ライフサイエンスコーパス: beta-myosin

1 old greater for rat beta-myosin than for pig beta-myosin.

2 leavage rates were nearly 30% faster for rat beta-myosin.

3 n, almost twice the velocities observed with beta-myosin.

4 erved in hearts expressing approximately 70% beta-myosin.

5 on was approximately 3.8-fold faster for rat beta-myosin (135 s(-)(1)) than for pig beta-myosin (35 s

6 r rat beta-myosin (135 s(-)(1)) than for pig beta-myosin (35 s(-)(1)).

7 s than slow myosins (MHC-II-1, also known as beta-myosin) and it has been well established that ADP b

8 e MYH7 (beta-myosin heavy chain) and MYBPC3 (beta-myosin-binding protein C).

9 -sliding velocity of alpha-myosin by 20% and beta-myosin by 36% compared with their respective non-ac

10 sliding velocity of alpha-myosin by 20% and beta-myosin by 36%, compared to their respective non-ace

11 alcium-independent positive inotropy in slow beta-myosin-dominant rabbit and human failing ventricula

12 C1 1-37) and the short loop of human cardiac beta-myosin (hcM398-414) have been shown to interact wit

13 In adult skeletal muscle, beta myosin heavy chain (betaMyHC) gene expression is pr

14 transgenic mice further exhibited decreased beta myosin heavy chain expression compared to age match

15 displayed cardiac hypertrophy and increased beta myosin heavy chain expression.

16 mechanism of regulation of cardiac alpha and beta myosin heavy chain gene by naturally occurring anti

17 psilonRACK resulted in selectively increased beta myosin heavy chain gene expression and normally fun

18 re abnormal in comparison with the alpha and beta myosin heavy chain knockdowns and controls.

19 3beta [GSK3beta], a 20-fold up-regulation of beta myosin heavy chain RNA and elevated G(s)alpha/G(i)a

20 in, we report the expression of an antisense beta myosin heavy chain RNA in the normal rodent myocard

21 genes coding for atrial natriuretic peptide, beta myosin heavy chain, medium chain acyl-CoA dehydroge

22 t 8 contractile protein genes, most commonly beta myosin heavy chain, myosin binding protein C, and c

23 tification of a mutation in the MYH7-encoded beta myosin heavy chain.

24 other structural proteins, such as alpha and beta myosin heavy chains and cardiac alpha actin, play c

25 nt with decreased alpha myosin and increased beta myosin heavy chains, suggesting an alpha-to-beta co

26 naturietic factor ( approximately 55-fold), beta-myosin heavy chain ( approximately 8-fold), and alp

27 performed in a genotyped HCM population with beta-myosin heavy chain (beta -MHC) mutations.

28 se chain reaction was conducted to coamplify beta-myosin heavy chain (beta-MHC) and alpha-skeletal ac

29 the fetal program of skeletal alpha-actin or beta-myosin heavy chain (beta-MHC) gene expression.

30 Reexpression of the fetally expressed beta-myosin heavy chain (beta-MHC) gene is a well docume

31 a4fl/fl) were crossed with mice containing a beta-myosin heavy chain (beta-MHC) or alpha-MHC promoter

32 ected reporter gene driven by 3542 bp of rat beta-myosin heavy chain (beta-MHC) promoter was increase

33 ese include atrial natriuretic factor (ANF), beta-myosin heavy chain (beta-MHC), and skeletal muscle

34 dium results in enhanced expression of fetal beta-myosin heavy chain (beta-MyHC) and reduced expressi

35 ) is the R403Q mutation in the gene encoding beta-myosin heavy chain (beta-MyHC).

36 gene profile was observed, ie, expression of beta-myosin heavy chain (betaMHC), atrial/brain natriure

37 and reactivates many fetal genes, including beta-myosin heavy chain (betaMyHC) and skeletal alpha-ac

38 To examine the role of the beta-myosin heavy chain (betaMyHC) distal muscle CAT (MC

39 In adult mouse skeletal muscle, beta-myosin heavy chain (betaMyHC) gene expression is pr

40 In adult mouse skeletal muscle, beta-myosin heavy chain (betaMyHC) gene expression is pr

41 er type transition concurrent with decreased beta-myosin heavy chain (betaMyHC) gene expression.

42 genic analyses revealed that a 600-base pair beta-myosin heavy chain (betaMyHC) promoter conferred me

43 The other is the endogenous beta-myosin heavy chain (bMHC) gene modified to code for

44 n SMC alpha-actin (encoded by ACTA2) and the beta-myosin heavy chain (encoded by MYH11).

45 n (CHIP), increased SRF activity, as well as beta-myosin heavy chain (MHC) and myocardin expressions.

46 point mutation at residue 403 (R403Q) in the beta-myosin heavy chain (MHC) caused a severe form of FH

47 heart contains two cardiac myosin isoforms: beta-myosin heavy chain (MHC) is found predominantly in

48 TPase (SERCA), phospholamban, and alpha- and beta-myosin heavy chain (MHC) proteins were assayed in h

49 The R403Q mutation in the beta-myosin heavy chain (MHC) was the first mutation to

50 pathy, DCM) associated with mutations in the beta-myosin heavy chain (MYH7) gene product (Myosin-7).

51 The most commonly affected is beta-myosin heavy chain (MYH7), where missense mutations

52 nd R719W) as highly malignant defects in the beta-myosin heavy chain (MYH7).

53 2S, G256E, F513C, V606M, R719Q, and L908V of beta-myosin heavy chain (MYH7); S179F of troponin T (TNN

54 (TH)-responsive genes, including alpha- and beta-myosin heavy chain (MyHC) and sarcoplasmic reticulu

55 HCM caused by a common point mutation in the beta-myosin heavy chain (MyHC) gene, R400Q.

56 tor (RAR) controlled by either the alpha- or beta-myosin heavy chain (MyHC) promoter were generated.

57 ), alpha-skeletal muscle actin (p<0.05), and beta-myosin heavy chain (p<0.05) were observed in AC6-KO

58 on of the slow molecular motor of the heart (beta-myosin heavy chain [MyHC]) is well known to occur i

59 d expression of hypertrophic markers BNP and beta-myosin heavy chain accompanied adult-onset cardiac

60 the use of a green fluorescent protein or a beta-myosin heavy chain adenovirus.

61 ith mild hypertrophy, elevated expression of beta-myosin heavy chain and alpha-skeletal actin genes,

62 sed by 28%, and upregulation of the mRNA for beta-myosin heavy chain and alpha-skeletal actin was obs

63 The expression of beta-myosin heavy chain and ANF mRNA was greater in male

64 wever, adult transgenic ventricles expressed beta-myosin heavy chain and atrial natriuretic factor.

65 enes associated with pathologic hypertrophy (beta-myosin heavy chain and atrial natriuretic peptide)

66 Both soleus beta-myosin heavy chain and cytochrome C oxidase express

67 ic response is increased cellular content of beta-myosin heavy chain and cytochrome oxidase subunit V

68 riuretic peptide, brain natriuretic peptide, beta-myosin heavy chain and myosin light chain (2- to 5-

69 MYH7 and MYBPC3, encoding beta-myosin heavy chain and myosin-binding protein C, re

70 Hypertrophic marker genes, including the beta-myosin heavy chain and transforming growth factor-b

71 Mutations in the MYH7 gene encoding for the beta-myosin heavy chain are the underlying genetic cause

72 Also, alpha- and beta-myosin heavy chain expression is modified in respon

73 enhancer factor 2C), and down-regulation of beta-myosin heavy chain expression, a key determinant of

74 ban:SERCA2 (>/=2.6:1) exhibited increases in beta-myosin heavy chain expression, associated with card

75 to determine the prevalence and phenotype of beta-myosin heavy chain gene MYH7 mutations in a large c

76 e been linked with missense mutations in the beta-myosin heavy chain gene.

77 ickness and a selective up-regulation of the beta-myosin heavy chain gene.

78 nergic signaling, the aberrant expression of beta-myosin heavy chain in adult Gsalpha-DF but not cont

79 sarcomeric reorganization, and expression of beta-myosin heavy chain in myocytes with IC(50) values o

80 , 5.11; theta=0), where the gene for cardiac beta-myosin heavy chain is encoded.

81 ated with preserved expression of alpha- and beta-myosin heavy chain isoforms and sarcoplasmic reticu

82 Comparison of mammalian cardiac alpha- and beta-myosin heavy chain isoforms reveals 93% identity.

83 tures and containing predominately alpha- or beta-myosin heavy chain isoforms were found to be consis

84 [AT(1)R]), p47(phox) NADPH oxidase subunit, beta-myosin heavy chain isozyme switch, accumulation of

85 Ca2+ sensitivity, a significant increase in beta-myosin heavy chain mRNA and protein, normal cardiac

86 expression of skeletal alpha-actin mRNA and beta-myosin heavy chain mRNA at 5 days, but it did not a

87 weight ratio, atrial natriuretic factor and beta-myosin heavy chain mRNA expression, myocyte area, a

88 ha-myosin heavy chain mRNA and a decrease in beta-myosin heavy chain mRNA.

89 st, there was no relationship between either beta-myosin heavy chain or cytochrome C oxidase expressi

90 binding by E1A, relieved E1A's repression of beta-myosin heavy chain promoter activity while having n

91 Embryos that express tbx5 driven by a beta-myosin heavy chain promoter throughout the primitiv

92 expressing one such allele, I183P, under the beta-myosin heavy chain promoter.

93 roteins decreased the activity of alpha- and beta-myosin heavy chain promoters to nearly the same ext

94 ansfected reporter genes driven by alpha- or beta-myosin heavy chain promoters was markedly diminishe

95 Overexpression of the beta-myosin heavy chain protein contributes to the patho

96 Moreover, an increased amount of beta-myosin heavy chain protein was found in hearts from

97 hypothesis, we screened 30 5- to 6-month-old beta-myosin heavy chain Q403 transgenic rabbits by echoc

98 al remodeling, including decreased alpha- to beta-myosin heavy chain ratios, and induced maladaptive

99 oponin T (TnT) and missense mutations in the beta-myosin heavy chain share abnormalities in common, a

100 However, the alpha- to beta-myosin heavy chain switch did not occur in Ang II-t

101 nsforming the disorder from a disease of the beta-myosin heavy chain to a disease of the cardiac sarc

102 t induction of atrial natriuretic factor and beta-myosin heavy chain transcripts, interstitial fibros

103 ed by the treatment, whereas upregulation of beta-myosin heavy chain was not reversed.

104 in hypothyroidism, whereas phospholamban and beta-myosin heavy chain were increased.

105 tic factor, alpha-skeletal muscle actin, and beta-myosin heavy chain) and collagens were observed bet

106 ryonic genes (atrial natriuretic peptide and beta-myosin heavy chain) and elevated nuclear factor kap

107 hypertrophic cardiomyopathy (HCM) are MYH7 (beta-myosin heavy chain) and MYBPC3 (beta-myosin-binding

108 brain natriuretic peptides, skeletal actin, beta-myosin heavy chain), and fibrosis (collagen III), a

109 trophy (atrial natriuretic factor, CARP, and beta-myosin heavy chain), uncoupling protein 2 (UCP2), a

110 genes (GRK2, atrial natriuretic factor, and beta-myosin heavy chain).

111 trophy markers atrial natriuretic factor and beta-myosin heavy chain).

112 an increase in NFAT-dependent expression of beta-myosin heavy chain, a sensitive marker for patholog

113 istry revealed de novo expression of desmin, beta-myosin heavy chain, alpha-actinin, cardiac troponin

114 n genes including atrial natriuretic factor, beta-myosin heavy chain, and alpha-skeletal actin.

115 TA-4, atrial natriuretic peptide, alpha- and beta-myosin heavy chain, and cardiac troponin T) by day

116 ism, electrical stimulation increased c-fos, beta-myosin heavy chain, and Cyt c promoter activities.

117 n, connexin 43, myosin light chain 2a, alpha/beta-myosin heavy chain, and troponin I.

118 s using muscle-specific promoters, alpha- or beta-myosin heavy chain, are partially rescued.

119 A mutation in the cardiac beta-myosin heavy chain, Arg403Gln (R403Q), causes a sev

120 of pathological hypertrophy like: alpha- and beta-myosin heavy chain, atrial natriuretic factor, phos

121 tion demonstrated an increased expression of beta-myosin heavy chain, brain natriuretic peptide, and

122 s in males, including fibrosis, induction of beta-myosin heavy chain, inactivation of glycogen syntha

123 expressed expected cardiac markers including beta-myosin heavy chain, myosin light chain 2v, and atri

124 -response genes (e.g., alpha-skeletal actin, beta-myosin heavy chain, natriuretic peptides) were simi

125 ) levels of atrial natriuretic factor (ANF), beta-myosin heavy chain, sarcoplasmic reticulum Ca2+-ade

126 tudy prompted a search of the genes encoding beta-myosin heavy chain, troponin T, troponin I, and alp

127 l (SMC)-specific isoforms of alpha-actin and beta-myosin heavy chain, two major components of the SMC

128 marker genes, atrial natriuretic factor and beta-myosin heavy chain, were not up-regulated in E33A-t

129 atriuretic factor, skeletal alpha-actin, and beta-myosin heavy chain, which in adult rat ventricle ar

130 performed in nontransgenic (n=24), wild-type beta-myosin heavy chain-arginine(403) (n=14), and mutant

131 ty with heart defects, whereas deletion with beta-myosin heavy chain-cre (betaMHC-cre) produced viabl

132 heavy chain-arginine(403) (n=14), and mutant beta-myosin heavy chain-glutamic acid(403) (n=24) transg

133 on and relaxation were reduced in the mutant beta-myosin heavy chain-glutamic acid(403) transgenic ra

134 hypoplasia and ventricular septal defects in beta-myosin heavy chain-miR-195 transgenic mice.

135 We randomized 24 beta-myosin heavy chain-Q(403) rabbits to treatment with

136 function, and reduced ERK1/2 activity in the beta-myosin heavy chain-Q(403) rabbits.

137 We tested this hypothesis in beta-myosin heavy chain-Q(403) transgenic rabbits.

138 rrhythmia in a transgenic (TG) rabbit model (beta-myosin heavy chain-Q403) of human hypertrophic card

139 myotrophin-induced mRNA levels of c-fos and beta-myosin heavy chain.

140 to 50-fold increase in steady state mRNA for beta-myosin heavy chain.

141 arkers such as atrial natriuretic factor and beta-myosin heavy chain.

142 retic factor, brain natriuretic peptide, and beta-myosin heavy chain.

143 stream effectors such as Jun, cyclin D1, and beta-myosin heavy chain.

144 the phenotype of those with mutations in the beta-myosin heavy chain.

145 igated the kinetic properties of rat and pig beta-myosin heavy chains (beta-MHC) in which we have fou

146 In the soleus muscle, mRNA for both beta-myosin heavy chains and cytochrome C oxidase III (n

147 tor (PDGF)-A and -B isoforms with alpha- and beta-myosin heavy chains as well as connexin43.

148 raction rate, surface area, or expression of beta-myosin heavy chains was significantly greater in AK

149 iac-specific genes, including the alpha- and beta-myosin heavy chains, skeletal alpha-actin, and brai

150 e tested whether patients with HCM caused by beta-myosin heavy-chain (beta-MHC) gene mutations exhibi

151 Mutations in the beta-myosin heavy-chain (betaMyHC) gene cause hypertroph

152 n the sarcoplasmic reticulum, and alpha- and beta-myosin heavy-chain isoforms) and of genes associate

153 Cardiac beta-myosin heavy-chain missense mutations (Ser532Pro an

154 er shown to be affected (in 2005) by a novel beta-myosin heavy-chain mutation that caused HCM, after

155 METHODS AND We treated 2-year-old beta-myosin heavy-chain Q403 transgenic rabbits with est

156 vy chain, we observed high concentrations of beta-myosin in distinct areas such as at the tip of papi

157 Protein isoform analysis revealed that beta-myosin is predominantly expressed even at the earli

158 ed with increased relative expression of the beta-myosin isoform (25+/-6 versus 63+/-5%beta, CTRL ver

159 c hypertrophy, and alterations in alpha- and beta-myosin isoform expression.

160 alpha-Myosin and beta-myosin isoform mRNAs were affected by CAN, but alph

161 eavy chain alpha, cardiac myosin heavy chain beta, myosin light chain 1A, myosin light chain 1V and N

162 A 112-residue segment of the beta-myosin S2 domain was subjected to constant-magnitud

163 ATPase activity was 2.9-fold greater for rat beta-myosin than for pig beta-myosin.

164 Cardiac beta-myosin variants cause hypertrophic (HCM) or dilated

165 ion of additional myosin genes (Myosin 1 and beta-Myosin) via the miR-499/Sox6 pathway.

166 of alpha-myosin were exchanged for those of beta-myosin were expressed in vivo.

167 muscle-specific isoforms of alpha-actin and beta-myosin, which are known to cause familial TAAD when