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1 s, was up-regulated during growth on glycine betaine.
2 miting the ability of most plants to produce betaine.
3 carry out corrinoid methylation with glycine betaine.
4 ts with severe MTHFR deficiency treated with betaine.
5 x S) plants showed increased accumulation of betaine.
6 anol, 3,4-dimethoxybenzoate, H2 plus CO2, or betaine.
7 esumably as a result of excess extracellular betaine.
8 to PCA, and showed little to no response to betaine.
9 ctive vitamin B-12 (holotranscobalamin), and betaine.
10 on; the most dramatic variation was seen for betaine.
11 ying increase in degradation of radiolabeled betaine.
12 NA and on interactions with solvent additive betaine.
13 ed importer of the compatible solute glycine betaine.
14 resence and absence of the osmolyte, glycine betaine.
15 mechanism that is distinct from glycine and betaine.
16 nhanced sorption of long-chain fluorotelomer betaines.
17 en the transoid and cisoid conformers of the betaines.
18 s by deprotonation of heterocyclic mesomeric betaines.
19 in the iminophosphorane intermediate to give betaines.
20 t sizes: choline, 0.35 (95% CI: 0.12, 0.57); betaine, 0.29 (95% CI: 0.01, 0.58); methionine, 0.31 (95
21 zoylimino-3,4-dihydro-6-methylisoquinolinium betaine (1a) reacts at RT with acrylonitrile in the pres
22 3-yl)quinolinium derivative or the mesomeric betaine 2-(1-methylquinolinium-3-yl)-1,3-dioxo-2,3-dihyd
24 calculations on the structures of mesomeric betaine 22a, the carbene 23a, and the mechanisms of the
25 - and 4-substituted benzoates, the mesomeric betaines 3- and 4-[(1-methylquinolinium-3-yl)ethynyl]ben
26 proline betaine (stachydrine), beta-alanine betaine, 4-guanidinobutyric acid, trigonelline, N,N,N-tr
27 those of 6:2 fluorotelomer sulfonamidoalkyl betaine, 6:2 and 8:2 fluorotelomer sulfonates, and short
29 ines (8:2-FTAB and 10:2-FTAB), fluorotelomer betaines (9:3-FTB, 11:3-FTB and 9:1:2 FTB) and 6:2 fluor
33 n intermediate stress level, consistent with betaine accumulation, but was increased by an upshift to
34 scriptomes included some involved in glycine betaine accumulation, mscL, ure genes, femH, spa and smp
38 betC genes, encoding choline dehydrogenase, betaine aldehyde dehydrogenase and choline sulfatase, re
39 ce-associated protein/B12D-related protein1, Betaine aldehyde dehydrogenase, and Unknown protein5.
43 esis and transport, respectively, of glycine betaine, an osmoprotectant used during osmotic stress.
44 s in chestnut, no one has appeared so far on betaines, an important class of nitrogen compounds ubiqu
45 iotracers are readily oxidized to respective betaine analogs, with metabolites detectable in plasma s
47 ored partitioning of dietary choline between betaine and CDP-PC among NP (MTHFR rs1801133 and MTR rs1
49 Although the OsmU system can take up glycine betaine and choline-O-sulfate, these two osmoprotectants
50 recombinant DSY3156 protein converts glycine betaine and cob(I)alamin to dimethylglycine and methylco
51 c amino acids, the well-known osmoprotectant betaine and flavonoids were also more abundant in S. lep
52 We observed a seasonal switch between the betaine and folate pathways and a probable limiting role
55 concentrations of homocysteine, choline, and betaine and genotyped them for 2 polymorphisms with effe
57 nventional preferential solvation arguments, betaine and glycine both increase the surface tension at
58 xidized by choline oxidase (ChOx) to produce betaine and H(2)O(2), which reacts with Amplex UltraRed
59 xidized by choline oxidase (ChOx) to produce betaine and H2O2 that generates the reactive oxygen spec
61 taine ratio from 15 GW and with lower plasma betaine and higher dimethylglycine from 24 to 27 GW, for
65 se in production of osmoprotectants, such as betaine and polyols, and metal-chelating organic acids.
66 ied surfactants with functionalities such as betaine and quaternary ammonium was improved with the Me
67 ract of C. sapidus, while homarine, lactate, betaine and taurine characterized E. verrucosa and C. pa
68 tus was low and that the association between betaine and tHcy depended on folate status at 24-27 and
70 Low folate status enhances the reduction in betaine and the increase in dimethylglycine during pregn
71 choline and its closely related metabolites, betaine and TMAO, with linear growth and stunting in you
74 tnut cultivated in Italy, the composition of betaines and ammonium compounds intermediates of their b
77 eous solution, the N-methyl-6-oxyquinolinium betaine, and analyze it in terms of far IR and THz frequ
81 ons between intakes of choline, vitamin B12, betaine, and folate during the first and second trimeste
82 f labile methyl groups (choline, methionine, betaine, and folate) is important for normal liver funct
83 flours, whereas an uncommon betaine, valine betaine, and glutamine betaine were present only in flou
84 ee osmolytes, trimethylamine N-oxide (TMAO), betaine, and glycine, on the hydrophobic collapse of an
88 edian (25th, 75th percentile) serum choline, betaine, and TMAO concentrations were 6.4 (4.8, 8.3), 12
89 tion coefficients of age with serum choline, betaine, and TMAO were -0.57 (P < 0.0001), -0.26 (P < 0.
90 ound that concentrations of the methyl donor betaine are decreased in MS cortex and are correlated wi
94 des--which represent a subclass of mesomeric betaines--are the exclusively detectable form in the NMR
97 Another mechanism for AdoMet synthesis uses betaine as the methyl donor via the enzyme betaine-homoc
98 hylation of homocysteine to methionine, with betaine as the methyl donor, and has previously been tho
99 ach to preventing diabetes, and increases in betaine at 2 years were also associated with lower diabe
100 s that followed the accident, as did several betaine-based PFASs (8:2-FTAB, 10:2-FTAB, 9:3-FTB, 11:3-
105 he crystallographic structure of the glycine betaine-binding protein ProX of Archaeoglobus fulgidus;
107 tudies using two UCST-type TRILs, protonated betaine bis(trifluoromethyl sulfonyl)imide ([Hbet][Tf2N]
109 er-deficit stresses which de novo synthesize betaine by the stepwise methylation of glycine, catalyze
111 with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype me
114 clic carbene 23a and that the energy for the betaine-carbene interconversion is DeltaG(double dagger)
115 ma-butyrobetaine antiporter belonging to the betaine/carnitine/choline transporter family of secondar
118 seudomonas syringae B728a, expression of the betaine catabolism genes was reduced by an osmotic upshi
120 We have developed a new class of cinchonium betaine catalysts bearing both a base moiety and an arom
123 illatory production of S-adenosylmethionine, betaine, choline, phosphocholine, glyceophosphocholine,
125 1, aflatoxin G1, aspergillic acid, aspyrone, betaine, chrysogine, deacetyl parasiticolide A, flufuran
126 betaine (tHyp-B) and cis-4-hydroxy-D-proline betaine (cHyp-B), and also the correct identification of
128 We included 955 pregnant women whose plasma betaine concentrations were measured at 26-28 wk of gest
130 our knowledge, DSY3156 is the first glycine betaine:corrinoid methyltransferase described, and a des
131 evelopment, we hypothesized that choline and betaine could also be positively related to academic ach
134 tood about the importance of the alternative betaine-dependent methylation pathway-catalyzed by betai
136 ke yielded higher concentrations of choline, betaine, dimethylglycine, and sarcosine (12-46%; P </= 0
137 ting plasma folate, cobalamin, free choline, betaine, dimethylglycine, and total homocysteine (tHcy)
138 a biomarkers of choline metabolism [choline, betaine, dimethylglycine, and trimethylamine N-oxide (TM
139 oassay and plasma concentrations of choline, betaine, dimethylglycine, retinol, essential fatty acids
140 ed in conjunction with the methylation agent betaine, dramatically increased survival in mice fed a n
141 ine, acetylcholine, L-carnitine, and glycine betaine effectively.The choline-binding protein ChoX exh
143 epoxidations, the degree of reversibility in betaine formation dominates both the diastereoselectivit
145 diastereoselectivities are determined in the betaine forming step and are more variable as a result.
146 onamide alkylbetaines (FTABs), fluorotelomer betaines (FTBs), 6:2 fluorotelomer mercaptoalkylamido su
147 tSs), zwitterionic fluorotelomer sulfonamido betaines (FtSaBs), and cationic 6:2 fluorotelomer sulfon
148 on in the absence of stress, suggesting that betaine functions both in nutrition and as an intracellu
150 ce levels of the glycine transporter-1a, the betaine/GABA transporter and the GABA transporter-4.
152 Two PC catabolites, choline and glycine betaine (GB), were sufficient to stimulate Anr activity,
157 arnitine, such as trimethylamine N-oxide and betaine, have recently been identified as novel risk fac
158 ine levels of betaine, also known as glycine betaine (hazard ratio 0.84 per SD log metabolite level,
161 AM from betaine (N,N,N-trimethylglycine) via betaine-homocysteine methyltransferase (BHMT), which is
162 e-dependent methylation pathway-catalyzed by betaine-homocysteine methyltransferase (BHMT)-for establ
163 s betaine as the methyl donor via the enzyme betaine-homocysteine methyltransferase (BHMT, EC 2.1.1.5
167 small heterodimer partner [SHP]-null mice), betaine-homocysteine S-methyltransferase (Bhmt), or both
169 first time the occurrence of pipecolic acid betaine (homostachydrine) and its precursor 1,2-N-methyl
170 The cyclizations involve the formation of betaines (imidazoliumylpyrrolides) under basic condition
171 oligopeptide importer (oppABCDF) and glycine betaine importer (gbuABC) allowed DeltadacA mutants to g
172 anthine, acetoacetate, 3-hydroxybutyrate and betaine in alcohol-fed mice and decreased cytidine, urac
173 ittle literature available on the content of betaine in cereal products, nor on betaine intake from c
179 ed maturing oocytes autonomously synthesized betaine in vitro in the presence of choline, whereas thi
180 cereal foods provide approximately 60-67% of betaine in Western diets, and 20-40% of betaine in South
181 We report the LC-ESI-MS/MS determination of betaines in commercial flours of cereals and pseudocerea
182 Together, these data indicate that dietary betaine increases Fgf21 levels to improve metabolic heal
186 ntify genetic factors associated with plasma betaine levels and determine their effect on risk of cor
187 rity, the DeltagbcAB mutant accumulated high betaine levels and low endogenous solutes and exhibited
189 rinary levels of TMAO and plasma choline and betaine levels by means of liquid chromatography and onl
192 ol-to-sulfolipid and a phosphatidycholine-to-betaine lipid replacement followed by a late accumulatio
197 and this reduction was due to the relief of betaine-mediated suppression of compatible solute synthe
198 ous folate-dependent mechanism but also from betaine metabolized by BHMT, likely a significant pool o
199 the nanomolar range for choline and glycine betaine, micromolar Kd for stachydrine and trigonelline
204 but only a few cell types generate SAM from betaine (N,N,N-trimethylglycine) via betaine-homocystein
205 that glycine betaine, trigonelline, proline betaine, N(epsilon)-trimethyllysine were metabolites com
206 ycerophosphocholine, phosphocholine, glycine betaine, N-methylproline, proline betaine (stachydrine),
208 s acute intake biomarkers of citrus (proline betaine), oily fish (methylhistidine), coffee (dihydroca
210 hat LuxR activates expression of the glycine betaine operon betIBA-proXWV, which enhances growth reco
212 er, overactivation of the receptor by excess betaine or by the allosteric modulator monepantel result
214 the maximal current amplitudes achieved with betaine or choline, making monepantel a superagonist.
215 THFR deficiency, of whom at least 1 received betaine, or (2) single patients with severe MTHFR defici
220 nd other pseudomonads that, with the glycine betaine pool, regulates osmoprotection and phospholipase
221 imentally manipulate the choline and glycine betaine pools by overexpression of the cognate catabolic
222 eruginosa maintains both choline and glycine betaine pools under a variety of conditions, in contrast
224 was associated with a higher dimethylglycine/betaine ratio from 15 GW and with lower plasma betaine a
225 tified the betaine transporter SNF-3 and the betaine receptor ACR-23 in the nematode C. elegans.
226 immunoprecipitation experiments showed that betaine regulates metabolic genes in human SH-SY5Y neuro
228 15 at CPS1), serine (rs478093 at PHGDH), and betaine (rs499368 at SLC6A12; rs17823642 at BHMT)-and on
230 nd methylation potential, higher creatinine, betaine, S-adenosylhomocysteine (SAH), and S-adenosylmet
232 e, glycine betaine, N-methylproline, proline betaine (stachydrine), beta-alanine betaine, 4-guanidino
234 to examine the association between maternal betaine status and neonatal birth size and adiposity in
238 ve metabolic health in mice and suggest that betaine supplementation merits further investigation as
240 lel with these beneficial metabolic effects, betaine supplementation robustly increased hepatic and c
242 nine, N1-acetylspermidine, xanthine, uracil, betaine, symmetric dimethylarginine, and asymmetric-dime
246 hate (CDP)-choline pathway at the expense of betaine synthesis even when use of betaine as a methyl d
248 Two photochromic spirodihydroindolizine/betaine systems for tethering to peptides and proteins v
250 ssive uptake of compatible osmolytes such as betaine, taurine, and myo-inositol is a protective respo
251 d for covalent immobilization of lectins and betaine terminated thiol to resist nonspecific interacti
254 2-epimerization of trans-4-hydroxy-L-proline betaine (tHyp-B) and cis-4-hydroxy-D-proline betaine (cH
255 A), alpha-linolenic acid (ALA), or ratios of betaine to choline and LA to ALA.The findings supported
257 dietary supplementation of the methyl donor betaine to modulate inflammatory and methylation status.
258 sitions from reliance on exogenously derived betaine to the use of endogenous solutes during adaptati
260 sic conditions and the tautomerizaton of the betaines to the corresponding NHCs, which are the reacti
261 eptides act as osmolytes, similar to glycine betaine, to disrupt intracellular osmotic pressure.
263 f height-for-age z score with serum choline, betaine-to-choline ratio, and TMAO-to-choline ratio were
267 tx-j mice reduced Tnf-alpha and ALT levels, betaine treatment increased S-adenosylmethionine and up-
273 ent K(m) and K(d) for sodium, as measured by betaine uptake, tryptophan fluorescence, and (22)Na(+) b
274 ccumulation of the compatible solute glycine betaine, ure genes of the urease operon, and mscL encodi
275 to all examined flours, whereas an uncommon betaine, valine betaine, and glutamine betaine were pres
276 intakes of riboflavin, folate, choline, and betaine varied significantly by season; the most dramati
277 The mean +/- SD plasma concentration of betaine was 13.2 +/- 2.7 mumol/L (range: 5.3-25.0 mumol/
279 nitric oxide donor sodium nitroprusside, and betaine was able to rescue H3K4me3 levels and respirator
280 tment for covariates, higher maternal plasma betaine was associated with lower birth weight (beta: -5
282 (0.93-6.40); P trend = 0.08], whereas plasma betaine was inversely associated with colorectal cancer
285 velopment in surviving patients treated with betaine was normal in all 5 early-treated patients but i
287 Conversely, higher concentrations of plasma betaine were associated with a favorable cardiometabolic
288 ses in the concentration of the methyl donor betaine were correlated with decreases in histone H3 tri
289 wed that by 24-27 GW, both plasma folate and betaine were inversely associated with tHcy when folate
290 ommon betaine, valine betaine, and glutamine betaine were present only in flours of barley, rye, oat,
291 roposed piezolytes glutamate, sarcosine, and betaine were used, as well as solutions containing the d
292 graphy (TOF-CIC) revealed that fluorotelomer betaines were a substantial portion of the organofluorin
295 ), who presented with low plasma choline and betaine, were studied to determine the metabolic charact
296 tions were the best overall common source of betaine, while the pseudocereal quinoa had the highest a
298 iense was found capable of growth on glycine betaine with electron acceptors such as nitrate or fumar
300 sed frequency of reactions to cocamidopropyl betaine, wool alcohol, lanolin, tixocortol pivalate, and
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