ライフサイエンスコーパス: beta-site APP cleaving enzyme

1 radation of the APP-cleaving beta-secretase, beta-site APP-cleaving enzyme.

2 beta (C99), generated by cleavage of APP by beta-site APP cleaving enzyme 1 (BACE-1), is the primary

3 ge of the amyloid precursor protein (APP) by beta-site APP cleaving enzyme 1 (BACE1) and gamma-secret

4 Under normal conditions, beta-site APP cleaving enzyme 1 (BACE1) cleaves APP at m

5 The beta-site APP cleaving enzyme 1 (BACE1) cleaves APP in a

6 elective small molecule (SR3677), suppressed beta-site APP cleaving enzyme 1 (BACE1) enzymatic action

7 r AD drug development.SIGNIFICANCE STATEMENT beta-site APP cleaving enzyme 1 (BACE1) is essential for

8 beta-site APP cleaving enzyme 1 (BACE1) is the beta-secr

9 The cellular levels of beta-site APP cleaving enzyme 1 (BACE1), the rate-limiti

10 beta-Site APP cleaving enzyme 1 (BACE1), the transmembra

11 dence for modulations in axonal transport or beta-site APP cleaving enzyme 1 protein levels and activ

12 BACE1 (beta-site APP cleaving enzyme 1) is responsible for the

13 Assessing BACE1 (beta-site APP cleaving enzyme 1) knockout mice for gener

14 ntegrin and metalloproteinase 10) and BACE1 (beta-site APP cleaving enzyme 1), respectively.

15 expression of AD-related genes [APP, BACE1 (beta-site APP cleaving enzyme 1)] as well as their trans

16 n of amyloid precursor protein (APP) and the beta-site APP cleaving enzyme 1.

17 beta-Site APP-cleaving enzyme 1 (BACE1) is required for

18 (APP) by the beta- and gamma-secretases, and beta-site APP-cleaving enzyme 1 (BACE1) is the beta-secr

19 eased protein levels, but not mRNA levels of beta-site APP-Cleaving Enzyme 1 (BACE1), a key enzyme in

20 duction of Abeta from APP is mediated by the beta-site APP-cleaving enzyme 1 (BACE1).

21 ma- and beta-secretases, the latter known as beta-site APP-cleaving enzyme 1 (BACE1, or herein BACE).

22 lpha-secretase activity but had no effect on beta-site APP-cleaving enzyme 1 activity.

23 This is accompanied by an increase of beta-site APP-cleaving enzyme 1 levels and an increase o

24 of the promoters of betaAPP, beta-secretase (beta-site APP-cleaving enzyme 1, BACE1), and of the four

25 beta-Site APP cleaving enzyme-1 (BACE-1) is the predomin

26 The beta-site APP cleaving enzyme-1 (BACE1) mediates the fir

27 beta-site APP cleaving enzyme-1 (BACE1), the rate-limiti

28 on factor 2alpha and enhanced translation of beta-site APP cleaving enzyme-1 (BACE1).

29 f amyloid precursor protein (APP) by BACE-1 (beta-site APP cleaving enzyme-1) is the rate-limiting st

30 eal that GGA1 is necessary for both LR11 and beta-site APP-cleaving enzyme-1 (BACE1) modulation of AP

31 otein (APP) is processed sequentially by the beta-site APP cleaving enzyme and gamma-secretase to gen

32 through consecutive proteolytic cleavages by beta-site APP-cleaving enzyme and gamma-secretase.

33 BACE1 (beta-secretase activity of the beta-site APP-cleaving enzyme), ApoE (apolipoprotein E),

34 genetic approach, we show that reduction of beta-site APP cleaving enzyme (BACE) in these ArcTau mic

35 The gene encoding a beta-secretase for beta-site APP cleaving enzyme (BACE) was identified rece

36 brain is a membrane-bound aspartyl protease beta-site APP cleaving enzyme (BACE).

37 tide from amyloid precursor protein (APP) by beta-site APP cleaving enzyme (BACE)1 and gamma-secretas

38 lly harmful amyloid beta (Abeta) peptides by beta-site APP cleaving enzymes (BACE).

39 nce that heparan sulfate (HS) interacts with beta-site APP-cleaving enzyme (BACE) 1 and regulates its

40 pe amyloid precursor protein (APP) and human beta-site APP-cleaving enzyme (BACE) and found that they

41 The newly identified beta-site APP-cleaving enzyme (BACE) cleaves APP at Asp1

42 The membrane-anchored aspartyl protease beta-site APP-cleaving enzyme (BACE) exhibits all of the

43 Beta-site APP-cleaving enzyme (BACE) is required for pro

44 oid precursor protein (APP), Abeta peptides, beta-site APP-cleaving enzyme (BACE), presenilin-1 (PS-1

45 A tail construct inhibited APP cleavage in a beta-site APP-cleaving enzyme (BACE)-dependent manner.

46 ntegral membrane aspartyl protease named the beta-site APP-cleaving enzyme (BACE).

47 from amyloid-beta precursor protein (APP) by beta-site APP-cleaving enzyme (BACE).

48 an aspartyl protease as the beta-secretase (beta-site APP cleaving enzyme, BACE) involved in APP pro

49 beta-site APP cleaving enzyme (BACE1) cleavage produces

50 of beta C-terminal fragments, the product of beta-site APP cleaving enzyme (BACE1) processing of amyl

51 droxyethyl amine (HEA) derived inhibitors of beta-site APP cleaving enzyme (BACE1) was optimized to a

52 TNF-alpha directly stimulated beta-site APP-cleaving enzyme (BACE1) expression and enh

53 or protein (APP) requires proteolysis by the beta-site APP-cleaving enzyme (BACE1).

54 The enzyme BACE (beta-site APP-cleaving enzyme) has recently been identif

55 ype I transmembrane aspartyl protease, BACE (beta-site APP cleaving enzyme), has been identified to b

56 Desflurane/hypoxia also increased levels of beta-site APP-cleaving enzyme in H4-APP cells.

57 xpression of this protease, termed BACE (for beta-site APP-cleaving enzyme) increased the amount of b

58 ial changes were abolished by treatment with beta-site APP-cleaving enzyme inhibitor IV.

59 el transmembrane aspartic protease BACE (for Beta-site APP Cleaving Enzyme) is the beta-secretase tha

60 We also observed that APP and the beta-site APP cleaving enzyme were, for the most part, n

61 ntly, a type I membrane protein termed BACE (beta-site APP cleaving enzyme) with characteristics of a