ライフサイエンスコーパス: bicyclic

1 er in DAT interaction than the corresponding bicyclics.

2 electrocyclization cascade provides a fused bicyclic 1,2-dihydropyridine as a key intermediate.

3 conditions resulted in the formation of two bicyclic 1,3-dioxan-5-ones via an unprecedented intramol

4 Novel bicyclic[1,2,3]triazoles (4, 7, 11, 15) have been synthe

5 Our results indicate that bicyclic[1,2,3]triazoles protect UVA-induced senescence-

6 excellent yields were obtained for the fused bicyclic 3-aza-heterocycles.

7 converged to provide short 2-step routes to bicyclic [3.2.1] or [2.2.2] L-iduronate lactones.

8 nonretinoid RBP4 antagonists, represented by bicyclic [3.3.0]-octahydrocyclopenta[c]pyrrolo analogue

9 oadducts, which possess a basic structure of bicyclic 6-(menthyloxy)hexahydropyrano[4,3-c]pyrrol-7(6H

10 two-step approach, without isolation of the bicyclic acetal intermediates.

11 Novel bis- and tetraepoxides and bicyclic acetal products, arising from rearrangements of

12 A series of fused-bicyclic acetals containing a disiloxane ring was invest

13 This reaction affords bicyclic acetals, which have been used as key intermedia

14 lysis of one of the major classes of NA (the bicyclic acids) to date.

15 n of one substrate to give the corresponding bicyclic adduct in excellent yield at the gram scale.

16 active dienophile in asymmetric synthesis of bicyclic adduct through Diels-Alder cycloaddition reacti

17 -hydroxypiperidines from a readily available bicyclic adduct.

18 rming olefin to the bridgehead carbon of the bicyclic affect the efficiency and stereochemical outcom

19 stitution pattern of the reacting alkyne and bicyclic alkene components.

20 and the addition of a C1 substituent to the bicyclic alkene on the reaction were explored, and moder

21 cyl camphorsultam-functionalized alkynes and bicyclic alkenes were examined, providing adducts with c

22 tures between N-propynoyl camphorsultams and bicyclic alkenes.

23 or norbornadiene (NBD) readily generate the bicyclic alkyl-/alkenyl-substituted stannylenes, ArSn(no

24 trategy allows for the synthesis of storable bicyclic (alkyl)(amino)carbenes (BICAACs), which feature

25 st to a cyclization/ring-opening route via a bicyclic allene described in previous reports.

26 m two closely related and readily accessible bicyclic alpha-aminonitriles.

27 by cyclization of the resulting urea to give bicyclic alpha-aryl hydantoin derivatives of substituted

28 Derivatives of the fully twisted bicyclic amide 7-hypoquinuclidone are synthesized using

29 lactam starting materials as well as certain bicyclic amino acid products provided insight into their

30 tial deprotection of the N- or C-terminus of bicyclic amino acids gave access to two conformationally

31 substrate cores ranging from cyclic to fused bicyclic and bridged bicyclic compounds.

32 of the resulting metallatriene gives rise to bicyclic and linear polycyclic compounds 6 and 7, some o

33 A series of N(6)-bicyclic and N(6)-(2-hydroxy)cyclopentyl derivatives of

34 ns of cyclic ene sulfonamides provide stable bicyclic and tricyclic aldimines and ketimines in good y

35 with substrate distortion was found for the bicyclic and tricyclic alkenes studied here.

36 -catalyzed C(sp(3))-H arylation of saturated bicyclic and tricyclic amine scaffolds.

37 D as halogenated C15-acetogenin 12-membered bicyclic and tricyclic ether bromoallene-containing mari

38 luding humulene (monocyclic); caryophyllene (bicyclic); and protoilludene, pentalenene, and isocomene

39 erocycles, as well as (5) fused, (6) bridged bicyclic, and (7) macrocyclic nitrogen heterocycles.

40 alent drugs, we have synthesized monocyclic, bicyclic, and tricyclic compounds containing 3 as an ele

41 t of furnishing unprecedented heterometallic bicyclic architectures with a high level of constitution

42 g rise to 12 examples of nitrogen-containing bicyclic architectures.

43 The bicyclic aromatic compound was observed in a complex wit

44 built on a tetrahydropyran ring linked to a bicyclic aromatic moiety through a syn-diol linker show

45 actions with different nucleophiles afforded bicyclic azasugars, cyclopropanated carbohydrate, dihydr

46 Bicyclic azetidines targeting Plasmodium falciparum phen

47 mechanisms of action, including a series of bicyclic azetidines that inhibit a new antimalarial targ

48 Our findings identify bicyclic azetidines with the potential to both cure and

49 The resulting [3.1.0] bicyclic aziridines prove to be versatile synthons for t

50 ation of synthetically useful chiral [3.1.0]-bicyclic aziridines with high diastereo- and enantiosele

51 ed, the reaction with phenols proceeds via a bicyclic aziridinium intermediate leading to the stereos

52 ies (dr >99/1, (1)H NMR) via interception of bicyclic aziridinium intermediates.

53 se of cucurbiturils as macrocyclic hosts and bicyclic azoalkanes as guests has now enabled a systemat

54 metal-free preparation of structurally novel bicyclic azocine-beta-lactams has been developed.

55 nstrating the unprecedented influence of the bicyclic backbone unsaturation for the preparation of th

56 Starting from bicyclic beta-amino acid 3 or 5, strategies involving Cu

57 ion of four such products to a new family of bicyclic beta-amino acids of high enantiomeric purity.

58 sed to synthesize hydroxamic acid-containing bicyclic beta-lactam cores.

59 The bicyclic beta-lactam/2-pyrrolidine precursor to all carb

60 ing isothiourea catalysts provided access to bicyclic beta-lactone-fused, N-heterocycles in moderate

61 of this donor results in the formation of a bicyclic beta-sulfonium ion that after addition of an al

62 inhibitors, particularly avibactam-like and bicyclic boronate compounds, have potential for treating

63 Here, we show that avibactam and a bicyclic boronate inhibit L2 (serine beta-lactamase) but

64 Importantly, avibactam, but not the bicyclic boronate is deactivated by L1 at a low rate; th

65 Bicyclic boronates are recently discovered inhibitors of

66 A compact and stable bicyclic bridged ketal was developed as a ligand for the

67 a range of functionalized sp(2)-sp(3) linked bicyclic building blocks, including oxetanes, piperidine

68 e generation of alpha-ethoxyenone-containing bicyclic byproducts.

69 +)3-PPi and ammonium or iminium analogues of bicyclic carbocation intermediates proposed for the natu

70 Bicyclic chiral scaffolds are privileged motifs in medic

71 e A, and intramolecular cyclizations to form bicyclic claulansine A were the key reactions.

72 One such bicyclic compound carrying an equatorial hydroxyl group

73 The bicyclic compound dihydroxyindolizidine (21) reduced the

74 toisomer along with an unusual and uncolored bicyclic compound formed through an intramolecular photo

75 assay with seven human tumor cell lines, the bicyclic compounds inhibited selectively the growth of t

76 ation tactic for the construction of diverse bicyclic compounds possessing highly functionalized cycl

77 The binding of bicyclic compounds was analyzed by molecular dynamics si

78 zolidines (BTZs) are carboxylate-containing, bicyclic compounds, considered as penicillin analogs wit

79 cally diverse structures, spanning mono- and bicyclic compounds, that either inhibited or activated M

80 ng from cyclic to fused bicyclic and bridged bicyclic compounds.

81 lbenzenes 2 provides sulfonyl oxabenzo[3.3.1]bicyclic core 4 in a cosolvent of toluene and HOAc (v/v

82 ramolecular Heck reaction to build the fused bicyclic core and a cobalt-catalyzed peroxidation to ins

83 structure modifications performed around the bicyclic core led to the identification of compounds end

84 H-benzo[b]-1,4-thiazepin-4-one, which is the bicyclic core of diltiazem and structurally related drug

85 a viable approach to the construction of the bicyclic core of neopeltolide.

86 lso demonstrated for the construction of the bicyclic core present in penostatin B in a concise and h

87 most known RiPPs, a tripeptide with a tight bicyclic core that appears to be cleaved from the middle

88 y of the molecular scaffold by introducing a bicyclic core.

89 nal imines, yielding synthetically versatile bicyclic cyclobutanones and beta-lactams, respectively.

90 spontaneous 4pi-electrocyclizations to form bicyclic cyclobutenes.

91 Monocyclic and bicyclic cyclobutylanilines successfully undergo the ann

92 ynthesis of functionalized cyclopentanes and bicyclic cyclopentane-based structures in moderate to hi

93 strategy provided a facile access to various bicyclic cyclopentenones fused with either a carbocyclic

94 Salinamide A belongs to a rare class of bicyclic depsipeptide antibiotics in which the installat

95 talyst-free synthesis of nitrogen-containing bicyclic derivatives through a three-bond forming proces

96 due macrocycles, and three 11- to 14-residue bicyclic designs, are close to the computational models.

97 The homocoupling of bicyclic dibromoalkenes is promoted by Pd(OAc)2 (10%) in

98 These reactions lead to bicyclic Diels-Alder adducts that spontaneously lose N2.

99 d from high throughput screening, an evolved bicyclic dihydronaphthyridinone was identified.

100 s were successfully achieved to afford fused bicyclic dihydropyridines in high yields (up to 94%) wit

101 Oxidation then affords bicyclic diones in good three-step yields.

102 y or indirectly with the pyran oxygen of the bicyclic distal PPT (NarG-Ser(719), NarG-His(1163), and

103 hosphate into a previously unknown 5,7-fused bicyclic diterpene, coined "pseudolaratriene." Combined

104 , here we show that andrographolide (AGP)--a bicyclic diterpenoid lactone isolated from Andrographis

105 yclic N-heterocycle-fused beta-lactone and a bicyclic enamine derived from in situ decarboxylation of

106 The reactions of bicyclic enone (BCE, 1) with cyclopentadiene (Cp, 2) and

107 and terpenoids from several optically active bicyclic enone systems and Nazarov reagents is presented

108 id-catalyzed Robinson annulation to give the bicyclic enone.

109 loallene D as a pentahalogenated 12-membered bicyclic ether bromoallene was synthesized by a face-sel

110 h a diazo ketone is converted into a bridged bicyclic ether, can be tuned to give either of the isome

111 llustrated with the synthesis of a family of bicyclic fluorinated 1,3-amino alcohols.

112 onalized boronic acids to afford a cis-fused bicyclic framework containing an alpha,beta-unsaturated

113 e units embedded in an enantiomerically pure bicyclic framework is reported.

114 The method allows for the rapid synthesis of bicyclic frameworks, generating all-carbon quaternary ce

115 oxy carbonyl protection yielded an important bicyclic furanopiperidine derivative.

116 one-pot approach to construct alpha-carbonyl bicyclic furans from easily accessible diynones is descr

117 cient approach for the construction of novel bicyclic fused cyclopentenones starting from Morita-Bayl

118 ral information, we designed a new series of bicyclic G7 peptides that progressively constrain the st

119 ocascade that generates cis- and trans-fused bicyclic gamma- and delta-lactones bearing up to four co

120 A general synthetic strategy to cis-fused bicyclic gamma-butyrolactones via the retro-Diels-Alder

121 ated and gamma-trifluoromethylated cis-fused bicyclic gamma-butyrolactones.

122 by the Lewis acid-mediated fragmentation of bicyclic gamma-silyloxy-beta-hydroxy-alpha-diazolactones

123 Two very soluble compounds having W2(bicyclic guanidinate)4 paddlewheel structures show recor

124 Pyridine substituted with one and two bicyclic guanidine groups has been studied as a potentia

125 -Wittig/Buchwald-Hartwig protocol leading to bicyclic guanidines has been elaborated.

126 detailed account of the synthesis of chiral bicyclic guanidinium salts is presented.

127 of the attempted syntheses of two additional bicyclic guanidinium salts.

128 features an initial [3+2] annulation to form bicyclic hemiaminals, followed by ring opening to genera

129 synthesis of a series of partially saturated bicyclic heteroaromatic scaffolds with enhanced sp(3) ch

130 eported on a number of structurally distinct bicyclic heteroarylsulfonamides as NaV1.7 inhibitors tha

131 ns leads to the formation of a novel [4.4.0] bicyclic heterocycle.

132 used imidazole-containing 5,5- and 5,6-fused bicyclic heterocycles is described.

133 erance of the S1P1 and S1P3 receptors toward bicyclic heterocycles of systematically varied shape and

134 the meta-selective C-H functionalization of bicyclic heterocycles via a highly strained, tricyclic-c

135 oloisoquinolines, an uncommon class of fused bicyclic heterocycles, in good yield.

136 The first syntheses of privileged [5,6]-bicyclic heterocycles, with ring-junction nitrogen atoms

137 les bearing multiple bonds leading to [2.2.1]bicyclic heterocycles.

138 mI2 -H2 O, provide straightforward access to bicyclic heterocyclic scaffolds containing bridgehead ni

139 iomerically enriched fluorinated benzo-fused bicyclic homoallylic amines have been synthesized throug

140 A few bicyclic hybrid sugar molecules comprising of oxa-aza, o

141 The hydrolysis of the bicyclic hydantoins under basic conditions gave a range

142 -diaminopiperidines from a readily available bicyclic hydrazine.

143 NMHCs (alkanes, cycloalkanes, aromatics, and bicyclic hydrocarbons) are released at parts per million

144 azines and biocatalytically generated chiral bicyclic imines selectively affords either tetracyclic p

145 oluene are not necessarily translated to the bicyclic indole core.

146 The bridged bicyclic intermediate could be stereo- and chemoselectiv

147 nism involving an intriguing rhodium-bridged bicyclic intermediate.

148 lf via the putative formation of a cis-fused bicyclic intermediate.

149 s it was later discovered that these bridged bicyclic intermediates can be trapped by various elimina

150 library of N-O containing cyclopropyl-fused bicyclic intermediates.

151 Two different scaffold types, one a bicyclic iodo-vinylidene tertiary amine/tertiary alcohol

152 ey architecture yields an assembly of stable bicyclic iodolactones, which are converted to form a wid

153 nsible for converting 8-oxogeranial into the bicyclic iridoid scaffold in a two-step reduction-cycliz

154 The isoxazol-3-one tautomer of the bicyclic isoxazole, 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-

155 aza-Wittig/Ugi three-component reaction of a bicyclic isoxazolidine-derived azido-hemiacetal.

156 These synthetically versatile bicyclic isoxazolidines allowed us to obtain complex gly

157 [3 + 2] cycloaddition can be used to obtain bicyclic isoxazolidines for which we report a set of rea

158 the cationic ring-opening polymerization of bicyclic ketal monomers, which were prepared by the meta

159 s obtained via a direct decarbonylation of a bicyclic lactam lactol.

160 ed, starting from a common chiral nonracemic bicyclic lactam lactone (BLL).

161 able by epoxidation of carboxamide-activated bicyclic lactam substrates derived from pyroglutamate us

162 esting results, including the formation of a bicyclic lactone arising from oxidative termination of t

163 stereoselectively a five-membered ring fused bicyclic lactone, the core structure present in gracilio

164 However, the method applied to generate bicyclic ligands based on phage-peptide alkylation is te

165 ted by a 3-4 unit alkyl linker with mono- or bicyclic, lipophilic arylsulfonamide moieties.

166 he diastereoselectivity of the alkylation of bicyclic malonates has been studied experimentally and c

167 aesthetically pleasing Fe-Pt heterometallic bicyclic metallacycles 6a and 6b, consisting of nine com

168 unctionalized hydrindanes, where the bridged bicyclic metallacyclopentenes from intramolecular [4 + 2

169 Bridged bicyclic metallacyclopentenes generated from the [4 + 2]

170 tion of rhodium-bound carbenes with strained bicyclic methylene aziridines results in a formal [3+1]

171 ouble bond of the allene to yield endocyclic bicyclic methyleneaziridines with excellent stereocontro

172 and combinations thereof, reveal that these bicyclic modulators generally exhibit steep SAR and with

173 of glycosidase inhibitors and especially the bicyclic molecules has led to design and assessment of m

174 For bicyclic monoallylic diol compounds, Pd(II) is capable o

175 r cyclization and dehydration in acyclic and bicyclic monoallylic diols, a formal S(N)2' reaction.

176 A thymidine-derived bicyclic monomer, 3',5'-cyclic 3-(3-butenyl) thymidine e

177 of Arabidopsis thaliana to a mixture of the bicyclic monoterpenes alpha-pinene and beta-pinene induc

178 linalool derivatives, borneol (up to 10.9%), bicyclic monoterpenes with pinane skeleton (pinocarvone

179 itions are treated with drugs containing the bicyclic motif, a common feature is that many of these l

180 of the useful and important skeleton of the bicyclic N,O-acetals is described.

181 report identification of over 30 individual bicyclic naphthenic acids as the bicyclane hydrocarbons.

182 The process provides rapid access to bicyclic nitrogenous structures resembling natural alkal

183 Bicyclic nitroxyl derivatives, such as 2-azaadamantane N

184 T is especially noteworthy at high pH, where bicyclic nitroxyls are inhibited by formation of an oxoa

185 ferent reactivity observed between TEMPO and bicyclic nitroxyls, such as ABNO (ABNO = 9-azabicyclo[3.

186 non-bile acid FXR agonists that introduce a bicyclic nortropine-substituted benzothiazole carboxylic

187 cked-nucleic-acid (LNA) or constrained-ethyl-bicyclic-nucleic-acid ((S)-cEt) modifications much more

188 f the compounds have been transformed to the bicyclic nucleoside derivatives applying Vorbruggen reac

189 ssfully utilized for convergent synthesis of bicyclic nucleosides (LNA monomers) T, U, A, and C.

190 A bicyclic olefin was discovered as a cocatalyst in a Cp*R

191 1)-C(6) cyclization yields a highly strained bicyclic olefin whose surface chemistry was hitherto unk

192 tanones including spiro-, bridged, and fused bicyclic ones can be readily accessed.

193 Tetrahydroisoquinolines are bicyclic organic frameworks present in a wide assortment

194 Bicyclic oxazaphospholidine monomers were used to prepar

195 tion with the formation of the corresponding bicyclic oxazine and five-membered cyclic nitrone, respe

196 cloadditions with carbonyl compounds to give bicyclic oxazolidine products in good overall yields.

197 molecular cyclization of a tosylate led to a bicyclic oxetane.

198 e and metabolically stable nonphosphorylated bicyclic peptide as a potent and selective Pin1 inhibito

199 The resulting bicyclic peptide has greatly enhanced proteolytic stabil

200 re, we determined the structure of the G7-B4 bicyclic peptide in complex with the Grb7-SH2 domain, bo

201 we report the crystal structure of a stapled bicyclic peptide inhibitor G7-B1 in complex with the Grb

202 llows screening of structurally more diverse bicyclic peptide libraries.

203 Screening of a bicyclic peptide library against tumor necrosis factor-a

204 Bicyclic peptide ligands were found to have good binding

205 e presented approach offers facile access to bicyclic peptide ligands with good binding affinities.

206 trimesic acid as the scaffold, the resulting bicyclic peptides are effective for binding to protein s

207 creening of large combinatorial libraries of bicyclic peptides displayed on rigid small-molecule scaf

208 successfully developed for the selection of bicyclic peptides from large random-sequence libraries.

209 Here we show that bicyclic peptides isolated by phage display can target t

210 Bicyclic peptides of this type may provide a general sol

211 h a cyclic cell-penetrating peptide produces bicyclic peptides that are cell-permeable and retain the

212 ysiologic conditions to yield monocyclic and bicyclic peptides.

213 egy was applied to generate a cell-permeable bicyclic peptidyl inhibitor against the NEMO-IKK interac

214 The structures of bicyclic phospholene oxide and two sultones were establi

215 ived Salinospora sp. bacterium and contain a bicyclic phosphotriester core structure, which is a rare

216 An array of six pyridyl-substituted fused bicyclic piperidines was prepared as novel cores for med

217 A stereoselective synthesis of bicyclic primary or secondary amines, based on tetralin

218 vor the tricyclic product over the undesired bicyclic product resulting from diene metathesis.

219 r the preparation of both enantiomers of the bicyclic product with near-identical stereocontrol.

220 as transient intermediates, en route to 5,5-bicyclic products 3.

221 The obtained bicyclic products are attractive building blocks for the

222 d reversible, and mixtures of monocyclic and bicyclic products are formed.

223 nd thermodynamically favorable, and only the bicyclic products are observed for the cascade reactions

224 Two (of four possible) bicyclic products are selectively formed by addition of

225 The bridged bicyclic products can be further functionalized or deriv

226 In addition, N-tethered bicyclic products further transformed into tricyclic com

227 tion/hetero-Diels-Alder reaction affords the bicyclic products in a highly diastereoselective manner.

228 propyl moiety, affecting only one of the two bicyclic products initially formed.

229 dienones, but in this case conversion to 5,4-bicyclic products is thermodynamically disfavored, and t

230 lity of the ACEs could be transferred to the bicyclic products with high efficiency.

231 ctrophilic activation of double bonds in the bicyclic products with m-CPBA is an efficient method for

232 moiety linked to the 4-position afforded the bicyclic products, which possess three stereogenic cente

233 kynes leads to alpha-methoxyenone-containing bicyclic products.

234 Over the years, we have reported covalent bicyclic prolyl oligopeptidase inhibitors that were high

235 on mechanism en route to the 5,7-trans-fused bicyclic pseudolaratriene scaffold.

236 Saturated bicyclic pyrazoles represent an important class of biolo

237 ta-amino amides and esters, pyrazolones, and bicyclic pyrazolidinones.

238 Dideoxy bicyclic pyrimidine nucleoside analogues (ddBCNAs) with

239 dride and aliphatic nitriles, which leads to bicyclic pyrimidines.

240 om temperature leading to the formation of a bicyclic pyrimidinium cation (C(8)H(7)N(2)(+)).

241 ct is observed leading to the formation of a bicyclic quinolizinium cation (C(9)H(8)N(+)).

242 rk, computer simulations were used to design bicyclic replacements for the CVP group.

243 tion of the resulting aminoallene adduct for bicyclic ring formation.

244 inhibitors: cytochalasin B, a nine-membered bicyclic ring fused to a 14-membered macrocycle, which h

245 Analogues with a bicyclic ring I carrying equatorial amino or hydroxyl gr

246 e, Tyr67, after hydrogen donation to achieve bicyclic ring inversion, is further hypothesized to serv

247 ot all iridoids share the exact five- to six-bicyclic ring scaffold of the Catharanthus iridoids.

248 f "locked" ribonucleoside mimics that lack a bicyclic ring structure.

249 This transformation was further extended to bicyclic ring substrates, providing the opportunity to e

250 e radical cyclization to access the strained bicyclic ring system.

251 Novel bridged bicyclic ring systems are accessible from the diol, alph

252 shown to catalyze successive hydroxylation, bicyclic ring-opening, and two epoxidations that generat

253 y locking the amide conformation using fused bicyclic rings.

254 nt three-step synthesis of a series of fused bicyclic s-[1,2,4]triazolo[1,5-a]pyridines 1 was accompl

255 ulk were introduced at the 5-position of the bicyclic scaffold (R5 = Me, Ph, CH2Ph), and different ac

256 The 5,6-bicyclic scaffold of these products is presumably derive

257 The exo- or endo-selectivity of bicyclic scaffolds depends on the selection of the base

258 d fragment screening campaign, we discovered bicyclic scaffolds like 1H-pyrazolo[3,4-d]pyrimidines bi

259 ion, and position within the molecule of the bicyclic scaffolds were assessed virtually.

260 es a distinct approach for accessing [3.2.2] bicyclic scaffolds which are challenging to prepare thro

261 oriented synthesis of an array of cyclic and bicyclic scaffolds with polyhydroxylated appendages with

262 at is generated by oxidative cleavage of the bicyclic sesquiterpene beta-trans-bergamotene.

263 acterized plant STSs by forming unified 15/5 bicyclic sesterterpene intermediates.

264 d allenes, which provides a distinct [4.2.1]-bicyclic skeleton containing two quaternary carbon cente

265 The rigid bicyclic skeleton of 2,4-methanoprolines allowed us to f

266 rally diverse scaffolds, ranging from simple bicyclic skeletons to complex polycyclic systems and nat

267 ecules bearing multiple bonds to give [2.1.1]bicyclic species.

268 elded access to novel types of diastereopure bicyclic spiramycin derivatives containing tetrahydrofur

269 rain imposed on the formation of the elusive bicyclic spirocyclopropanone 20 results in a divergence

270 Caged (or bridged) bicyclic structural elements offer a variety of diverse

271 Surprisingly, the generated bicyclic structure featuring three stereocenters was a m

272 onverted into a conformationally constrained bicyclic structure through the formation of a pair of di

273 Despite the intrinsic constraints of the bicyclic structure, we demonstrate that their synthesis

274 s to construct aziridine/oxazolidinone-fused bicyclic structures.

275 reversible beta-hydride elimination from the bicyclic substituted aryl/alkyl stannylenes 2a or 2b and

276 Nazarov cyclizations of a series of bridged bicyclic substrates were modeled with the M06-2X density

277 someric quinolinone sulfonamide inhibitors [ Bicyclic sulfonamide compounds as sodium channel inhibit

278 51 (FKBP51), we designed two new classes of bicyclic sulfonamides to probe the contribution of confo

279 Mitsunobu coupling of these bicyclic sulfonamides with a protected adenosine derivat

280 followed by ring expansion to generate novel bicyclic sulfones.

281 nlocked the path to alternate monocyclic and bicyclic synthons representing the basis of a myriad of

282 the 3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl bicyclic system were potent (TTK IC50 < 10 nM, HCT116 GI

283 on (respectively, axial or equatorial to the bicyclic system).

284 can be substituted at every position of the bicyclic system.

285 (or formal cycloadditions), in which bridged bicyclic systems are established, or nucleophilic trappi

286 intermolecular settings to generate hindered bicyclic systems, vicinal quaternary centers, and even c

287 )one, afforded a number of pyrrolidine-based bicyclic systems.

288 efforts that led to the identification of a bicyclic template with potent activity against the NS5B

289 The combination of substituents on the bicyclic templates and the nature of the core structure

290 Bridged bicyclic tertiary allylic amines aza-norbornene 1 and is

291 The lycojaponicumins' fused bicyclic tetrahydroisoxazole ring system was proposed to

292 y substituted 1,4-dihydropyridines and fused bicyclic tetrahydropyridines carrying a quaternary all-c

293 The fused bicyclic thiazolo[5,4-d]thiazole heterocycle allows the

294 The synthesis of a novel bicyclic thymidine analogue carrying a beta-fluoro subst

295 ntadiene structure awaits, reached through a bicyclic transition state.

296 perimentally unidentified class of condensed-bicyclic triazolo-thiadiazoles targeting PTP1B and its a

297 Condensed-bicyclic triazolo-thiadiazoles were synthesized via an e

298 The ring closures of these bridged bicyclic trienes are up to a million-fold faster (DeltaD

299 e rings fused together by inflexible bridged bicyclic units.

300 uence of related substrates allows access to bicyclic uracil derivatives.