ライフサイエンスコーパス: betatrophin

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1 Betatrophin, a 198-amino acid protein secreted by liver

2 The recent discovery of betatrophin, a protein secreted by the liver and white a

3 ta show strong positive associations between betatrophin and FBG and insulin resistance in non-diabet

4 Betatrophin/ANGPTL8 is a newly identified hormone produc

5 These results put into question whether betatrophin can be developed as a therapeutic approach f

6 Expression of betatrophin correlates with beta cell proliferation in o

7 receptor antagonist S961, shown to increase betatrophin gene expression and stimulate beta-cell repl

8 owed that subjects in the highest tertile of betatrophin had higher odds of having T2D (odd ratio [OR

9 Betatrophin has not yet been shown to have an effect on

10 Betatrophin has previously been named RIFL, lipasin, and

11 None of these factors, including betatrophin, have displayed the same activity in clinica

12 Transient expression of betatrophin in mouse liver significantly and specificall

13 TC and LDL showed negative association with betatrophin in T2D subjects.

14 Betatrophin is a newly described hormone, which potently

15 Therefore, lipasin/betatrophin is nutritionally-regulated hepatokine that i

16 ny endocrine and paracrine factors, of which betatrophin is the newest described, increase beta cell

17 n (also known as C19ORF80, RIFL, ANGPTL8 and betatrophin) is a newly discovered circulating factor th

18 lternatively called TD26, RIFL, Lipasin, and Betatrophin) is a newly recognized ANGPTL family member

19 Little is known about betatrophin level in humans and its association with T2D

20 Our data show a significant difference in betatrophin levels between non-diabetic (731.3 (59.5-106

21 Serum betatrophin levels in humans correlate with improved adi

22 At present, however, the effects of betatrophin on human beta-cells are not known.

23 ike protein 8 (ANGPTL8) was the long-sought "betatrophin" that could control pancreatic beta cell pro

24 Using this model, we identify a hormone, betatrophin, that is primarily expressed in liver and fa

25 Thus, betatrophin treatment could augment or replace insulin i

26 Plasma level of betatrophin was measured by ELISA in 1603 subjects: 1047

27 Betatrophin was positively correlated with age, BMI, wai

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