ライフサイエンスコーパス: beta-sheet structure

1 usly assembles into amyloid fibrils of cross-beta sheet structure.

2 inal monomer, contain substantial amounts of beta sheet structure.

3 pha-helical conformation to one dominated by beta-sheet structure.

4 ntacts; a prominent alpha-helix supports the beta-sheet structure.

5 main participate in the in-register parallel beta-sheet structure.

6 ontaining approximately 5-nm-long regions of beta-sheet structure.

7 ntrolled by the region that acquires a cross-beta-sheet structure.

8 red 3(1)-helical conformation and an ordered beta-sheet structure.

9 ally recognizes alpha-helical structure over beta-sheet structure.

10 ) and A53T-alphaSyn(2SS) take on significant beta-sheet structure.

11 h-molecular weight species and adoption of a beta-sheet structure.

12 ists of at least 78% alpha-helix with little beta-sheet structure.

13 nsignificant presence of an alpha-helical or beta-sheet structure.

14 tion were associated with the development of beta-sheet structure.

15 high percentage of random coil and possibly beta-sheet structure.

16 s 25-27 A wide protofilaments having a cross beta-sheet structure.

17 rmolecular beta-sheets, which form the cross-beta-sheet structure.

18 T, suggesting that they contain an organised beta-sheet structure.

19 large unilamellar vesicles (LUV), adopting a beta-sheet structure.

20 ial fibrinogen was mainly contributed by the beta-sheet structure.

21 rapidly displayed CD spectra consistent with beta-sheet structure.

22 e peptides in register in H-bonded, parallel beta-sheet structure.

23 e conversion is associated with formation of beta-sheet structure.

24 y NMR to contain a substantial population of beta-sheet structure.

25 in each of these species contains a similar beta-sheet structure.

26 n by the propensity of this sequence to form beta-sheet structure.

27 nd an intermolecular aggregation of extended beta-sheet structure.

28 protein self-association or a conversion to beta-sheet structure.

29 hile X-ray crystallography revealed only 17% beta-sheet structure.

30 ure, into a disease specific isoform rich in beta-sheet structure.

31 ies of the folding mechanism of this unusual beta-sheet structure.

32 on of ABri are required for the formation of beta-sheet structure.

33 t in a stable monomeric form that is rich in beta-sheet structure.

34 This band is assigned to the parallel beta-sheet structure.

35 nt to specify and stabilize the single-layer beta-sheet structure.

36 ifting from a predominantly alpha-helical to beta-sheet structure.

37 helical structure and formation of extensive beta-sheet structure.

38 amyloid proteins because of their extensive beta-sheet structure.

39 hift from a predominantly alpha-helical to a beta-sheet structure.

40 hthalene-8-sulphonic acid and lack extensive beta-sheet structure.

41 at of bacterial porins, indicating extensive beta-sheet structure.

42 ichroism showed that OmpG contains largely a beta-sheet structure.

43 protein, suggesting partial unfolding of the beta-sheet structure.

44 posite phase with oxygen, is consistent with beta-sheet structure.

45 pected, the protein exhibits a predominantly beta-sheet structure.

46 -helical, the stable intermediate is rich in beta-sheet structure.

47 al content of the wild type, while retaining beta-sheet structure.

48 sense, form compact, fibrillar solids with a beta-sheet structure.

49 natural tendency of each variant to acquire beta-sheet structure.

50 C strands of the four-stranded V1/V2 domain beta-sheet structure.

51 conformation upon aggregation and gain some beta-sheet structure.

52 ta) proteins with parallel in-register cross-beta-sheet structure.

53 d interacts with the stalk to form a compact beta-sheet structure.

54 ntramolecular disulfides stabilize a largely beta-sheet structure.

55 helix secondary structure and an increase in beta-sheet structure.

56 gregation into oligomers and fibrils rich in beta-sheet structure.

57 completely engaged in protective-presumably beta-sheet-structure.

58 sistent with the formation of folded dimeric beta-sheet structures.

59 icantly red-shifted for the two antiparallel beta-sheet structures.

60 serve to nucleate the formation of extended beta-sheet structures.

61 in turn stability and formation of extended beta-sheet structures.

62 as high propensity to assemble as aggregated beta-sheet structures.

63 mation of extended, linear preprotofibrillar beta-sheet structures.

64 eta species and induced a rapid formation of beta-sheet structures.

65 Protein chains coil into alpha-helices and beta-sheet structures.

66 of very slow rates of rearrangement of their beta-sheet structures.

67 stos coating proteins contain high levels of beta-sheet structures.

68 lus of these highly ordered, hydrogen-bonded beta-sheet structures.

69 As a result of their distinct beta-sheet structure, 1-108-alphaS fibrils resist incorp

70 ually results in the emergence of detectable beta-sheet structures according to thioflavin-T assay.

71 is sufficient to nucleate some antiparallel beta-sheet structure; addition of beta-capping units and

72 he occurrence of new bands due to aggregated beta-sheet structures, all of which indicate protein den

73 hange including a reduction in the extent of beta sheet structures and an increase in coil-turn confo

74 domains and indicate a parallel in-register beta-sheet structure and a general loss of native confor

75 s is generally accompanied by an increase in beta-sheet structure and a propensity to aggregate into

76 d proteins characterized by a specific cross-beta-sheet structure and are typically associated with n

77 (N)-CH(3) and CH(3)-CH(3) NOEs confirmed the beta-sheet structure and assisted in the positioning of

78 cular template and turn units that enforce a beta-sheet structure and block aggregation.

79 the assembly of the extended strands into a beta-sheet structure and confirmed the assignment of the

80 P fibril is held together by hydrogen bonded beta-sheet structure and contribute to the understanding

81 Consistent with this, similar changes in beta-sheet structure and decreases in in vitro methylati

82 n-containing proteins found they are rich in beta-sheet structure and disordered segments.

83 This fibril core has an in-register parallel beta-sheet structure and does not include the Q-rich, pr

84 proteins of known structure, lacks extensive beta-sheet structure and does not traverse the outer mem

85 The packed RT-loops form a beta-sheet structure and expose the backbone to promote

86 knowledge, unstable aggregates of Abeta with beta-sheet structure and fibrous morphology have not bee

87 this variant has a reduced tendency to form beta-sheet structure and forms deposits with much less s

88 E2 in rhodopsin shows beta-sheet structure and forms part of the chromophore-b

89 ne-inserted conformation of PrP is richer in beta-sheet structure and has a disruptive effect on the

90 beta-Sheet structure and inclusion formation, on the oth

91 tion from an alpha-helical conformation to a beta-sheet structure and oligomerization of huPrP90-231

92 t pre-nucleation intermediates sample intra- beta-sheet structure and place bounds on the possible nu

93 trachomatis is a trimer with predominantly a beta-sheet structure and porin function.

94 of the data indicates that the formation of beta-sheet structure and protein oligomerization likely

95 nonbranched polymeric proteins with a cross beta-sheet structure and the ability to alter the optica

96 a-sandwich core of the domain, disrupted the beta-sheet structure and the loop-sheet-helix motif.

97 two "Hao" amino acids that help template the beta-sheet structure and the two delta-linked ornithine

98 The 16-residue peptide forms stable beta-sheet structure and undergoes molecular self-assemb

99 ed by increases in intra- and intermolecular beta-sheet structures and a decrease in random coil and

100 l environment, with nonlocal interactions in beta-sheet structures and alpha-helical structures domin

101 perimental conditions, promotes formation of beta-sheet structures and amyloid fibrils.

102 assuming an equilibrium between antiparallel beta-sheet structures and conformations in which the C-t

103 seases contain antiparallel, out-of-register beta-sheet structures and identifies a target for struct

104 of peptides containing Hfl in the context of beta-sheet structures and may be useful in interpreting

105 activators promote a mixture of unfolded and beta-sheet structures and rapidly form large aggregates,

106 s tend to form gels (due to the formation of beta-sheet structures) and, as a result, are not readily

107 ibril surfaces bound Congo red, a marker for beta sheet structures, and exhibited a slow linear backg

108 c fibril morphology, a significant amount of beta-sheet structure, and exhibited green birefringence

109 yptophan at position 66, has a predominantly beta-sheet structure, and is less stable than the wild t

110 erent molecules lead to a disturbance of the beta-sheet structure, and polymorphism in ssNMR spectra

111 of alpha-syn shows strong tendencies to form beta-sheet structures, and deletion of this region has b

112 le of being prions form parallel in-register beta-sheet structures, and our data indicate the same co

113 Long straight fibrils composed of pure beta-sheet structure are formed at lower concentrations,

114 ised 3-fold hollow model with a more regular beta-sheet structure are in much better agreement with t

115 ls containing a mixture of alpha-helical and beta-sheet structures are formed at higher concentration

116 Our simulations also show that beta-sheet structures are stabilized when a beta-hairpin

117 d to lipids, (KIGAKI)3-NH2 did indeed form a beta-sheet structure as evidenced by Fourier transform i

118 re, BoNT/A in aqueous solution has about 47% beta-sheet structure as revealed by infrared spectroscop

119 natured state show evidence of some residual beta-sheet structure as well as other band components no

120 as been refolded into both alpha-helical and beta-sheet structures as well as various intermediates i

121 e binding and contain a characteristic cross-beta sheet structure, as revealed by x-ray scattering.

122 accompanied a conformational conversion to a beta-sheet structure, as judged with circular dichroism

123 ular hydrogen bonding, including an extended beta-sheet structure, as well as aromatic interactions.

124 particularly important for the formation of beta-sheet structures, as the polypeptide chain searches

125 DPPG (7/3 mol ratio) adopted an antiparallel beta-sheet structure at all surface pressures studied >

126 l and random-coil structures to the parallel beta-sheet structure at the air/water interface.

127 RBF predicts a DNA-binding motif involving a beta-sheet structure at the N-terminal domain.

128 alpha-helices at low temperatures and large beta-sheet structures at high temperatures.

129 on peptides adopt predominantly antiparallel beta-sheet structures at the membrane surface.

130 eutral pH to the more ordered, predominantly beta-sheet, structure at low pH.

131 monstrates that betanova has a predominantly beta-sheet structure between 5 and 82 degrees C.

132 l acidic region of Ng peptide pries open the beta-sheet structure between the Ca(2+) binding loops pa

133 t both variants have an in-register parallel beta-sheet structure, both in the fully hydrated form an

134 -oligomer is not preceded by precursors with beta-sheet structure but by a partially unfolded clearly

135 denosine triphosphate induces disassembly of beta-sheet structures but not the alpha-helical contents

136 CD spectra consistent with anticipated major beta-sheet structures but underwent spectral changes upo

137 ied YapV passenger is functional and rich in beta-sheet structure, but lacks a approximately 20 kDa C

138 The loops adapt nascent antiparallel beta-sheet structures, but the positions are slightly di

139 FOs are soluble at 100,000 x g, rich in beta-sheet structures, but yet bind weakly to thioflavin

140 We show that a beta-sheet structure can be maintained when a large numb

141 fibrils containing the in-register, parallel beta-sheet structure commonly found in WT-Abeta40 fibril

142 the mutation site and in spatially adjacent beta-sheet structures comprising the hydrophobic core.

143 Amyloids, protein aggregates with a cross beta-sheet structure, contribute to inflammation in debi

144 nvironment further perturbed and some of the beta-sheet structure converted to disordered structure.

145 A higher content of beta-sheet structure correlated with increased propensit

146 content of teleost osteocalcin increases and beta-sheet structure decreases upon calcium binding, sim

147 n be induced to form either alpha-helical or beta-sheet structure depending on its concentration and

148 ne fusion, adopts either an alpha-helical or beta-sheeted structure depending on the cholesterol conc

149 it forms either a beta-solenoid or a stacked beta-sheet structure, depending on the integrity of the

150 -UV CD studies show that the small amount of beta-sheet structure developed by hIAPP(8-37) 3xP after

151 Parallel and twisted beta-sheet structures do not develop a highly split amid

152 rgoes a spontaneous conversion to oligomeric beta-sheet structure even in the absence of guanidine HC

153 Binding of agonists to the beta-sheet-structured extracellular domain opens an ion

154 ed fibril bundles have indicated an extended beta-sheet structure for Alzheimer's beta-amyloid fibril

155 re2p fibrils support an in-register parallel beta-sheet structure for the PD core of Ure2p fibrils.

156 igned reversing turns in terms of nucleating beta-sheet structure formation.

157 ons, suggesting that an in-register parallel beta-sheet structure formed by the C-terminal end may be

158 The in-register parallel beta sheet structure found for several infectious yeast

159 ongo red and thioflavin T), and antiparallel beta-sheet structure (Fourier transform infrared spectro

160 instead of the formation of alpha-helical or beta-sheet structures, group 1 LEA proteins retain a hig

161 ies of amino acids to form alpha-helical and beta-sheet structures has been important in clarifying s

162 arallel dimer, which is close to the amyloid beta-sheet structure, has fewer interpeptide hydrogen bo

163 Fibrillary protein aggregates rich in beta-sheet structure have been implicated in the patholo

164 rtion of disulfide bridges on the surface of beta-sheet structures have implications for enhancing th

165 oppositely charged ionic segments that form beta-sheet-structured hydrogel assemblies via polyion co

166 All constructs have predominant beta sheet structure in membranes with physiologically r

167 olecular template and turn units that induce beta-sheet structure in a heptapeptide strand that forms

168 sive activity concomitant with a loss of the beta-sheet structure in a membranous environment.

169 ate forms during the lag phase with parallel beta-sheet structure in a region that is ultimately a pa

170 The discovery of beta-sheet structure in Alzheimer's amyloid fibrils, and

171 anged in a rigid conformation, and confirm a beta-sheet structure in an assigned stretch of three ami

172 partially parallel, arrangement for cystatin beta-sheet structure in mature amyloids and propose a mo

173 that the majority of alanine was found in a beta-sheet structure in post-spun egg case silk.

174 The amino acid sequence rules that specify beta-sheet structure in proteins remain obscure.

175 se two regions promote aggregation and adopt beta-sheet structure in the fibrils, and may also do so

176 ll-known intermolecular in-register parallel beta-sheet structure in the mature fibrils.

177 insertion of the reactive loop region into a beta-sheet structure in the protein core.

178 antagonist, SQ29,548, could induce more of a beta-sheet structure in the TP than that of the agonist,

179 actions account for the in-register parallel beta-sheet structure in Ure2p(10)(-)(39) fibrils and tha

180 tide system, which forms stable antiparallel beta-sheet structure in water, is destabilized in urea s

181 A 16-amino acid oligopeptide forms a stable beta-sheet structure in water.

182 central core of Abeta consists of a parallel beta-sheet structure in which identical residues on adja

183 similar peptides will also exhibit parallel beta-sheet structures in amyloid fibrils.

184 establish that these compounds fold to form beta-sheet structures in aqueous solutions.

185 SFHILLINleSAQSLLVPSIIFILAYSLK) formed stable beta-sheet structures in both sodium dodecyl sulfate mic

186 Antiparallel beta-sheet structures in the majority of fibrils are ind

187 orm the more amino terminal of two predicted beta-sheet structures in the tail.

188 eptides is due to formation of multistranded beta-sheet structures in this conformation.

189 asubstituted diphenylacetylenes that display beta-sheet structures in two directions.

190 At the same time, when protofilaments form, beta-sheet structure increases to about 54% from the app

191 (FTIR) amide I band shows that antiparallel beta-sheet structure increases with syneresis in the tau

192 In arrestin, a modest loss of beta-sheet structure indicates an increase in flexibilit

193 The less toxic oligomer is devoid of beta-sheet structure, insoluble, and non-immunoreactive

194 We therefore conclude that this beta-sheet structure is a crucial region for MIF activit

195 lpha-helical conformation into an oligomeric beta-sheet structure is about 50 times faster than that

196 Because beta-sheet structure is not observed when the peptide is

197 among proteins, which suggests that parallel beta-sheet structure is not stabilized by such disulfide

198 A marked loss of beta-sheet structure is observed in the second intermedi

199 of a prion domain further suggests that the beta-sheet structure is of the parallel in-register type

200 ay scattering data indicate that much of the beta-sheet structure is retained in acidic solution and

201 NMR structure reveals that the native Pin WW beta-sheet structure is retained upon incorporating a st

202 NMR analysis reveals that parallel beta-sheet structure is terminated beyond the disulfide

203 e transition of huPrP90-231 to an oligomeric beta-sheet structure is the presence of salt.

204 This M.Pvu IIalpha/beta-sheet structure is very similar to those of M.Hha I

205 Such a formation of very stable beta-sheet structures is found in the amyloid of a numbe

206 ation is an increase in the frequency of the beta-sheet structure, leading to hydrogen bonding betwee

207 A twist in the antiparallel beta-sheet structure leads to a significant increase in

208 These results, in the context of a primarily beta-sheet structure, led us to build detailed models of

209 fectious amyloid has an in-register parallel beta-sheet structure, like that of the S. cerevisiae Ure

210 suggesting that the formation of a specific beta-sheet structure may be required for the peptide to

211 is distinct from the intermolecular parallel beta-sheet structure observed in mature fibrils.

212 similar to those described for antiparallel beta-sheet structure observed in protein X-ray crystal s

213 ion algorithms indicate that the majority of beta-sheet structure occurs in the p53 core DNA binding

214 t side-chain ordering in a key region of the beta-sheet structure occurs on a slower time scale than

215 However, a time-dependent transition to beta-sheet structure occurs upon addition of both urea a

216 In summary, a beta-sheet structure of a highly flexible peptide in sol

217 fibrils have the characteristic antiparallel beta-sheet structure of amyloid fibrils, as measured by

218 On the basis of the universal cross-beta-sheet structure of amyloid fibrils, these principle

219 the clearest evidence yet that the intrinsic beta-sheet structure of an in vitro Abeta aggregate depe

220 that was originally modeled to reproduce the beta-sheet structure of antiangiogenic proteins.

221 chanism that involves through-H-bonds of the beta-sheet structure of Az, likely also those in the Cu

222 e that is distinct from the type 1 trimeric, beta-sheet structure of Dut80alpha.

223 teraction of a collagen beta-strand with the beta-sheet structure of Fn modules seen in the high reso

224 l increase in stability was observed for the beta-sheet structure of hGHbp which included sites dista

225 thesize that NUCB1 binds to the common cross-beta-sheet structure of protofibril aggregates to "cap"

226 Contrary to the regular beta-sheet structure of the amyloid fibril, the dimers e

227 ghboring peptide chains in the predominantly beta-sheet structure of the amyloid fibrils.

228 Evidently, the beta-sheet structure of the Fv propagates the effects of

229 The beta-sheet structure of the SAM-binding domain is well-c

230 lpha-helix and the parallel and antiparallel beta-sheet structures of alanine polypeptides are analyz

231 h very high sequence identity can form cross-beta-sheet structures of sufficient stringency for incor

232 sferred to corresponding larger oligopeptide beta-sheet structures of up to five strands of eight res

233 re treatments modified the alpha-helical and beta-sheet structures of wine proteins.

234 when incoming Abeta peptide forms a parallel beta-sheet structure on the fibril edge.

235 (nonselective peptides) or an intermolecular beta-sheet structure only able to permeabilize DMPG vesi

236 tion, depend on the ability of Abeta to form beta-sheet structures or amyloid fibrils.

237 An in-register parallel beta-sheet structure permits polar zipper interactions a

238 mising attributes and unique features of the beta-sheet-structured PIC hydrogels described here highl

239 acid sequence may not participate in a rigid beta-sheet structure, possibly including portions of the

240 his difference may be due to a predominantly beta-sheet structure present in RBP in contrast to the a

241 lsE's native and non-native superhelical and beta-sheet structures readily occur (pH 7, 20 degrees C)

242 een the consensus components, we show that a beta sheet structured region separating the consensus el

243 PIN1 WW domain, a 34-residue three-stranded beta-sheet structure, removes a favorable electrostatic

244 redominates in the normal PrP isoform into a beta-sheet structure resistant to proteinase K (PK).

245 intermediates proceed to convert into stable beta-sheet structured species and maintain their stackin

246 The population of beta-sheet structured species is >5% within 5 min of agg

247 Two beta-sheet structures (strands A-E and F-J) surround a c

248 nsisting of a centrally located six-stranded beta-sheet structure surrounding the C-terminal alpha-he

249 ding protein (IFABP) primarily comprises two beta-sheet structures surrounding a large internal cavit

250 In contrast, the carbonyl groups in beta-sheet structures tend to exhibit a greater charge d

251 olded in Tris buffer contained slightly less beta-sheet structure than detergent-folded Msp(Fl); both

252 tein was more hydrophobic and contained more beta-sheet structure than did soya.

253 dynamics in general are more retarded around beta-sheet structures than alpha-helical motifs.

254 Amyloids are proteins with cross-beta-sheet structure that contribute to pathology and in

255 IF protein, these two binding regions form a beta-sheet structure that includes the MIF oxidoreductas

256 forms have a mixed parallel and antiparallel beta-sheet structure that is different from fibrils whic

257 R-S-S-TTR)(1) retaining a stable 16-stranded beta-sheet structure that is equivalent to the dimer not

258 Both possess a degree of beta-sheet structure that is intermediate between that o

259 easurements showed that Crp4 has an expected beta-sheet structure that is not evident in the pro-Crp4

260 beta (11-25) fibrils are clearly composed of beta-sheet structure that is observable as striations ac

261 0-19), encompasses the A strand of the inner beta-sheet structure that lines the thyroid hormone bind

262 opts a compact, three-stranded, antiparallel beta-sheet structure that mediates protein-protein inter

263 c16-AHL(3)K(3)-CO(2)H, capable of forming a beta-sheet structure that propagates into larger fibrous

264 consistent with formation of triple-stranded beta-sheet structures that assemble into two-dimensional

265 heterogeneous, containing both antiparallel beta-sheet structures that can grow into full fibrils as

266 fold in CDCl3 solution to form well-defined beta-sheet structures that dimerize through parallel bet

267 In addition to beta-sheet structure, the oligomeric form of the protein

268 infrared spectra are attributed primarily to beta-sheet structures, these findings indicate that the

269 Slow formation of the stable beta-sheet structure thus shows kinetic irreversibility.

270 esults indicate that an in-register parallel beta-sheet structure underlies the [PSI(+)] prion phenom

271 NAC in solution altered from random coil to beta-sheet structure upon ageing, a process that has pre

272 l structure upon lipid membrane binding or a beta-sheet structure upon aggregation.

273 luble fibrillar aggregates with antiparallel beta-sheet structure upon incubation at physiological te

274 that the extracellular sequence of C99 forms beta-sheet structure upon interaction with membrane bila

275 de (hIAPP) that is known to misfold into the beta-sheet structure upon interaction with membranes.

276 They all exhibit a high content of beta-sheet structure upon oligomerization at near-neutra

277 leavage, likely reflecting the extent of the beta-sheet structure, varies mostly as a function of the

278 Enhancement of the beta-sheet structure was observed in MB-A/D and MB-A/I,

279 on of PrP from alpha-helical structures into beta-sheet structures was confirmed by circular dichrois

280 No beta-sheet structures were detected for any of the PspA

281 GAKI)(3)-NH(2), designed to form amphipathic beta-sheet structure when bound to lipid bilayers, posse

282 IGAKI-NH(2) was designed to form amphiphilic beta-sheet structures when bound to lipid bilayers.

283 non-inhibitory peptides, readily formed high beta-sheet structures when placed under the conditions o

284 It is known that the fibrils have a cross-beta-sheet structure where main chain hydrogen bonding o

285 ther neurodegenerative diseases have a cross beta-sheet structure, where main chain hydrogen bonding

286 to TMDs three and six assumed predominantly beta-sheet structures, whereas those corresponding to TM

287 erstand the topological properties of larger beta-sheet structures which frequently contain four-stra

288 ar dichroism suggest that eIF4H has a mostly beta-sheet structure, which appears similar to other RNA

289 that the aggregate adopts a fibrillar double beta-sheet structure, which is formed by packing the RT-

290 egates undergo structure rearrangements into beta-sheet structures, which are able to recruit monomer

291 into unstructured Abeta aggregates with some beta-sheet structures, which could prevent both the prim

292 1 and [Gly(6)]ccTP 1a exhibited well-ordered beta-sheet structures, while the less constrained [Gly(6

293 gle cross-beta unit is then a double-layered beta-sheet structure with a hydrophobic core and one hyd

294 The protein is dominated by an open alpha/beta-sheet structure with a prominent V-shaped cleft: Ad

295 esponding to the G helix forms a hyperstable beta-sheet structure with its strands oriented perpendic

296 The peptide associates into a double beta-sheet structure with tightly packed alpha-helices d

297 Region II exhibits a beta-sheet structure with which the bipartite motif may

298 ly reported, support an in-register parallel beta-sheet structure, with one Rnq1 molecule per 0.47-nm

299 e gKDelta31-68 mutation spans a well-defined beta-sheet structure within the amino terminus of gK, wh

300 to H-bonding by residues in core regions of beta-sheet structure within the fibril.