ライフサイエンスコーパス: beta2 microglobulin

1 for kidney function (creatinine, cystatin C, beta2-microglobulin).

2 ion and species origin of the MHC-I L chain (beta2-microglobulin).

3 alpha3 domain and covalently linked to human beta2-microglobulin).

4 d via a flexible linker to the N terminus of beta2 microglobulin.

5 y canine kidney II cells together with human beta2-microglobulin.

6 therapies, or concentration of hemoglobin or beta2-microglobulin.

7 such as N-acetyl-beta-D-glucosaminidase and beta2-microglobulin.

8 rance of N-acetyl-beta-D-glucosaminidase and beta2-microglobulin.

9 physically associated with the TfR and with beta2-microglobulin.

10 e linker to the N terminus of the associated beta2-microglobulin.

11 ut ZAG does not bind the class I light chain beta2-microglobulin.

12 clin D1 to the constitutively expressed gene beta2-microglobulin.

13 n vitro the fibrillogenesis of the wild-type beta2-microglobulin.

14 rees C in the presence of excess peptide and beta2-microglobulin.

15 enced by the substitution of human for mouse beta2-microglobulin.

16 0/mm3 and also correlated inversely with CSF beta2-microglobulin.

17 tand the amyloidogenicity of the full-length beta2-microglobulin.

18 modify the tissue distribution of wild type beta2-microglobulin.

19 two clinically important protein biomarkers, beta2-microglobulin (11.8 kDa) and cystatin C (13.4 kDa)

20 ) but not in fetal thymic organ culture from beta2-microglobulin(-/-) 2C transgenic animals.

21 g/dL; calcium, 9.1 mg/dL; albumin, 3.4 g/dL; beta2-microglobulin, 5.7 mg/L; lactate dehydrogenase (LD

22 e produced double knockout mice for Bmp6 and beta2-microglobulin (a surrogate for the loss of Hfe) an

23 e individual counts were compared to that of beta2 microglobulin, a housekeeping gene.

24 abnl group to have a higher concentration of beta2 microglobulin, a marker for central nervous system

25 Finally, beta2-microglobulin, a cosubunit of class I MHC, and CD3

26 vanced glycation end products (AGE)-modified beta2-microglobulin (AGE-beta2M) is a dominant constitue

27 value of circulating PCs was independent of beta2-microglobulin, albumin, and C-reactive protein.

28 tumor necrosis factor type II receptors and beta2-microglobulin, all markers of HIV progression in h

29 ss I-deficient by a functionally inactivated beta2-microglobulin allele (beta2m(null)).

30 9 residue long) disulfide-containing protein beta2-microglobulin allowed the backbone amide protectio

31 mic force microscopy to map the formation of beta2-microglobulin amyloid fibrils with distinct morpho

32 , with promising therapeutic implications in beta2-microglobulin amyloid-related diseases.

33 s I molecule, H-2Db, chemically biotinylated beta2 microglobulin and a peptide epitope derived from t

34 Combining elevated beta2 microglobulin and lactic dehydrogenase (neither el

35 ndent prognostic marker and can be used with beta2 microglobulin and t(4;14) to identify a group of p

36 vary cells binds the class I MHC light-chain beta2-microglobulin and a mixture of endogenous peptides

37 on was restored by T2B7 cell incubation with beta2-microglobulin and a single HPLC fraction containin

38 Fibril formation of beta2-microglobulin and associated inflammation occur in

39 subset of gammadelta T cells independent of beta2-microglobulin and bound peptides.

40 Other genes within the complex include beta2-microglobulin and H3b.

41 nd heteropolymeric fibrils formed from human beta2-microglobulin and its truncated variant DeltaN6.

42 ome developed, the urinary concentrations of beta2-microglobulin and N-acetyl-beta-glucosaminidase ro

43 lar and pathological properties of wild type beta2-microglobulin and of the D76N variant offers a uni

44 (R2 = 0.53) whereas tubular reabsorption of beta2-microglobulin and RBP were found to be the best pr

45 eabsorption of low-molecular-weight proteins beta2-microglobulin and retinol binding protein (RBP)],

46 cDNA demonstrate that wild-type HLA-H binds beta2-microglobulin and that the C282Y mutation, but not

47 egion associated (Ia) heavy chains, although beta2-microglobulin and the nonclassical class Ib protei

48 Based on univariable regression analyses, beta2-microglobulin and the number of O-FC courses were

49 cle reviews older prognostic factors such as beta2-microglobulin and thymidine kinase activity that h

50 l to the antigen-processing pathway, such as beta2-microglobulin and transporters associated with ant

51 onically infected with murine rotavirus, and beta2 microglobulin -/- and other mice depleted of CD8+

52 he fully assembled proteins, namely peptide, beta2 microglobulin, and heavy chain.

53 ion with probes for MHC class I heavy chain, beta2 microglobulin, and TAP1 and TAP2 mRNAs revealed in

54 rimolecular complex composed of MHC class I, beta2-microglobulin, and a specific foreign peptide comp

55 polypeptides wherein the antigenic peptide, beta2-microglobulin, and heavy chain are attached by fle

56 pinal fluid lactate dehydrogenase isozyme 5, beta2-microglobulin, and immunoglobulin heavy chain rear

57 ly, CIITA-mediated induction of MHC class I, beta2-microglobulin, and invariant chain genes was also

58 renal injury markers (clusterin, cystatin-C, beta2-microglobulin, and liver fatty acid binding protei

59 nge, as has been described for amyloid beta, beta2-microglobulin, and prion proteins.

60 (17p), del(11q), IGHV mutation status, serum beta2-microglobulin, and serum thymidine kinase.

61 ein product of the UL18 gene associates with beta2-microglobulin, and the stability of this complex d

62 -PCR) and Southern blot hybridization, using beta2-microglobulin as a housekeeping gene to normalize

63 iting in association with MHC-I H chains and beta2-microglobulin as a trimolecular complex.

64 4, serum IL-6, monoclonal immunoglobulin and beta2-microglobulin, as well as bone marrow plasma cell

65 at the cell surface of APC as both classical beta2-microglobulin-associated B27 and B27 free H chain

66 t the major histocompatibility complex-like, beta2-microglobulin-associated CD1 molecules might funct

67 heterogeneous density of peptide-associated beta2-microglobulin-associated HLA HC (pepA-beta2aHC), p

68 ly reduced complex formation between m06 and beta2-microglobulin-associated MHC-I.

69 of CD8+ T cells cannot be compensated for by beta2-microglobulin-associated molecules other than clas

70 CD1.1 is a heavily glycosylated, beta2-microglobulin-associated surface protein.

71 enetic abnormalities, age at least 60 years, beta2-microglobulin at least 2 mg/L, albumin less than 3

72 a seven residue peptide (NHVTLSQ) from human beta2-microglobulin at pH 2.0, which renders +2.0 units

73 HLA-B27 mice lacking endogenous beta2-microglobulin (B27+ beta2m(o)) develop disease aft

74 Here we identify beta2-microglobulin (B2M), a component of major histocom

75 nity studies confirmed that this protein was beta2-microglobulin (B2M).

76 investigated the impaired serum clearance in beta2-microglobulin (B2M-/-) deficient mice.

77 idation study is presented using the protein beta2-microglobulin (beta(2)M) as the model system.

78 Beta2-microglobulin (beta2-m) can form dialysis-related

79 is study demonstrates for the first time how beta2-microglobulin (beta2-M) supports lethal metastasis

80 id beta (Abeta) (1-40) and on that from D76N beta2-microglobulin (beta2-m) which is related to heredi

81 By multivariate analysis, beta2-microglobulin (beta2-M; P < .01), and molecular re

82 ined immunodeficient (NOD/SCID) and NOD/SCID beta2 microglobulin (beta2M) null models demonstrated th

83 NK cells from beta2 microglobulin (beta2m)-deficient mice and NK cells

84 We used B6 Ly49C-transgenic and B6 beta2 microglobulin (beta2m)-knockout Ly49C-transgenic m

85 using gene-targeted B-cell (IgH-6(-/-))- or beta2-microglobulin (beta2m(-/-))-deficient mice, respec

86 The human protein beta2-microglobulin (beta2m) aggregates as amyloid fibri

87 Here we show that the internalization of beta2-microglobulin (beta2m) amyloid fibrils is dependen

88 formational changes induced by assembly with beta2-microglobulin (beta2m) and by peptide binding.

89 he binding of the recombinant HFE protein to beta2-microglobulin (beta2M) and disrupts its transport

90 ient cells, CD1d associates prematurely with beta2-microglobulin (beta2m) and is able to rapidly exit

91 minates the ability of HFE to associate with beta2-microglobulin (beta2m) and prevents cell-surface e

92 es as well as experiments with MHC class II, beta2-microglobulin (beta2m) and TAP1 knockout mice, the

93 (R3A) of the amyloid fibril-forming protein beta2-microglobulin (beta2m) and the molecular chaperone

94 Here, using beta2-microglobulin (beta2m) as a model system, we show

95 of long-term treatment is the deposition of beta2-microglobulin (beta2m) as amyloid fibers within th

96 Beta2-microglobulin (beta2m) associates with MHC and rel

97 pression of the common MHC class I component beta2-microglobulin (beta2M) by cancer cells directly pr

98 association of HLA class I heavy chains with beta2-microglobulin (beta2m) changes their antigenic pro

99 and examines the effect of reuse on urea and beta2-microglobulin (beta2M) clearance by low-flux and h

100 d the three-dimensional structure of an m144/beta2-microglobulin (beta2m) complex at 1.9A resolution.

101 Previously, one report described beta2-microglobulin (beta2m) deficiency as another monog

102 Although in HTA 1 there was only a trace of beta2-microglobulin (beta2m) detected by lactoperoxidase

103 ion modulators upon membrane interactions of beta2-microglobulin (beta2m) fibrils.

104 genic mice expressing a single chain H-2D(d)/beta2-microglobulin (beta2M) fusion protein on a beta2M-

105 Distinct mutations in the beta2-microglobulin (beta2m) gene were identified in eac

106 ed that monoclonal antibodies (mAbs) against beta2-microglobulin (beta2M) have a remarkably strong ap

107 yloidogenic and nonamyloidogenic variants of beta2-microglobulin (beta2m) in atomic detail.

108 Removal of both H2-DMalpha and beta2-microglobulin (beta2m) in cardiac grafts lead to g

109 Following association with beta2-microglobulin (beta2m) in the endoplasmic reticulu

110 Refolding RT1-Aa heavy chain (HC) with rat beta2-microglobulin (beta2m) in the presence of a specif

111 The aggregation of beta2-microglobulin (beta2m) into amyloid fibrils in viv

112 beta2-Microglobulin (beta2M) is believed to have arisen

113 om dialysis-related amyloidosis, the protein beta2-microglobulin (beta2M) is deposited as an amyloid;

114 A serum beta2-microglobulin (beta2M) level below 3 mg/L and a he

115 frequently with stage IV disease and higher beta2-microglobulin (beta2M) levels, whereas mcr-rearran

116 ls from mice with mutations in the genes for beta2-microglobulin (beta2m) or for TAP-1 express only l

117 deficient in perforin due to knockout of the beta2-microglobulin (beta2M) or perforin gene, respectiv

118 dehydrogenase (Gapdh), beta-actin (Actb), or beta2-microglobulin (beta2m) showed the highest fluctuat

119 We demonstrate that exogenous beta2-microglobulin (beta2m) stabilizes human cell surfa

120 Human D76N beta2-microglobulin (beta2m) variant is the prototype of

121 R)II, soluble interleukin-2R, neopterin, and beta2-microglobulin (beta2M) were documented over 5-8 we

122 ally engineered structural variants of human beta2-microglobulin (beta2m) were produced by sequence e

123 beta2-Microglobulin (beta2m), a key component of the maj

124 HLA-B27 molecule is a trimer of heavy chain, beta2-microglobulin (beta2m), and short peptide.

125 Mice deficient in beta2-microglobulin (beta2m), but expressing the human m

126 extensional flow on the aggregation of BSA, beta2-microglobulin (beta2m), granulocyte colony stimula

127 larity, L(q) has a stronger association with beta2-microglobulin (beta2m), is expressed at higher lev

128 The protein factor beta2-microglobulin (beta2M), purified from the conditio

129 occurring structural variant, D76N, of human beta2-microglobulin (beta2m), the ubiquitous light chain

130 gated the amyloidogenesis mechanism of human beta2-microglobulin (beta2m), which is thought to be tri

131 In beta2-microglobulin (beta2m)-deficient mice, all of the

132 ed transgenic mice expressing a single-chain beta2-microglobulin (beta2m)-H-2Dd.

133 iants in the naturally amyloidogenic protein beta2-microglobulin (beta2m).

134 r (TfR)-1, transferrin receptor (TfR)-2, and beta2-microglobulin (beta2M).

135 Cu(2+) ions destabilizes the native state of beta2-microglobulin (beta2m).

136 mplexes that include pheromone receptors and beta2-microglobulin (beta2m).

137 HC class I-type proteins and associates with beta2-microglobulin (beta2M).

138 vy chain, an antigenic peptide fragment, and beta2-microglobulin (beta2m).

139 mpared to levels of the "housekeeping" gene, beta2-microglobulin (beta2M).

140 nsfected cell line in vitro independently of beta2-microglobulin (beta2m).

141 tinine (Cr), vancomycin (V), inulin (I), and beta2-microglobulin (beta2M).

142 ate from calnexin following association with beta2-microglobulin (beta2m).

143 ot bind peptides or the class I light chain, beta2-microglobulin (beta2m).

144 ce derived from the amyloidogenic E chain of beta2-microglobulin (beta2m).

145 infection was studied in inbred C57Bl/6 (B6) beta2-microglobulin+/+ (beta2m+/+) and beta2m-/- knockou

146 consists of a heavy chain and a light chain (beta2-microglobulin, beta2m), which assemble with a shor

147 luble IL-2R-alpha (sIL-2R-alpha) and soluble beta2-microglobulin (beta2mu) (P < .001), and prolonged

148 m soluble Tac (IL-2Ralpha) and soluble human beta2-microglobulin (beta2mu) by ELISA.

149 Loss of beta2-microglobulin binding is due to a restructuring of

150 beta2-Microglobulin binding to an isolated alpha3 domain

151 The beta2-microglobulin -binding nanobody, Nb24, more potent

152 acts with oligomeric prefibrillar species of beta2-microglobulin but not with monomeric or fibrillar

153 plus LT protected MHC class I knockout mice [beta2-microglobulin (-/-)] but not MHC class II knockout

154 This subset is absent in mice that lack beta2-microglobulin, but not in K(b)D(b)-double-knockout

155 d critical prognostic factors (cytogenetics, beta2-microglobulin, C-reactive protein, albumin, creati

156 that the amyloid transformation of wild-type beta2-microglobulin can be induced by the variant only a

157 jugating the binding ligand derived from the beta2-microglobulin chain of the human MHC class I molec

158 Flux, estimated on the basis of beta2-microglobulin clearance, was 3+/-7 ml per minute i

159 nificantly fewer contacts between alpha3 and beta2-microglobulin compared with other MHC class I prot

160 144 and verified that it forms a heavy chain-beta2-microglobulin complex.

161 atified by three factors: normal or elevated beta2 microglobulin concentration at registration (</=2.

162 r high risk on the basis of cytogenetics and beta2-microglobulin concentrations.

163 factor, monocyte chemotactic protein-1, and beta2-microglobulin correlated well with survival and ma

164 The amyloidogenic variant of beta2-microglobulin, D76N, can readily convert into genu

165 Studies on the amyloidogenic variant of beta2-microglobulin, D76N, causing hereditary systemic a

166 lysin and the rapid death after infection of beta2 microglobulin deficient mice in humans has drawn a

167 nt Ly49(+) subsets in BMC rejection by using beta2-microglobulin deficient (beta2m(-/-)) mice as dono

168 CD8 T cells in regulating Ab responses using beta2-microglobulin deficient (beta2m-/-) mice.

169 model of gammaHV68 lymphomagenesis in BALB/c beta2 microglobulin-deficient mice (BALB beta2m-/-).

170 ll lines in nonobese diabetic/LtSz-scid/scid beta2 microglobulin-deficient mice engrafted with human

171 ses were reduced to about the same extent in beta2 microglobulin-deficient, or in anti-CD8-treated wi

172 We have investigated the response of beta2-microglobulin-deficient (beta2m-) mice of the H-2d

173 Using TCR-transgenic (N15tg) beta2-microglobulin-deficient (beta2m-/-) RAG-2(-/-) H-2

174 ecognize CD1, are reportedly absent in young beta2-microglobulin-deficient (beta2m-knockout (KO)) and

175 rely in both the thymus and the periphery of beta2-microglobulin-deficient (beta2m[-/-]) mice.

176 icted transgenic T cells is impaired in both beta2-microglobulin-deficient and transporter associated

177 We show that beta2-microglobulin-deficient class I-negative melanoma

178 Vbeta-specific regulation is not observed in beta2-microglobulin-deficient mice and is inhibited, in

179 e marrow chimera experiments using Rag-1 and beta2-microglobulin-deficient mice as hosts demonstrated

180 However, IL-12, IFN-gamma, and beta2-microglobulin-deficient mice failed to develop muc

181 Alloreactive CD8+ TCR repertoire in beta2-microglobulin-deficient mice is preferentially pep

182 cient mice unable to generate antibodies and beta2-microglobulin-deficient mice unable to express MHC

183 B6 and RAG-1(-/-) mice, but not in isogeneic beta2-microglobulin-deficient mice.

184 s (MTB) has been suggested by studies of the beta2-microglobulin-deficient mouse, which is unable to

185 after in vivo priming with ovalbumin-loaded beta2-microglobulin-deficient splenocytes and show that

186 Experiments in mice either beta2-microglobulin-deficient, lacking MHC class I molec

187 ed amyloidosis (DRA) is a cleaved variant of beta2-microglobulin (DeltaN6) lacking the first six N-te

188 4(+) T cells express alphabeta TCRs, neither beta2-microglobulin-dependent MHC class I nor any MHC cl

189 s only partially dependent on perforin; (ii) beta2-microglobulin-dependent T cell populations distinc

190 globulin light chains (light-chain amyloid), beta2 microglobulin (dialysis-related amyloid), and apol

191 e demonstrates that FcRn uses its alpha2 and beta2-microglobulin domains and carbohydrate to interact

192 low molecular weight polypeptides, including beta2-microglobulin, epidermal growth factor, prolactin,

193 ty acid-promoted de novo fibril formation of beta2-microglobulin even at substoichiometric concentrat

194 n is a potential extracellular chaperone for beta2-microglobulin even in moderately acidic conditions

195 as compared to wild-type or to HLA-B7/human beta2 -microglobulin-expressing monocytes.

196 LA-G correlated with T cell recognition, but beta2-microglobulin expression was essential.

197 nanobody, Nb24, more potently inhibits D76N beta2-microglobulin fibrillogenesis than doxycycline wit

198 previously described inhibitors of wild type beta2-microglobulin fibrillogenesis, doxycycline and sin

199 stability similar to that of homogenous D76N beta2-microglobulin fibrils and significantly higher tha

200 ese results suggest that the surface of D76N beta2-microglobulin fibrils can favor the transition of

201 e wild-type even once it is absorbed on D76N beta2-microglobulin fibrils.

202 survival time and bacterial loads, were the beta2-microglobulin(-/-), followed by transporter associ

203 R3DL2 binding more strongly to HLA-B27 (B27) beta2-microglobulin free H chain (FHC) dimers than other

204 ngenic mice homozygous for disruption of the beta2-microglobulin gene tended to be higher, indicating

205 ficient mice with a targeted mutation in the beta2-microglobulin gene.

206 Chromosome 13 deletion and elevated beta2-microglobulin, generally considered poor prognosti

207 thepsin S, C1q B-chain of complement (C1qB), beta2-microglobulin, glial fibrillary acidic protein (Gf

208 13% of patients had a 17p deletion; 64% had beta2-microglobulin > 3.5 mg/L.

209 tive Oncology Group performance status >/=1, beta2-microglobulin >/=3.5 mg/L, TK >/=10 U/L, unmutated

210 e heart failure and increased level of serum beta2 microglobulin (>/= 0.0035 g/L [3.5 mg/L]) were dom

211 in two major constituents, full-length human beta2-microglobulin (hbeta2m) and a truncation variant,

212 The amyloidogenic protein human beta2-microglobulin (hbeta2m) can co-polymerize with its

213 in addition to plasma cell labeling indices, beta2-microglobulin, hemoglobin, and plasmablastic morph

214 Using beta2-microglobulin, immunoglobulin G1, and human growth

215 of CD8 did not alter outcome, but absence of beta2 microglobulin improved survival.

216 cible, and binds to MHC class I coupled with beta2-microglobulin in the endoplasmic reticulum.

217 By application to amyloid assembly of beta2-microglobulin in vitro under constant mechanical s

218 type II NKT cells, after interaction with a beta2-microglobulin-independent CD1d receptor.

219 ditional HLA-C ligands, can bind to the same beta2-microglobulin-independent ligand as KIR2DS2.

220 the KIR2DS2 reporter responses, indicating a beta2-microglobulin-independent ligand for KIR2DS2.

221 s most frequently reported concentrations of beta2-microglobulin, indoxyl sulfate, homocysteine, uric

222 atment rescue was used to immunize CD4, CD8, beta2-microglobulin, inducible nitric oxide synthase (iN

223 ng platform that partially overlaps with the beta2-microglobulin interface on the MHC-I heavy chain,

224 beta2-microglobulin is essential for the association bet

225 Fibrillar beta2-microglobulin is resistant to lysosomal degradatio

226 beta2-Microglobulin is responsible for systemic amyloido

227 07 to <0.001), whereas alpha1-microglobulin, beta2-microglobulin, KIM-1, and TFF-3 associated with de

228 In beta2-microglobulin knock out mice, the D76N beta2-micro

229 xpressing cells were also undiminished after beta2-microglobulin knockdown, and they were not blocked

230 onically infected with murine rotavirus, and beta2 microglobulin knockout (beta2m -/-) mice have dela

231 /6 mice deficient in MHC class I expression (beta2 microglobulin knockout [beta2KO] mice), in IFN-gam

232 in murine models, including those using the beta2 microglobulin knockout mouse, have suggested an im

233 mmunity in protective immunity, we immunized beta2-microglobulin knockout (beta2M-/-) mice with irrad

234 beta2-microglobulin knockout mice could be protected rea

235 uency was identical in spleens of normal and beta2-microglobulin knockout recipients, but significant

236 10(b)) were crossed to class I MHC-deficient beta2-microglobulin-knockout (beta2m degrees) mice, and

237 tetramers containing either human or murine beta2-microglobulin L chains was tested for all five Ly4

238 ensitivity and specificity was achieved with beta2-microglobulin labeled with (131)I or (111)In.

239 d from D76N or the natural truncated form of beta2-microglobulin lacking the first six N-terminal res

240 older age, male sex, and elevated levels of beta2-microglobulin, lactate dehydrogenase, and creatini

241 yte count of 35.9 x 10(9)/L and median serum beta2 microglobulin level of 6.45 mg/L were treated.

242 II (n = 295), including ISS stage III (serum beta2-microglobulin level > 5.5 mg/L) and high-risk CA o

243 S) I (n = 871), including ISS stage I (serum beta2-microglobulin level < 3.5 mg/L and serum albumin l

244 with a poor prognosis, as defined by a high beta2-microglobulin level (more than 8 mg per liter).

245 re to respond to fludarabine, elevated serum beta2-microglobulin level (P < 0.001), low serum albumin

246 time from diagnosis to randomization, serum beta2-microglobulin level, and whether peripheral neurop

247 alysis showed pretransplant cytogenetics and beta2-microglobulin levels as critical prognostic featur

248 as identified, quantified, and compared with beta2-microglobulin levels using a competitive reverse t

249 Serum beta2-microglobulin levels were significantly lower in p

250 d with age and with interleukin-6 (IL-6) and beta2-microglobulin levels.

251 mpared with CAMphi and selectively expressed beta2-microglobulin, lysozyme, ferritin heavy and light

252 Considering how the amyloidogenesis of the beta2-microglobulin mechanism has been scrutinized in de

253 sentation and T cell costimulation, that is, beta2-microglobulin, MHC II, CD40, and ICOSL.

254 Class I-deficient beta2-microglobulin-/- mice show increased susceptibilit

255 ha3 domain and the non-covalently associated beta2-microglobulin molecule, demonstrating long-range d

256 CD8(+)TCR-alpha/beta(1) IELs is dependent on beta2-microglobulin molecules, the nature of the major h

257 he molecular mechanism by which a novel anti-beta2-microglobulin monoclonal antibody (beta2M mAb), sh

258 Our results showed that the beta2-microglobulin(-/-) mouse had a greatly decreased s

259 In the absence of beta2 microglobulin, naive CD8 T cells scarcely prolifer

260 beta2-microglobulin knock out mice, the D76N beta2-microglobulin/ Nb24 pre-formed complex, is cleared

261 Hu-PBL-C.B-17-scid mice, and Hu-PBL-NOD-scid beta2-microglobulin-null (NOD-scid-B2mnull) mice support

262 tibility class II-deficient mice, but not in beta2-microglobulin or perforin knockout mice implying t

263 tor type II receptors (sTNFR-II), neopterin, beta2-microglobulin, or CD4 cell counts can be used to p

264 mice, as monitored by serum levels of human beta2-microglobulin (P < 0.01), and prolonged survival o

265 ors such as refractory disease and increased beta2-microglobulin, patients with cytogenetic abnormali

266 lity of each peptide to productively form Kb/beta2-microglobulin/peptide complexes.

267 jor histocompatibility complex (MHC) class I:beta2-microglobulin:peptide complexes, generating an ass

268 lasma cell infiltration, M protein, albumin, beta2-microglobulin, performance status, International S

269 However, the species of beta2-microglobulin populated in the presence of haptogl

270 , interacts with the prefibrillar species of beta2-microglobulin, preventing its fibril formation and

271 The mouse and human beta2-microglobulin protein orthologs are 70% identical

272 e best predictors of tubular reabsorption of beta2-microglobulin (R2 = 0.53) whereas tubular reabsorp

273 of northern blot analysis when examined for beta2-microglobulin, Rab geranylgeranyl transferase, and

274 not microalbumin levels, and the detectable beta2-microglobulin rate increased in the manufacturers

275 Small interfering RNA knockdown of beta2-microglobulin reduced the expression of class I H

276 Urea and beta2-microglobulin reduction rates were 64.5% +/- 0.4%

277 Serum beta2-microglobulin (Sbeta2M), serum albumin, platelet c

278 nd alpha3 domains, as well as the associated beta2-microglobulin subunit.

279 een plasma HIV RNA and CSF levels of HIV and beta2-microglobulin suggests that both viral load and CN

280 f the approach for the amyloidogenic protein beta2-microglobulin that folds via an intermediate state

281 ng intermediate of the amyloidogenic protein beta2-microglobulin that has a half-lifetime of only 20

282 globulin but not with monomeric or fibrillar beta2-microglobulin that may underlie the molecular mech

283 ocompatibility complex class I heavy chains, beta2-microglobulin, the transporter associated with ant

284 MUC5AC and beta2-microglobulin transcripts were expressed at a rati

285 27 were reported in cells from HLA-B27/human beta2-microglobulin transgenic (HLA-B27 transgenic) rats

286 -loading complex, incorporating MHC class I, beta2 microglobulin, transporter associated with Ag proc

287 genes, NLRC5 also induced the expression of beta2-microglobulin, transporter associated with antigen

288 nferior response were age 70 years or older, beta2-microglobulin twice the upper limit of normal (2N)

289 hat haptoglobin prevents fibril formation of beta2-microglobulin under conditions of physiological ac

290 e Inhibitor of Metalloproteinases-1 (TIMP1), beta2-Microglobulin, Vascular Endothelial Growth Factor

291 single chain secreted CD1 proteins in which beta2-microglobulin was fused to the N termini of the CD

292 yloidogenic and nonamyloidogenic variants of beta2-microglobulin, we identify the interactions that i

293 tivariate analysis, stage C disease and high beta2 microglobulin were independent predictors of a pos

294 The MHC heavy chain and beta2-microglobulin were firmly associated, and the mole

295 us monkey MHC class I molecule Mamu-A*01 and beta2-microglobulin were refolded in the presence of an

296 ted tetramers in which recombinant HLA-E and beta2-microglobulin were refolded with an MHC leader-seq

297 NKL/OPG ratio, C-reactive protein (CRP), and beta2-microglobulin were the only independent prognostic

298 igen presentation, including MHC class I and beta2 microglobulin, were highly susceptible to mycolact

299 and T cell receptors, but is not present in beta2-microglobulin, which does not show any stabilizati

300 beta2-Microglobulin, which, unlike other loci, was assoc