ライフサイエンスコーパス: bicuspid aortic valve

1 ociated cardiac malformation that included a bicuspid aortic valve.

2 ne had truncus arteriosus, and another had a bicuspid aortic valve.

3 women, 161 (46%) had either a unicuspid or a bicuspid aortic valve.

4 ying aortic valve abnormalities as seen with bicuspid aortic valve.

5 stify surgical intervention in patients with bicuspid aortic valves.

6 ng aorta with ventricular septal defect, and bicuspid aortic valves.

7 the development of atrial septal defects and bicuspid aortic valves.

8 ); partially fused aortic valve, 12% (n=25); bicuspid aortic valve, 23% (n=47); and unicuspid aortic

9 yndrome (21.5% versus 3.1%; P<0.001) but not bicuspid aortic valve (3.6% versus 3.2%; P=0.77).

10 ression) and, as a clinical correlate, human bicuspid aortic valves (63% reduction).

11 rison, outcomes of 13,205 adults (2,079 with bicuspid aortic valves, 73 with Marfan syndrome, and 11,

12 Patients with bicuspid aortic valves also showed significantly increas

13 -dominant aortic valve disease consisting of bicuspid aortic valve and aortic valve calcification was

14 In patients with bicuspid aortic valve and dilated proximal ascending aor

15 One had baseline bicuspid aortic valve and mild aortic regurgitation that

16 In the community, asymptomatic patients with bicuspid aortic valve and no or minimal hemodynamic abno

17 s imply higher energy losses associated with bicuspid aortic valves and dilated ascending aortic geom

18 e risk of aortic dissection in patients with bicuspid aortic valves and severe aortic enlargement: th

19 ar septal defects, patent ductus arteriosus, bicuspid aortic valve, and coarctation of the aorta as w

20 ts were more likely to have Marfan syndrome, bicuspid aortic valve, and prior aortic surgery (all, p

21 ch1, or RBPJ displayed enlarged valve cusps, bicuspid aortic valve, and septal defects, indicating th

22 Partially fused aortic valve, bicuspid aortic valve, and unicuspid aortic valve were s

23 isk factors for dissection: Marfan syndrome, bicuspid aortic valves, and larger aortic dimensions.

24 paroxysmal, persistent, or chronic AF, with bicuspid aortic valves, and patients who died within 48

25 Making the decision regarding the timing of bicuspid aortic valve aneurysm surgery even more difficu

26 Bicuspid aortic valves are associated with valve dysfunc

27 Bicuspid aortic valve (BAV) (39%) and Marfan syndrome (M

28 ay a role contributing to the progression of bicuspid aortic valve (BAV) aortopathy.

29 tic valve (TAV) replacement in patients with bicuspid aortic valve (BAV) disease (TAV-in-BAV).

30 The correlation between bicuspid aortic valve (BAV) disease and aortopathy is no

31 Bicuspid aortic valve (BAV) disease is frequently accomp

32 Ascending aortic dilation is important in bicuspid aortic valve (BAV) disease, with increased risk

33 Familial clustering of HLHS and bicuspid aortic valve (BAV) has been observed, and pedig

34 al tricuspid aortic valve (TAV) in 172 and a bicuspid aortic valve (BAV) in 66 subjects.

35 Bicuspid aortic valve (BAV) is a heritable condition tha

36 Bicuspid aortic valve (BAV) is a heritable congenital he

37 determine whether the morphologic subtype of bicuspid aortic valve (BAV) is associated with valve int

38 Importance: Bicuspid aortic valve (BAV) is considered an autosomal d

39 Bicuspid aortic valve (BAV) is regarded as a relative co

40 Bicuspid aortic valve (BAV) is the most common adult con

41 Bicuspid aortic valve (BAV) is the most common congenita

42 ittle is known about the association between bicuspid aortic valve (BAV) morphologic findings and the

43 ltered ascending aorta (AAo) hemodynamics in bicuspid aortic valve (BAV) patients and its association

44 tic root in first-degree relatives (FDRs) of bicuspid aortic valve (BAV) patients.

45 This large multicenter, international bicuspid aortic valve (BAV) registry aimed to define the

46 y who also exhibited LVOT defects, including bicuspid aortic valve (BAV), coarctation of the aorta (C

47 evelops in most patients with a congenitally bicuspid aortic valve (BAV), in others with this anomaly

48 dies have established familial clustering of bicuspid aortic valve (BAV), presumably indicating genet

49 Bicuspid aortic valve (BAV), the most common congenital

50 RATIONALE: The pathogenesis of bicuspid aortic valve (BAV)-associated aortopathy is poo

51 efined compared to Marfan syndrome (MFS) and bicuspid aortic valve (BAV).

52 te the genetic relationship between HLHS and bicuspid aortic valve (BAV).

53 tion in the ascending aorta in patients with bicuspid aortic valves (BAV) have influenced strategies

54 ic aortic aneurysms (ATAAs) in patients with bicuspid aortic valves (BAV) versus patients with tricus

55 Bicuspid aortic valves (BAVs) are associated with premat

56 Explanted, stenotic bicuspid aortic valves (BAVs) from pediatric patients we

57 idney and cardiovascular malformation (i.e., bicuspid aortic valve, bicuspid aortic valve with coarct

58 Bicuspid aortic valves calcify at a significantly higher

59 ith Marfan syndrome compared with those with bicuspid aortic valves confirm that operative management

60 Severe calcification of a congenital bicuspid aortic valve continues to be an important cause

61 ng aortic aneurysm surgery in the setting of bicuspid aortic valve disease is complex, with multiple

62 oracic aortopathy after AVR in patients with bicuspid aortic valve disease is substantially different

63 aortic disease such as the Marfan syndrome, bicuspid aortic valve disease, and hereditary aortic ane

64 h aortic regurgitation, and in patients with bicuspid aortic valve disease.

65 Because we have previously found that bicuspid aortic valve experience greater stretch, we inv

66 hymal transition, and NOTCH1 mutations cause bicuspid aortic valve; however, the temporal requirement

67 lities, including Marfan's syndrome in four, bicuspid aortic valve in four, and aortitis in one.

68 Bicuspid aortic valve is frequent and is reported to cau

69 Bicuspid aortic valve is frequently an antecedent to aor

70 1,000 live births if the potentially serious bicuspid aortic valve is included), and of all forms inc

71 Bicuspid aortic valve is the most common type of cardiac

72 similar to the pattern seen in nonsyndromic bicuspid aortic valve, is equally prevalent (20-30%) in

73 addition, another 20/1,000 live births have bicuspid aortic valves, isolated anomalous lobar pulmona

74 tricuspid aortic valves (n = 27), calcified bicuspid aortic valves (n = 23), and control tissue from

75 Bicuspid aortic valve occurs in 1% of the population, ma

76 In addition, bicuspid aortic valve occurs in more than one-half of th

77 85), ventricular septal defect (P=0.12), and bicuspid aortic valve (P=0.14) did not carry an increase

78 METHODS AND We studied 969 consecutive bicuspid aortic valve patients (50+/-13 years; 87% men)

79 In bicuspid aortic valve patients with dilated proximal asc

80 with age, and it is often associated with a bicuspid aortic valve present in 1-2% of the population.

81 m that operative management of patients with bicuspid aortic valves should not be extrapolated from M

82 rates of Marfan syndrome and lower rates of bicuspid aortic valve than those undergoing bio-CVG or m

83 neurysmal progression in Npr2(+/-) mice with bicuspid aortic valves than those with tricuspid valves.

84 Furthermore, pediatric stenotic bicuspid aortic valves that have lost normal extracellul

85 tic valve, partially fused aortic valve, and bicuspid aortic valve+unicuspid aortic valve, respective

86 ricle, aberrant semilunar valve development, bicuspid aortic valve, ventricular septal defects, and e

87 Bicuspid aortic valve was associated with more intense h

88 County, Minn (age, 32+/-20 years; 65% male), bicuspid aortic valve was diagnosed between 1980 and 199

89 Bicuspid aortic valve was diagnosed in 227 patients (73.

90 During cardiac surgery, a congenital bicuspid aortic valve was found to be the predisposing f

91 Bicuspid aortic valve was identified in 74 individuals (

92 ortic aneurysms variably associated with the bicuspid aortic valve was used for identification of add

93 rm and ectoderm caused glandular defects and bicuspid aortic valve, which indicates that the FGF8 end

94 r malformation (i.e., bicuspid aortic valve, bicuspid aortic valve with coarctation of the aorta, or

95 Incompetent bicuspid aortic valves with dilated aortic annuli are al

96 Bicuspid aortic valves with raphe had a significantly hi

97 of mice heterozygous for Npr2 had congenital bicuspid aortic valves, with worse aortic valve function