ライフサイエンスコーパス: beta3 integrin

1 PP1gamma phosphatase activated by alpha(IIb)beta3 integrin.

2 te, it is unlikely that PKA acts directly on beta3 integrin.

3 resistant acid phosphatase, cathepsin K, and beta3 integrin.

4 after expression of a constitutively active beta3 integrin.

5 critical for interaction between VEGFR-2 and beta3 integrin.

6 by activating pp60(c-Src) kinase and alpha(v)beta3 integrin.

7 fluorescent analogue targeted at the alpha(v)beta3 integrin.

8 downstream of the M-CSF receptor and alpha(v)beta3 integrin.

9 ar matrix (ECM) substrates that bind alpha(v)beta3 integrin.

10 active sites are not required for binding to beta3 integrin.

11 etic depletion or functional inactivation of beta3 integrin.

12 ts and surface GluA2 levels compared with WT beta3 integrin.

13 ducing a kink in the transmembrane domain of beta3-integrin.

14 emaphorin-integrin (PSI) domain of inactive, beta3 integrins.

15 f an inability to activate beta1, beta2, and beta3 integrins.

16 uperfamily that interacts with and activates beta3 integrins.

17 F3 domain of talin is sufficient to activate beta3 integrins.

18 an mediate scaling through the regulation of beta3 integrins.

19 es in talin-mediated activation of beta1 and beta3 integrins.

20 ent manner without altering total alpha5 and beta3 integrins.

21 nction-blocking antibodies against beta1 and beta3 integrins.

22 t is activated by signaling across beta1 and beta3 integrins.

23 re augmented significantly in the absence of beta3 integrins.

24 onstrated to associate in cis with beta1 and beta3 integrins.

25 en alpha-actinin competes with talin to bind beta3 integrins.

26 ytoplasmic tails of alpha4, beta1, beta2 and beta3 integrins.

27 do not contain paxillin, vinculin, and beta1/beta3 integrins.

28 on and activity are independent of beta1 and beta3 integrins.

29 ing beta1-integrins and mimicked by blocking beta3-integrins.

30 on, demonstrating a mechanistic link between beta3 integrin-activated Src and EGFR regulation of the

31 in ligand) in the absence or presence of the beta3 integrin-activating mAb AP-5 and were identified b

32 s were plated on fibronectin with or without beta3 integrin-activating mAb AP-5.

33 LANs associated with either DEX treatment or beta3 integrin activation contained syndecan-4, PIP(2),

34 Analysis of beta3 integrin activation indicates that inclusion of th

35 f inside-out signaling in platelets, whereby beta3 integrin activation involves the direct binding of

36 Control of alphaIIb beta3 and alphav beta3 integrin activation is critical for cardiovascular

37 phavbeta3 Integrin expression levels and the beta3 integrin activation state were determined by fluor

38 CD40 ligation also caused beta3 integrin activation, although this was not accompa

39 reover, c-Src mediates growth factor-induced beta3 integrin activation, ligand binding, beta3 integri

40 the function of individual N-glycan sites in beta3 integrin activation.

41 he head domain of talin and thereby promotes beta3 integrin activation.

42 Podocyte beta3-integrin activation dropped significantly after PE

43 outcome, suPAR levels, and in vitro podocyte beta3-integrin activation was investigated over a median

44 lowering of plasma suPAR as well as podocyte beta3-integrin activation.

45 asurements detected talin1(W359A) binding to beta3 integrin, albeit with a 2.9-fold lower affinity th

46 We establish that, like the endothelial beta3 integrin alpha(V)beta(3), the platelet integrin al

47 ct residues in the alpha-subunits of the two beta3 integrins alphaIIbbeta3 and alphaVbeta3, but a pot

48 tations resulting in a D723H mutation in the beta3 integrin and a P53L mutation in glycoprotein (GP)

49 We compared beta3 integrin and actinin-1 dynamics in focal contacts

50 Here we investigate the nature of beta3 integrin and AMPAR interaction underlying the beta

51 servations suggest a functional link between beta3 integrin and AMPAR, little is known about the mech

52 resorption by its inclusion with the alpha v beta3 integrin and c-Src in a signaling complex, which i

53 as preferential binding to activated alpha(v)beta3 integrin and can track the injury-induced vascular

54 their cognate cell-surface receptors (i.e., beta3 integrin and CD44), nor plasminogen are essential

55 We show that beta3 integrin and GluA2 subunit form a complex in mouse

56 We show that fibrinogen acts as a ligand for beta3 integrin and induces the transactivation of EGF re

57 These data suggest that RGD interaction with beta3 integrin and its subsequent endocytosis trigger sp

58 d spreading on fibrinogen, colocalization of beta3 integrin and kindlin-3 in focal adhesions, and enh

59 ich is caused by maternal antibodies against beta3 integrin and occasionally by maternal antibodies a

60 lated complex formation between its receptor beta3 integrin and protein-tyrosine phosphatase SHP-2.

61 ion kinase (FAK) and vinculin to the alpha(v)beta3 integrin and reduced FAK and Src activation in res

62 6 antibody contributes to its binding to the beta3 integrin and subsequent antibody-induced platelet

63 equirements for the cross-activation between beta3 integrin and tyrosine kinase receptor 2 for vascul

64 eraction between the bent conformation beta5/beta3 integrins and an arginine-glycine-aspartic acid (R

65 to serve as an adhesion coreceptor for beta1/beta3 integrins and as an enzyme that catalyzes the cros

66 ed fibrin structure via interactions between beta3 integrins and fibrin.

67 MBP-primed Th2 cells expressed alpha5 and beta3 integrins and functional blocking antibodies again

68 tTG functions as a co-receptor for beta1 and beta3 integrins and stabilizes extracellular matrix prot

69 These observations identify a link between beta3 integrins and VEGF in tumor growth and angiogenesi

70 The central importance of beta3 integrins and VEGF responses in vascular leak and

71 ractions leave periodic rows of matrix bound beta3-integrin and paxillin while generating waves of re

72 endent of fibrinogen, von Willebrand factor, beta3 integrin, and platelets.

73 y deprivation elevates surface expression of beta3 integrins, and in turn, beta3 integrins are requir

74 d their increased association with beta1 and beta3 integrins, and the production of pro-matrix metall

75 -49) M28L, chosen for its selectivity toward beta3-integrins, and rEch (1-40) M28L, a carboxy-termina

76 R4A1 regulates expression of both beta1- and beta3-integrins, and unlike other beta1-integrin inhibit

77 tegrins) and monoclonal antibody m7E3 (a rat beta3 integrins antagonist) inhibited the effects of OPN

78 Soluble beta3 integrin antibodies, however, induced CLANs and ac

79 proteins was blocked by anti-beta1 and anti-beta3 integrin antibodies.

80 anti-beta1 integrin antibody but not by anti-beta3 integrin antibody.

81 orylation were inhibited only by murine anti-beta3 integrin antisera and human anti-HPA-1a IgG purifi

82 The relationship between VEGFR-2 and beta3 integrin appears to be synergistic, because VEGFR-

83 s suggest that nascent adhesions composed of beta3 integrins are initially linked to the actin cytosk

84 e 4 (CCR4) chemokine receptors and beta1 and beta3 integrins are necessary to transduce these chemome

85 expression of beta3 integrins, and in turn, beta3 integrins are required for synaptic scaling.

86 l cycle in mammary epithelial cells, whereas beta3-integrins are involved in migration.

87 ransition (EMT) and metastasis, we exploited beta3 integrin as a therapeutic target to treat TNBC by

88 In contrast, beta3 integrin associates with GluA1 AMPAR subunit only

89 efinitive demonstration of a role for P66 in beta3 integrin attachment by intact borreliae.

90 er our data indicate that reduction of talin-beta3 integrin binding affinity results in decelerated a

91 beta3 integrin blockade with eptifibatide had no effect,

92 reproduced in neonates by injection of anti-beta3 integrin, but not anti-GPIbalpha antisera.

93 t has normal expression of beta1, beta2, and beta3 integrins, but all are dysfunctional.

94 lin and alpha-actinin compete for binding to beta3 integrins, but cooperate in binding to beta1 integ

95 cally-derived cells express beta1, beta2 and beta3 integrins, but defective inside-out signaling caus

96 onstrated that Src associated with wild-type beta3 integrins, but Src and integrins lacking the C ter

97 A second shRNA to either alphav-integrin or beta3-integrin, but not to another alphav-binding partne

98 e was increased angiogenesis in mice lacking beta3-integrins, but no difference in structure of the v

99 Mutations affecting alpha(IIb)beta3 integrin cause the bleeding disorder termed Glanzm

100 in decreased EC expression of the alphav and beta3 integrin chains.

101 We further found beta1- and beta3-integrins colocalize with IgE-FcepsilonRI at patte

102 beta3 integrin contains a serine residue at position 752

103 indicate that both endothelial and platelet beta3 integrins contribute to extracellular PDI binding

104 Here, we report that postsynaptic beta3 integrins control synaptic strength by regulating

105 pecific for platelet antigens, most commonly beta3 integrin, cross the placenta and destroy fetal pla

106 was mediated by the C-terminal region of the beta3 integrin cytodomain, and mutants of beta3 that wer

107 The beta3 integrin cytoplasmic domain, and specifically S752

108 phorylation-independent interaction with the beta3 integrin cytoplasmic domain.

109 l adhesion protein, interacts with beta1 and beta3 integrin cytoplasmic domains.

110 into a molecular complex with the beta1A and beta3 integrin cytoplasmic domains.

111 ing of the cytoskeletal protein talin to the beta3 integrin cytoplasmic tail is required for beta3 ac

112 an increase in serine phosphorylation of the beta3 integrin cytoplasmic tail.

113 ing by both undermining talin binding to the beta3-integrin cytoplasmic tail and inducing a kink in t

114 focal complexes and strengthening of alphav/beta3-integrin-cytoskeleton connections during the initi

115 Platelet beta3-integrin deficiency was sufficient to disrupt hemo

116 t pathogenic hantaviruses, similar to alphav beta3 integrin-deficient cells, specifically enhance VEG

117 in diet-induced vascular disease, we studied beta3 integrin-deficient mice (lacking platelet integrin

118 In contrast, beta3-integrin-deficient (beta3-/-) mice are not protect

119 Myeloid-specific beta3-integrin deletion was sufficient to perturb bone m

120 onists inhibit expression of both beta1- and beta3-integrin, demonstrating a novel mechanism-based ap

121 t matrix-bound BMP-2 is sufficient to induce beta3 integrin-dependent C2C12 cell spreading by overrid

122 These kinases are also regulated by beta3 integrin-dependent cell adhesion via a phosphoryla

123 d beta3 integrin activation, ligand binding, beta3 integrin-dependent cell adhesion, directional migr

124 Truncated R-Ras also stimulates more beta3 integrin-dependent cell migration than full-length

125 ntegrin and AMPAR interaction underlying the beta3 integrin-dependent control of synaptic AMPAR expre

126 MRI revealed a pattern of increased alpha(v)beta3-integrin distribution within the atherosclerotic w

127 Additional loss of beta3 integrins dramatically aggravates the bleedings an

128 cular dynamics simulations of fully hydrated beta3 integrin ectodomains revealed strikingly different

129 The beta3 integrin/EGFR pathway also has a positive role in

130 etween the calf-1 and calf-2 domains and the beta3 Integrin-Epidermal Growth Factor (I-EGF) 2 to 4 do

131 The CA beta3 integrin-expressing cell line showed increased alp

132 Compensatory beta3 integrin expression also 1) enhances the growth of

133 U0126 (an ERK inhibitor) blocked LPS induced beta3 integrin expression and WISP1 enhanced TNF-alpha r

134 t of both VEGF production by fibroblasts and beta3 integrin expression in HMVEC can rescue capillary-

135 erefore examined the role of NFATc1 in human beta3 integrin expression in osteoclast differentiation.

136 odeling, can be tracked by targeting alpha(v)beta3 integrin expression in vivo.

137 Carotid alpha(v) and beta3 integrin expression was maximal at 1 week and decr

138 TGF-beta-stimulated beta3 integrin expression was not affected by PPARalpha

139 ibeta3 was sufficient to effectively silence beta3 integrin expression, attenuate TGFbeta-mediated EM

140 pendent upon this HoxA10-induced increase in beta3 integrin expression.

141 Knockdown of beta3-integrin expression attenuates Rac1 activity, impa

142 Undetected in normal muscle, beta3-integrin expression in mouse hindlimb muscles is i

143 The source of beta3-integrin expression is found to be activated satel

144 inhibitory effects of decreased endothelial beta3-integrin expression.

145 xpression of mutants on substrates that bind beta3 integrins (fibronectin and vitronectin) versus sub

146 We have crossed beta3-integrin-floxed (beta3-floxed) mice to 2 endotheli

147 beled peptide (NC100692) targeted at alpha(v)beta3 integrin for imaging in an established murine mode

148 and 2), that can activate beta1, beta2, and beta3 integrins, for their effects on integrin signaling

149 by lipids, plays opposite roles in beta1 and beta3 integrin function and in neither case is responsib

150 In UMR106 cells, inhibition of beta1/beta3 integrin function had no effect on strain-related

151 ng of alpha2beta1, but not alpha1 or alpha(v)beta3 integrin function halted morphogenesis.

152 Furthermore, neither anti-mouse beta3 integrin function-blocking monoclonal antibody (mA

153 e muddied by the use of a global knockout of beta3-integrin function.

154 h pathogenic hantavirus inhibition of alphav beta3 integrin functions, and hantavirus-directed permea

155 pression of green fluorescent protein-tagged beta3 integrin (GFP-beta3) and actinin-1 (GFP-actinin-1)

156 et membrane glycoprotein, usually alpha(IIb)/beta3 integrin (GPIIb/IIIa) when the drug is present.

157 conformational states similarly to beta2 and beta3 integrins has not been characterized.

158 on on stability of the metal ion at LIMBS in beta3 integrins has not been explored.

159 These results suggest that beta3-integrins have cell-specific roles in complex biol

160 s recently discovered that certain beta1 and beta3 integrin heterodimers are critical mediators of HC

161 which was inhibited by a dominant-negative >beta3 integrin; however, an active form of Akt failed to

162 l migration through extracellular matrix via beta3 integrins, identifying a unique mechanism to regul

163 Here, we show that the loss of beta3 integrin in fibroblasts results in enhanced focal

164 Both tagged proteins localize with alpha(v)beta3 integrin in focal contacts distributed towards the

165 transgenic mice expressing dominant-negative beta3 integrin in oligodendrocytes display no myelinatio

166 The surface level of beta3 integrin in postsynaptic neurons directly correlat

167 ng this remodeling phase, mRNA expression of beta3 integrin in the heart decreases significantly as v

168 e confirm a role for macrophage cell surface beta3 integrin in this dl922-947-induced inflammation.

169 omplex formation between VEGF receptor-2 and beta3 integrin in wild-type but not in mutant beta3 knoc

170 hibited the activation of platelet beta1 and beta3 integrins in response to platelet agonists.

171 rdination was recently reported for EGFR and beta3 integrins in the context of HCMV entry.

172 is constitutively associated with beta1 and beta3 integrins in the presence or absence of growth fac

173 dissect the roles of osteoclast and platelet beta3 integrins in this model of bone metastasis, osteoc

174 Clustering of beta3 integrins in vivo activates c-Src and induces phos

175 e responses are explained by the presence of beta3-integrin in beta1-integrin-null cells, indicating

176 3KOM strains of mice, we studied the role of beta3-integrin in hemostasis, bone resorption, and subcu

177 nerated to study the conditional deletion of beta3-integrin in platelets [knockout in platelets (KOP)

178 Conditional deletion of myeloid beta3-integrins in beta3KOM mice resulted in osteopetros

179 Tissue-specific deletion of platelet beta3-integrins in beta3KOP mice did not affect bone mas

180 anscription of the ITGB3 gene, which encodes beta3 integrin, increases during myeloid differentiation

181 DEX pretreatment increased beta3 integrin-induced CLAN formation nearly sixfold and

182 blocking antibodies against both alpha5 and beta3 integrins inhibited the ability of MBP-primed Th2

183 We show that acute depletion of endothelial beta3-integrin inhibits tumor growth and angiogenesis pr

184 Pharmacological blockade of beta3-integrins inhibits neointimal lesion formation in

185 se observations suggest that OPN, acting via beta3 integrins, inhibits IL-1beta-stimulated increases

186 We report that both platelet beta1 and beta3 integrins interact in an activation-dependent mann

187 The alpha(v)beta3 integrin is activated in angiogenic vessels and re

188 Expression of the beta3 integrin is required for normal osteoclast functio

189 Thus, beta3-integrin is a mediator of satellite cell different

190 However, as beta3-integrin is expressed by a wide variety of cells,

191 Cell, Desgrosellier et al. (2014) show that beta3-integrin is required downstream of hormonal signal

192 Because previous studies coupled beta3 integrin (ITGB3) to epithelial-mesenchymal transit

193 d kindlin-3 in focal adhesions, and enhanced beta3 integrin-kindlin-3 association in immunoprecipitat

194 Using beta3 integrin knockout mice injected intraperitoneally

195 In 2002, we reported that beta3-integrin-knockout mice exhibit enhanced tumor grow

196 stripe of fluorescence is bleached across a beta3 integrin-labeled focal contact, recovery is comple

197 However, NY-1V uniquely induced beta3 integrin-linked potassium channels, which could pl

198 xamine the endothelial-specific contribution beta3-integrin makes to tumor growth and angiogenesis.

199 of major cell adhesion receptors (alphav and beta3 integrins), matrix metalloproteinases (MMP-2 and -

200 Only anti-beta3 integrin-mediated FNAIT reduced brain and retina v

201 o reverses the suppression by NO of alphaIIb/beta3 integrin-mediated platelet adhesion on immobilized

202 y occurred in fetuses and neonates with anti-beta3 integrin-mediated, but not anti-GPIbalpha-mediated

203 that force-dependent reinforcement of alphav/beta3-integrin-mediated cell-matrix connections requires

204 blocking studies demonstrated that alphaIIb beta3 integrin mediates platelet adhesion to fibrinogen,

205 The alpha(v)beta3-integrin mediates intimal SMC accumulation that co

206 beta3 integrin(-/-) mice have defective platelet and ost

207 -N452 N-glycan at the I-EGF1 domain rendered beta3 integrin more active than the wild type.

208 with impaired capacity to interact with the beta3 integrin MPR (L325R) or NPLY sequence (W359A).

209 in hippocampal pyramidal neurons, expressing beta3 integrin mutants with either increased or decrease

210 In addition, a beta3-integrin-neutralizing antibody similarly blocked m

211 tegrin inhibitors which induce prometastatic beta3-integrin, NR4A1 antagonists inhibit expression of

212 Furthermore, beta3 integrin-null endothelial cells, when treated with

213 A similar response was seen in beta3 integrin-null platelets.

214 d muscle regeneration in cardiotoxin-injured beta3-integrin-null mice are impaired, as indicated by d

215 myeloid lineage commitment were mediated by beta3 integrin on hematopoietic progenitors.

216 e released TSP-1 interacted with the alpha(v)beta3 integrin on the EC surface.

217 hantaviruses inhibit the function of alphav beta3 integrins on endothelial cells, and hemorrhagic di

218 rrow transplants suggest that the absence of beta3-integrins on bone marrow-derived host cells contri

219 beta3 Integrin or CD47 activation significantly increase

220 ite outgrowth is reversed by blocking either beta3 integrin or phoshorylation of EGFR.

221 Here we report that mice lacking beta3 integrins or both beta3 and beta5 integrins not on

222 f osteoclasts or platelets from mice lacking beta3 integrins or c-Src.

223 erved in tumors grown in mice lacking either beta3-integrins or selectins.

224 By interacting with fibrin and platelet beta3 integrin, pFn plays a self-limiting regulatory rol

225 The alpha(v)beta3 integrin plays a critical role in cell proliferati

226 Activated beta3 integrin-positive adhesions increased nearly fivef

227 rom binding to the cytoplasmic domain of the beta3 integrin prevents outside-in signaling and infecti

228 AMPARs via Rap1 signaling, and expression of beta3 integrins produces robust changes in the abundance

229 -calcineurin pathway in regulating the human beta3 integrin promoter was further confirmed using the

230 nNFAT inhibited RANKL induction of the human beta3 integrin promoter.

231 Pharmacological perturbation targeting beta3 integrins promotes endocytosis of GluR2-containing

232 by trans-activation of IGF-IR induced by the beta3 integrin receptor.

233 The alphaIIb/beta3-integrin receptor is present at high levels only i

234 ssion of the glycoprotein IIb/IIIa (alphaIIb/beta3 integrin) receptor on the surface of activated pla

235 capsid, retargeting the virus to the alphav beta3 integrin receptors, which are overexpressed in tum

236 beta3 integrin regulates a multistep process to control

237 -type 1 matrix metalloprotease [MT1-MMP] and beta3 integrin) required for invadosome formation in res

238 Of importance, compensatory expression of beta3 integrin rescues the growth and pulmonary metastas

239 Inhibition of beta1 or beta3 integrin resulted in a significant decrease in mig

240 this study, we show that PKD1 complexes with beta3-integrin, resulting in activation of mitogen-activ

241 stream signaling events reveals that loss of beta3 integrin results in a loss of protein kinase A-dep

242 Tumors with "activatable" but not "inactive" beta3 integrin secrete high levels of VEGF, which in tur

243 beled peptide (NC100692) targeted at alpha(v)beta3 integrin selectively localized to endothelial cell

244 ta1 integrin function-blocking antibodies on beta3 integrin serine phosphorylation and EC-ralpha4LN f

245 have tested an hypothesis that PKA regulates beta3 integrin serine phosphorylation indirectly through

246 protein kinase (PKA) activity and increases beta3 integrin serine phosphorylation.

247 I domain occur in an order different than in beta3 integrins, showing that integrin beta subunits can

248 -induced CLAN formation may involve enhanced beta3 integrin signaling in HTM cells, possibly by an in

249 ory cytokine interferon-gamma (IFNgamma) and beta3 integrin signaling in murine HSC function by a nov

250 beta3 Integrin signaling involvement was determined usin

251 hose formation can be regulated by beta1 and beta3 integrin signaling pathways.

252 f a cyclic RGD-mimetic-specific inhibitor of beta3 integrin significantly attenuates the cytokine rel

253 erapeutic target to treat TNBC by delivering beta3 integrin siRNA via lipid ECO-based nanoparticles (

254 nd elicits robust compensatory expression of beta3 integrin solely in malignant MECs, but not in thei

255 ntegrin elicits metastatic progression via a beta3 integrin-specific mechanism, indicating that dual

256 for pup) enabled us to predict the Thy-1 and beta3-integrin status of stem cells in neonate and pup t

257 ential (DeltaPsim)(lo), Ep-CAM(+), Thy-1(+), beta3-integrin(+) stem cells in neonate rat testes becom

258 Sc(lo), DeltaPsim(hi), Ep-CAM(+), Thy-1(lo), beta3-integrin(-) stem cells in pup rat testes.

259 In hippocampal neurons, the beta3 integrin subtype is required for homeostatic synap

260 Expression of an inactive beta3 integrin subunit abolishes p190RhoGAP tyrosine pho

261 l and strong cytoplasmatic expression of the beta3 integrin subunit but also an intense expression of

262 stration protocol reduced the content of the beta3 integrin subunit in postsynaptic density of the ac

263 ected the entire intracellular domain of the beta3 integrin subunit to unbiased random mutagenesis an

264 atelets binds to the cytoplasmic tail of the beta3 integrin subunit via its SH3 domain.

265 when expressed at the cytoplasmic end of the beta3 integrin subunit, was able to enhance alphavbeta3-

266 wild type (WT) or constitutively active (CA) beta3 integrin subunit.

267 odies against the alpha5, alphaV, beta1, and beta3 integrin subunits inhibited M-cell invasion by 52

268 t from the more ordered, membrane-associated beta3 integrin tail.

269 -1 and kindlin-2 interactions with beta1 and beta3 integrin tails and describe the effect of kindlin

270 The rod domain competes with beta3-integrin tails for binding to F3, and the structur

271 of bleached focal contacts that contain GFP-beta3 integrin takes longer than 30 min.

272 alpha(v)beta3-Integrin-targeted, paramagnetic nanoparticles were

273 ic mechanism, indicating that dual beta1 and beta3 integrin targeting is necessary to alleviate metas

274 Cells that express a constitutively active beta3 integrin that contains a point mutation in the con

275 y deficits are consequences of dysfunctional beta3 integrins that normally regulate permeabilizing va

276 wn to bind constitutively and selectively to beta3 integrins through an interaction involving the c-S

277 pression depends upon the ability of alpha v beta3 integrin to cluster and promote phosphorylation of

278 rowth factor receptor (EGFR) cooperates with beta3 integrin to regulate p190RhoGAP activity in mouse

279 when targeting the endothelial expression of beta3-integrin to inhibit tumor growth and angiogenesis.

280 Osteoclasts express high levels of alpha(v)beta3 integrin, to which peptides containing the Arg-Gly

281 odel system, structure determinations of the beta3 integrin transmembrane segment and flanking sequen

282 tment and activation of c-Src and subsequent beta3 integrin tyrosine phosphorylation are critical for

283 ere that adhesion- and growth factor-induced beta3 integrin tyrosine phosphorylation are directly med

284 ergistic, because VEGFR-2 activation induces beta3 integrin tyrosine phosphorylation, which, in turn,

285 enerated knock-in mice that express a mutant beta3 integrin unable to undergo tyrosine phosphorylatio

286 The specific requirement for beta3 integrin was apparent when the effect of WISP1 was

287 As bone is replete with ligands for beta3 integrin, we next demonstrated that alphavbeta3 in

288 Mice with a targeted deletion of beta3 integrin were used to examine the process by which

289 In this study, beta3 integrins were overexpressed in smooth muscle cell

290 talin for binding to the cytoplasmic tail of beta3-integrin, whereas it cooperates with talin for act

291 Surprisingly, platelets lacking beta3 integrins, which are unable to form thrombi on the

292 Mice deficient in beta2 or beta3 integrins, which have decreased neutrophil and/or

293 Proliferating C2C12 myoblasts also express beta3-integrin, which is further up-regulated transientl

294 Here, we report a regulatory role of beta3-integrin, which was previously thought not express

295 ERp5 binds to beta3 integrin with an equilibrium dissociation constant

296 n of yellow fluorescent protein (YFP)-tagged beta3 integrin with c(RGDfK) peptide.

297 ta1 activation, and talin F3 binds beta1 and beta3 integrins with comparable affinity, expression of

298 this end, we retrovirally expressed various beta3 integrins with cytoplasmic tail mutations in beta3

299 though previous reports associated beta1 and beta3 integrins with TGF-beta stimulation of EMT and met

300 all, our results show that BMP receptors and beta3 integrin work together to control Smad signaling a