ライフサイエンスコーパス: beta4 integrin

1 ntial for its binding with the cytodomain of beta4 integrin.

2 th the upregulation of MMP-9 and cleavage of beta4 integrin.

3 atic MNNG-HOS cells have increased levels of beta4 integrin.

4 p63 was rescued by signalling downstream of beta4 integrin.

5 s, epitope-tagged PMP22 forms a complex with beta4 integrin.

6 e.g. hCLCA2, mCLCA5, mCLCA1, and bCLCA2) and beta4 integrin.

7 if within the extracellular I-like domain of beta4 integrin.

8 essed in endothelia, failed to interact with beta4 integrin.

9 elial cells, which express little endogenous beta4 integrin.

10 autoantibodies in OCP sera specific for the beta4 integrin.

11 y up-regulated genes, including survivin and beta4-integrin.

12 was positive, yet attenuated, for alpha6 and beta4 integrins.

13 uced the expression of hemidesmosomal alpha6/beta4-integrins.

14 Phosphorylation of the beta4 integrin, a hemidesmosome component, induces disas

15 The levels of beta4 integrin, a molecule involved in the linkage betwe

16 epithelial cells upregulate and internalize beta4-integrin along with its matrix substrate, laminin.

17 bnormalities in the expression of the alpha6 beta4 integrin, an integral component of hemidesmosomes.

18 dc)-1 engaging the cytoplasmic domain of the beta4 integrin and coupling of the integrin to human epi

19 eviously uncharacterized interaction between beta4 integrin and ezrin, a membrane-cytoskeletal linker

20 portantly, the concomitant overexpression of beta4 integrin and FAK significantly correlates with mal

21 physical and functional interactions between beta4 integrin and FAK that influence breast cancer mali

22 beta4 integrin and focal adhesion kinase (FAK) are often

23 a4 integrin, which, in turn, recruits FAK to beta4 integrin and leads to FAK activation and signaling

24 inflammation was delayed, and expression of beta4 integrin and p21 was reduced in lysates of constit

25 cular arrest of cancer cells via adhesion to beta4 integrin and promote early, intravascular, metasta

26 However, the amount of Rac1 associating with beta4 integrin and the activity of both Rac1 and cofilin

27 transfected constructs encoding the mutated beta4 integrins and a GFP-conjugated wild type beta4 int

28 e following levels: p < 0.001 for alpha6 and beta4 integrins and the beta3 chain of laminin 5; p < 0.

29 In these same cells, BPAG1e, the truncated beta4 integrin, and type XVII collagen (Col XVII), a tra

30 three signaling pathways (NF-kappaB, alpha6-beta4-integrin, and IL-1) as differentially upregulated

31 Anti-beta4 integrin antibody attenuated rLN-alpha2G-mediated

32 Circulating anti-beta4 integrin antibody may have an important role in th

33 Treatment of K8(-/-) mice with anti-beta4-integrin antibody up-regulated survivin, and induc

34 ta-catenin was markedly elevated in PBK, and beta4 integrin appeared to be reduced in PBK.

35 uring early stages of myelination, PMP22 and beta4 integrin are coexpressed at the cell surface and c

36 also a functional connection between CD9 and beta4 integrins, as evidenced by anti-CD9 antibody effec

37 es and JEB keratinocytes, induced to express beta4 integrin, assemble laminin-332 in linear tracks ov

38 Here, we tested the hypothesis that the beta4 integrin-associated plakin protein, bullous pemphi

39 keratinocytes also display reduced levels of beta4 integrins at the cell surface but increased total

40 tinct sites at the extreme C terminus of the beta4 integrin cytoplasmic domain.

41 beta4 integrin-deficient (JEB) keratinocytes display abe

42 odia, and directed migration are restored in beta4 integrin-deficient cells by inducing expression of

43 typical of confluent, stationary cells, and beta4 integrin dynamics are reduced in knockdown cells c

44 on was accompanied by increases in beta1 and beta4 integrin epidermal progenitor markers.

45 r hemidesmosomal proteins, nor the amount of beta4 integrin expressed at the cell surface.

46 Our analysis revealed that manipulation of beta4 integrin expression and signaling impacted SPARC e

47 Suppression of beta4 integrin expression by shRNA and disruption of bet

48 These findings suggest a role for beta4 integrin expression in the metastatic phenotype in

49 These data begin to integrate ezrin and beta4 integrin expression into a model of action for the

50 on appears to be critical for maintenance of beta4 integrin expression.

51 helial cells contingent upon epithelial cell beta4-integrin expression.

52 The beta4 integrin-ezrin interaction appears to be critical

53 escribes a pro-metastatic EGFR/Src-dependent beta4 integrin/FAK complex that is involved in breast ca

54 Upon disruption of the beta4 integrin/FAK complex, tumorigenesis and metastasis

55 tegrin expression by shRNA and disruption of beta4 integrin function by transfection of dominant-nega

56 ta4 integrins and a GFP-conjugated wild type beta4 integrin (GFP-beta4WT) into 804G cells, which asse

57 Although the expression of beta4 integrin had no effect on the rate of cell movemen

58 the 90- and 35-kDa CLCA subunits bind to the beta4 integrin in a metal ion-dependent manner.

59 re rescued following expression of wild-type beta4 integrin in JEB cells.

60 A chimeric beta4 integrin in which the indicated SDL sequence had b

61 Expression of the alpha6 beta4 integrin is altered at the dermal-epidermal baseme

62 In this study, we show that beta4 integrin is highly expressed in human osteosarcoma

63 The corresponding CLCA-binding domain of the beta4 integrin is localized to the specific determining

64 Instead, the cytoplasmic tail of beta4 integrin is necessary for basal and epidermal grow

65 , suggesting that signaling through beta1 or beta4 integrins is sufficient for survival.

66 The alpha6beta4 integrin (referred to as "beta4" integrin) is a receptor for laminins that promote

67 e gene encoding the hemidesmosome-associated beta4 integrin (ITGB4), and in the gene for the hemidesm

68 Hemidesmosomal alpha3- and beta4-integrin levels were not affected even though ther

69 In summary, both the beta4 integrin ligand-binding and cytoplasmic domains to

70 d a mutation within the I-like domain of the beta4 integrin, lying outside the SDL region (GFP-beta4V

71 ncreased proliferation (Ki-67) and adhesion (beta4 integrin) markers, and induced inflammatory cell i

72 ense mutation in the extracellular domain of beta4 integrin may affect ligand binding or dimerization

73 We report here that alphaE-catenin inhibits beta4 integrin-mediated activation of SRC tyrosine kinas

74 alpha6 integrin knockdown cells, alpha3 and beta4 integrin mRNAs levels are unaffected.

75 of either primary human keratinocytes (NHK), beta4 integrin-null human keratinocytes (beta4-), or tho

76 ve in keratinocytes exhibiting deficiency in beta4 integrin or knockdown of the plakin protein Bullou

77 to migrate and can be induced by EGF through beta4 integrin phosphorylation.

78 and ITGB4 genes which encode the alpha6 and beta4 integrin polypeptides, respectively.

79 ITGA6 and ITGB4, which encode the alpha6 and beta4 integrin polypeptides, respectively.

80 These findings indicate that the beta4 integrin promotes prostate tumorigenesis by amplif

81 , re-expression of alpha6 integrin increases beta4 integrin protein at the cell surface, which result

82 es expressing both full-length and truncated beta4 integrin proteins.

83 stiffness and composition is sensed through beta4 integrin, Rac1, and the PI3K pathway, and suggest

84 entified a novel phosphorylation site on the beta4 integrin: S(1424).

85 ng that the clustering of alpha6beta4 with a beta4 integrin-specific antibody promotes p53-dependent

86 -catenin involves negative regulation of the beta4 integrin-SRC signaling pathway and that SRC-mediat

87 h Sdc1 engages the cytoplasmic domain of the beta4 integrin subunit allowing HER2-dependent motility

88 Expression of either the alpha6 or beta4 integrin subunit also restored some aspects of a l

89 provide evidence that the SDL segment of the beta4 integrin subunit is required for ligand binding an

90 s associated with the phosphorylation of the beta4 integrin subunit on serine residues.

91 n of the alpha2beta1 integrin, the alpha6 or beta4 integrin subunit was expressed in our Mm5MT model.

92 their ability to increase expression of the beta4 integrin subunit, a component of the alpha6beta4 i

93 as well as reduced labeling for plectin, the beta4 integrin subunit, and for type XVII collagen.

94 of patients with MMP and OCP recognize only beta4 integrin subunit, and sera of OP patients recogniz

95 cicatricial pemphigoid (OCP) sera recognize beta4 integrin subunit, oral pemphigoid sera recognize a

96 er adhesion-independent cross-linking of the beta4 integrin subunit.

97 he notion of close association of the alpha6 beta4 integrin subunits and further attest to the critic

98 ults in up-regulation of both the alpha6 and beta4 integrin subunits but no change in the alpha1, alp

99 rther investigate the role of the alpha6 and beta4 integrin subunits in mediating the phenotypic chan

100 ligand binding or dimerization of alpha6 and beta4 integrin subunits.

101 urface expression of the alpha2, alpha3, and beta4 integrin subunits.

102 generated point mutations within the SDL of beta4 integrin tagged with green fluorescent protein (GF

103 mammary tumors lacking functional beta1 and beta4 integrin through activation of NFkappaB, and overe

104 was also shown to colocalize with Rab27B and beta4 integrin to early adhesion initiation sites in spr

105 in ECS cells, where it interacts with alpha6/beta4 integrin to stimulate FAK and Src signaling, leadi

106 ative genes, 14-3-3sigma, S100P, S100A6, and beta4 integrin, to neoplastic cells in pancreatic tumors

107 M. leprae interacts with cells by binding to beta4 integrin via an LN-alpha2G bridge.

108 an keratinocytes (beta4-), or those in which beta4 integrin was reexpressed (beta4+), were tracked du

109 unction by transfection of dominant-negative beta4 integrin was sufficient to revert this highly meta

110 istant metastases express high levels of the beta4 integrin, which binds to laminin-5.

111 y inducing expression of a truncated form of beta4 integrin, which lacks binding sites for BPAG1e and

112 ing triggers the tyrosine phosphorylation of beta4 integrin, which, in turn, recruits FAK to beta4 in

113 otility depends on cytoplasmic engagement of beta4 integrin with Sdc4.