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1 aits via binding to various receptors (e.g., beta2-adrenergic receptor).
2 us positions in purified preparations of the beta2 adrenergic receptor.
3 and the modulation of these channels by the beta2 adrenergic receptor.
4 bserved in Galphas upon binding of Gs to the beta2 adrenergic receptor.
5 ion of both the transferrin receptor and the beta2 adrenergic receptor.
6 prototypical recycling membrane protein, the beta2-adrenergic receptor.
7 lin, and PDE4D (phosphodiesterase 4D) to the beta2-adrenergic receptor.
8 tions of the potential energy surface of the beta2-adrenergic receptor.
9 rnalization of a set of mutants of the human beta2-adrenergic receptor.
10 or the activation of the MAPK pathway by the beta2-adrenergic receptor.
11 ne (Gly/Gly), at aminoacid residue 16 of the beta2-adrenergic receptor.
12 e Arg16Gly and Gln27Glu polymorphisms of the beta2-adrenergic receptor.
13 5 and TM6), similar to that observed for the beta2-adrenergic receptor.
14 to recruit the ubiquitin ligase Nedd4 to the beta2-adrenergic receptor.
15 nophosphate phosphodiesterases to Gs-coupled beta2-adrenergic receptors.
16 bligate for resensitization and recycling of beta2-adrenergic receptors.
17 of terbutaline is mediated by activation of beta2-adrenergic receptors.
21 re prevented by treatment with the selective beta2-adrenergic receptor (ADRB2) antagonist ICI118,551
22 previous study, the Gly16Arg genotype of the beta2-adrenergic receptor (ADRB2) gene did not influence
23 with reduced expression of the gene for the beta2-adrenergic receptor (ADRB2) in CD4(+) lymphocytes
24 mozygous for arginine at aminoacid 16 of the beta2-adrenergic receptor (ADRB2) might not benefit from
28 ell-specific analysis of the function of the beta2 adrenergic receptor (Adrbeta2) and various genes i
29 enotype at the 16th aminoacid residue of the beta2-adrenergic receptor affects the long-term response
30 s alone or in combination with a long-acting beta2 -adrenergic receptor agonist (LABA) on GCM in the
31 dependent stimulation of beating rate by the beta2 adrenergic receptor agonist procaterol was signifi
32 yses revealed that formoterol, a long-acting beta2 adrenergic receptor agonist, caused significant im
33 in the rat cerebral cortex is induced by the beta2-adrenergic receptor agonist clenbuterol (CLE).
36 or treating airway obstructive diseases, and beta2 adrenergic receptor agonists have been the most co
37 nition in Ts65Dn mice, formoterol or similar beta2 adrenergic receptor agonists with ability to cross
39 ing mechanism of Rett syndrome and introduce beta2-adrenergic receptor agonists as potential therapeu
40 empty G-protein binding site of an activated beta2 adrenergic receptor and form salt-bridge interacti
42 gamma receptor, a polymorphism marker in the beta2-adrenergic receptor and a low-inducible allele of
43 ased on the recent crystal structures of the beta2-adrenergic receptor and A2a-adenosine receptor.
44 gion of a constitutively active mutant human beta2-adrenergic receptor and attaching Renilla reniform
45 n of the LCP-Tm assay to an engineered human beta2-adrenergic receptor and bacteriorhodopsin revealed
47 ave found that signaling via the erythrocyte beta2-adrenergic receptor and heterotrimeric guanine nuc
49 ptor b2, whereas two Rhodopsin-family GPCRs, beta2-adrenergic receptor and mCannR2, exhibit colocaliz
52 -binding and transmembrane segments from the beta2-adrenergic receptor and the cytoplasmic domains fr
53 y feature of the EE effect was activation of beta2-adrenergic receptors and downstream cAMP/PKA signa
55 iated activation of RhoA in AEC occurred via beta2-adrenergic receptors and involved Gs-PKA as demons
56 tudies demonstrating disparate regulation of beta2-adrenergic receptors and microRNA between pediatri
57 nd epinephrine, proceeding through the beta1/beta2-adrenergic receptors and protein kinase A, resulti
58 he immunocomplex between a membrane protein, beta2 adrenergic receptor, and anti-FLAG antibody has be
59 ing the crystal structures of rhodopsin, the beta2-adrenergic receptor, and the ligand-free opsin, wh
60 ippocampal LTP, decreased neuronal levels of beta2-adrenergic receptors, and activated microglia in w
61 ), cecal peritonitis with dopexamine and the beta2-adrenergic receptor antagonist ICI 118,551 (n = 4)
64 were subjected to the nonselective (beta1 + beta2) adrenergic receptor antagonists propranolol or na
67 er kidney cells, the human beta1-but not the beta2-adrenergic receptor (AR) is totally resistant to a
68 yocardial contractile response to beta1- and beta2-adrenergic receptor (AR) stimulation is severely i
70 the angiotensin II type 1A receptor (AT1R), beta2-adrenergic receptor (AR), and alpha2B-AR in HEK293
71 s (BF) and heavy/non-buoyant fractions (HF); beta2-adrenergic receptors (AR) in BF; and AC5/6, beta1-
73 owever, in contrast to the activation of the beta2-adrenergic receptor, arrestin was not necessary fo
75 estin-3 and its 3A mutant that readily binds beta2-adrenergic receptors as well as two mutants impair
77 inine at the 16th amino acid position of the beta2-adrenergic receptor (B16 Arg/Arg) benefit less fro
78 tudies showed that epinephrine activates the beta2-adrenergic receptor (B2AR), impairing keratinocyte
79 The luteinizing hormone receptor (LHR) and beta2-adrenergic receptor (B2AR), two GPCRs sorted to th
82 n the tumor microenvironment is regulated by beta2-adrenergic receptor (beta-AR) signaling in host im
83 ompartmentalize cAMP signaling transduced by beta2-adrenergic receptors (beta(2)ARs); such compartmen
85 study, we report that mice with no beta1- or beta2-adrenergic receptors (beta1AR-/-/beta2AR-/-) have
87 nificant elevation of phosphorylation of the beta2 -adrenergic receptor (beta2 AR) at both the protei
90 cAMP stimulated by two Gs-coupled receptors, beta2-adrenergic receptor (beta2-AR) and D1 dopamine rec
93 publication of the crystal structure of the beta2-adrenergic receptor (beta2-AR) proved that G prote
94 ll phenotypic pharmacology of ligands at the beta2-adrenergic receptor (beta2-AR) stably expressed in
96 endent activation and internalization of the beta2-adrenergic receptor (beta2-AR), a prototypic G-pro
97 eport here that following stimulation of the beta2-adrenergic receptor (beta2-AR), a prototypical 7TM
98 phosphorylated form of the G protein-coupled beta2-adrenergic receptor (beta2-AR), have recently emer
99 pendent phosphate cotransporter (Npt2a), and beta2-adrenergic receptor (beta2-AR), through their resp
100 ribute to selective interactions between the beta2-adrenergic receptor (beta2-AR)-Galphas and V1A rec
101 itide 3-kinase (PI3K) has been implicated in beta2-adrenergic receptor (beta2-AR)/G(i)-mediated compa
103 o the plasma membrane upon coexpression with beta2-adrenergic receptors (beta2-ARs) through an intera
105 ssing the stimulatory G protein fused to the beta2 adrenergic receptor (beta2AR) and AC were incubate
106 ism of their activation process, as only the beta2 adrenergic receptor (beta2AR) and rhodopsin have b
107 Here we show that the rapidly recycling beta2 adrenergic receptor (beta2AR) binds via a determin
109 carboxyl-terminal cytoplasmic domain of the beta2 adrenergic receptor (beta2AR) mediates both PDZ bi
111 helix 6 (Cys-265), (19)F NMR spectra of the beta2 adrenergic receptor (beta2AR) reconstituted in mal
112 (Cmpd-15) is an allosteric modulator of the beta2 adrenergic receptor (beta2AR) that was recently is
114 fer imaging, we examine TM6 movements in the beta2 adrenergic receptor (beta2AR) upon exposure to ort
115 we reconsider oligomerization of the class A beta2 adrenergic receptor (beta2AR), and reevaluate BRET
116 adenosine 2B receptor (A2BR), but not of the beta2 adrenergic receptor (beta2AR), leading to an enhan
117 ing the membrane-proximal amino acids of the beta2 adrenergic receptor (beta2AR), the sphingosine 1-p
118 uestion by comparing human Wntless (Wls) and beta2 adrenergic receptor (beta2AR), which require retro
120 ral data on a number of GPCRs, including the beta2 adrenergic receptor (beta2AR)-G-protein complex, h
122 re we show in atomistic detail how the human beta2-adrenergic receptor (beta2AR) - a prototypical G p
125 cle hypertrophy stimulated by clenbuterol, a beta2-adrenergic receptor (beta2AR) agonist, was signifi
127 l and small clinical studies have shown that beta2-adrenergic receptor (beta2AR) agonists enhance AFC
129 he model G-protein-coupled receptors (GPCRs) beta2-adrenergic receptor (beta2AR) and Mu-opioid recept
130 y we predicted the 3D structure of the human beta2-adrenergic receptor (beta2AR) and of the binding s
132 -binding and transmembrane segments from the beta2-adrenergic receptor (beta2AR) and the cytoplasmic
133 observed for agonist-bound structures of the beta2-adrenergic receptor (beta2AR) and the M2 muscarini
136 ous for arginine (ArgArg) at codon 16 of the beta2-adrenergic receptor (beta2AR) have been shown to h
137 participating in the phosphorylation of the beta2-adrenergic receptor (beta2AR) have in part been li
138 r (CB1-Gi), guided by the x-ray structure of beta2-adrenergic receptor (beta2AR) in complex with Gs (
139 noprecipitated with overexpressed TPbeta and beta2-adrenergic receptor (beta2AR) in HEK 293 cells, bu
140 rine network exists in skin, but the role of beta2-adrenergic receptor (beta2AR) in wound healing is
143 Agonist-stimulated desensitization of the beta2-adrenergic receptor (beta2AR) is caused by both a
145 release of catecholamines, which engage the beta2-adrenergic receptor (beta2AR) on murine alveolar m
146 rine models of asthma, agonist-activation of beta2-adrenergic receptor (beta2AR) or Protease-activate
149 y determined crystal structures of the human beta2-adrenergic receptor (beta2AR) provide a long-await
152 lphas-CFP, YFP-N-beta1/YFP-C-gamma7, and the beta2-adrenergic receptor (beta2AR) resulted in internal
153 -coupled receptor kinases (GRKs) desensitize beta2-adrenergic receptor (beta2AR) signaling, and these
154 by a B cell is increased following CD86 and beta2-adrenergic receptor (beta2AR) stimulation, through
156 al dynamics of the cytoplasmic domain of the beta2-adrenergic receptor (beta2AR) using (19)F-fluorine
157 (GRK) site phosphoserines 355 and 356 of the beta2-adrenergic receptor (beta2AR) were characterized i
158 ort the requirement of an association of the beta2-adrenergic receptor (beta2AR) with the pore formin
159 we demonstrate that a prototypical GPCR, the beta2-adrenergic receptor (beta2AR), can be incorporated
160 specific Cy3 fluorescence probe in the human beta2-adrenergic receptor (beta2AR), we observed that in
161 this study, we describe for the first time a beta2-adrenergic receptor (beta2AR)-activating monoclona
168 in three different conformational states of beta2-adrenergic receptor (beta2AR): 1), the inverse-ago
169 hma, the response to beta-agonists acting at beta2-adrenergic receptors (beta2AR) displays extensive
171 We report here that a population of human beta2-adrenergic receptors (beta2AR), a canonical G prot
173 We previously demonstrated the importance of beta2-adrenergic receptors (beta2ARs) in the regulation
176 ficant population of Galphai and its coupled beta2-adrenergic receptor (betaAR), are localized to cav
178 through adrenergic receptors (ARs), of which beta2-adrenergic receptors (betaARs) are of particular i
186 -regulating genes (those encoding beta1- and beta2-adrenergic receptors, calcium ATPase in the sarcop
188 cent high resolution x-ray structures of the beta2-adrenergic receptor confirmed a close salt-bridge
189 We found that in Src-deficient cells the beta2-adrenergic receptor could activate the MAPK pathwa
190 hosphorylation of the Tyr-350 residue of the beta2-adrenergic receptor creates a conditional, canonic
191 receptor (DOR) molecular model based on the beta2-adrenergic receptor crystal structure are explored
192 this study we have defined a sequence in the beta2-adrenergic receptor cytoplasmic tail that confers
194 nase A-dependent manner, an effect lost when beta2-adrenergic receptor-deficient B cells were used.
195 is of the delta-opioid receptor, but not the beta2-adrenergic receptor, defining a role for CLCs in t
197 Importantly, phosphorylation of the inactive beta2-adrenergic receptor enhanced its interactions with
199 We used this microfluidic device to quantify beta2 adrenergic receptors expressed in insect cells (SF
202 implicated in the switching of signaling of beta2-adrenergic receptors from adenylylcyclase coupling
203 orters; and 2), rhodopsin and the beta1- and beta2-adrenergic receptors from the G-protein coupled re
204 , variation in haplotype frequencies for the beta2 adrenergic receptor gene was found to be associate
207 s important in understanding the function of beta2-adrenergic receptor gene (ADRbeta2) on disease sus
208 6 to 6.09; P=0.001; FDR, P=0.036) and a Q27E beta2-adrenergic receptor gene polymorphism (OR, 1.40; 9
210 Pase exocytosis in AEC via the activation of beta2-adrenergic receptor, Gs, PKA, Gi, RhoA, and ROCK.
211 ealed an architecture similar to that of the beta2-adrenergic receptor-GS complex, including a flexib
215 tic polymorphisms at codons 16 and 27 of the beta2-adrenergic receptor have been associated with alte
216 active and active experimental structures of beta2 adrenergic receptor (hbeta2AR) and M2 muscarinic a
218 ere consistent with the crystal structure of beta2 adrenergic receptor in complex with Gs Conformatio
219 a molecule that is rapidly recruited to the beta2-adrenergic receptor in a beta-arrestin1-dependent
220 s simulations to explore dimerization of the beta2-adrenergic receptor in lipid bilayers containing c
222 th processes by recruiting PDEs to activated beta2-adrenergic receptors in the plasma membrane of mam
223 sing a model G protein-coupled receptor, the beta2-adrenergic receptor, including experiments that ch
225 and beta-arrestin 2 play essential roles in beta2-adrenergic receptor internalization, they are not
230 the prototypical G protein-coupled receptor beta2-adrenergic receptor is partially preassociated in
231 Although the location of carazolol in the beta2-adrenergic receptor is very similar to that of ret
232 of endothelial Adrb2, the gene encoding the beta2-adrenergic receptor, leads to inhibition of angiog
233 found that downregulation of Rnd3 attenuated beta2-adrenergic receptor lysosomal targeting and ubiqui
234 ous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-act
235 a critical role for C/EBPdelta in regulating beta2-adrenergic receptor-mediated NGF expression in viv
236 of hippocampal synaptic plasticity including beta2-adrenergic receptor-mediated plasticity, and selec
238 of CD86 (formerly known as B7-2) and/or the beta2-adrenergic receptor on a CD40 ligand/interleukin-4
239 e effects of two common polymorphisms of the beta2-adrenergic receptor, one at codon 16 and one at co
241 meric receptor composed of rhodopsin and the beta2-adrenergic receptor (Opto-beta2AR) with in vivo op
243 evealed that recruitment of arrestin3 to the beta2-adrenergic receptor orchestrates the sequestration
244 tural analysis of two other GPCRs, beta1 and beta2 adrenergic receptors, our results could reveal a g
245 act ventricular myocytes via both beta1- and beta2-adrenergic receptor pathways, but the beta2-depend
246 ch is associated with significant changes in beta2 -adrenergic receptor phosphorylation at protein ki
250 anglionectomy or pharmacological blockade of beta2-adrenergic receptors prevents NPPE release into th
252 , which in turn resulted in the elevation of beta2-adrenergic receptor protein levels leading to the
253 ent high-resolution crystal structure of the beta2-adrenergic receptor revealed the presence of possi
254 the signaling profiles of 28 variants of the beta2-adrenergic receptor reveals three clearly distinct
255 tes is able to normalize the distribution of beta2 adrenergic receptor signal by preventing PKA signa
256 n the myofilaments is because of an enhanced beta2 adrenergic receptor signal selectively directed to
257 We further demonstrate that the endosomal beta2-adrenergic receptor signal confers uniformity on t
258 ntroduction of caveolin-3 is able to confine beta2 adrenergic receptor signaling and restore myocyte
259 rophic rabbit myocytes, selectively enhanced beta2 adrenergic receptor signaling toward the myofilame
260 pool of PKA that regulates learning-induced beta2-adrenergic receptor signaling and ERK activation i
261 rosine kinases to examine the role of Src in beta2-adrenergic receptor signaling to the MAPK pathway
262 receptor internalization is not required for beta2-adrenergic receptor signaling to the MAPK pathway
263 h high-fat diet (HFD) feeding on the cardiac beta2 -adrenergic receptor signalling and the impacts on
265 is effect, we determined whether CD86 and/or beta2-adrenergic receptor stimulation regulated transcri
266 C- and NF-kappaB1-dependent manner, and that beta2-adrenergic receptor stimulation up-regulates the e
267 haracterized a homogeneous population of the beta2 adrenergic receptor subtype expressed on these cel
268 We report the crystal structure of a human beta2-adrenergic receptor-T4 lysozyme fusion protein bou
269 -AR chimera containing the type I PDZ of the beta2-adrenergic receptor that does not bind to SAP97 fa
270 enhanced affinity for the agonist-activated beta2-adrenergic receptor that traffics into endocytic v
271 GE(2) by > 50%; (ii) had no effect on EP4 or beta2 adrenergic receptors, the cAMP assay itself, or th
272 eral G protein-coupled receptors such as the beta2-adrenergic receptor, the kappa-opioid receptor, an
275 eceptors at the plasma membrane, such as the beta2 adrenergic receptor, they remain associated with o
276 ine Ca2+ influx, and can be modulated by the beta2 adrenergic receptor through PKA in a highly compar
277 of ligands and investigated their impacts on beta2-adrenergic receptor through a total of 12 x 100 ns
279 thereby explaining failure of the wild type beta2-adrenergic receptor to recycle efficiently by defa
280 ol-sensitive AFC in mice with beta1- but not beta2-adrenergic receptors to beta1AR-/-/beta2AR-/- mice
282 by a mechanism that attenuates Rnd3-mediated beta2-adrenergic receptor ubiquitination, which leads to
283 ity to map the oligomerization energy of the beta2-adrenergic receptor using approximately 10(9)-fold
285 n beta-arrestin 2 the internalization of the beta2-adrenergic receptor was impaired, whereas the acti
289 g data for a set of small molecules with the beta2 adrenergic receptor, we demonstrate that deconvolu
290 Starting from the crystal structure of the beta2-adrenergic receptor, we have used coarse grain com
291 for homomers of the cognate human beta1- and beta2-adrenergic receptors, we have carried out approxim
292 rged amino acids in the proximal tail of the beta2-adrenergic receptor were also important for GRK-de
293 edema formation in sepsis by stimulation of beta2-adrenergic receptors, whereas the alpha1 adrenocep
294 l of ERK2 more efficiently than alpha 1b and beta2 adrenergic receptors, which form transient recepto
297 racellular and transmembrane portions of the beta2-adrenergic receptor with cytoplasmic domains of Rf
299 was inhibited by blockade of the beta1- and beta2-adrenergic receptors with propranolol, and by bloc
300 eviously to be required for recycling of the beta2 adrenergic receptor yet is functionally interchang
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