ライフサイエンスコーパス: bifunctional

1 sms, beta-H elimination, or the metal-ligand bifunctional.

2 etric Pfau-d'Angelo reaction by exploiting a bifunctional 1 degrees amine thiourea catalyst system is

3 , we characterized kinetic properties of the bifunctional 5-InsP7 kinase/InsP8 phosphatase activities

4 The results of this study reinforce the bifunctional ability of carboxy-extended phytocystatins

5 e the cooperative catalytic activity of such bifunctional acid-base catalysts.

6 We report a new family of chiral bifunctional acid/base type organocatalysts, 2-aminoDMAP

7 and LpDsbD2) (compared with E. coli) permit bifunctional activities without creating a futile cycle.

8 ilms, leading to significant enhancements in bifunctional activity essential for fuel cells and metal

9 t genes encoding the separate domains of the bifunctional acyl-acyl carrier protein (ACP) synthetase/

10 eatment of male mice with melphalan (MLP), a bifunctional alkylating agent widely used in chemotherap

11 core trisaccharide in both organisms, and a bifunctional alpha-galactosyltransferase from CAZy famil

12 Two bifunctional alpha-phenyl-N-cyclohexyl nitrones were syn

13 Specifically, bifunctional amino reagents are used for sequential nucl

14 lyses, we identified a single homotetrameric bifunctional ammonia-lyase (PTAL) among eight BdPAL enzy

15 romide perovskites incorporating a series of bifunctional ammonium dications as templates which also

16 A bifunctional analogue, macropa-NCS, was conjugated to tr

17 found that a major shift in function from a bifunctional ancestor that could phosphorylate either gl

18 ure of the zinc-finger (ZnR) domain from the bifunctional and bipolar ZitP pilus assembly/motility re

19 current work investigates the effect of new bifunctional and mononuclear Pt(II) compounds, the cis-

20 The resulting NP catalysts are bifunctional, and compared to bulk alpha-MoC1-x and beta

21 We report a method to generate bifunctional antibodies by grafting full-length proteins

22 al growth factor receptor (EGFR) to create a bifunctional aptamer that labels cell-surface EGFR on ma

23 d protein and was shown to interact with the bifunctional ATPase FlaI and FlaH.

24 paration technique by using well-established bifunctional Au-Fe3O4 nanocomposites as the separation n

25 bodies in DKO mice, we used a novel class of bifunctional autoantibodies, IgM/DNA dual variable domai

26 An E2 elimination mechanism catalyzed by a bifunctional base that directly forms an N-protonated en

27 This modified electrode was termed bifunctional because it allowed to simultaneously immobi

28 f this study was to develop an aptamer-based bifunctional bio-nanogate, which could selectively respo

29 By developing a bifunctional biotinylated capture probe, the Friedlander

30 Described herein is a bifunctional borane/borinic acid derivative (2) in which

31 Our study showed that Houk's bifunctional Bronsted acid-hydrogen bonding model, which

32 The key finding is a chiral bifunctional Bronsted acid/base catalyst that can delive

33 A bifunctional Bronsted base catalyst bearing a squaramide

34 ansferase PsoE requires participation of the bifunctional C-methyltransferase/epoxidase PsoF to compl

35 Here, we demonstrate that a bifunctional catalase-peroxidase, MakatG1, in the locust

36 f the fiber-shaped zinc-air battery, i.e., a bifunctional catalyst composed of atomically thin layer-

37 a highly durable and efficient carbide-based bifunctional catalyst consisting of iron-molybdenum carb

38 The Fe3 Pt/Ni3 FeN bifunctional catalyst enables Zn-air batteries to achiev

39 between the Co3 O4 and N-rGO nanosheets, the bifunctional catalyst exhibits high activity and superio

40 free catalyst was further used as an OER-HER bifunctional catalyst for oxygen and hydrogen gas produc

41 Thus, the pyrolyzed MPSA/GO is a promising bifunctional catalyst for renewable energy technologies,

42 oated porous graphene oxide can be used as a bifunctional catalyst for tandem oxidation and hydrogena

43 hway where the phosphinic acid operates as a bifunctional catalyst in the intramolecular substitution

44 arily high performance of the Fe3 Pt/Ni3 FeN bifunctional catalyst makes it a very promising air cath

45 ificantly enhance both reactions, yielding a bifunctional catalyst that surpasses the performance of

46 olyzed MPSA/GO acted as the first metal-free bifunctional catalyst with high activities for both oxyg

47 The hydrogen bonding donor ability of the bifunctional catalyst, as shown in the proposed transiti

48 Here, we show that water-soluble bifunctional catalysts (anthranilates and phosphanilates

49 ultra-small NiFeOx nanoparticles are active bifunctional catalysts exhibiting high activity and stab

50 m chromium to gold for ionic hydrogenations, bifunctional catalysts for hydrogen oxidation and evolut

51 -phosphorous-derived films (Co-P) can act as bifunctional catalysts for overall water splitting.

52 thesis of chiral thiosquaramides, a class of bifunctional catalysts not previously described in the l

53 overs an entirely new strategy for designing bifunctional catalysts with double-activation behavior a

54 ve power and enables effective design of new bifunctional catalysts with enhanced ORR/OER activities.

55 Computational studies indicate a bifunctional catalytic mechanism whereby the thioimidate

56 of the catalyst and NMR spectra analysis, a bifunctional catalytic model was suggested to explain th

57 rf14 within the conjugation module encodes a bifunctional cell wall hydrolase CwlT that consists of a

58 with extracellular ceramide in vitro using a bifunctional ceramide analog preloaded into exosomes and

59 e distribution was consistent with that of a bifunctional ceramide analogue UV cross-linked and visua

60 chain transfer (RAFT) polymerization using a bifunctional chain transfer agent (Peptide2CTA).

61 TRPM7 and TRPM6 were the first identified bifunctional channels to contain their own kinase domain

62 by use of ligands conjugated to traditional bifunctional chelates limits the amount of (225)Ac(3+) t

63 In the perspective of developing bifunctional chelating agents (BCAs), this new synthetic

64 [Mn(PyC3A)(H2O)](-) was modified to form a bifunctional chelator and 4 chelates were conjugated to

65 Described herein are a series of bifunctional chelators (BFCs), L1-L5, that were designed

66 methylerythritol cyclodiphosphate (MEcPP), a bifunctional chemical entity serving as both a precursor

67 of (Ar)Pd(II) complexes using vinylBPin as a bifunctional chemical probe with Pd(II)-dependent cross-

68 to activating CHIR-A, inhibitory CHIR-B, and bifunctional CHIR-AB.

69 50.6% monomer conversion, by newly designed bifunctional chiral catalyst 4 that incorporates three k

70 Bifunctional Cinchona alkaloid thioureas efficiently cat

71 xybutanoate (rac-(t)Bu 3,4-EB) and CO2 using bifunctional cobalt(III) salen catalysts.

72 re, we present the cryo-EM structure of this bifunctional complex at a resolution of 7 A using a new

73 rapy, we believe that this emerging class of bifunctional compounds may introduce a new generation of

74 inking it to the RNase inhibitor 1 forms the bifunctional conjugate 7A, which inhibits the production

75 In fungi, all six known STSs are bifunctional, containing C-terminal trans-prenyltransfer

76 Bifunctional coupling of two different catalytic site ty

77 d accessible amino groups in the enzyme with bifunctional cross-linking agents and identified the lin

78 succinimide, a photoactivable amino reactive bifunctional crosslinker, was used and greater than 90%

79 n existing UV absorbance assay for FabA, the bifunctional dehydration/epimerization enzyme and key ta

80 The key attribute of the membrane is a bifunctional design that allows for the digestion of pro

81 Removal of the second DKA branch of bifunctional DKAs, and the amino group in position 7 of

82 products, which are repair intermediates of bifunctional DNA glycosylases.

83 Using a panel of eukaryotic and prokaryotic bifunctional DNA glycosylases/lyases (NEIL1, Nei, Fpg, N

84 ain FtsZ also retain the predicted ancestral bifunctional dynamin.

85 zed by a hierarchically porous Ni3S2/Ni foam bifunctional electrocatalyst (Ni3S2/NF).

86 ctrocatalytic properties to Pt and RuO2 as a bifunctional electrocatalyst for ORR and OER, and hold a

87 orous MoO2 nanosheet as an active and stable bifunctional electrocatalyst for overall water splitting

88 ing the spinel-type LT-Li0,5CoO2 a potential bifunctional electrocatalyst for rechargeable metal-air

89 espectively, which is comparable to the best bifunctional electrocatalyst reported in the literature.

90 A nanocomposite CoO-NiO-NiCo bifunctional electrocatalyst supported by nitrogen-doped

91 that electrodeposited NiSe2 can be used as a bifunctional electrocatalyst under alkaline conditions t

92 As a bifunctional electrocatalyst, Ni2 P NPA/NF is not only a

93 Rational design of highly efficient bifunctional electrocatalysts based on 3D transition-met

94 e zinc-air batteries lies in the inefficient bifunctional electrocatalysts for the oxygen reduction a

95 ack of high-efficient, low-cost, and durable bifunctional electrocatalysts that act simultaneously fo

96 of precious-metal catalysts, especially the bifunctional electrocatalysts with high activity for bot

97 It exhibits excellent bifunctional electrocatalytic activities for oxygen redu

98 graphene edge effects are essential for the bifunctional electrocatalytic activity of our material.

99 l rate-determining step to achieve excellent bifunctional electrocatalytic activity.

100 Furthermore, this bifunctional electrode can be used for highly efficient

101 We report on a bimetallic, bifunctional electrode where a platinum (Pt) surface was

102 Such a bifunctional electrolyte reconciles both inert and activ

103 on-buffering nitrosyl's role is subtler as a bifunctional electron reservoir.

104 Glyoxal (gx) is a bifunctional electrophile capable of cross-linking DNA.

105 n triploblastic bilaterians evolved from the bifunctional endomesoderm (gastrodermis) of a diploblast

106 relatives have evolved and secrete a unique bifunctional endoxylanase/arabinofuranosidase in the sam

107 u5Ac derivative that is modified at C-5 by a bifunctional entity composed of a complex synthetic hepa

108 The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,

109 Within this pathway, the bifunctional enzyme adenylosuccinate (ADS) lyase plays a

110 Here, we use a novel bifunctional enzyme AgeMTPT to protect linear peptides b

111 NfnII is therefore proposed to be a bifunctional enzyme and also to catalyze a bifurcating r

112 The bifunctional enzyme and other secreted enzymes attack th

113 ase activities in vitro and it can work as a bifunctional enzyme capable of synthesizing glycerol dir

114 CoVs code for nsp14, a bifunctional enzyme carrying RNA cap guanine N7-methyltr

115 cts of the GNE gene which encodes a critical bifunctional enzyme for sialic acid biosynthesis, lead t

116 PBP4 is a bifunctional enzyme having both dd-carboxypeptidase and

117 Soluble epoxide hydrolase (sEH) is a bifunctional enzyme located within cytosol and peroxisom

118 The bifunctional enzyme N(5),N(10)-methylenetetrahydrofolate

119 a, PRODH and P5CDH are fused together in the bifunctional enzyme proline utilization A (PutA) whereas

120 nase/fructose-2,6-bisphosphatase (F2KP), the bifunctional enzyme responsible for both the synthesis a

121 hizobium meliloti (SmPutA) is a 1233-residue bifunctional enzyme that contains the DUF in addition to

122 LT) A4 hydrolase/aminopeptidase (LTA4H) is a bifunctional enzyme that converts the highly unstable ep

123 , there are contrasting views on whether the bifunctional enzyme, PleC, acts as a kinase or phosphata

124 They are bifunctional enzymes containing a trans-esterase activit

125 Aldehyde/alcohol dehydrogenases (ADHEs) are bifunctional enzymes that commonly produce ethanol from

126 The novel bifunctional epoxidation reagent, 2-carboperoxy-3,4,5,6-

127 d WarB have structural similarities with the bifunctional Escherichia coli lipopolysaccharide (LPS) O

128 Bifunctional FAD synthetases (FADSs) fold in two indepen

129 Here we present a bifunctional fatty acid chemical reporter, x-alk-16, whi

130 The bifunctional flavoenzyme proline utilization A (PutA) ca

131 We report a bifunctional fluorescent probe that combines a rhodium m

132 y of target capture in immunoassays, using a bifunctional fusion protein construct which incorporates

133 oration of the theoretical limits for such a bifunctional gain for several model reactions.

134 oxide supports, offers hope for significant bifunctional gains.

135 show that Helicobacter htrA is an essential bifunctional gene with crucial intracellular and extrace

136 code TrpF specialists, HisA specialists, and bifunctional generalists.

137 A bifunctional graphene catalyst with abundant topological

138 KatG is a bifunctional, heme-dependent enzyme in the front-line de

139 formation structure is highly similar to the bifunctional HisA homologue PriA in complex with PRFAR,

140 f the sensor histidine kinases belong to the bifunctional HisKA family, displaying both kinase and ph

141 hosphatase activity of the largest family of bifunctional histidine kinases in response to the change

142 ostyrenes are catalyzed by different chiral, bifunctional hydrogen-bonding catalysts, based on thiour

143 Bifunctional IL-17(+)FOXP3(+) exhibited a phenotype of i

144 Bifunctional iminophosphorane catalysts are found to use

145 a-substituted acrylate esters catalyzed by a bifunctional iminophosphorane organocatalyst under mild

146 ing the bioavailability and efficacy of this bifunctional inhibitor strategy toward combined MEK1/PI3

147 We propose that EFA-6 acts as a bifunctional injury-responsive regulator of axonal MT dy

148 by the convergent union of an enimide with a bifunctional iodoether.

149 Guerbet process, has been developed using a bifunctional iridium catalyst coupled with bulky nickel

150 This bifunctional isocyanide was found to undergo mild cyclod

151 fulfil previously published criteria for any bifunctional kinase/phosphatase to exhibit concentration

152 The last enzyme of the pathway, bifunctional L-histidinol dehydrogenase (HDH, EC 1.1.1.2

153 ich catalytically most closely resembles the bifunctional labda-7,13E-dien-15-ol synthase of the lyco

154 he working mechanistic hypothesis involves a bifunctional Lewis acid/base catalysis strategy involvin

155 esis, and validation of new highly effective bifunctional linchpins for type II anion relay chemistry

156 Using our bifunctional linker coupling strategy, we show that the

157 nctionalized polymers using a small-molecule bifunctional linker.

158 use biotinylated anti-bacteria antibodies as bifunctional linkers (BLs) to mediate the aggregation of

159 Herein, we report a strategy to synthesize a bifunctional luminomagnetic Gd2-xEuxO3 (x = 0.05 to 0.5)

160 A bifunctional macrocycle, with hydrogen bond donors at on

161 This bifunctional marker was efficiently cleaved during virus

162 n YFP and mCherry because of cleavage of the bifunctional marker, which manifested as a marked shift

163 we designed a labeling strategy based on the bifunctional mCherry-2xCL-YFP-Vpr construct, in which 2x

164 The alternative bifunctional mechanism is verified by combined electroch

165 to formaldehyde through a new ligand-ligand bifunctional mechanism, where two hydrogen atoms of CH3O

166 that PS1 regulates Abeta levels by a unique bifunctional mechanism.

167 that PS1 regulates Abeta levels by a unique bifunctional mechanism.

168 The synthesis of a series of single entity, bifunctional MEK1/PI3K inhibitors achieved by covalent l

169 rrying a mutation (R175Q) in the cytoplasmic bifunctional methylenetetrahydrofolate dehydrogenase/met

170 Bifunctional Mo complexes, [CpMo(CO)(kappa(3)-P2N2)](+)

171 Here we report that GIV is a bifunctional modulator of G proteins; it serves as a gua

172 as a model, we identified a highly specific bifunctional molecule able to mediate the engulfment and

173 The bifunctional molecule, 1-pyrenebutanoic acid succinimidy

174 Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that recruit an E3 ligase to a ta

175 minerals in a model system, two families of bifunctional molecules that target bone without requirin

176 Antibodies are bifunctional molecules, containing a variable Fab domain

177 75 repeat units long (28 kDa) from a single bifunctional monomer and Cu(I) .

178 ), a naturally occurring and biomass-sourced bifunctional monomer, contains both a highly reactive ex

179 ent the efficacy and tolerability profile of bifunctional MOP/NOP receptor agonists, but also provide

180 metic series, we reported the development of bifunctional mu-opioid receptor (MOR) agonist and delta-

181 We report here the generation of a bifunctional mutant of HEPD (E176H) that exhibits the ac

182 In some bacteria bifunctional N-acetylglutamate synthase-kinase (NAGS-K)

183 n this direction, we have designed the first bifunctional nanobiosensor for chemokine screening and d

184 cribes new findings of an investigation of a bifunctional nanocomposite probe for the detection of ca

185 The as-prepared bifunctional nanocomposites can be used to simultaneousl

186 cific pVIII fusion protein (fusion-pVIII), a bifunctional nanoprobe (CS-AuNPs@fusion-pVIII) for S. au

187 Thus, the bifunctional nature of ROC provides the RA-based signali

188 stable under all conditions, preserving the bifunctional nature of the catalyst.

189 he catalytic hydrogenation and highlight the bifunctional nature of the mechanism that is preferred f

190 Notably, the self-illuminating and bifunctional nature of these LumiFluor reporters enables

191 rotective activity is mediated through their bifunctional nature: a variable Fab domain mediates anti

192 importantly, real air cathodes made from the bifunctional NCNT/CoO-NiO-NiCo catalysts further demonst

193 Here we report the design of a catalytic, bifunctional nitrile template that binds a heterocyclic

194 possible that have not yet been realized in bifunctional noncovalent organocatalysis.

195 Molecular metal/NH bifunctional Noyori-type catalysts are remarkable in tha

196 ylation of the N-H functionality within M/NH bifunctional Noyori-type catalysts leads to detrimental

197 s on the overall long-term durability of the bifunctional OER/ORR electrocatalyst.

198 Bifunctional oligonucleotides containing an I-SceI aptam

199 A squaramide-containing tertiary amine based bifunctional organocatalyst efficiently activates the o-

200 e prepared using a Cinchona alkaloid-derived bifunctional organocatalyst for the Michael addition ste

201 alization of silyl-diene enol ethers under a bifunctional organocatalyst provokes a dramatic change i

202 catalyzed by a cinchona alkaloid-squaramide bifunctional organocatalyst was studied using density fu

203 and 3-substituted isochromans using a chiral bifunctional organocatalyst.

204 The sulfonamides were especially suited as bifunctional organocatalysts as they gave the products i

205 Herein, we report an advanced bifunctional oxygen electrocatalyst consisting of porous

206 o the bipolar electrode (BE) modified with a bifunctional oxygen electrocatalyst, it was possible to

207 uggest that both JNA_RD8 and JNA_RD11 may be bifunctional PCE/PCB RDases.

208 he peptidoglycan cell wall is synthesized by bifunctional penicillin-binding proteins such as PBP1b t

209 nt CLE peptide hormones leads to a synthetic bifunctional peptide that exerts activities beyond the o

210 vely, this study presents the selection of a bifunctional peptide-based anti-infective agent and its

211 he roles of catalase (encoded by hktE) and a bifunctional peroxiredoxin-glutaredoxin (encoded by pdgX

212 OM invagination and imparts a unique mode of bifunctional PG synthase regulation by selectively modul

213 Mutational analysis supports the bifunctional PH domain mediation of DH-RhoA interactions

214 New bifunctional phase transfer agents were synthesized and

215 ubstituted bis-protonated proton sponge as a bifunctional phase-transfer catalyst is reported.

216 In the presence of an L-threonine-derived bifunctional phosphine, 3,4-dihydropyrans were obtained

217 A new bifunctional pincer ligand framework bearing pendent pro

218 s and Smoluchowski continuum modeling of the bifunctional Plasmodium falciparum dihydrofolate reducta

219 he formation of plasmonic Au@hexaniobate and bifunctional plasmonic-magnetic Au-Fe3 O4 @hexaniobate n

220 ye can be stably conjugated to a mAb using a bifunctional platinum(II) linker.

221 The system builds upon a bifunctional polypeptide consisting of a fluorogen-activ

222 port the fabrication of spatially orthogonal bifunctional porous catalysts, through the stepwise temp

223 We show here that the MTHFD2L enzyme is bifunctional, possessing both CH2-THF dehydrogenase and

224 zole linked maleimide-based single molecular bifunctional probe 1 has been synthesized for the colori

225 This methodology affords bifunctional products in good yield with excellent n-sel

226 ntiviral activity of antibodies reflects the bifunctional properties of these molecules.

227 restingly, we observed that DnaJC15 exhibits bifunctional properties.

228 This bifunctional protein duplicated into specialized mitocho

229 Armet is a well-characterized bifunctional protein in mammalian systems.

230 The bifunctional protein kinase-endoribonuclease Ire1 initia

231 It is a bifunctional protein resulting from the fusion of a G-pr

232 gs reveal for the first time that OPHN1 is a bifunctional protein that is able, through distinct mech

233 Our data demonstrate that RstA is a bifunctional protein that upregulates sporulation throug

234 This bifunctional protein was identified as triokinase.

235 Peroxiredoxin 6 (Prdx6), a bifunctional protein with phospholipase A2 (aiPLA2) and

236 question regarding the significance of this bifunctional protein.

237 m that includes many pathogenic species, are bifunctional proteins that both charge mitochondrial tRN

238 d L. major genes (FKP40 and AFKP80) encoding bifunctional proteins with kinase/pyrophosphorylase acti

239 Additionally, bifunctional proteolysis targeting chimeras (PROTACs) co

240 predicts that the core channeling pathway of bifunctional PutA enzymes is conserved in monofunctional

241 ate channeling has previously been shown for bifunctional PutAs, but whether the monofunctional enzym

242 Bifunctional QM4 undergoes two types of reactions with n

243 o biological systems, such as for the use of bifunctional QMs to achieve DNA cross-linking.

244 Bifunctional quinolinonyl DKA derivatives were first des

245 f rac-/(R)-benzyl glycidate with CO2 using a bifunctional rac-/(S,S)-cobalt salen catalyst in high ca

246 king of CYP3A4 oligomers with thiol-reactive bifunctional reagents as well as the luminescence resona

247 channel gating, we perform cross-linking by bifunctional reagents of multiple predicted pairs of cys

248 and optimized a synergic system based on two bifunctional reagents, a thiosemicarbazide-functionalize

249 unveiling an unrecognized role for CD16 as a bifunctional receptor capable of engendering long-lastin

250 Thus, SynEtr1 is a bifunctional receptor that mediates responses to both li

251 redox targeting reactions of LiFePO4 with a bifunctional redox mediator, 2,3,5,6-tetramethyl-p-pheny

252 Foxp3(+) biTregs are a novel and independent bifunctional regulatory T cell lineage distinct from cTr

253 Here, we have tested a bifunctional resistance gene for its suitability as a se

254 tilizing a biological circuit generated by a bifunctional retinoid oxidoreductive complex (ROC).

255 muscle using fluorescence polarization from bifunctional rhodamine probes at four sites on the C-ter

256 ered thick filament structure as reported by bifunctional rhodamine probes on the cRLC: the myosin he

257 We identified a novel bifunctional riboflavin kinase/regulator (RbkR), which c

258 mechanistic insight enabled the design of a bifunctional ROAMP-reversible addition-fragmentation cha

259 chanism in which the ClBcat reagent serves a bifunctional role by sequentially activating the alkyne,

260 gether, our results reveal the unanticipated bifunctional role of VDAC2 to target Bax specifically to

261 A new series of bifunctional Ru complexes with pendent Lewis acidic bora

262 The bifunctional salicylate synthase MbtI catalyzes the firs

263 Using a bifunctional SAM containing PEG moieties and a tethered

264 he fabrication of an all-integrated PI/Cu/PI bifunctional separator for dendrite detection can be ful

265 A bifunctional separator modified by black-phosphorus nano

266 lithium dendrites inside batteries through a bifunctional separator, which offers a third sensing ter

267 Herein, we demonstrate that a bifunctional small molecule "switch" consisting of folat

268 Targeted protein degradation, using bifunctional small molecules (Protacs) to remove specifi

269 ulate microRNAs (miRNAs) biogenesis by using bifunctional small molecules that consist of a pre-miRNA

270 eine (cysteine) and L-Arginine (arginine) as bifunctional species with (or without) urea or oxalic ac

271 g electron paramagnetic resonance (EPR) of a bifunctional spin label (BSL) bound stereospecifically t

272 hing two different spin labels, MTSL or BSL (bifunctional spin-label) onto the F or G helices and usi

273 With bifunctional squaramide catalyst, the desired tetralone

274 employing a very low loading of 1 mol % of a bifunctional squaramide organocatalyst.

275 alogues was achieved using L-proline derived bifunctional squaramide which outperformed commonly used

276 Novel supported chiral bifunctional squaramides have been easily prepared start

277 spectra of precursor fluoride adducts of the bifunctional steroid "reduced pregnenolone" (containing

278 rahydropyrans, which are next used as chiral bifunctional substrates on the Ugi five-center three-com

279 ctive non-classical sigma,pi-activation with bifunctional substrates.

280 PhoQ is bifunctional such that, when not active as a kinase, it

281 This convergent approach is based on bifunctional sugar building blocks with two temporarily

282 determined using polarized fluorescence from bifunctional sulforhodamine probes.

283 sible cysteines were expressed, labeled with bifunctional sulforhodamine, and exchanged into demembra

284 he engineering of recombinant antibody-based bifunctional switches that consist of a tumor antigen-sp

285 activators of the class A PBPs (aPBPs)(3,4), bifunctional synthases capable of polymerizing and cross

286 ted cyclopentene-1,3-dione is catalyzed by a bifunctional tertiary aminourea derivative, utilizes air

287 cascade reaction has been developed using a bifunctional thiourea organocatalyst.

288 ereomeric P-chiral beta-aminophosphine-based bifunctional thioureas displayed significantly different

289 Herein, we report the synthesis of bifunctional thioureas with a chiral moiety that include

290 se exhibits activity on Si attributable to a bifunctional TiO2 layer, which protects the Si electrode

291 Thus, Utp14 is bifunctional; together with Bud23, it is needed for stab

292 Hunchback (Hb) is a bifunctional transcription factor that activates and rep

293 Our results suggest that p7, a bifunctional transcription factor, uses distinct mechani

294 titis C virus (HCV) with an AAV expressing a bifunctional TuD against an anti-HCV shRNA sense strand

295 or glycolysis and gluconeogenesis, including bifunctional unidirectional fructose 1,6-bisphosphate al

296 The presence of bifunctional units comprising electrophilic chloroquinol

297 Co phosphate is successfully fabricated for bifunctional water electrolysis.

298 o investigate the long-term performance of a bifunctional water splitting catalyst, specifically amor

299 rimidines through the expression of a single bifunctional yeast fusion gene, cytosine deaminase/uraci

300 fiber networks, and restored by treatment of bifunctional Zn(II)-terpyridine-capped PEO to redisperse