ライフサイエンスコーパス: beta-position

1 esence of an extra oxygen substituent in the beta position.

2 , including those with hydrogen atoms in the beta position.

3 of that recorded for hydrolysis at the alpha-beta position.

4 he alpha position and 1.013 +/- 0.006 at the beta position.

5 he alpha position and 1.017 +/- 0.005 at the beta position.

6 ring a vinyl group at a chiral carbon at the beta-position.

7 he direct functionalization of amines in the beta-position.

8 cyano-substituted aryl rings at the carbonyl beta-position.

9 hydes bearing heteroatom substituents in the beta-position.

10 zines, they decrease the reactivities of the beta-position.

11 carbon-sulfur bond yielding a radical in the beta-position.

12 a single deuterium atom at the former enone beta-position.

13 nfavorable delta(deltaH) when SiH3 is in the beta-position.

14 ontaining electron-withdrawing groups at the beta-position.

15 lkyl-substitution patterns at the alpha- and beta-positions.

16 thynyl]phenyl group at diametrically opposed beta-positions (2, 12).

17 pyrromethene (BODIPY) dyes formylated in the beta'-position (2b, 2c) have been treated with L-cystein

18 he (R)-phenyl vicinal diol via attack at the beta-position, albeit with significantly reduced efficie

19 Betidamino acids (a contraction of "beta" position and "amide") are N'-monoacylated (optiona

20 Betidamino acids (a contraction of "beta" position and "amide") are N'-monoacylated (optiona

21 noperoxidation of the carbonyl groups in the beta-positions and the transformation of the delta-carbo

22 vel, p-tolyl substituents at opposing (2,12) beta-positions, and the absence (H-BC) or presence (MeO-

23 s of analogs with substitutions at the 4 and beta positions are influenced by sequences distal to thi

24 ion or a tertiary carbon at the beta- and/or beta'-position are recalcitrant or have limited biodegra

25 erted pyrrole ring connected via alpha'- and beta-positions are described.

26 rporation of a single deuterium at the enone beta-position as an equimolar mixture of epimers, inferr

27 ves as an electrophile being attacked at the beta-position by the amine nitrogen atom.

28 lled by the chiral peptide chain, and at the beta-position by using chiral allylic substrates.

29 h expressers migrated more slowly toward the beta position compared with the pre-beta-mobility of non

30 cts and transfers the 4 beta-proton to the 6 beta-position, contribute 10(4.7) and 10(5.6) to the rat

31 ary role in dictating orientation, but the V beta positions diverge widely.

32 ing stereocontrol elements at the alpha- and beta-positions exhibit variable and unpredictable select

33 step, monolignols invariably couple at their beta-positions, generating chiral centers.

34 ficient route to pyrroles substituted in the beta-position has been achieved in four high yielding st

35 ion from the phosphotyrosyl (pTyr) mimetic's beta-position has previously been shown to enhance Grb2

36 stereomer (differing in configuration at the beta-position (i.e. its beta-epimer)) was produced only

37 s, overcoming their propensity to add to the beta position in the absence of a catalyst, but do so wi

38 results indicate that modification of the 3 beta-position in 1 and 2 maintains activity at the neuro

39 nes yields the pyrrolines substituted in the beta-position in excellent yields.

40 enzyme binds a single divalent cation at the beta-position in the active site via ligation to Glu-131

41 dyl variant quite dramatically, favoring the beta-position in the newly formed cyclopentenone ring.

42 as 2- and 3-thiophene and 2-furan favor the beta-position in the newly formed cyclopentenone ring.

43 amides 1-4 with variations at the alpha- and beta-positions in the gamma-turn.

44 ses conductance, whereas placing them at the beta-position increases conductance: for example, the C-

45 C-H bond; in this case, C-H addition at the beta-position is followed by beta-migration of the arylo

46 l, annulation chemoselectively occurs at the beta position, leading to a range of aliphatic cyclic et

47 imary and secondary acetates bearing, at the beta'-position, linear or branched alkyl groups and aryl

48 erized hydrolysis of 8-oxo-dGTP at the alpha-beta position, MutT cleaves at the beta-gamma phosphate

49 lectron-withdrawing substituents at the heme beta-positions, nu(FeN) and nu(NO) become positively cor

50 mplexes possessing alkyl substituents at the beta-position occurred at rates that were similar to tho

51 Alkyl branching at the beta position of a polyketide intermediate is an importa

52 irect displacement of alkoxy groups from the beta position of aromatic and unsaturated esters and ket

53 le to record (1)H dispersion profiles at the beta positions of Asx, Cys, Ser, His, Phe, Tyr, and Trp

54 sp(3) C-H functionalization at the alpha-and beta positions of cyclic amines to their corresponding 3

55 ately equal to 1.032 was observed at the C3 (beta) position of cyclohexenone, while a much smaller 12

56 philic attack of the iodonium ylide on the C(beta) position of the diphenylketene, followed by cycliz

57 all-carbon quaternary carbon centers at the beta-position of aliphatic acids.

58 placement of an aryl/heteroaryl group at the beta-position of alpha-cyano aliphatic acids for the fir

59 e investigation of vinyl substitution at the beta-position of alpha-cycloalkyl-substituted glycines.

60 macrocycles that employ ring closure at the beta-position of key pTyr-mimicking residues.

61 ha-position and formation of C-O bond at the beta-position of styrenes was achieved under metal-free

62 ectivity upon hydrogen-alkyl exchange at the beta-position of the alkene.

63 However, substituents at the alpha- or beta-position of the alpha,beta-enal substrate are typic

64 s to enhance activity by modification of the beta-position of the beta-alanyl carboxylate group of 29

65 fferent arylsilanes with substitution at the beta-position of the enamide and functionalization on th

66 The presence of two fluorine atoms at the beta-position of the enamide moiety endows unique electr

67 Hydride abstraction from the beta-position of the enolato ligand of the previously re

68 at is, products derived from coupling at the beta-position of the enone.

69 Introduction of sulfur at the beta-position of the flexible alkyl chain reverses this

70 study, a polyamide with an acetamide at the beta-position of the gamma-turn resulted in animal morbi

71 troduced aryl or aralkyl substituents at the beta-position of the hydroxamate analogue of 2.

72 The introduction of a syn methyl at the beta-position of the lactone further improved chemical s

73 ected by a hexatriene linker at the meso- or beta-position of the macrocycle is not because of the in

74 duction of a small methyl substituent at the beta-position of the N3 side-chain improved the GnRH bin

75 a transfer of hydride from the flavin to the beta-position of the olefinic bond, concomitant with or

76 talysts indicated that the acid group at the beta-position of the pyrrolidine ring of the catalyst pl

77 hydrogen appears to be transferred from the beta-position of the thiazole to the methyl group in the

78 3l, with deuterium exclusively at the former beta-position of the vinyl moiety.

79 oupling of activated aryl groups attached to beta-positions of the porphyrin ring provides convenient

80 wo steps: C-C bond homocouplings between the beta-positions of thiophenes and annelation between the

81 a methyl group on the side chain nitrogen ("beta" position) of the same analogues, with one of the d

82 As with a quaternary carbon at the alpha- or beta-position or a tertiary carbon at the beta- and/or b

83 ar N...S interaction, whereas linkage in the beta-position prevents intramolecular N...S interaction,

84 the C-H bond cleavage occurs directly at the beta position rather than at the alpha position followed

85 SiH3 substitution in the beta-position (relative to the sulfur atom) is found to

86 iral acyl hydride with a stereocenter at the beta-position reveal that ionization of the carbanion oc

87 he phenyl ring, the indole nitrogen, and the beta position show up to 40-fold potency differences for

88 At ambient temperature, racemization of the beta-position through a putative reversible Michael addi

89 ytic fragmentation of the substituent in the beta-position to generate the olefin cation radical (5).

90 ectivity of the process is extended from the beta-position to the remote delta-position of the 2,4-di

91 he corresponding pyrroles substituted in the beta-position was achieved.

92 ones linked to the steroidal nucleus via the beta-position were more potent glucocorticoid agonists t

93 ubstituted with simple alkyl groups at the 3 beta-position were synthesized and found to be active in

94 a single regioisomer (o-xylyl groups in both beta-positions) while coupling of 1,3-dimethyl-5-(phenyl

95 enediynes that possess a carbonyl group in a beta position with respect to the one of acetylenic term

96 lic ketones, can be directly arylated at the beta-position with complete site-selectivity and excelle

97 Tryptamines disubstituted at the beta-position with fluorine have been synthesized as par

98 eneral and gives pyrroles substituted in the beta-position with linear and branched alkyl, benzyl, or

99 evidence that 5-OH-CA cross couples (at its beta-position) with syringyl and guaiacyl units (at thei