ライフサイエンスコーパス: beta2 integrin

1 d block LTB(4)-regulated adhesion molecules (beta2 integrins).

2 not abolished by the TTT/AAA mutation in the beta2 integrin.

3 ndent upon intracellular calcium, and on the beta2 integrin.

4 alphavbeta3 integrin, and leukocyte CD44 and beta2 integrin.

5 ein regulating PMN trafficking downstream of beta2 integrins.

6 ndent post-translational regulation of beta1/beta2 integrins.

7 ating on surfaces that cross-linked cellular beta2 integrins.

8 g through selectins to firm adhesion through beta2 integrins.

9 ating neutrophils displayed normal levels of beta2 integrins.

10 fting usage away from beta1 integrins toward beta2 integrins.

11 of beta1 and beta3 subfamilies, but not with beta2 integrins.

12 despite the normal display of high-affinity beta2 integrins.

13 ectin and expression of membrane-bound beta1/beta2-integrins.

14 operation between selectins, G-proteins, and beta2-integrins.

15 pression of ICAM-1, the ligand for leukocyte beta2-integrins.

16 CXCR2 functions, including the activation of beta2-integrins.

17 adhesion, and an antibody against CD18 (the beta2 integrin) abolished adhesion.

18 However, the role of Skap2 in beta2 integrin activation and neutrophil recruitment is

19 smic domain, thereby being indispensable for beta2 integrin activation and neutrophil recruitment.

20 RIAM deficiency results in a loss of beta2 integrin activation in multiple leukocyte populati

21 ated, Rap1-GTPase-dependent pathway of rapid beta2 integrin activation in neutrophils.

22 lls exhibited a striking defect in beta1 and beta2 integrin activation in response to Mn(2+) or Mg(2+

23 unteracted selectin- and chemokine-triggered beta2 integrin activation on PMNs by activating protein

24 seven mAb epitopes that are associated with beta2 integrin activation, suggesting that it exhibited

25 tivated PTPRG blocks chemoattractant-induced beta2 integrin activation.

26 its in patients with pDGS by disrupting both beta2-integrin activation and activating receptor accumu

27 a novel Rap1 effector, regulates beta1- and beta2-integrin activation and controls neutrophil chemot

28 inhibitory effect of GDF-15 on CXCL1-induced beta2-integrin activation and neutrophil diapedesis.

29 Rapid beta2-integrin activation is indispensable for leukocyte

30 nitial pathogen recognition by TLRs to rapid beta2-integrin activation may critically regulate acute

31 l causes severe inhibition of cell adhesion, beta2-integrin activation, and chemotaxis.

32 the integrin, whether P-selectin can trigger beta2-integrin activation, remains controversial.

33 hil adhesion and motility by linking Rap1 to beta2-integrin activation.

34 ulatory input of PI3K into the regulation of beta2 integrin activity, and processes dependent on this

35 By modulating beta2 integrin activity, ARAP3 guards neutrophils in the

36 lood) and mouse lung ILC2s express beta1 and beta2 integrin adhesion molecules and whether these inte

37 assessed for surface expression of beta1 and beta2 integrin adhesion molecules by using flow cytometr

38 ion explored the mechanism for inhibition of beta2 integrin adhesion molecules when neutrophils are e

39 noclonal antibody to the CD18 subunit of the beta2 integrin adhesion receptors (rhuMAb CD18), in redu

40 lung ILC2s express high levels of beta1 and beta2 integrin adhesion receptors.

41 hils, we show that FlnA negatively regulates beta2 integrin adhesion to complement component iC3b and

42 DAP expression yet show defects in beta1 and beta2 integrin adhesion, leukocyte function-associated a

43 between ITGAM and SLE implicates the alpha(M)beta2-integrin adhesion pathway in disease development.

44 5b rescues the expression of activated beta1/beta2-integrins, adhesion and bone marrow homing of Klf5

45 ars that P. gingivalis proactively modulates beta2 integrin adhesive activity for intracellular uptak

46 d in vitro and in vivo, exhibiting increased beta2 integrin affinity and avidity.

47 TLR2 and TLR5 ligation increased beta2-integrin affinity, as assessed by the detection of

48 lpha(4)beta(1), low levels of beta7, and the beta2-integrins alphaLbeta2 and alphaMbeta2.

49 ein-coupled receptor-dependent activation of beta2 integrins and binding to endothelial ICAM-1.

50 In cis interactions between Jurkat T-cell beta2 integrins and CD47 were detected by fluorescence l

51 tion of type I IFN signaling by ITAM-coupled beta2 integrins and demonstrate that ITAM signaling qual

52 w that high-avidity ligation of ITAM-coupled beta2 integrins and FcgammaRs in macrophages inhibited t

53 Preligation of ITAM-coupled beta2 integrins and FcgammaRs inhibited proximal signali

54 s suggest that the relative contributions of beta2 integrins and ICAM-3 to neutrophil adhesion is reg

55 esults demonstrate that CD47 associates with beta2 integrins and is necessary to induce high-affinity

56 moattractant-induced activation of beta1 and beta2 integrins and of chemotaxis is defective in mononu

57 m at least two other pathways acting through beta2 integrins and protein kinase Cepsilon.

58 CD177 associates with beta2 integrins and recognizes platelet endothelial cell

59 ukocyte (PMN) adhesion via downregulation of beta2-integrins and decreases the efficiency of PMN in t

60 we show that loss of the interaction between beta2-integrins and kindlin-3 abolishes the actin-linkag

61 Plastic adhesion, activation of beta2 integrins, and incubation with tumor necrosis fact

62 Thus, Skap2 is essential to activate the beta2 integrins, and loss of Skap2 function is sufficien

63 ls were attenuated by blocking antibodies to beta2 integrins, and the caspase-3 cleavage was attenuat

64 rest of rolling leukocytes is very rare when beta2 integrins are absent or blocked by a mAb.

65 beta2 integrins are critically important for leukocyte e

66 Beta2 integrins are leukocyte-specific membrane receptor

67 Confocal microscopic analysis revealed that beta2 integrins are present on monocytes after initial a

68 CD177 ligation enhanced its interaction with beta2 integrins, as revealed by fluorescence lifetime im

69 n of vimentin, alpha-smooth muscle actin and beta2-integrin, as well as the production of abundant ex

70 egulation of alphav/beta3, alphav/beta5, and beta2 integrins, associated with increased cortactin exp

71 d key signaling molecules, and activation of beta2-integrin at the IS.

72 adhesion deficiency-1 (LAD-I) do not express beta2 integrins because of mutations in the gene specify

73 t that the cooperativity of alpha4beta1 with beta2 integrins becomes evident when they are concurrent

74 E(-)H(+) beta2 integrins bind intercellular adhesion molecules (I

75 sing IL-8 production and interrupting ICAM-1-beta2 integrin binding of melanoma cells to the endothel

76 beta2 integrin binding to an ICAM provided an essential

77 cted for adhesive function, we find that the beta2 integrin bonds activated in Mn2+ or Mg2+ possess s

78 4- or fMLP-stimulated expression of beta1 or beta2 integrins, but did exert a small inhibitory effect

79 products induce the functional activation of beta2 integrins, but the signaling events that link memb

80 de, we identified colocalization of Ly6G and beta2-integrins by confocal microscopy and confirmed clo

81 Mutation of the kindlin-3 binding site in beta2 integrins caused a loss of firm adhesion of T cell

82 The beta2 integrins (CD11/CD18) are heterodimeric leukocyte

83 of acute inflammation critically depends on beta2 integrins (CD11/CD18).

84 itutive endothelial cell surface ICAM-1, the beta2-integrin (CD11/CD18) counter-receptor.

85 Although the beta2 integrin CD11a plays an important role in the migr

86 ly identified as a cis-acting ligand for the beta2 integrin CD11b/CD18 (Mac-1).

87 The beta2 integrin CD11b/CD18 is an integral membrane protei

88 ling from Toll-like receptor 2 (TLR2) to the beta2 integrin CD11b/CD18, leading to the induction of t

89 for LPS uptake are CD14, TLR4, MD2, and the beta2-integrin CD11b/CD18.

90 on of CD11b, the alpha subunit of the alphaM/beta2 integrin (CD11b/CD18), macrophage-1 antigen, or co

91 immobilization was mediated by the activated beta2 integrin (CD11b/CD18).

92 stitutively and physically associated with a beta2 integrin, CD11b, and cross-linking of CD66b induce

93 uitment that was reversed by blockade of the beta2 integrin, CD11b.

94 population that constitutively expresses the beta2 integrin CD11c and displays a biased central memor

95 rmal expression of the gene that encodes the beta2 integrin CD11c.

96 is characterized by absent or dysfunctional beta2 integrin (CD18), leading to defective chemotaxis,

97 eficient in the alphaE integrin (CD103), the beta2 integrin (CD18), or the recombination activating g

98 Using mice deficient in all beta2 integrins (CD18 null mice), we demonstrate that ex

99 Although leukocyte beta2 integrins (CD18) play a critical role, significant

100 In vivo blocking of beta2 integrins (CD18) significantly reduced ILC2 number

101 immunodeficiency caused by mutations in the beta2 integrin, CD18, that impair CD11/CD18 heterodimer

102 mice expressing reduced levels of the common beta2 integrin chain develop aggravated Lyme carditis, c

103 Blocking CD11b or CD18 beta2 integrin chains, or using neutrophils from CD11b g

104 Mac-1 (CD11b/CD18) is a beta2 integrin classically regarded as a pro-inflammator

105 Moreover, CD37 ablation did not affect beta2 integrin clustering.

106 Neutrophil recruitment, mediated by beta2 integrins, combats pyogenic infections but also pl

107 s in response to C. albicans mediated by the beta2 integrin, complement receptor 3 (CR3, CD11b/CD18,

108 monocytes, resulting in monocytic beta1- and beta2-integrin conformational change toward an extended,

109 lity, resulting from augmented exocytosis of beta2 integrin-containing granules.

110 Here, we show that the TTT motif in beta2 integrins controls kindlin-3 binding.

111 he data provide a novel example of beta1 and beta2 integrin crosstalk in stem/progenitor cell mobiliz

112 feron-gamma-inducible protein-10, beta1- and beta2-integrins, cyclooxygenase-2 (COX-2), monocyte chem

113 and binding of talin-1 and kindlin-3 to the beta2 integrin cytoplasmic domain, thereby being indispe

114 Combined beta2 integrin deficiency and alpha4 integrin blockade a

115 Overall, our results indicate that beta2 integrin deficiency does not abrogate B. burgdorfe

116 the leukocyte recruitment defect observed in beta2 integrin-deficient (CD18(-/-)) mice, Hck(-/-)Fgr(-

117 Correspondingly, migration of beta2-integrin-deficient neutrophils was no longer inhib

118 ll-cell contact-dependent signaling involved beta2 integrins, dendritic cell-specific ICAM-3-grabbing

119 and c-Jun N-terminal kinase 1 that was also beta2-integrin dependent; pharmacologic inhibition of th

120 However, its role in the regulation of beta2 integrin-dependent adhesion, as well as in other c

121 onsistent with a reduced capacity to undergo beta2 integrin-dependent adhesion.

122 asts from the subject demonstrated deficient beta2 integrin-dependent adhesive function similar to th

123 ular stores to the venular surface triggered beta2 integrin-dependent arrest of neutrophils rolling o

124 Thus, FlnA is a negative regulator of beta2 integrin-dependent cell adhesion and reactive oxyg

125 that Vav proteins are required for multiple beta2 integrin-dependent functions, including sustained

126 We conclude that CD177 signals in a beta2 integrin-dependent manner to orchestrate a set of

127 neutrophils to the pulmonary parenchyma by a beta2 integrin-dependent mechanism.

128 In this review, the beta2 integrin-dependent mechanisms that modulate the de

129 regulation of beta2 integrin-independent and beta2 integrin-dependent migration, respectively, reveal

130 We tested the hypothesis that close, beta2 integrin-dependent neutrophil-EC contact mediates

131 or of neutrophil recruitment to the lung and beta2 integrin-dependent signaling.

132 flammation and many neutrophil functions are beta2 integrin-dependent.

133 ough a novel pathway involving regulation of beta2-integrin-dependent adhesion, NADPH oxidase, and a

134 ding that Siglec-8 engagement promotes rapid beta2-integrin-dependent eosinophil adhesion.

135 hil migration to sites of inflammation via a beta2-integrin-dependent mechanism.

136 shown to function as a negative regulator of beta2-integrin-dependent neutrophil recruitment to the l

137 ties by interacting with ICAM-1 and blocking beta2-integrin-dependent neutrophil recruitment.

138 le blocking mAb to the alpha subunits of the beta2 integrins each partially blocked the O2- response.

139 h face cumulative stimulations by TNF-alpha, beta2-integrin engagement, C5a, and ANCA by the FcgammaR

140 okine receptor (CCR2) and adhesion receptor (beta2 integrin) engagement leads to an interaction betwe

141 CD11c/CD18, a beta2 integrin expressed on human monocytes and a subset

142 We hypothesized that beta2 integrins, expressed on leukocytes, might play a p

143 adoptive transfer and early accumulation of beta2 integrin-expressing CD4+ T cells in the gastrointe

144 D177-driven cell activation enhanced surface beta2 integrin expression and affinity, impaired interna

145 s demonstrate that hypoxia induces leukocyte beta2 integrin expression and function by transcriptiona

146 psoriasiform dermatitis due to reduced CD18/beta2 integrin expression to 2-16% of wild-type levels,

147 ptosis and (iii) the HIF-mediated regulation beta2 integrin expression.

148 nal upregulation of integrin signaling, with beta2-integrin expression being modulated by NOTCH1 muta

149 f5(Delta/Delta) mice, and reduced beta1- and beta2-integrin expression on hematopoietic progenitors s

150 teractions induce a conformational change in beta2 integrins, facilitating leukocyte adhesion.

151 These genes encode the alpha subunits of the beta2 integrin family of leukocyte adhesion receptors.

152 Mac-1 (CD18/CD11b) is a member of the beta2-integrin family of adhesion molecules and is impli

153 naling involves specific phosphorylations of beta2 integrin followed by interactions with cytoplasmic

154 tion: a first signal that also activates PMN beta2 integrins, followed by a second, beta2 integrin-me

155 leukocytes are thought to arrest by engaging beta2 integrins following cellular activation.

156 very low doses of cytochalasin D disconnect beta2-integrins from their cytoskeletal links, allowing

157 a role for Cav1 in membrane organization and beta2 integrin function in primary CD8 T cells.

158 These results suggest that impaired beta2 integrin function in WASp-deficient PMNs may contr

159 Beta1 and beta2 integrin function on leukocytes is crucial for a s

160 against the possibility that CD37 regulates beta2 integrin function via a direct molecular interacti

161 a second exposure is required for increased beta2 integrin function, intravascular neutrophil aggreg

162 ed alpha4 integrin function while increasing beta2 integrin function.

163 plate flow chamber to define the dynamics of beta2-integrin function during recruitment and transmigr

164 Our data suggest that strategies to target beta2 integrin have clinical potential to alleviate or p

165 Selectins and beta2 integrins have been implicated in the multistep pr

166 Although beta2 integrins have been shown to mediate neutrophil tr

167 lular adhesion, in particular the CD11b/CD18 beta2 integrin heterodimer complement receptor type 3/Ma

168 he subunit common to all four known types of beta2 integrin heterodimer.

169 ack of CD18 results in the deficiency of all beta2 integrins, i.e., CD11a/CD18 (LFA-1), CD11b/CD18 (M

170 The beta2-integrin-ICAM-1 interaction alone was not sufficie

171 IL12b-/-Itgb2-/- mice, lacking beta2-integrins, IL-12, and IL-23 showed significantly b

172 irect assay for the off-rates of ICAM-1 from beta2 integrin in each experiment.

173 bition of RhoA results in an accumulation of beta2 integrin in the unretracted tails.

174 Thus, we investigated the role of these beta2 integrins in angiogenesis.

175 To determine the roles of the various beta2 integrins in controlling the development of aggrav

176 In this study we investigated the role of beta2 integrins in experimental BP.

177 The role of beta1 and beta2 integrins in ILC2 trafficking to the lungs was ass

178 acquisition of cooperation between beta1 and beta2 integrins in the cell/substrate adhesive interacti

179 f the corresponding ICAM-1-binding leukocyte beta2-integrins in experimental diabetes.

180 Anti-Ly6G Ab impaired surface expression of beta2-integrins in LTB(4)-stimulated neutrophils and mim

181 rdance with these findings, we observed that beta2 integrins, including Mac-1, trigger proliferation

182 comitant negative and positive regulation of beta2 integrin-independent and beta2 integrin-dependent

183 ed a profound defect in adhesion mediated by beta2 integrins indicative of a variant form of LAD-1.

184 es, we confirmed that viral interaction with beta2 integrin induced strong NET formation.

185 ulation of beta1-integrin, overexpression of beta2-integrin, inhibited phosphorylation of focal adhes

186 effectively rescued by treatment with either beta2-integrin inhibitory antibodies or FAK inhibitors.

187 These cells exhibit increased beta2 integrin inside-out signaling (binding affinity an

188 Consistently, disruption of the 14-3-3/beta2-integrin interaction abrogated the enhanced ICAM-1

189 However, the specific roles of kindlin-3-beta2-integrin interactions in T-cell adhesion and homin

190 prevented by depleting neutrophils, blocking beta2 integrin-intercellular adhesion molecule 1 interac

191 sregulated Rac-1 activation, and accelerated beta2 integrin internalization.

192 The subfamily of beta2 integrins is implicated in macrophage fusion, a ha

193 eptide of ruminant CD18, the beta subunit of beta2 integrins, is not cleaved and hence remains intact

194 pted in mice lacking adhesion molecules like beta2-integrins (Itgb2-/-) which have defective neutroph

195 w that basal Ab levels are normal in TTT/AAA beta2-integrin KI mice, but B cell numbers in lymph node

196 ell activation in vivo was normal in TTT/AAA beta2 integrin knock-in mice.

197 In this study, we used TTT/AAA beta2-integrin knock-in (KI) mice and TCR-transgenic (OT

198 esulted in profound defects in clustering of beta2 integrins, leading to defective adhesion and trans

199 RP1 also is implicated because inhibition of beta2-integrins led to increased VWF levels in control (

200 of intercellular adhesion molecule-1 to the beta2-integrin leukocyte function associated antigen-1 (

201 Inside-out signaling regulation of the beta2-integrin leukocyte function-associated antigen-1 (

202 The beta2 integrin LFA-1 (CD11a/CD18) mediates adhesion of l

203 Adhesion through beta2 integrin LFA-1 is a common requirement of CTLs and

204 ll receptors, we show that engagement of the beta2 integrin LFA-1 on NK cells by intercellular adhesi

205 o target cells was not attributed to altered beta2 integrin LFA-1 properties but was instead due to r

206 In particular, redistribution of the beta2 integrin LFA-1 to the immunological synapse is com

207 The analysis of beta2 integrins LFA-1 and macrophage-1 Ag (Mac-1) showed

208 synapse was dependent on the presence of the beta2 integrin ligand ICAM-1.

209 dhesion of CD37-deficient neutrophils to the beta2 integrin ligand, ICAM-1, despite the normal displa

210 vealed haptokinetic spreading was induced by beta2 integrin ligation.

211 eactive oxygen species (ROS) following CD11b beta2-integrin ligation with fibrinogen in a sialic acid

212 ntegrin-responsive actin assembly and alphaM/beta2 integrin localization are compromised in Arpc2(-/-

213 y molecule CD154, the CD4 coreceptor, or the beta2 integrin lymphocyte function-associated antigen (L

214 uring inflammation critically depends on the beta2 integrins lymphocyte function-associated antigen 1

215 treated with C1q were found to activate the beta2 integrins lymphocyte function-associated antigen 1

216 The beta2-integrin lymphocyte function-associated antigen-1

217 sels before an adhesion step mediated by the beta2 integrins, lymphocyte function-associated antigen

218 Engagement of the beta2 integrin Mac-1 through its adhesion to its ligands

219 heterophilic interaction with the leukocyte beta2 integrin Mac-1, thereby mediating interactions bet

220 - in particular, increased expression of the beta2-integrin Mac-1 (alphaMbeta2, or CD11b/CD18), which

221 n to be a counter receptor for the leukocyte beta2-integrin Mac-1 (CD11b/CD18), thereby mediating int

222 tment was prevented in mice deficient in the beta2-integrin Mac-1 but not in those deficient in LFA-1

223 , via its apo(a) moiety, is a ligand for the beta2-integrin Mac-1, thereby facilitating inflammatory

224 moiety Lp(a) specifically interacts with the beta2-integrin Mac-1, thereby promoting the adhesion of

225 reted ACT binds to macrophages utilizing the beta2 integrin, Mac-1 (CR3, CD11b/CD18), and subsequent

226 optosis that is inhibited by antibody to the beta2 integrin, Mac-1, and requires NADPH oxidase-derive

227 Blocking of the beta2 integrin macrophage-1 Ag but not lymphocyte functi

228 Thus, beta2 integrins may play a regulatory role in B. burgdor

229 beta2 integrins mediate many aspects of the inflammatory

230 In response to SS RBCs, leukocyte CD44 and beta2 integrins mediated PBMC adhesion to ECs, a process

231 ulation with TNFalpha was found to result in beta2 integrin-mediated activation of the cytoplasmic ty

232 tibodies (mAb) that blocked or did not block beta2 integrin-mediated adhesion.

233 ils had markedly impaired chemokine-induced, beta2 integrin-mediated arrest, spreading, and migration

234 a surrogate vessel wall and can also support beta2 integrin-mediated immobilization of neutrophils if

235 Thus, beta2 integrin-mediated neutrophil crawling on endotheli

236 Furthermore, beta2 integrin-mediated post-adhesion processes-adhesion

237 s PMN beta2 integrins, followed by a second, beta2 integrin-mediated signal, which occurs physiologic

238 utrophils exhibited normal selectin-induced, beta2 integrin-mediated slow rolling, in sharp contrast

239 Collectively, beta2 integrin-mediated systemic NET overflow is a novel

240 uble MPO, namely the cell contact-dependent, beta2 integrin-mediated transfer from neutrophils.

241 ed to the membrane of neutrophils engaged in beta2-integrin-mediated adhesion, while these antigens a

242 grins on hematopoietic cells, especially the beta2 integrins, mice and primates were treated with ant

243 whole blood revealed prominent induction of beta2 integrin mRNA and protein ex vivo.

244 Analysis of beta2 integrin mRNA and protein in U937 cells revealed a

245 Furthermore, murine beta2 integrin mRNA was found to be significantly induce

246 ils that trigger activation of high-affinity beta2-integrins necessary for transition to shear-resist

247 y promoted the high affinity conformation of beta2 integrins of PMNs.

248 alphaLbeta2 immobilized on microspheres and beta2 integrin on neutrophils, we quantified an impressi

249 alphaLbeta2 immobilized on microspheres and beta2 integrin on neutrophils, we quantified an impressi

250 and mechanical strengths of ICAM-1 bonds to beta2 integrin on the cell surface.

251 Partial activation of beta1 and beta2 integrins on blood eosinophils, reported by monocl

252 osinophil adhesion to HCEs in vitro involved beta2 integrins on eosinophils but not intercellular adh

253 uidic device, that a substantial fraction of beta2 integrins on human neutrophils acquire an unexpect

254 is critical in hemostasis, and the beta1 and beta2 integrins on leukocytes have many roles in cell-me

255 ion molecule-1 (ICAM-1) on melanoma cells to beta2 integrins on PMNs, which is mediated by endogenous

256 sent study we examine bond formation between beta2-integrins on neutrophils and immobilized ICAM-1 wh

257 Simultaneous engagement of ITAM-coupled beta2 integrins or Dectin-1 with TLR4 did not affect TLR

258 metalloproteinase 9 (MMP-9), G-CSF receptor, beta2 integrins, or selectins responded to Ptx treatment

259 beta2 integrins play a crucial role during neutrophil re

260 These data suggest that beta2 integrins play differential roles in experimental

261 onsequently, attenuation of IFN responses by beta2 integrins protected primary human macrophages from

262 Binding of LtxA to its beta2 integrin receptor (lymphocyte function-associated

263 neutrophils from beta2 null mice identified beta2 integrin receptors as a master switch for NET indu

264 Further experiments suggested that beta2 integrin receptors such as complement receptor 3 (

265 based on experiments performed with chimeric beta2-integrins recombinantly expressed in a cell line t

266 n of Rab5 family members, mediators of beta1/beta2-integrin recycling in the early endosome, is decre

267 y to the alpha-subunit of Mac-1, a leukocyte beta2 integrin required for innate immunity to invading

268 firm adhesion are known to be selectins and beta2 -integrins, respectively, the precise dynamic mech

269 Cross-inhibition of IFNAR signaling by beta2 integrins resulted in decreased Jak1 activation an

270 itor, piceatannol, which blocks 'outside-in' beta2 integrin signalling in leukocytes, detached the ad

271 N-terminally truncated beta2 integrin stalk fragments were well expressed and s

272 Rerefined beta2 integrin structures reveal details including pyrog

273 Blocking mAb to the shared beta2 integrin subunit, CD18, completely inhibited the O

274 stablish a structure and function map of the beta2 integrin subunit, we mapped the epitopes of a pane

275 Pretreatment of monocytes with mAb to the beta2-integrin subunit CD18 decreased adhesion and aboli

276 Phosphorylation of a threonine in the beta2 integrin tail has been shown to modulate beta2/14-

277 Thus, ligand-reinforced beta2-integrin tail interactions restrict cytokine recep

278 pathways to induce conformational changes in beta2 integrins that allow these phagocytes to effective

279 signaling, by means including activation of beta2 integrins that are coupled to the ITAM-containing

280 coronin 1A (Coro1A) as a novel regulator of beta2 integrins that interacts with the cytoplasmic tail

281 Furthermore, a mechanism involving beta2-integrins that binds both VWF and LRP1 also is imp

282 promoting the high affinity conformation of beta2 integrins, thereby facilitating PMN trafficking du

283 irect assay for the off-rates of ICAM-1 from beta2 integrin throughout the course of each experiment.

284 del of psoriasis, reduced expression of CD18/beta2 integrin to 2-16% of wild-type levels is associate

285 g on P-selectin but is essential to activate beta2 integrins to slow rolling on ICAM-1.

286 Wild-type PMNs redistributed clustered beta2 integrins to the uropod of the cell during active

287 4 that binds TLR4 to elicit the extension of beta2-integrin to an intermediate affinity state.

288 rs that deliver a distinct signal to upshift beta2-integrins to a high-affinity state.

289 ction circuit that rapidly converts extended beta2-integrins to high-affinity shear-resistant bond cl

290 eficient, neutrophils into mice deficient in beta2 integrins transiently decreases neutrophilia and r

291 to induce strong activation of the beta1 and beta2 integrins via an avidity-modulation mechanism.

292 dency of these inflammatory processes on the beta2 integrins was investigated in CD18 hypomorph mice,

293 The functionality of beta1 and beta2 integrins was restored by treatment of CF monocyte

294 dependent on chemokines but not on beta1 or beta2 integrins, was observed in loose fibronectin and c

295 To determine the function of individual beta2 integrins, we examined CD8 T cell responses to Lis

296 n addition, the adhesion molecules beta1 and beta2 integrins were found to be crucial for EAR secreti

297 hat initial monocyte adhesion is mediated by beta2 integrins, whereas during the induction of macroph

298 Beta2-integrins, which mediate adhesion and cytoskeletal

299 tin in vitro and in vivo, failed to activate beta2 integrins while rolling, and did not emigrate into

300 ng segment 1 fibronectin and interactions of beta2 integrins with endothelial intercellular adhesion