ライフサイエンスコーパス: biaryl

1 atropselective transformation of an existing biaryl.

2 ective synthesis of unsymmetrical oxygenated biaryls.

3 ducts that are oxidized to the corresponding biaryls.

4 nder mild conditions to form polysubstituted biaryls.

5 is demonstrated on the phosphorus-containing biaryls.

6 ange of oxygenated dienes yielded the target biaryls.

7 ovide an expedient route to multifluorinated biaryls.

8 functional groups leading to silicon-bridged biaryls.

9 enzyme in the biosynthesis of axially chiral biaryls.

10 hylene bridge is developed from N-sulfonyl-4-biaryl-1,2,3-triazole derivatives via Rh-catalyzed denit

11 arrier study was performed on eight tertiary biaryl 2-amides using variable-temperature (VT) NMR and

12 using dihalobenzamides for the synthesis of biaryl 5-phenylisoindolin-1-ones.

13 yl gp120 inhibitors revealed that around the biaryl, a fine crevice might exist in the gp120 binding

14 lactamization for closure of the 12-membered biaryl AB ring system, and the defined order of CD, AB,

15 on of NMR-based screening yielded an initial biaryl acid with an affinity (K(d)) of approximately 300

16 A biaryl acyl sulfonamide hit from this library was elabor

17 The biaryl acyl sulfonamides reported herein may also offer

18 st interaction is efficiently antagonized by biaryl alpha-d-mannopyranosides.

19 range of functional groups, and a variety of biaryl amide derivatives were successfully prepared in g

20 nzo[d]imidazole platform that evolved from a biaryl amide lead.

21 oduct can be controlled by the design of the biaryl amide substrate, and the method is compatible wit

22 report efficient syntheses of axially chiral biaryl amides in yields ranging from 80-92%, and with en

23 ed design, two novel series of highly potent biaryl amine mitogen-activated protein kinase kinase (ME

24 nthesis of sterically hindered atropisomeric biaryl amines.

25 Truncation of the S3 substituent of the biaryl aminothiazine 2, a potent BACE1 inhibitor, led to

26 ate phosphine-ligated palladium catalyst for biaryl and alkyl aryl sulfide formation.

27 pensive, robust, and convenient synthesis of biaryl and heterobiaryl compounds.

28 ssing firefly luciferase, we prioritized the biaryl and N-arylpiperazine analogues by oral bioavailab

29 the resting states are unsymmetrical Ni(II)-biaryl and Ni(II)-bithiophene complexes.

30 ation, all Ni-catalyzed routes to functional biaryls and heterobiaryls are now easily accessible.

31 red substrates such as tri-ortho-substituted biaryls and tetra-ortho-substituted diarylamines can be

32 the reactions (no side-formation of arenes, biaryls, and C2F5 derivatives) has allowed for the isola

33 -R-allylpalladium complexes containing bulky biaryl- and bipyrazolylphosphines with extremely broad l

34 Biaryl anthranilides are reported as potent and selectiv

35 n by arylsilanes (Ar(2)-SiMe(3)) to generate biaryls (Ar(1)-Ar(2)), with little or no homocoupling (A

36 t, thus offering access to unexplored chiral biaryl architectures.

37 Multifluorinated biaryls are challenging to synthesize and yet are an imp

38 ration of the biaryl axis (stereochemistry), biaryls are notoriously difficult to synthesize.

39 Selected examples involving allenes, biaryls, arylamides and transient axially chiral short-l

40 Axially chiral biaryls, as exemplified by 1,1'-bi-2-naphthol (BINOL), a

41 The ability to isolate enantiomerically pure biaryl atropisomers using a benzyl oxazolidinone is disc

42 After extensive optimization, biaryl Au(I) catalyst 21 was found to overcome the inher

43 pling was developed for the synthesis of the biaryl axes present in useful P-chiral dihydrobenzooxaph

44 rphenyls bearing 1,2-type or 1,3-type chiral biaryl axes was achieved by HPLC on a chiral phase.

45 atropisomerism, with one or two stereogenic biaryl axes.

46 idative 2-naphthol coupling to establish the biaryl axial chirality.

47 regiochemistry) and the configuration of the biaryl axis (stereochemistry), biaryls are notoriously d

48 thesis (9a-11) hinted at the location of the biaryl axis and the presence of acetyl groups as importa

49 was revealed to possess an (aS)-configurated biaryl axis by X-ray crystallographic analysis.

50 was employed in the formation of the C9-C9' biaryl axis in 1.

51 ct to the configurational stability of their biaryl axis using dynamic chiral HPLC; subtle effects of

52 lling the otherwise configurationally labile biaryl axis.

53 xamples) can be synthesized from substituted biaryl azides at 60 degrees C using substoichiometric qu

54 stereoselective formation of carbazoles from biaryl azides.

55 A catalyst that couples a photoswitch to the biaryl backbone of a chiral bis(phosphine) ligand, thus

56 us center and the 2' and 6' positions of the biaryl backbone play an important role in inhibiting oxi

57 Ligands containing biaryl backbones with smaller dihedral angles generate c

58 Synthesis and micellar behavior of biaryl-based benzyl ether dendritic molecules prepared f

59 tudy describes novel N-sulfonyl-aminobiaryl (biaryl-benzenesulfonamides) as potent anticancer agents

60 lpalladium complexes incorporated a range of biaryl/bipyrazolylphosphine ligands, while extremely bul

61 ring in N-phenylpyrazoles to afford either a biaryl bis-pyrazole (via dehydrogenative homocoupling) o

62 bonylations, and two dehydrogenations, giant biaryl bisquinones (compounds 13, 14, 15, 18, and 21).

63 coupling for installation of the hindered AB biaryl bond (90%) on which the atropisomer stereochemist

64 The congested N,C-biaryl bond establishes an axis of chirality that, for m

65 romobenzyltertiary alcohol to yield the homo-biaryl bond followed by intramolecular C-O bond formatio

66 The generation of 4 involves an unusual biaryl bond formation under reductive conditions.

67 , and a Suzuki homocoupling to forge the key biaryl bond.

68 Biaryl bonds of the nonplanar p-terphenyl nuclei were co

69 n used to generate side chain to side chain, biaryl-bridged 14- to 21-membered macrocyclic peptides.

70 Biaryl bridges possessing three different configurations

71 ther dendritic molecules prepared from a new biaryl building block are described.

72 ic method for the synthesis of atropisomeric biaryls by a cation-directed O-alkylation.

73 An efficient catalytic route to biaryls by employing (generally) only 0.25 mol % of Pd(O

74 ions also afford good to excellent yields of biaryls by the homocoupling of arylboronic acids.

75 Moreover, biaryl C-C coupling along with alkyl-aryl C-C coupling c

76 The leading biaryl carbamate demonstrated exceptional metabolic stab

77 Herein we demonstrate using a series of biaryl cation radicals with varying dihedral angles that

78 scope of subsequent Suzuki couplings on the biaryl chlorides is explored.

79 convergent syntheses utilize an enantiopure biaryl common intermediate, which is formed via an enant

80 reaction of the unsymmetrically substituted biaryl compound biphenyl-3,4',5-tricarboxylic acid with

81 ynthesis and evaluation of a guanidinomethyl biaryl compound {1-((4'-(tert-butyl)-[1,1'-biphenyl]-3-y

82 Axially chiral biaryl compounds are frequently encountered in nature wh

83 for the synthesis of tetra-ortho-substituted biaryl compounds containing orthogonally functionalized

84 equential manner for the direct synthesis of biaryl compounds in excellent yields.

85 E as the catalyst system affords the desired biaryl compounds in good yields with excellent rates and

86 he presence of 5 mol % Cl2Pd(dppf) furnishes biaryl compounds in good yields; similarly, reaction wit

87 rylation of benzene enables the formation of biaryl compounds in the presence of aryl iodides.

88 oaryl bromides furnishes 1,2-azaborine-based biaryl compounds including 6-[pyrid-2-yl]-1,2-azaborines

89 ses of coherent charge-transfer mechanism in biaryl compounds the rates follow a squared cosine trend

90 amides for the synthesis of widely occurring biaryl compounds through N-C amide bond activation is re

91 ve synthesis that delivers chiral nonracemic biaryl compounds with excellent optical purity and good

92 ion of secondary alcohols and axially chiral biaryl compounds with selectivity factors of up to 37 an

93 nature for the formation of atroposelective biaryl compounds.

94 pling of arenes provides efficient access to biaryl compounds.

95 c conditions to reveal enantiomerically pure biaryl compounds.

96 boronic acids with aryl chlorides to provide biaryl compounds.

97 been extended to intermolecular synthesis of biaryl compounds.

98 rine content to systematically build complex biaryls containing between two and five Caryl-F bonds vi

99 ctive for the synthesis of heterobiaryls and biaryls containing electrophilic functionalities sensiti

100 med the foundation for the assembly of novel biaryls containing pyridine moieties with differently su

101 e direct formation of a variety of unnatural biaryl-containing amino acids in good to excellent yield

102 anthone scaffold followed by copper-mediated biaryl coupling allowed for efficient access to these co

103 Interestingly, this biaryl coupling also works in the presence of potassium

104 nd six steps, including a key Suzuki-Miyaura biaryl coupling and a directed remote metalation (DReM)-

105 loped employed an enantioselective oxidative biaryl coupling and a double cuprate epoxide opening, al

106 enzylamines undergo a one-pot N-deprotection/biaryl coupling followed by oxidation, thus offering an

107 he Suzuki-Miyaura coupling, an unprecedented biaryl coupling ortho to the borono group was observed.

108 complete stereocontrol observed in this key biaryl coupling step is due to the asymmetric induction

109 In this third case, the biaryl coupling was performed first and a Glaser-Hay cou

110 -state oxidase reactivity (aerobic oxidative biaryl coupling).

111 venture include a catalytic enantioselective biaryl coupling, a PIFA-induced naphthalene hydroxylatio

112 A regioselective bromination, a biaryl coupling, and an intramolecular cyclization are t

113 synthesis relies on Suzuki-Miyaura-mediated biaryl coupling, which model studies suggested would be

114 s macrocyclizations conducted using a Suzuki biaryl coupling.

115 is formed via an enantioselective catalytic biaryl coupling.

116 cal biaryls, indicative of a net Kumada-like biaryl coupling.

117 ing a "transition metal-free" intramolecular biaryl-coupling of o-halo-N-arylbenzylamines has been de

118 nough to mediate hindered, ortho-substituted biaryl couplings but mild enough for use on peptides and

119 The SET-induced biaryl cross-coupling reaction is established as the fir

120 Biaryl cyclohexene carboxylic acids were discovered as f

121 e application of the Diels-Alder approach to biaryls (DAB) is described for the synthesis of tetra-or

122 For example, G3-dendron of biaryl dendrimer can bind six molecules of chymotrypsin,

123 Facially amphiphilic biaryl dendrimers are compared with the more classical b

124 internal layers of the facially amphiphilic biaryl dendrons are solvent-exposed and accessible for r

125 ed in 14 steps and 5% overall yield from the biaryl derivative 1.

126 In this process, three cyclopalladated biaryl derivatives have been isolated and characterized

127 itution reaction which yields axially chiral biaryl derivatives in excellent yields with e.r. values

128 boronic esters, leading to the synthesis of biaryl derivatives in good yields.

129 More lipophilic biaryl derivatives mostly displayed similar or reduced p

130 a 'one-pot' fashion to afford functionalized biaryl derivatives that, upon subsequent 'one-pot', high

131 directing groups leading to functional biaryl derivatives, polyheterocycles and polydentate lig

132 palladacyclic precatalyst supported by a new biaryl(dialkyl)phosphine ligand (VPhos) in combination w

133 efficient access to chiral ortho-substituted biaryl diamines.

134 ct spectroscopy NMR studies suggest that the biaryl dihedral angle and the electronic nature of ortho

135 ki coupling and cycloreversion deliver a key biaryl dihydrodiol intermediate, which is rapidly conver

136 gly, reheating a dimethoxy-substituted giant biaryl (e.g., 21) in nitrobenzene at 260 degrees C does

137 isclose a detailed SAR study that led to the biaryl ether 6.

138 id-catalyzed hydrolysis of oxygen (O)-linked biaryl ether 8-2'-deoxyguanosine (dG) adducts produced b

139 stitution reaction for macrocyclization with biaryl ether formation completed the assemblage of the c

140 In this approach and with the ABCD biaryl ether ring system in place, the key Larock cycliz

141 es with phenols has been achieved to provide biaryl ethers that are prevalent in biologically active

142 Biaryl ethers were recently reported as potent NNRTIs.

143 s, and arylzinc reagents was found to afford biaryls exhibiting alkoxy, alkylthio, amino, ketone, cya

144 linking oxygen for nitrogen (or piperazine), biaryl extension, and replacement of phenyl rings by pyr

145 The design of four new fluorinated biaryl fluorescent labels and their attachment to nucleo

146 n constitute a reliable alternative tool for biaryl formation.

147 The synthesis of biaryls from benzyne intermediates offers an alternative

148 activity relationship studies of these novel biaryl gp120 inhibitors revealed that around the biaryl,

149 technique to generate highly functionalized biaryls has been demonstrated via the synthesis of chira

150 lusive 5-exo-dig hydroarylation of o-alkynyl biaryls has been demonstrated.

151 gy for increasing the barrier to rotation in biaryls has been developed that allows for the incorpora

152 migration between the o- and o'-positions of biaryls has been observed in organopalladium intermediat

153 A series of sterically hindered biaryls have been obtained by palladium- and nickel-phos

154 the field of the atropisomeric synthesis of biaryls have hence been undertaken over the past decade.

155 An intramolecular biaryl Heck coupling reaction, catalyzed using the Herma

156 lts reveal a new method for the synthesis of biaryls, heteroaryls, and dienes, as well as a general m

157 al methodology for the chemical synthesis of biaryl, heterobiaryl, and polyaryl molecules by the cros

158 ture of its structure, the 5-membered chiral biaryl heterocyclic scaffold represents a departure from

159 and the structurally diverse 2,2'-dihydroxy biaryl (i.e., BINOL-type), as well as 2-amino-2'-hydroxy

160 ned to give a mixture of cyclooctatriene and biaryl in varying amounts depending on heat and light ex

161 s formation of di- and tri-ortho-substituted biaryls in 87-98% yield under mild reaction conditions e

162 l bromides as well as aryl chlorides to give biaryls in excellent yields.

163 oxygenated and functionalized unsymmetrical biaryls in good to excellent yields by the direct oxidat

164 table catalyst NiCl(2)(PCy(3))(2) to furnish biaryls in good to excellent yields.

165 benzyl lactones, 3-arylacetals (ketals), and biaryls in moderate to good yields.

166 es which gave di- and tri -ortho-substituted biaryls in up to 92% yield.

167 e synthesis of di- and tri-ortho-substituted biaryls in very short reaction times.

168 uki-Miyaura cross-coupling to axially chiral biaryls, in particular for the most challenging reaction

169 to the cutting-edge strategies for creating biaryls; in particular the 2-fold C,H activation is of s

170 ure water leads to symmetrical/unsymmetrical biaryls, indicative of a net Kumada-like biaryl coupling

171 When substituents in the biaryl inhibit rotation about the linking bond, stable n

172 e or byproduct of the synthesis of the giant biaryls is a reagent or catalyst necessary for the conve

173 The successful resolution of one of the biaryls is achieved through derivatization with menthyl

174 ho substituents on the phosphorus-containing biaryls is demonstrated.

175 hesis of a series of tetra-ortho-substituted biaryls is described utilizing a Diels-Alder reaction be

176 native approach to selective fluorination of biaryls is to couple an arene that already possesses C-F

177 tate, B(OPh)(3), and a molecule of a vaulted biaryl ligand (VAPOL or VANOL).

178 talysts were assembled in situ from a chiral biaryl ligand, an amine, water, BH3.SMe2, and an alcohol

179 tion process was not observed for the linear biaryl ligands BANOL and BINOL, although the new deracem

180 ead use of axially chiral, or atropisomeric, biaryl ligands in modern synthesis and the occurrence of

181 d deracemization of the C2-symmetric vaulted biaryl ligands VANOL and VAPOL has been investigated.

182 copper complexes of these diamines with the biaryl ligands.

183 a representative example of the enantiopure biaryl-like CATPHOS class of diphosphines, (S)-9,9'-dime

184 representative example of the electron-rich biaryl-like KITPHOS class of monophosphine, 11-dicyclohe

185 er bearing an sp(2)-nitrogen adjacent to the biaryl link.

186 as exploited to conformationally constrain a biaryl linkage and allow contact with key residues in GK

187 Biaryl linkage, C(1) linkage, and aromatic sulfide linka

188 /dimerization to generate the requisite 2,2'-biaryl linkage.

189 des of reactivity, allowing the formation of biaryl linkages, were revealed and here exploited for th

190 We have reported that compounds containing a biaryl linked unit (Ar-X-Ar') modulated Na(+) currents b

191 polymerization of propylene oxide (PO) using biaryl-linked bimetallic salen Co catalysts was investig

192 A catalytic synthesis of novel biaryl-linked divalent glycosides was achieved using an

193 was optimized for the synthesis of divalent biaryl-linked mannopyranosides that was subsequently gen

194 lomycins and lipoglycopeptides consists of a biaryl-linked, N-methylated peptide macrocycle attached

195 hieved with unstrained enones that contain a biaryl linker.

196 y structure-based design and optimization of biaryl mannoside FimH inhibitors.

197 The photophysical properties of the biaryl-modified nucleosides, dNTPs, and DNA were studied

198 ps of small compounds (including adenine and biaryl moieties) were identified as cN-II binders and a

199 Bioisosteric replacement of this biaryl moiety by arylpiperazine resulted in a soluble, o

200 of the aromatic A-ring, (2) a heteroaryl or biaryl moiety, or (3) multiple substituents on the aroma

201 somerization mechanism of a complex, bridged biaryl molecule with imbedded biphenyl, amine, and lacta

202 A new biaryl monophosphine ligand (AlPhos, L1) allows for the

203 pared [LPd(II)Ar(F)] complexes, where L is a biaryl monophosphine ligand and Ar is an aryl group, and

204 ia ortho-deprotonation of a L.Pd(Ar)OTf (L = biaryl monophosphine) species by CsF and thus competes d

205 The enantioenriched biaryl N-oxide compounds catalyze the asymmetric allylat

206 4-Aryl-3-bromo-N-benzylmaleimides and 3,4-biaryl-N-benzylmaleimides have been synthesized by a mod

207 The conversion of the cyclobutene into biaryl occurs through a [1,3] sigmatropic carbon shift f

208 ki coupling provides rapid access to diverse biaryls of unprecedented topology.

209 in one-pot to form a 2-amino-2'-hydroxy-1,1'-biaryl or 1-amino-1'-hydroxy-4,4'-biaryl, respectively.

210 ied to investigate other, similarly hindered biaryl or teraryl systems either derived from natural so

211 an be subsequently transformed into phenols, biaryls, or dihydrobenzofurans via oxidation, Suzuki-Miy

212 lkynylation using the chiral imidazole-based biaryl P,N ligand StackPhos to establish the absolute st

213 os, a newly developed imidazole-based chiral biaryl P,N ligand, and copper bromide to effect a three-

214 Using this concept, an imidazole-based biaryl P,N-ligand has been designed and prepared as a si

215 temperature coupling of deactivated/hindered biaryl partners.

216 -hydroxyphenylboronic acid or ester 20 gives biaryl phenol 19, which then undergoes copper(I) thiophe

217 eric crowding at the Pd catalyst by either a biaryl phosphine ligand and/or substrate.

218 as intermediate Pd(II) complexes with bulky biaryl phosphine ligands disfavor amine binding to favor

219 A new biaryl phosphine with P-bound 3,5-(bis)trifluoromethylph

220 ligated L.Pd(II)(Ar)X complexes (L = dialkyl biaryl phosphine) have been prepared and studied in an e

221 s data, we suggest a possible mechanism for (biaryl phosphine) Pd-catalyzed amination reactions that

222 of in situ prepared L.Pd(Ar)X complexes (L = biaryl phosphine) with [(11)C]HCN.

223 lides and sulfonates utilizing a monodentate biaryl phosphine-Pd catalyst.

224 the importance of the key feature(s) of the biaryl phosphines (a methyl group ortho to the phosphoru

225 data suggest that electronic donation by the biaryl pi-system accelerates the formation of rhodium ni

226 oped in recent decades, since nonsymmetrical biaryls play an evident role in natural product synthesi

227 The use of a racemic biaryl precursor allowed for the synthesis of both hibar

228 These features expedite biaryl preparation, as demonstrated by synthesis of the

229 This strategy allows the preparation of biaryls previously inaccessible via decarboxylative meth

230 The alkoxy/alkyl/halogen-substituted biaryls produced are useful precursors for accessing sub

231 rise to a [4+2] cycloaddition/cycloreversion biaryl product and a bicyclo[4.2.0]octadiene resulting f

232 The biaryl product forms via C-H activation of two arenes to

233 hylphenylacetylene gave much poorer yield of biaryl product.

234 ethylsilanolates and aryl bromides result in biaryl products with the same configuration and similar

235 d to the synthesis of a variety of different biaryl products, using directing groups including pyridi

236 nalization of unactivated arenes to form the biaryl products.

237 molecules of life, derivatives thereof, and biaryl protein architecture mimetics.

238 cribed, which vary in the linker between the biaryl pyrazole and imidazole/triazole group.

239 is of structural comparison with a different biaryl pyrazole template and supported by dozens of high

240 Atropisomeric biaryl pyridine and isoquinoline N-oxides were synthesiz

241 azine-diarylplatinum(II) complex accelerates biaryl reductive elimination by a factor of 64,000.

242 eactions for the synthesis of nonsymmetrical biaryls represent one of the most significant transforma

243 droxy-1,1'-biaryl or 1-amino-1'-hydroxy-4,4'-biaryl, respectively.

244 Dimeric analogues linked through the biaryl ring show an impressive 8-fold increase in potenc

245 lization closure of the strained 16-membered biaryl ring system found in complestatin (1, chloropepti

246 Diverse modifications to the biaryl ring to improve druglike physical and pharmacokin

247 of a chiral Bronsted acid and a C1-symmetric biaryl saturated-imidazolium precatalyst was required to

248 selectivity with a new tailored C1-symmetric biaryl-saturated imidazolium-derived NHC catalyst.

249 convenient procedure for the construction of biaryl scaffolds.

250 potencies to these in contrast to the parent biaryl series.

251 of aryne chemistry to access a huge range of biaryl structures from a versatile and highly customizab

252 ormation is described that affords versatile biaryl structures without recourse to transition-metal c

253 The most effective agents are biaryl structures, synthesized in six steps with overall

254 On the basis of our observation that the biaryl substituent of iminopyrimidinone 7 must be in a p

255 d that (i) DAGL-alpha tolerates a variety of biaryl substituents, (ii) the sulfonamide is required fo

256 for the transformation of a variety of ortho-biaryl substituted alkynes into polycyclic homo- and het

257 These results suggest that biaryl substituted aminopyrimidines represented by compo

258 the biaryl substrate 4/7/9/11 and not by the biaryl substrate 2a.

259 C-H bond was possible and facilitated by the biaryl substrate 4/7/9/11 and not by the biaryl substrat

260 kinetic asymmetric transformation of racemic biaryl substrates on the basis of axial-to-central chira

261 volving a synthetic tripeptide known to bind biaryl substrates through tailored hydrogen bonding to c

262 or the dynamic kinetic resolution of racemic biaryl substrates.

263 us other fused 6,5-heterocyclic moieties and biaryl sulfone or sulfonamide motifs.

264 ions of these molecules afforded many potent biaryl sulfone-containing Nampt inhibitors which also ex

265 and offers facile access to a wide range of biaryl sulfonyl fluorides as bioorthogonal "click" reage

266 6,7-dihydro-5H-dibenzo[c,e]azepines over the biaryl sultam formation.

267 Using an appropriate substrate, a biaryl sultam has been obtained exclusively.

268 lfonanilides, providing a workable access to biaryl sultams annulated into a six-membered ring that a

269 was largely controlled over the formation of biaryl sultams containing a seven member ring.

270 of this protocol including the synthesis of biaryl sultams containing a seven-membered ring and anal

271 p as new benzyne precursors enable inventive biaryl syntheses under mild conditions.

272 A new biaryl synthesis via silver-catalyzed hydroarylation of

273 iew will cover all aryne methods relevant to biaryl synthesis, drawing together key ideas from the ol

274 ive route to functionalized methylene-linked biaryl systems.

275 C(sp(2))-H bonds using heteroaryl-aryl-based biaryl systems.

276 difications to arrive at the simple achiral, biaryl target structures.

277 These biaryl templates are available in two steps from the cor

278 Further functionalization of the biaryl templates is described.

279 A rapid Diels-Alder approach to halogenated biaryl templates is described.

280 hesis of halogenated 2-amino-2'-hydroxy-1,1'-biaryls that are currently either inaccessible or challe

281 In the case of more substituted biaryls, the compounds are atropisomeric, and thermodyna

282 tly than either tetrahedral carbon or chiral biaryls, they may create complementary chiral environmen

283 den if they include a particular sequence of biaryl torsional states that causes excessive steric str

284 lbiaryl junctures, only slightly relaxes the biaryl twist angle from 89.6 degrees to approximately 80

285 Biaryls (two directly connected aromatic rings, Ar(1)-Ar

286 A class of biaryl-type compounds that is assembled by convenient sy

287 g group-free or minimized total synthesis of biaryl-type phytoalexins.

288 A biaryl urea group, prone to self-aggregation, was functi

289 The axial chirality of the biaryls was determined using TDDFT ECD and VCD calculati

290 he preparation of 1,1'-linked functionalized biaryls was developed.

291 The different substitution pattern of the biaryls was used for tuning of emission maxima in the br

292 A wide range of biaryls were synthesized by palladium-catalyzed Negishi

293 of cyclopentadienones, to afford substituted biaryls, were studied using an expanded substrate base.

294 lings of benzoates with aryl halides to give biaryls, which is cooperatively catalyzed by copper/pall

295 he experimental data and DFT calculations of biaryls with different dihedral angles unequivocally sup

296 yield the resultant tetra-ortho-substituted biaryls with excellent regioselectivity.

297 photoinduced metal-free synthesis of (hetero)biaryls with no need of a (photo)catalyst or of other ad

298 an aryl Truce-Smiles rearrangement to afford biaryls with sulfur dioxide extrusion.

299 key improvement for achieving nonsymmetrical biaryls with superb selectivity and synthetic attractive

300 opos P,N) ligands require a specific type of biaryl, with one component carrying a pendant phosphine