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1 f the angiotensin II type 1 receptor and the beta2 adrenoceptor.
2 ting G protein-coupled receptors such as the beta2-adrenoceptor.
3 wn and does not occur in the closely related beta2-adrenoceptor.
4 used beta-blockers are agonists at the human beta2-adrenoceptor.
5 than that in cells expressing the wild-type beta2-adrenoceptor.
6 beta1-adrenoceptors and unlike those seen at beta2-adrenoceptors.
7 heir ability to internalize GFP-tagged human beta2-adrenoceptors.
8 (log KD -8.95) and is very selective for the beta2-adrenoceptor (1000-fold selectivity over the beta1
9 obodies) to directly probe activation of the beta2-adrenoceptor, a prototypical GPCR, and its cognate
14 who will inevitably be taking a long-acting beta2-adrenoceptor agonist (LABA)/ICS combination therap
17 odimer combinations (with the Y4 receptor or beta2-adrenoceptor), agonist and antagonist pharmacology
19 series of novel, potent, and selective human beta2 adrenoceptor agonists incorporating a sulfone moie
20 can be significantly enhanced by long-acting beta2-adrenoceptor agonists (LABAs) and may contribute t
21 opamine were as potent as several well-known beta2-adrenoceptor agonists (salbutamol, procaterol, and
22 ding kinetics of several clinically relevant beta2-adrenoceptor agonists and antagonists and demonstr
23 h drugs that are currently available such as beta2-adrenoceptor agonists and corticosteroids, it take
24 ent COPD therapy involving anticholinergics, beta2-adrenoceptor agonists and/or corticosteroids, do n
25 buterol has been one of the most widely used beta2-adrenoceptor agonists for the relief of the sympto
27 clic catecholamine surrogates present in the beta2-adrenoceptor agonists procaterol and BI-167107 (4)
28 tivation is attenuated following exposure to beta2-adrenoceptor agonists such as salbutamol, an effec
31 r, was discovered much later than beta1- and beta2-adrenoceptors and exhibits unique properties which
32 lbutamol or by the addition of the selective beta2-adrenoceptor antagonist and inverse agonist ICI 11
34 t and that the administration of the beta1-, beta2-adrenoceptor antagonist propranolol decreases card
35 IBa was reversed by ICI-118,551, a specific beta2-adrenoceptor antagonist, but not by CGP 20712A, a
37 n at least two active conformations, whereas beta2-adrenoceptors are able to induce signaling via dif
38 umulation and CRE gene transcription via the beta2-adrenoceptor at concentrations at which protein ki
43 of receptors and is implicated in switching beta2 adrenoceptor (beta2AR) G protein specificity in ca
45 lation sites into the C-terminal tail of the beta2-adrenoceptor (beta2AR) and demonstrate that this m
46 tion of high-affinity agonist binding at the beta2-adrenoceptor (beta2AR) expressed in Sf9 insect cel
49 that Vps34 is required for recycling of the beta2-adrenoceptor (beta2AR), a prototypical GPCR, and t
50 ists such as adrenaline, which activates the beta2-adrenoceptor (beta2AR), bind with relatively low a
51 ynamics simulations of lipid-embedded active beta2-adrenoceptor (beta2AR*) in complex with C-terminal
53 Labetalol, a combined alpha1, beta1, and beta2 adrenoceptor-blocking drug, has been shown to have
55 l signaling and highlight the ability of the beta2-adrenoceptor/cAMP/PKA axis to rewire EphA2 signali
58 is currently thought that activation of the beta2-adrenoceptor causes c-AMP dependent activation of
59 cyclase activity in cells expressing the CAM beta2-adrenoceptor correlated well with the level of exp
61 s was not observed after exposure of the CAM beta2-adrenoceptor-expressing cells to alprenolol, and a
62 embrane (TM) regions of the human beta1- and beta2-adrenoceptors, followed by single point mutations,
63 In contrast, arrestin-3 interaction with a beta2-adrenoceptor fused to the carboxyl-terminal tail o
64 Functionally relevant polymorphisms of the beta2-adrenoceptor gene (ADRB2) are common in white popu
65 tution at the 16 position (rs1042713) in the beta2-adrenoceptor gene (ADRB2) is associated with enhan
67 f C57BL/6J mice, pharmacologic activation of beta2 adrenoceptors improved the severity of shock, incl
70 e potent compounds able to increase cAMP via beta2-adrenoceptors in U937 cells, and may have potentia
72 report evidence that agonist binding to the beta2 adrenoceptor induces a conformational change aroun
73 n of these amino acids to those found in the beta2-adrenoceptor (L195Q and W199Y), or mutation of a s
75 ionship between structural properties of the beta2-adrenoceptor ligands and their interactions with m
76 orepinephrine, which then act on presynaptic beta2-adrenoceptors located on the neighboring nitrergic
80 t both systems converge in the activation of beta2-adrenoceptors of splenic regulatory lymphocytes to
81 ects via their binding to the active site of beta2-adrenoceptors on ASM, which triggers a signaling c
82 to express stably either the wild-type human beta2-adrenoceptor or a constitutively active mutant (CA
83 not demonstrate up-regulation of either CAM beta2-adrenoceptor or G(Salpha) mRNA, and up-regulation
84 O had no effect on signaling and function of beta2-adrenoceptor or numerous procontractile GPCRs, but
85 ptors, reduced homologous desensitization of beta2-adrenoceptors) or AMP-independent mechanisms (e.g.
86 sion levels of both beta-adrenoceptors, with beta2-adrenoceptors outnumbering beta1-adrenoceptors in
88 AMP-dependent (e.g., increased expression of beta2-adrenoceptors, reduced homologous desensitization
90 determine the exact amino acids in the human beta2-adrenoceptor responsible for this very high select
91 e protein LMBRD2 as a potential regulator of beta2 adrenoceptor signaling, underscoring the value of
93 timulation mediated via canonical beta1- and beta2-adrenoceptor signaling pathways; and (5) evidence
95 ransregulation of M2 muscarinic receptors by beta2-adrenoceptor stimulation can be demonstrated at th
98 y engineering phosphorylation sites into the beta2-adrenoceptor the receptor showed prolonged interac
99 y agonists induce a chemical modification in beta2-adrenoceptors (via phosphorylation) that reduces a
100 Betaxolol-mediated up-regulation of the CAM beta2-adrenoceptor was both time and concentration depen
103 Pretreatment of cells harboring the CAM beta2-adrenoceptor with betaxolol resulted in a large (4
104 growth factor receptor (EGFR) with EGF, the beta2-adrenoceptor with dopamine, or the hepatocyte grow
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