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1 sms, beta-H elimination, or the metal-ligand bifunctional.
2 etric Pfau-d'Angelo reaction by exploiting a bifunctional 1 degrees amine thiourea catalyst system is
3 , we characterized kinetic properties of the bifunctional 5-InsP7 kinase/InsP8 phosphatase activities
7 and LpDsbD2) (compared with E. coli) permit bifunctional activities without creating a futile cycle.
8 ilms, leading to significant enhancements in bifunctional activity essential for fuel cells and metal
9 t genes encoding the separate domains of the bifunctional acyl-acyl carrier protein (ACP) synthetase/
10 eatment of male mice with melphalan (MLP), a bifunctional alkylating agent widely used in chemotherap
11 core trisaccharide in both organisms, and a bifunctional alpha-galactosyltransferase from CAZy famil
14 lyses, we identified a single homotetrameric bifunctional ammonia-lyase (PTAL) among eight BdPAL enzy
15 romide perovskites incorporating a series of bifunctional ammonium dications as templates which also
17 found that a major shift in function from a bifunctional ancestor that could phosphorylate either gl
18 ure of the zinc-finger (ZnR) domain from the bifunctional and bipolar ZitP pilus assembly/motility re
19 current work investigates the effect of new bifunctional and mononuclear Pt(II) compounds, the cis-
22 al growth factor receptor (EGFR) to create a bifunctional aptamer that labels cell-surface EGFR on ma
24 paration technique by using well-established bifunctional Au-Fe3O4 nanocomposites as the separation n
25 bodies in DKO mice, we used a novel class of bifunctional autoantibodies, IgM/DNA dual variable domai
26 An E2 elimination mechanism catalyzed by a bifunctional base that directly forms an N-protonated en
28 f this study was to develop an aptamer-based bifunctional bio-nanogate, which could selectively respo
34 ansferase PsoE requires participation of the bifunctional C-methyltransferase/epoxidase PsoF to compl
36 f the fiber-shaped zinc-air battery, i.e., a bifunctional catalyst composed of atomically thin layer-
37 a highly durable and efficient carbide-based bifunctional catalyst consisting of iron-molybdenum carb
39 between the Co3 O4 and N-rGO nanosheets, the bifunctional catalyst exhibits high activity and superio
40 free catalyst was further used as an OER-HER bifunctional catalyst for oxygen and hydrogen gas produc
41 Thus, the pyrolyzed MPSA/GO is a promising bifunctional catalyst for renewable energy technologies,
42 oated porous graphene oxide can be used as a bifunctional catalyst for tandem oxidation and hydrogena
43 hway where the phosphinic acid operates as a bifunctional catalyst in the intramolecular substitution
44 arily high performance of the Fe3 Pt/Ni3 FeN bifunctional catalyst makes it a very promising air cath
45 ificantly enhance both reactions, yielding a bifunctional catalyst that surpasses the performance of
46 olyzed MPSA/GO acted as the first metal-free bifunctional catalyst with high activities for both oxyg
47 The hydrogen bonding donor ability of the bifunctional catalyst, as shown in the proposed transiti
49 ultra-small NiFeOx nanoparticles are active bifunctional catalysts exhibiting high activity and stab
50 m chromium to gold for ionic hydrogenations, bifunctional catalysts for hydrogen oxidation and evolut
52 thesis of chiral thiosquaramides, a class of bifunctional catalysts not previously described in the l
53 overs an entirely new strategy for designing bifunctional catalysts with double-activation behavior a
54 ve power and enables effective design of new bifunctional catalysts with enhanced ORR/OER activities.
56 of the catalyst and NMR spectra analysis, a bifunctional catalytic model was suggested to explain th
57 rf14 within the conjugation module encodes a bifunctional cell wall hydrolase CwlT that consists of a
58 with extracellular ceramide in vitro using a bifunctional ceramide analog preloaded into exosomes and
59 e distribution was consistent with that of a bifunctional ceramide analogue UV cross-linked and visua
61 TRPM7 and TRPM6 were the first identified bifunctional channels to contain their own kinase domain
62 by use of ligands conjugated to traditional bifunctional chelates limits the amount of (225)Ac(3+) t
64 [Mn(PyC3A)(H2O)](-) was modified to form a bifunctional chelator and 4 chelates were conjugated to
66 methylerythritol cyclodiphosphate (MEcPP), a bifunctional chemical entity serving as both a precursor
67 of (Ar)Pd(II) complexes using vinylBPin as a bifunctional chemical probe with Pd(II)-dependent cross-
69 50.6% monomer conversion, by newly designed bifunctional chiral catalyst 4 that incorporates three k
72 re, we present the cryo-EM structure of this bifunctional complex at a resolution of 7 A using a new
73 rapy, we believe that this emerging class of bifunctional compounds may introduce a new generation of
74 inking it to the RNase inhibitor 1 forms the bifunctional conjugate 7A, which inhibits the production
77 d accessible amino groups in the enzyme with bifunctional cross-linking agents and identified the lin
78 succinimide, a photoactivable amino reactive bifunctional crosslinker, was used and greater than 90%
79 n existing UV absorbance assay for FabA, the bifunctional dehydration/epimerization enzyme and key ta
83 Using a panel of eukaryotic and prokaryotic bifunctional DNA glycosylases/lyases (NEIL1, Nei, Fpg, N
86 ctrocatalytic properties to Pt and RuO2 as a bifunctional electrocatalyst for ORR and OER, and hold a
87 orous MoO2 nanosheet as an active and stable bifunctional electrocatalyst for overall water splitting
88 ing the spinel-type LT-Li0,5CoO2 a potential bifunctional electrocatalyst for rechargeable metal-air
89 espectively, which is comparable to the best bifunctional electrocatalyst reported in the literature.
91 that electrodeposited NiSe2 can be used as a bifunctional electrocatalyst under alkaline conditions t
94 e zinc-air batteries lies in the inefficient bifunctional electrocatalysts for the oxygen reduction a
95 ack of high-efficient, low-cost, and durable bifunctional electrocatalysts that act simultaneously fo
96 of precious-metal catalysts, especially the bifunctional electrocatalysts with high activity for bot
98 graphene edge effects are essential for the bifunctional electrocatalytic activity of our material.
105 n triploblastic bilaterians evolved from the bifunctional endomesoderm (gastrodermis) of a diploblast
106 relatives have evolved and secrete a unique bifunctional endoxylanase/arabinofuranosidase in the sam
107 u5Ac derivative that is modified at C-5 by a bifunctional entity composed of a complex synthetic hepa
113 ase activities in vitro and it can work as a bifunctional enzyme capable of synthesizing glycerol dir
115 cts of the GNE gene which encodes a critical bifunctional enzyme for sialic acid biosynthesis, lead t
119 a, PRODH and P5CDH are fused together in the bifunctional enzyme proline utilization A (PutA) whereas
120 nase/fructose-2,6-bisphosphatase (F2KP), the bifunctional enzyme responsible for both the synthesis a
121 hizobium meliloti (SmPutA) is a 1233-residue bifunctional enzyme that contains the DUF in addition to
122 LT) A4 hydrolase/aminopeptidase (LTA4H) is a bifunctional enzyme that converts the highly unstable ep
123 , there are contrasting views on whether the bifunctional enzyme, PleC, acts as a kinase or phosphata
125 Aldehyde/alcohol dehydrogenases (ADHEs) are bifunctional enzymes that commonly produce ethanol from
127 d WarB have structural similarities with the bifunctional Escherichia coli lipopolysaccharide (LPS) O
132 y of target capture in immunoassays, using a bifunctional fusion protein construct which incorporates
135 show that Helicobacter htrA is an essential bifunctional gene with crucial intracellular and extrace
139 formation structure is highly similar to the bifunctional HisA homologue PriA in complex with PRFAR,
140 f the sensor histidine kinases belong to the bifunctional HisKA family, displaying both kinase and ph
141 hosphatase activity of the largest family of bifunctional histidine kinases in response to the change
142 ostyrenes are catalyzed by different chiral, bifunctional hydrogen-bonding catalysts, based on thiour
145 a-substituted acrylate esters catalyzed by a bifunctional iminophosphorane organocatalyst under mild
146 ing the bioavailability and efficacy of this bifunctional inhibitor strategy toward combined MEK1/PI3
149 Guerbet process, has been developed using a bifunctional iridium catalyst coupled with bulky nickel
151 fulfil previously published criteria for any bifunctional kinase/phosphatase to exhibit concentration
153 ich catalytically most closely resembles the bifunctional labda-7,13E-dien-15-ol synthase of the lyco
154 he working mechanistic hypothesis involves a bifunctional Lewis acid/base catalysis strategy involvin
155 esis, and validation of new highly effective bifunctional linchpins for type II anion relay chemistry
158 use biotinylated anti-bacteria antibodies as bifunctional linkers (BLs) to mediate the aggregation of
159 Herein, we report a strategy to synthesize a bifunctional luminomagnetic Gd2-xEuxO3 (x = 0.05 to 0.5)
162 n YFP and mCherry because of cleavage of the bifunctional marker, which manifested as a marked shift
163 we designed a labeling strategy based on the bifunctional mCherry-2xCL-YFP-Vpr construct, in which 2x
165 to formaldehyde through a new ligand-ligand bifunctional mechanism, where two hydrogen atoms of CH3O
168 The synthesis of a series of single entity, bifunctional MEK1/PI3K inhibitors achieved by covalent l
169 rrying a mutation (R175Q) in the cytoplasmic bifunctional methylenetetrahydrofolate dehydrogenase/met
172 as a model, we identified a highly specific bifunctional molecule able to mediate the engulfment and
174 Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that recruit an E3 ligase to a ta
175 minerals in a model system, two families of bifunctional molecules that target bone without requirin
178 ), a naturally occurring and biomass-sourced bifunctional monomer, contains both a highly reactive ex
179 ent the efficacy and tolerability profile of bifunctional MOP/NOP receptor agonists, but also provide
180 metic series, we reported the development of bifunctional mu-opioid receptor (MOR) agonist and delta-
183 n this direction, we have designed the first bifunctional nanobiosensor for chemokine screening and d
184 cribes new findings of an investigation of a bifunctional nanocomposite probe for the detection of ca
186 cific pVIII fusion protein (fusion-pVIII), a bifunctional nanoprobe (CS-AuNPs@fusion-pVIII) for S. au
189 he catalytic hydrogenation and highlight the bifunctional nature of the mechanism that is preferred f
191 rotective activity is mediated through their bifunctional nature: a variable Fab domain mediates anti
192 importantly, real air cathodes made from the bifunctional NCNT/CoO-NiO-NiCo catalysts further demonst
193 Here we report the design of a catalytic, bifunctional nitrile template that binds a heterocyclic
196 ylation of the N-H functionality within M/NH bifunctional Noyori-type catalysts leads to detrimental
199 A squaramide-containing tertiary amine based bifunctional organocatalyst efficiently activates the o-
200 e prepared using a Cinchona alkaloid-derived bifunctional organocatalyst for the Michael addition ste
201 alization of silyl-diene enol ethers under a bifunctional organocatalyst provokes a dramatic change i
202 catalyzed by a cinchona alkaloid-squaramide bifunctional organocatalyst was studied using density fu
204 The sulfonamides were especially suited as bifunctional organocatalysts as they gave the products i
206 o the bipolar electrode (BE) modified with a bifunctional oxygen electrocatalyst, it was possible to
208 he peptidoglycan cell wall is synthesized by bifunctional penicillin-binding proteins such as PBP1b t
209 nt CLE peptide hormones leads to a synthetic bifunctional peptide that exerts activities beyond the o
210 vely, this study presents the selection of a bifunctional peptide-based anti-infective agent and its
211 he roles of catalase (encoded by hktE) and a bifunctional peroxiredoxin-glutaredoxin (encoded by pdgX
212 OM invagination and imparts a unique mode of bifunctional PG synthase regulation by selectively modul
216 In the presence of an L-threonine-derived bifunctional phosphine, 3,4-dihydropyrans were obtained
218 s and Smoluchowski continuum modeling of the bifunctional Plasmodium falciparum dihydrofolate reducta
219 he formation of plasmonic Au@hexaniobate and bifunctional plasmonic-magnetic Au-Fe3 O4 @hexaniobate n
222 port the fabrication of spatially orthogonal bifunctional porous catalysts, through the stepwise temp
224 zole linked maleimide-based single molecular bifunctional probe 1 has been synthesized for the colori
232 gs reveal for the first time that OPHN1 is a bifunctional protein that is able, through distinct mech
237 m that includes many pathogenic species, are bifunctional proteins that both charge mitochondrial tRN
238 d L. major genes (FKP40 and AFKP80) encoding bifunctional proteins with kinase/pyrophosphorylase acti
240 predicts that the core channeling pathway of bifunctional PutA enzymes is conserved in monofunctional
241 ate channeling has previously been shown for bifunctional PutAs, but whether the monofunctional enzym
245 f rac-/(R)-benzyl glycidate with CO2 using a bifunctional rac-/(S,S)-cobalt salen catalyst in high ca
246 king of CYP3A4 oligomers with thiol-reactive bifunctional reagents as well as the luminescence resona
247 channel gating, we perform cross-linking by bifunctional reagents of multiple predicted pairs of cys
248 and optimized a synergic system based on two bifunctional reagents, a thiosemicarbazide-functionalize
249 unveiling an unrecognized role for CD16 as a bifunctional receptor capable of engendering long-lastin
251 redox targeting reactions of LiFePO4 with a bifunctional redox mediator, 2,3,5,6-tetramethyl-p-pheny
252 Foxp3(+) biTregs are a novel and independent bifunctional regulatory T cell lineage distinct from cTr
254 tilizing a biological circuit generated by a bifunctional retinoid oxidoreductive complex (ROC).
255 muscle using fluorescence polarization from bifunctional rhodamine probes at four sites on the C-ter
256 ered thick filament structure as reported by bifunctional rhodamine probes on the cRLC: the myosin he
258 mechanistic insight enabled the design of a bifunctional ROAMP-reversible addition-fragmentation cha
259 chanism in which the ClBcat reagent serves a bifunctional role by sequentially activating the alkyne,
260 gether, our results reveal the unanticipated bifunctional role of VDAC2 to target Bax specifically to
264 he fabrication of an all-integrated PI/Cu/PI bifunctional separator for dendrite detection can be ful
266 lithium dendrites inside batteries through a bifunctional separator, which offers a third sensing ter
269 ulate microRNAs (miRNAs) biogenesis by using bifunctional small molecules that consist of a pre-miRNA
270 eine (cysteine) and L-Arginine (arginine) as bifunctional species with (or without) urea or oxalic ac
271 g electron paramagnetic resonance (EPR) of a bifunctional spin label (BSL) bound stereospecifically t
272 hing two different spin labels, MTSL or BSL (bifunctional spin-label) onto the F or G helices and usi
275 alogues was achieved using L-proline derived bifunctional squaramide which outperformed commonly used
277 spectra of precursor fluoride adducts of the bifunctional steroid "reduced pregnenolone" (containing
278 rahydropyrans, which are next used as chiral bifunctional substrates on the Ugi five-center three-com
283 sible cysteines were expressed, labeled with bifunctional sulforhodamine, and exchanged into demembra
284 he engineering of recombinant antibody-based bifunctional switches that consist of a tumor antigen-sp
285 activators of the class A PBPs (aPBPs)(3,4), bifunctional synthases capable of polymerizing and cross
286 ted cyclopentene-1,3-dione is catalyzed by a bifunctional tertiary aminourea derivative, utilizes air
288 ereomeric P-chiral beta-aminophosphine-based bifunctional thioureas displayed significantly different
290 se exhibits activity on Si attributable to a bifunctional TiO2 layer, which protects the Si electrode
294 titis C virus (HCV) with an AAV expressing a bifunctional TuD against an anti-HCV shRNA sense strand
295 or glycolysis and gluconeogenesis, including bifunctional unidirectional fructose 1,6-bisphosphate al
298 o investigate the long-term performance of a bifunctional water splitting catalyst, specifically amor
299 rimidines through the expression of a single bifunctional yeast fusion gene, cytosine deaminase/uraci
300 fiber networks, and restored by treatment of bifunctional Zn(II)-terpyridine-capped PEO to redisperse
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