ライフサイエンスコーパス: biantennary

1 crystal structure of SBA cross-linked with a biantennary analog of the blood group I carbohydrate ant

2 Studies with monoantennary and biantennary analogs and mixtures suggest that Stx1, Stx2

3 The results suggest that SLex biantennary and triantennary are N-linked oligosaccharid

4 inked oligosaccharides, with specificity for biantennary and triantennary complex glycans.

5 acokinetic profiles were identified for SLex biantennary and triantennary oligosaccharides but not fo

6 tribution studies established that both SLex biantennary and triantennary oligosaccharides distribute

7 type with the core-fucosylated disialylated biantennary and trisialylated triantennary structures pr

8 ealed an N-linked asialo, agalacto, bisected biantennary, and a core-fucosylated oligosaccharide in t

9 and nonfucosylated forms of hybrid, complex biantennary, and triantennary glycans account for 12% of

10 oss-linked with four isomeric analogs of the biantennary blood group I carbohydrate antigen.

11 relative affinities of the proteins for the biantennary carbohydrate.

12 aled nanotubes were covalently modified with biantennary carbohydrates, improving dispersibility and

13 st how DGL discriminates against binding the biantennary complex carbohydrate relative to ConA.

14 xy analogs of the core trimannoside and to a biantennary complex carbohydrate were determined by isot

15 show substantially reduced affinities for a biantennary complex carbohydrate with terminal GlcNAc re

16 ermodynamics of binding of DGL and ConA to a biantennary complex carbohydrate.

17 linked carbohydrates, but lower affinity for biantennary complex carbohydrates.

18 However, unlike ConA, DGL does not bind to biantennary complex carbohydrates.

19 This was confirmed by showing that biantennary complex glycopeptides do not bind to a DGL-S

20 he three carbohydrate structures were of the biantennary complex type, but only the ones from fetal b

21 Both glycans are xylose containing biantennary complex types that share the common core str

22 high mannose-type (33.3%), (ii) disialylated biantennary complex-type (19.2%), and (iii) alpha-galact

23 igosaccharide oxazoline corresponding to the biantennary complex-type N-glycan was synthesized and te

24 cNAcbeta1-O-pNP and to a GlcNAc-terminating, biantennary, complex N-glycan, with or without a core fu

25 One group represents sialylated biantennary compounds with an N-glycan core terminating

26 with the alpha1-3Man branch of the complex, biantennary Fc glycan preferentially sialylated.

27 heir amino acid sequence and by the complex, biantennary Fc-associated N-linked glycan.

28 ne-linked consensus motif, was modified with biantennary fucosylated oligosaccharide structures.

29 N-linked glycans in tACE to be mostly of the biantennary, fucosylated complex type.

30 and glycopeptide acceptors, particularly to biantennary, GlcNAc-terminated acceptors.

31 ositional isomers of a single sialic acid on biantennary glycan antennae were resolved.

32 The most abundant compound was a biantennary glycan carrying sulfated GlcA on the 6-branc

33 on site on the Fc domain to which a complex, biantennary glycan is attached.

34 A synthetic biantennary glycan precursor was (13)C-labeled on all fo

35 ntennary glycans, and the relative amount of biantennary glycan versus tri- and tetraantennary glycan

36 The detailed structure of the trifucosylated biantennary glycan was confirmed, together with the stru

37 ar, we observed the increase of bisialylated biantennary glycan, A2G2S[3,6]2, 12 hours after surgery,

38 Previous studies examined binding to biantennary glycans expressing Pk trisaccharide mimics i

39 alylated glycopeptides identified carry more biantennary glycans than tri- and tetraantennary glycans

40 tyllactosamine oligosaccharide antennae from biantennary glycans using MS3, and the location of a bis

41 h, and the major complex-type structures are biantennary glycans with Lewisx (Galbeta1-4(Fucalpha1-3)

42 ally distributed, with N46 containing mostly biantennary glycans, N83 containing primarily tri- and t

43 ary glycans, and N247 containing exclusively biantennary glycans.

44 ases in some nonfucosylated paucimannose and biantennary glycans.

45 ith the structures of another 12 fucosylated biantennary glycans.

46 fer to study the solution conformations of a biantennary glycopeptide and its partially trimmed produ

47 lcNAc preferentially to a GlcNAc-terminating biantennary glycopeptide that contains a core fucose res

48 In the intact biantennary glycopeptide, the donor-acceptor distance di

49 The major monosialyl biantennary glycopeptides (see below) were used as subst

50 ides were used for conformational studies of biantennary glycopeptides by energy transfer.

51 Biantennary glycopeptides from bovine fibrinogen were fl

52 lated Fc compared with similarly sialylated, biantennary glycoproteins, thus suggesting that a specif

53 It was found to be modified predominantly by biantennary hybrid structures.

54 ed (sialylated, neutral and core fucosylated biantennary IgG glycans) carbohydrates.

55 ve alpha-mannosidase trims some N-glycans to biantennary Man(3)GlcNAc(2).

56 on showed that TbSTT3A selectively transfers biantennary Man(5)GlcNAc(2) to specific glycosylation si

57 e showed that TbGnTI transfers UDP-GlcNAc to biantennary Man3GlcNAc2, but not to triantennary Man5Glc

58 ing that Pg 1 L-lysine binding sites and the biantennary, mannose-containing N-linked oligosaccharide

59 ion of the alpha2,6-sialylated terminus of a biantennary N-glycan by viscumin.

60 zed using the MS signal for the disialylated biantennary N-glycan derived from fetuin.

61 cetylglucosaminyltransferase II activity for biantennary N-glycan production.

62 In this study, it was found that the biantennary N-glycan structure with two terminal alpha-2

63 With a biantennary N-glycan substrate, it exhibited a 5-fold pr

64 cells was a dramatic reduction of sialylated biantennary N-glycans carrying the terminal NeuGcalpha2-

65 are primarily highly processed complex-type biantennary N-glycans linked to N-glycosylation sites th

66 e Gal(beta4)GlcNAc terminal structure of the biantennary N-glycans on the Fc domain.

67 Radiolabeled biantennary N-glycans synthesized by Pro(-)5Lec20 were p

68 ary N-glycans and of O-glycans, 2) increased biantennary N-glycans, and 3) reduced LacNAc and sLe(X)

69 1-4GlcNAcbeta1-)(n)) sequences, complex-type biantennary N-glycans, or novel chitin-derived glycans m

70 convergent synthesis of the sialic acid-rich biantennary N-linked glycan found in human glycoprotein

71 he composition of the complex, Fc-associated biantennary N-linked glycan.

72 carbohydrates ranging from trisaccharides to biantennary N-linked glycans.

73 2 binds selectively to galactose-terminated, biantennary N-linked glycans.

74 and tetraantennary N-linked glycoforms from biantennary N-linked glycoforms bearing terminal sialic

75 he baculovirus system typically lack complex biantennary N-linked oligosaccharide side chains contain

76 oduce recombinant glycoproteins with complex biantennary N-linked oligosaccharides structurally ident

77 e to select glycopeptides containing complex biantennary N-linked, hybrid, and high-mannose glycans,

78 acid appended to glycopeptides with complex biantennary N-linked, hybrid, and high-mannose glycans.

79 g human serum glycoproteins carrying complex biantennary N-linked, hybrid, and high-mannose oligosacc

80 neous compound containing an N-linked asialo biantennary nonasaccharide glycan moiety of defined cova

81 d the complex with its reaction product, the biantennary octasaccharide, Gal-beta(1-4)-GlcNAc-beta(1-

82 The complex biantennary oligosaccharide at Asn297 of IgG is essentia

83 In an N-linked biantennary oligosaccharide chain, one antenna is attach

84 residues along one of the two antenna in the biantennary oligosaccharide has a small effect on the di

85 formational property for the 6' antenna of a biantennary oligosaccharide that is influenced by core f

86 A core fucosylated biantennary oligosaccharide was converted to a glycosyla

87 ate moiety of both asialoglycopeptides was a biantennary oligosaccharide with a core alpha(1-->6)-lin

88 he conformation of each antenna of a complex biantennary oligosaccharide.

89 has high mannose-, hybrid-, and complex-type biantennary oligosaccharides including structures with f

90 Our data indicated that biantennary oligosaccharides lacking galactosylation had

91 have three characteristics (core-fucosylated biantennary oligosaccharides with one or two N-glycolyln

92 tained typical Fc glycans (core-fucosylated, biantennary oligosaccharides with zero to two Gal residu

93 ans present on rituximab are neutral complex biantennary oligosaccharides with zero, one, and two ter

94 saccharide is similar to that seen for other biantennary oligosaccharides, with the exception of two

95 significant accumulation of core-fucosylated biantennary oligosaccharides.

96 teractions that are unique to complexes with biantennary or triantennary complex glycans.

97 Simultaneous dosing of SLex biantennary or triantennary oligosaccharide with a mouse

98 es were conjugated to biotinylated mono- and biantennary platforms, allowing for the display of two t

99 he modular synthesis of robust, biotinylated biantennary sialylglycoconjugates and their ability to d

100 ol for the simultaneous installation of both biantennary side-chains of the dodecasaccharide as well

101 was shown to be a homogenous "complex type" biantennary structure.

102 n64 of heavy chain 2: all these were complex biantennary structures composed of (Asn)-GlcNAc2-Man-(Ma

103 The N-glycans were complex biantennary structures present in either a mono- or disi

104 All are complex biantennary structures with a common N-linked pentasacch

105 carrying N-glycans revealed the presence of biantennary structures with terminal sialic acid residue

106 y with the decrease of most core-fucosylated biantennary structures, as well as the increase in sialy

107 spectrometry and found to contain sialylated biantennary structures.

108 oline-rich glycoproteins is a trifucosylated biantennary sugar with one difucosylated and one unfucos

109 yses showed that SfSWT-1 cells could produce biantennary, terminally sialylated N-glycans.

110 roportion of sialylated and core-fucosylated biantennary, triantennary and tetra-antennary oligosacch

111 of the results obtained for the 6 antenna of biantennary with previous fluorescence energy transfer s