ライフサイエンスコーパス: beta1 integrin

1 between AR and TrkA, which is controlled by beta1 integrin.

2 tion, likely via downregulation of NCAM1 and beta1 integrin.

3 s by dampening the RhoA pathway or silencing beta1 integrin.

4 involves loss of RAP1-mediated activation of beta1 integrin.

5 s downstream of cleaved CDCP1 complexed with beta1 integrin.

6 e haploinsufficient for both fibrillin 1 and beta1 integrin.

7 ntegrins and reduces the activation state of beta1 integrin.

8 l proliferation at least partly by targeting beta1 integrin.

9 in substrates restores focal localization of beta1 integrin.

10 ng electrotaxis via electric field-activated beta1 integrin.

11 ing following normal endocytosis of inactive beta1-integrin.

12 nd with E353 to mediate its high affinity to beta1-integrin.

13 onformationally active population of surface beta1 integrins.

14 l adhesion kinase (FAK) and ligand-activated beta1 integrins.

15 eased total protein levels of keratin-14 and beta1 integrins.

16 ive junctions, and "inside-out" signaling to beta1 integrins.

17 ation of Akt and the recruitment of talin to beta1 integrins.

18 sts with QHREDGS was found to be mediated by beta1-integrins.

19 nia, which enables uptake via mammalian host beta1-integrins.

20 were eliminated by neutralizing antisera for beta1-integrins.

21 We observed that beta1-integrins accumulate on the luminal membrane of up

22 beta1-integrin accumulation is due to increased ceramide

23 icking mutant talin1(S425D) led to increased beta1 integrin activation and generated biologic effects

24 d in ICAP-1 destabilization, which increased beta1 integrin activation and led to increased RhoA-depe

25 We show that KRIT1 functions as a switch for beta1 integrin activation by antagonizing ICAP1 (Integri

26 showed that KRIT1 functions as a switch for beta1 integrin activation by antagonizing ICAP1-mediated

27 ta3 in human erythroleukemia (HEL) cells and beta1 integrin activation in macrophage-like RAW264.1 ce

28 ediated phosphorylation of talin1 leading to beta1 integrin activation is a novel mechanism that incr

29 Our data support that up-regulation of beta1 integrin activation participates in the progressio

30 onditions induced protein kinase C-dependent beta1 integrin activation, and FN assembly in normal glu

31 podocytes caused only a modest reduction in beta1 integrin activation, podocyte cell adhesion, and c

32 that talin1, but not talin2, is important in beta1 integrin activation.

33 is study, we identified a novel mechanism of beta1 integrin activation.

34 le for talin1 phosphorylation and subsequent beta1 integrin activation.

35 growth factor (VEGF) secretion and enhanced beta1 integrin activation.

36 ts from these mice show unaltered beta3- and beta1-integrin activation and consequently normal adhesi

37 r data indicate that abatacept may stabilize beta1-integrin activation in podocytes and reduce protei

38 resses result in a transcellular gradient in beta1-integrin activation with vinculin, focal adhesion

39 tion, paxillin and PAK4 phosphorylation, and beta1-integrin activation.

40 Notably, SCs in aged mice show altered beta1-integrin activity and insensitivity to Fgf2.

41 Augmenting beta1-integrin activity with a monoclonal antibody resto

42 Loss of AMPK promotes beta1-integrin activity, the formation of centrally loca

43 Transient expression of tensins increases beta1-integrin activity, whereas tensin silencing reduce

44 g either talin or kindlin failed to activate beta1 integrins, adhere to fibronectin (FN) or maintain

45 ontrols surface topology of nanometer-scaled beta1 integrin adhesion domains in cis, whereas its liga

46 We conclude that regulation of beta1 integrin adhesion through talins and kindlins may

47 CCRL2, and the activation of dendritic cell beta1 integrin affinity.

48 Using an inducible system to delete beta1 integrin after completion of airway branching, we

49 Among the identified hits, we confirmed an beta1-integrin agonist, pyrintegrin, as a podocyte-prote

50 Indeed, inhibition of beta1 integrins also leads to loss of electrotaxis in ke

51 As beta1-integrin also activates NF-kappaB, our findings re

52 i-dependent glycosylation and trafficking of beta1 integrin and decreased phosphorylation of focal ad

53 zed that the collaborative signaling between beta1 integrin and gp130 (IL-6 beta receptor, IL-6 signa

54 izes with and regulates the levels of active beta1 integrin and of phosphorylated FAK and ERK.

55 tosis, as monitored using antibody-clustered beta1 integrin and previous studies on other proteins, w

56 B1 cells constitutively expressed activated beta1 integrin and relocated from the peritoneum to the

57 ncover a potential role for PKP2 upstream of beta1 integrin and RhoA in integrating cell-cell and cel

58 ar matrix (ECM) also converge on GIV-GEF via beta1 integrins and that focal adhesions (FAs) serve as

59 ression by influencing the crosstalk between beta1 integrins and Twist to increase VEGF production.

60 At the molecular level, CYLD decreased beta1-integrin and inhibited pJNK induction by tumor nec

61 confirmed that level of bisecting GlcNAc on beta1-integrin and N-cadherin was increased in Fut8(-/-)

62 Direct interactions between beta1-integrin and NF-kappaB p65 were induced in nonmali

63 cal adhesions, cadherin-11 co-localizes with beta1-integrin and paxillin and physically interacts wit

64 Expression of the modified CLC reduces beta1-integrin and transferrin receptor recycling, as we

65 These changes were abolished by blocking beta1-integrins and mimicked by blocking beta3-integrins

66 beta1D integrin and other costameric proteins were lost

67 ional beta-catenin, stimulates clustering of beta1 integrins, and enhances the conformationally activ

68 eptor-beta, transactivates synaptic TrkB and beta1-integrin, and via mechanisms dependent on integrin

69 ne 2 (CMG2), tumor endothelial marker 8, and beta1-integrin, and, with the assistance of other host p

70 Here we show that Thy-1 supports beta1 integrin- and syndecan-4 (Syn4)-mediated contracti

71 y, the formation of centrally located active beta1-integrin- and tensin-rich mature fibrillar adhesio

72 face beta1-integrin internalization via anti-beta1-integrin antibodies or the RGD peptide ligand-or b

73 ignificantly inhibited in cells treated with beta1 integrin antibody or Rap1A siRNA.

74 A functional-activating beta1-integrin antibody rescued Hcy-suppressed adhesion

75 Therefore, beta1 integrin appears to serve as a motility-regulating

76 The residual 3% of beta1 integrins are able to trigger intracellular signal

77 We previously showed that beta1 integrins are activated in metastatic prostate can

78 However, how beta1 integrins are activated in PCa cells is unknown.

79 hile that thinned Ld lipid domains increased beta1-integrin-Arg-Gly-Asp-peptide affinity and valency,

80 human aortic endothelial cells, BA increased beta1-integrin-Arg-Gly-Asp-peptide affinity by 18% with

81 We identified active beta1 integrin as a biochemical and functional partner o

82 nia enterocolitica, an enteric pathogen, use beta1 integrins as pathogen recognition receptors detect

83 hmidtea mediterranea as a model, we identify beta1-integrin as a crucial regulator of blastema archit

84 the PKC- and CaMKII-dependent activation of beta1-integrins, as well as their exocytosis.

85 ction experiments demonstrated that TIM4 and beta1 integrins associate upon receptor clustering.

86 rphogenesis and promotes the accumulation of beta1 integrin at sites of failed angiogenic sprouting.

87 nockdown retarded the efficient recycling of beta1-integrin back to the plasma membrane following nor

88 beta1 integrins (beta1) transduce mechanical signals in

89 rming growth factor-beta1 precursor (pro-TGF-beta1), integrins bind to the prodomain, apply force, an

90 aA directly affected the amount of host cell beta1 integrin but not other cellular integrins.

91 plasma membrane expression and activation of beta1 integrins, but not alpha4, alpha5, or alpha6 integ

92 e hydrogen bonds were not observed in talin1/beta1-integrin, but did exist in talin1(C336S)/beta1-int

93 ip binding and reduces surface expression of beta1-integrin by interference with recycling following

94 alpha-actinin promote talin association with beta1-integrin by restricting the motion of the cytoplas

95 Here the authors develop beta1 integrins carrying traceable tags in the extracell

96 tion by sema3E in trans regulates individual beta1 integrin catch bonds.

97 ke serine proteases with aprotinin prevented beta1 integrin/CDCP1 complexing and downstream FAK/Akt s

98 X4, reduced monocyte migration and decreased beta1-integrin cell surface expression.

99 Loss of plexinD1 expression reduces beta1 integrin clustering, thereby diminishing avidity,

100 Thus, c-Met and beta1-integrin co-internalize and become progressively r

101 itronectin) versus substrates that only bind beta1 integrins (collagen).

102 ta1-integrin, but did exist in talin1(C336S)/beta1-integrin complex.

103 in cell cultures and in live animals, active beta1 integrin complexed preferentially with functionall

104 Further, using beta1 integrins containing a HaloTag in combination with

105 Importantly, beta1 integrins containing an extracellular pH-sensitive

106 These beta1 integrins control distinct antifungal effector fun

107 We further show that beta1-integrin cooperates with fibroblast growth factor

108 in and the membrane-distal NPxY motif in the beta1 integrin cytoplasmic domain.

109 In addition, TNS4 interaction with beta1-integrin cytoplasmic tail positively regulates bet

110 1-integrin R760, and between talin2 K327 and beta1-integrin D759.

111 beta1 integrin-deficient alveolar epithelial cells produ

112 not observed in mice with neuronal-targeted beta1-integrin deletion, supporting the hypothesis that

113 We found that beta1 integrin-dependent cell adhesion is critical for s

114 mesenchymal cells both in vivo and in vitro beta1 integrin-dependent cell adhesion relied on the rel

115 hed Galpha13-beta1 interaction and inhibited beta1 integrin-dependent cell spreading and migration.

116 These complexes are involved in promoting beta1 integrin-dependent directional migration in undiff

117 We also found that this phenotype relies on beta1 integrin-dependent local activation of the small G

118 o Tie2 increases Tie1-Tie2 interactions in a beta1 integrin-dependent manner and that Tie1 regulates

119 that the Galpha13-beta1 interaction mediates beta1 integrin-dependent Src activation and transient Rh

120 LPA initiates EMT in ovarian tumors through beta1-integrin-dependent activation of Wnt/beta-catenin

121 This beta1-integrin-dependent c-Met-sustained signalling on A

122 ion was also identified as a novel target of beta1-integrin-dependent TUDC action, which is frequentl

123 diminished VEGF production, and knockdown of beta1 integrins diminished Twist and VEGF production by

124 mmunoprecipitation studies demonstrated that beta1-integrin directly interacts with the bone morphoge

125 cal correction of ceramide levels-normalizes beta1-integrin distribution and sphingosine levels in CF

126 beta1-integrins downregulate acid ceramidase expression,

127 dies define distinct functions of epithelial beta1 integrin during both early and late lung developme

128 Whether beta1 integrin ectodomains visit conformational states s

129 Silencing beta1 integrin efficiently inhibited RCP-induced Slug ex

130 echanotransducers (focal adhesion kinase and beta1-integrin) ex vivo A 3-week low-energy shockwave re

131 ngs in other organs, loss of JAM-A decreased beta1 integrin expression and impaired filamentous actin

132 n, such that elevated Pyk2 levels stabilized beta1 integrin expression necessary to initiate the meta

133 Differences in the chemokine receptor and beta1 integrin expression profiles of progenitors betwee

134 tion, adhesion, and migration and suppressed beta1-integrin expression and activity in human CD34(+)

135 This study suggested that COX-2 upregulates beta1-integrin expression and cell invasion in NSCLC by

136 nt study investigated the effect of COX-2 on beta1-integrin expression and cell invasion in NSCLC.

137 FoxC2 siRNA suppressed beta1-integrin expression and EP1-mediated cell invasion

138 Thus beta1-integrin expression by EZCs reduces movement of BM

139 Prostaglandin E2 (PGE2) treatment increased beta1-integrin expression in NSCLC cell lines.

140 was further reduced by IR with downregulated beta1-integrin expression.

141 EP1 siRNA blocked PGE2-mediated beta1-integrin expression.

142 2 and p38 inhibitors suppressed EP1-mediated beta1-integrin expression.

143 ts show that CM Tln2 is essential for proper beta1D-integrin expression and that Tln1 can substitute

144 Furthermore, our data implicates beta1 integrin, FAK, and paxillin in mediating the obser

145 down-regulated under normoxic condition; (2) beta1 Integrin/FAK signaling pathway was activated in my

146 t CDCP1 cleavage, occurring at the apex of a beta1 integrin/FAK/PI3K/Akt signaling cascade, may repre

147 ECM signals through a beta1-integrin/FAK/p190RhoGAP complex to downregulate a

148 Surprisingly, however, the major leukocyte beta1 integrin family member, alpha4beta1, was only part

149 mMYLK resulted in "inside-out" activation of beta1 integrin, followed by "outside-in" activation of c

150 uction of beta1D integrin isoform and active beta1 integrin from the buoyant domains in the heart; (4

151 Ablation of beta1-integrin from EZCs in vivo reduced the number of E

152 Additionally, blocking alpha5 or beta1 integrin function with antibodies reduced metastas

153 KCa1.1 channels regulate beta1-integrin function and cell adhesion in rheumatoid

154 ignaling mechanism by which KCa1.1 regulates beta1-integrin function and therefore invasiveness of RA

155 of KIND1, a cytoskeletal protein involved in beta1-integrin function, causes Kindler syndrome, a gene

156 Restricted beta1 integrin gene deletion in embryos using Ttr-Cre or

157 a independent and dependent on regulation of beta1-integrin gene expression by NR4A1 which can be inh

158 We show that although short-term loss of beta1-integrin has no obvious consequences for normal li

159 We demonstrate that inactivation of beta1 integrin impairs TGF-beta from stimulating the mot

160 yocyte Cav3 correlates with increased active beta1 integrin in adult CM; (5) in vivo pressure overloa

161 stal NPxY motif in the cytoplasmic domain of beta1 integrin in early endosomes.

162 In this study, the functional importance of beta1 integrin in lung epithelium during mouse lung deve

163 oxygen species, suggesting a direct role for beta1 integrin in regulating alveolar homeostasis.

164 administration reduced the levels of active beta1 integrin in the podocytes, which was prevented by

165 Herein, we investigated the role of beta1 integrins in regulating this process.

166 Mechanistically, loss of beta1-integrin in hepatocytes impairs ligand-induced pho

167 First, loss of beta1-integrin in hepatocytes with liver injury triggere

168 NM II-C1C2 can interact and colocalize with beta1-integrin in neurites.

169 rucial role and novel mechanism of action of beta1-integrins in liver regeneration and demonstrate th

170 Loss of beta1-integrin increased SMAD1/5/8 and p38 signaling, su

171 Conditional knock-out of beta1-integrin increases GFAP expression and astrocytic

172 We demonstrate that expression of beta1-integrin increases in EZCs following SCI in mice.

173 ization and homing to the injured vessel via beta1-integrin inhibition, which partially contributes t

174 sor AMP-activated protein kinase (AMPK) as a beta1-integrin inhibitor in fibroblasts.

175 beta1- and beta3-integrins, and unlike other beta1-integrin inhibitors which induce prometastatic bet

176 iated protein-1) to the cytoplasmic tails of beta1 integrins inhibits integrin activation.

177 nd C4-2B4 PCa cells, decreased activation of beta1 integrins, integrin-mediated adhesion, motility an

178 CagA translocation by Hp is mediated by beta1 integrin interaction of the cag-T4SS.

179 1 integrin that was accompanied by decreased beta1 integrin internalization and degradation.

180 ing this vicious cycle by triggering surface beta1-integrin internalization via anti-beta1-integrin a

181 Reintroduction of beta1 integrin into miR-223-ovexpressing cells was suffi

182 egrin by competing with talin for binding to beta1-integrin intracellular domain.

183 We conclude that beta1 integrin is essential for the attachment of the pr

184 ial for these processes, the in vivo role of beta1 integrins is a matter of debate.

185 Here we show that beta1-integrin is an essential niche molecule that maint

186 rons and the surface expression of activated beta1-integrins is reduced on dendrites of Ndr2-deficien

187 veolae; (3) loss of Cav3 caused reduction of beta1D integrin isoform and active beta1 integrin from t

188 tion, although levels of the muscle-specific beta1D-integrin isoform were reduced by 50%.

189 On laminin, which binds APP and beta1 integrins (Itgb1), DS neurons formed enlarged and

190 c astrogliosis after conditional deletion of beta1-integrin (Itgbeta1).

191 nt inhibition of hepatocyte proliferation by beta1-integrin knockdown or p21 overexpression, resultin

192 integrin activation, and restore adhesion in beta1 integrin knockout fibroblasts.

193 ic responses were also absent in conditional beta1-integrin knockouts, and with inhibition of matrix

194 Here, we show that the beta1-Integrin laminin receptor is required for RGC posi

195 nt study, we demonstrate that RCP stabilizes beta1 integrin leading to increased beta1 integrin level

196 isrupting TPC function halted trafficking of beta1-integrin, leading to its accumulation in EEA1-posi

197 abilizes beta1 integrin leading to increased beta1 integrin levels and activation of a signaling casc

198 n stress fibers, focal adhesions, and active beta1-integrin levels in cultured cells.

199 A activity is critical for cell migration on beta1 integrin ligands.

200 Previous work showed that beta1 integrin localizes to invadopodia, but its role in

201 brotic skin by activating an LTbeta receptor/beta1 integrin (LTbetaR/beta1 integrin) pathway on ADSCs

202 f the molecular brightness of mCherry-tagged beta1-integrins measured using fluorescence correlation

203 the loss of TGF-beta signaling and elevated beta1-integrin mechanosignaling engaged a positive feedb

204 P1GAP levels in injured podocytes maintained beta1 integrin-mediated adhesion and prevented cellular

205 e shown that collaborative signaling between beta1 integrin-mediated adhesion to fibronectin and inte

206 f CD46 decreased proliferative potential and beta1 integrin-mediated adhesion.

207 rties in the perfused rat liver in an alpha5 beta1 integrin-mediated way.

208 ly understood how niche-derived cues such as beta1-integrin-mediated signaling are translated into NS

209 n essential role for Cas adaptor proteins in beta1-Integrin-mediated signaling events critical for th

210 ncogenic signaling pathways, including EGFR, beta1 integrin, MEK, and AKT, leading to loss of tissue

211 bitors, we define here a MAP4K4-moesin-talin-beta1-integrin molecular pathway that promotes efficient

212 own or treatment with OS2966, a neutralizing beta1 integrin monoclonal antibody, attenuated aggressiv

213 gulating PLD or Rap1A or by treatment with a beta1 integrin neutralizing antibody.

214 hanism of developmental failure in implanted beta1 integrin-null blastocysts and found that primitive

215 segregation phenotype was also reproduced in beta1 integrin-null embryoid bodies, in which primitive

216 Targeting this mechanosensing alpha6(beta1)-integrin offers a novel anti-fibrotic strategy ag

217 requires multimerization and associates with beta1 integrin on the cell surface.

218 he formation of ceramide platforms that trap beta1-integrins on the luminal pole of bronchial epithel

219 g in stimulatory or inhibitory ways with its beta1 integrin or Plexin C1 receptors, respectively.

220 In contrast, in vivo blocking of beta1 integrins or alpha4 integrins did not affect lung

221 ling-adaptor proteins, and in the absence of beta1-Integrin or Cas function retinal neurons form ecto

222 Knockdown of beta1-integrins or inhibition of cellular contractility

223 s integrins, and defects in either alpha3 or beta1 integrin, or the alpha3beta1 ligand laminin result

224 motion and metastasis of tumor cells through beta1 integrin partnering.

225 llectively, these findings implicate a Rap1A/beta1 integrin pathway, activated downstream of G-protei

226 Targeting the COX-2/EP1/PKC/MAPK/E2F-1/FoxC2/beta1-integrin pathway might represent a new therapeutic

227 g an LTbeta receptor/beta1 integrin (LTbetaR/beta1 integrin) pathway on ADSCs.

228 Thus, beta1 integrins promote resistance to antiangiogenic the

229 In cells growing in suspension, beta1-integrin promotes sustained c-Met-dependent ERK1/2

230 er, ZNF304 is a transcriptional regulator of beta1 integrin, promotes cancer cell survival and protec

231 Furthermore, beta4 and beta1 integrin protein and mRNA expression is elevated i

232 g key hydrogen bonds between talin2 N326 and beta1-integrin R760, and between talin2 K327 and beta1-i

233 The binding of Inv to beta1 integrins rapidly induces IL-18 mRNA expression, s

234 agen and lymphangiogenesis via activation of beta1-integrin receptor.

235 id-induced epithelial MV miR-17/221 promoted beta1 integrin recycling and presentation back onto the

236 miR-17/221 that in turn modulates macrophage beta1 integrin recycling, promoting macrophage recruitme

237 ha5beta1-integrin and facilitating effective beta1-integrin recycling back to the plasma membrane.

238 kdown of STXBP4 also substantially inhibited beta1-integrin recycling in human monocytes.

239 ubiquitin-mediated degradation and promoting beta1-integrin recycling.

240 Ablation of beta1-integrin reduced overall levels of BMP receptors b

241 to inefficient localization of the enzyme to beta1-integrin-rich cell adhesion complexes at the plasm

242 B2 and increased association of ErbB2 with a beta1-integrin-rich complex, which depended on GRB7-SH2

243 beta1-integrin(RNAi) animals formed small head blastemas

244 ls and progenitor cells were mislocalized in beta1-integrin(RNAi) animals without significantly alter

245 Therefore, beta1-integrin senses the SC niche to maintain responsiv

246 beta1 integrins signal through the Abl2/Arg (Abl-related

247 Sig1R promoted the formation of hERG/beta1-integrin signaling complexes upon extracellular ma

248 beta1-Integrin signaling within migrating GCL cells requ

249 well as short-hairpin RNA downregulation of beta1 integrin significantly reduced FAK/Akt phosphoryla

250 beta1-integrin silencing suppressed COX-2-mediated tumou

251 ted gene deletion or intravenous delivery of beta1-integrin siRNA formulated into nanoparticles that

252 e marrow stromal cells (BMSC) showed similar beta1 integrin-specific enhancement of PYK2 and STAT3 si

253 probability density plots thus revealed that beta1-integrin-specific interactions are predominately a

254 ly, survival signaling in melanoma cells via beta1-integrin, Src, and FAK.

255 tegrin cytoplasmic tail positively regulates beta1-integrin stability.

256 ancer cell aggressiveness through sequential beta1 integrin stabilization, activation of an ILK/EGFR/

257 inins 211, 411, and receptors containing the beta1 integrin subunit are required for radial sorting;

258 extend beyond those requiring binding to the beta1 integrin subunit NPxY motif.

259 Knocking down DDR2, but not the beta1 integrin subunit, a common subunit for all collage

260 ide or with a monoclonal antibody binding to beta1-integrin subunit and binding assays in different c

261 The expression of SEMA7A and its receptor beta1-integrin subunit increase during liver injury and

262 subunit of KCa1.1 coimmunoprecipitates with beta1 integrins, suggesting that this physical associati

263 oss of AMPK up-regulates tensins, which bind beta1-integrins, supporting their activity and promoting

264 wever, this effect was not due to changes in beta1 integrin surface expression or activation.

265 , which also elicited enhanced beta2 but not beta1 integrin surface expression, suggesting increased

266 Furthermore, expression of SNX31 rescues beta1 integrin surface levels and stability in SNX17-dep

267 reby permitting ICAP-1alpha binding onto the beta1 integrin tail.

268 Similarly like SNX17, binding of SNX31 with beta1 integrin tails in early endosomes occurs between t

269 ly diminished the interaction of talin2 with beta1- integrin tails.

270 ow here that talin2 has a higher affinity to beta1-integrin tails than talin1.

271 rated a significant increase in cell surface beta1 integrin that was accompanied by decreased beta1 i

272 -/-) mice exhibited reduced levels of active beta1 integrin that were responsible for reduced RhoA ac

273 Complexing of beta1 integrin the 70-kDa with CDCP1 fragment induced in

274 h of activating and inhibitory antibodies to beta1 integrins, the conformational states that these an

275 ate that GMFG mediates the ubiquitination of beta1-integrin through knockdown or overexpression of GM

276 xogenously to the cells provoked a change in beta1 integrin to an active, high-affinity conformation

277 Accordingly, we found beta1 integrin to be functionally upregulated in tumor s

278 pecifically the B isoform (alpha6B), couples beta1-integrin to mediate MMP-2-dependent pericellular p

279 nd trafficking-relevant site Thr(788/789) of beta1-integrin to stimulate the PKC- and CaMKII-dependen

280 vitro and in vivo, at least in part through beta1-integrin translocation leading to fibronectin asse

281 f GMFG in monocyte chemotaxis, adhesion, and beta1-integrin turnover.

282 ctivated forms of the BDNF receptor TrkB and beta1-integrins, two synaptic receptors that engage acti

283 Dysregulation of beta1-integrin underlies Kindler syndrome skin fragility

284 We concluded that beta1 integrin upregulation in BRGs likely reflects an o

285 y, but rather by matrix architecture-induced beta1-integrin upregulation.

286 silencing suppressed EP1-mediated FoxC2 and beta1-integrin upregulation.

287 duces membrane recruitment and activation of beta1 integrin via the low density lipoprotein receptor-

288 resulting in differential regulation of the beta1 integrins VLA3 (alpha3beta1) and VLA5 (alpha5beta1

289 Conversely, ectopic expression of beta1 integrin was sufficient to induce Slug expression.

290 ol-I binding molecules, an antibody-blocking beta1-integrin was used.

291 ial adhesins invasin and YadA with host cell beta1 integrin, we compared the sterol dependence of wil

292 COX-2 and beta1-integrin were co-expressed in NSCLC tissues.

293 FlnA loss leads to diminished expression of beta1-integrin, whereas FlnB loss promotes integrin expr

294 ment membrane extracellular matrix (ECM) via beta1 integrins which activate both ILK and Rac1 and are

295 ZNF304 transcriptionally regulates beta1 integrin, which subsequently regulates Src/focal a

296 cultured podocytes induced loss of activated beta1 integrin, which was similarly observed in kidney b

297 rolling the affinity states of two different beta1 integrins, which in turn elicit distinct effector

298 parallel, NR4A1 also regulated expression of beta1-integrin, which with PAX3-FOXO1A, contributed to t

299 dynamics simulations of a 3D model of alpha5 beta1 integrin with TUDC bound revealed significant conf

300 ort the generation of functional recombinant beta1 integrins with traceable tags inserted in an extra