon (IFN-beta).

193 of IRF3-dependent antiviral genes, including beta interferon (IFN-beta).

194 signaling, which leads to the activation of beta interferon (IFN-beta).

195 r adventitial fibroblasts (BRAFs), levels of beta interferon (IFN-beta,) STAT1, and STAT2 transcripts

196 y a role in innate immunity, including alpha/beta interferons (IFN).

197 been reported to be a poor inducer of alpha/beta interferons (IFN-alpha/beta) and partially resistan

198 , which is essential for production of alpha/beta interferons (IFN-alpha/beta) and upregulates expres

199 The type I alpha/beta interferons (IFN-alpha/beta) are known to play an i

200 Alpha/beta interferons (IFN-alpha/beta) are not only a powerfu

201 Alpha/beta interferons (IFN-alpha/beta) are potent, endogenous

202 To define the role of alpha/beta interferons (IFN-alpha/beta) in simian immunodefici

203 Alpha/beta interferons (IFN-alpha/beta) induce potent antivira

204 Type I alpha and beta interferons (IFN-alpha/beta) limit HuNoV replicon f

205 BV X protein and apparently due to alpha and beta interferons (IFN-alpha/beta), as the effects could

206 tial virus (HRSV) is a poor inducer of alpha/beta interferons (IFN-alpha/beta).

207 l components can be potent inducers of alpha/beta interferons (IFN-alpha/beta).

208 Alpha/beta interferons (IFN-alpha/betas) are known to antagoni

209 at activate the genes that encode alpha- and beta-interferon (IFN).

210 Alpha/beta-interferon (IFN-alpha/beta) treatment improves card

211 ealed a conundrum: reovirus T3D induces more beta-interferon (IFN-beta) mRNA in cardiac myocytes, yet

212 (LCMV) induces type I interferon (alpha and beta interferon [IFN-alpha and IFN-beta]) upon infection

213 observed for other relevant proteins (alpha/beta interferon [IFN-alpha/beta] and IL-10).

214 Type I interferon (alpha/beta interferon [IFN-alpha/beta]) and type II interferon

215 sly, we showed that type I interferon (alpha/beta interferon [IFN-alpha/beta]) can inhibit foot-and-m

216 d the expression of type I interferon (alpha/beta interferon [IFN-alpha/beta]) in mouse oligodendrocy

217 ferentially induce type I interferons (alpha/beta interferon [IFN-alpha/beta]) in myeloid dendritic c

218 ated the role that type I interferons (alpha/beta interferon [IFN-alpha/beta]) might play in H5N1 pat

219 Type I interferon (alpha/beta interferon [IFN-alpha/beta]) stimulates the express

220 ice deficient in receptors for type I (alpha/beta interferon [IFN-alpha/beta]), type II (IFN-gamma),

221 IL-1, IL-6, tumor necrosis factor alpha, and beta interferon [IFN-beta]) important in the innate immu

222 r mutants' sensitivity to type I interferon (beta interferon [IFN-beta]) in restrictive cells, we not

223 AstV-1) infection induces type I interferon (beta interferon [IFN-beta]) production in differentiated

224 , macrophage inflammatory protein 1beta, and beta interferon [IFN-beta]) that can be induced through

225 tor (IL-12p40, IL-4), and interferon system (beta interferon [IFN-beta], IFN-gamma, protein Mx1 GTPas

226 e induction of type I interferons (alpha and beta interferons [IFN-alpha and -beta]) constitutes the

227 Since alpha/beta interferons (IFNs) are pivotal players both in nons

228 Alpha/beta interferons (IFNs-alpha/beta) are cytokines that pl

229 Alpha/beta interferon immune defenses are essential for resist

230 e expression levels and sensitivity to alpha/beta interferon in cultured cells indicated that each mi

231 ass II (MHC-II), and cytokines such as alpha/beta interferon in immature DCs.

232 al cytokines tumor necrosis factor alpha and beta interferon in macrophages, and this induction was i

233 ptor involvement; however, the expression of beta interferon in MyD88-/- Mphi suggests involvement of

234 studies demonstrated superior efficacy over beta-interferon in reducing disability progression over

235 e recombinase under the control of the alpha/beta interferon-inducible (MX) promoter.

236 is finding, RSV-induced beta interferon (IFN-beta), interferon-inducible protein 10 (IP-10), chemokin

237 Alpha/beta interferon induction by polyinosinic-polycytidylic

238 tability of HBV CCC DNA in response to alpha/beta interferon induction was examined in HNF1alpha-null

239 plication intermediates in response to alpha/beta interferon induction.

240 ry factor 7 and inhibit virus-mediated alpha/beta interferon induction.

241 ial (IMPACT)] became the fourth study of the beta interferons (interferon-beta-1a, in this case) to d

242 or necrosis factor alpha, interleukin-6, and beta interferon is observed during rWSN NS1 R38A infecti

243 r of interferon-responsive genes, as well as beta interferon itself.

244 The sensitivity to murine alpha/beta interferon-mediated antiviral activity was previous

245 o assess the association between exposure to beta-interferon medications and disease progression amon

246 ed viral replication and increased levels of beta interferon, MMP-3, MMP-12, and TIMP-1 mRNA.

247 t, we found that coadministration of an anti-beta interferon monoclonal antibody with the plasmid DNA

248 ly, the compounds reversed the inhibition of beta interferon mRNA induction during infection, which i

249 In the latter cell line, accumulation of beta interferon mRNA occurred after infection by these N

250 oes not bind CPSF30 in vitro and causes high beta interferon mRNA production and reduced virus replic

251 production of all cellular mRNAs, including beta interferon mRNA.

252 to support the transcriptional induction of beta interferon mRNA.

253 and gB establish an antiviral state in alpha/beta interferon null cells, illustrating that primary in

254 of cytokines with antiviral activity, alpha/beta interferon, occurred too late to prevent virus repl

255 ed mice which are unable to respond to alpha/beta interferon or gamma interferon.

256 n respiratory epithelial cells and what role beta interferon played in this response.

257 cessing of all cellular pre-mRNAs, including beta interferon pre-mRNA.

258 ponsive signaling pathways that induce alpha/beta interferon production and engage intracellular immu

259 Ebola virus VP35 inhibits alpha/beta interferon production and functions as a viral poly

260 ry factor-3 (IRF-3) activation directs alpha/beta interferon production and interferon-stimulated gen

261 ring Toll-like receptor 9 and inducing alpha/beta interferon production by plasmacytoid dendritic cel

262 persisting in cells with no defects in alpha/beta interferon production or signaling.

263 navirus papainlike protease protein to block beta interferon promoter activation.

264 ed RNA-dependent activation of a transfected beta interferon promoter construct.

265 tor 3 (IRF3) and accumulation of IRF3 at the beta interferon promoter in gammaherpesvirus-infected pr

266 otein unable to inhibit the induction of the beta interferon promoter mediated by virus infection.

267 One of these HBx binding partners is beta interferon promoter stimulator 1 (IPS-1), an adapto

268 anscription, inhibits transcription from the beta interferon promoter, and promotes the proteasomal d

269 proteins prevent MDA5 from signaling to the beta interferon promoter, but the consequences of LGP2 t

270 s ability to bind to DNA and to activate the beta interferon promoter.

271 ndent reporter luciferase production via the beta interferon promoter.

272 m interferon-stimulated response elements or beta-interferon promoters in a dose-dependent manner.

273 es showed that while cells lacking the alpha/beta interferon receptor exhibited decreased levels of t

274 These results indicate that while the alpha/beta interferon receptor is needed to curb viral replica

275 However, alpha/beta interferon receptor knockout (IFNAR(-/-)) mice were

276 Infection of alpha/beta interferon receptor knockout (IFNAR(-/-)) mice with

277 ouse embryonic fibroblasts lacking the alpha/beta interferon receptor, the gamma interferon receptor,

278 In the absence of the alpha/beta interferon receptor, we observed increased viral re

279 rulence thresholds in mice lacking the alpha/beta interferon receptor.

280 SFV-RDR infection of mice lacking alpha/beta interferon receptors resulted in widespread virus d

281 erferons, cloning of human IFN-alpha and IFN-beta, interferon receptors, activities and therapeutic u

282 expression of CCAAT/enhancer-binding protein-beta, interferon regulatory factor 4, and peroxisome pro

283 rs, including CCAAT/enhancer-binding protein-beta, interferon regulatory factor 4, and peroxisome pro

284 NAs were low for interleukin (IL)-2 receptor-beta, interferon regulatory factor-1, and signal transdu

285 Genetic elements including the beta-interferon scaffold attachment region (SAR) have be

286 reduced amounts of interleukin-18 and alpha/beta interferon secreted in the TLR2 KO mice.

287 SM does not directly stimulate alpha/beta interferon secretion but instead induces STAT1, an

288 ed by specific stimuli, mainly via the alpha/beta interferon signaling pathway.

289 T3D, represses one antiviral response: alpha/beta interferon signaling.

290 of cytokines interleukin-6 (IL-6), IL-8, and beta interferon than cells infected with wild-type polio

291 s-infected cells produced greater amounts of beta interferon than wild-type virus-infected cells.

292 sponse factor 3 (IRF3) activation, a lack of beta interferon transcript induction, loss of interferon

293 being sufficient to enhance HCMV-stimulated beta interferon transcription and secretion.

294 les involved in HCMV-mediated IRF3-dependent beta interferon transcription are virtually unknown.

295 approaches to investigate the association of beta-interferon treatment with delaying disability progr

296 ed by TIR domain-containing adapter-inducing beta interferon (TRIF) during establishment and reactiva

297 , and TIR-domain-containing adaptor-inducing beta interferon (TRIF), or RIG-I/MDA5 adaptor, interfero

298 g the TIR domain-containing adaptor inducing beta interferon (TRIF).

299 tor (TIR) domain-containing adaptor-inducing beta-interferon (TRIF, also called TIR-domain-containing

300 While secreted alpha/beta interferon was required for increased expression of