ライフサイエンスコーパス: bigenic

1 The bigenic ampullary glands and vas deferens were extremely

2 Bigenic and control mice were evaluated prospectively fr

3 The resulting bigenic animals (i6A-/Tag) and control WT/Tag mice were

4 PC synapses in comparison to vehicle-treated bigenic animals and tamoxifen-treated PrP-floxed-SCA7-92

5 Differentiating chondrocytes in bigenic animals could be ablated at different developmen

6 Brca1-/-; TgN x BRCA1GEN bigenic animals develop normally and can be maintained a

7 sgenic strain prone to mammary gland cancer, bigenic animals develop tumors with greatly accelerated

8 ading carcinoma cells in both MMTV-DNIIR and bigenic animals showed loss of DNIIR transgene expressio

9 elayed time to neu-mediated tumorigenesis in bigenic animals.

10 c beta(2)-AR x DNp38alpha MAPK mice, but not bigenic beta(1)-AR x DNp38alpha MAPK mice, and failed to

11 beta(2)-AR Tg mice and was still present in bigenic beta(1)-AR x DNp38alpha MAPK mice, but not bigen

12 d LVEF and reduced apoptosis and fibrosis in bigenic beta(2)-AR x DNp38alpha MAPK mice, but not bigen

13 c beta(1)-AR x DNp38alpha MAPK mice, but not bigenic beta(2)-AR x DNp38alpha MAPK mice.

14 reveal fine structural details of podocytes, bigenic Coll1alpha1GCE;Gt(ROSA)26Sor(tm9(CAG-tdTomato))

15 enin (Pro-Cat and Ubi-Cat, respectively) and bigenic crosses between these lines (Pro-Cat x JOCK1 and

16 el deficiency and the molecular mechanism of bigenic disease.

17 PRDX3 with the LRRK2 kinase mutant G2019S in bigenic Drosophila ameliorated the G2019S mutant-induced

18 d in response to irradiation, we generated a bigenic EC-SOD mouse model (OE mice) that expressed high

19 Moreover, bigenic expression of caBmpr1a rescued the differentiati

20 l fibrillary acidic protein (GF)-IL-12 mice, bigenic for the p35 and p40 genes, developed neurologic

21 Using bigenic Gli1-CreER(t2); R26tdTomato reporter mice, we ob

22 mance developed significantly more slowly in bigenic HD knock-in/Snell dwarf mice.

23 igral neuropil aggregates were diminished in bigenic HD knock-in/Snell dwarf mice.

24 th weight loss blunted significantly in male bigenic HD knock-in/Snell dwarf mice.

25 This demonstrates that bigenic heterozygosity can lead to FSGS and suggests tha

26 Moreover, bigenic heterozygosity for synaptopodin and CD2AP is suf

27 ther combinations of genetic heterozygosity (bigenic heterozygosity) that alone do not result in clin

28 d to determine the potential for deleterious bigenic interactions; approximately 4800 complex hemizyg

29 In bigenic L126Z/WT-hSOD1:YFP mice, disease was not acceler

30 a by crossing the moAPP transgenic mice to a bigenic line expressing human APPswe with PS1dE9.

31 We also generated bigenic mice (MHC-cyclin T1/CLP-1(+/-)) by crossing MHC-

32 last cell-fate determinant OSX compared with bigenic mice (Osx(f/f)/SCID).

33 Bigenic mice (termed GFAP-IL6/sgp130 mice) were generate

34 orter in the WT/ERE-Luc and REA(+/-)/ERE-Luc bigenic mice and by the higher expression levels of estr

35 -inducible recombination was demonstrated in bigenic mice at age 3 and 6 weeks, using each of 3 indep

36 d precursor protein + presenilin-1 (APP+PS1) bigenic mice attenuates AD pathogenesis.

37 in terms of AR function, we further derived bigenic mice by crossing AR activity indicator mice with

38 Analyses of the resultant bigenic mice by in vivo imaging and luciferase assays sh

39 Neither APP47 nor APP48 nor the bigenic mice develop extracellular amyloid plaques.

40 /Abeta, although only APP(E693Q) X PS1Delta9 bigenic mice developed amyloid plaques.

41 Both single transgenic and bigenic mice developed intraneuronal accumulation of APP

42 These bigenic mice displayed exacerbated Abeta-induced cogniti

43 The bigenic mice exhibit enhanced susceptibility to hypertro

44 Bigenic mice exhibited an age-dependent increase in BLI

45 dification of tau in cultured neurons and in bigenic mice expressing Abeta and human tau.

46 ertrophic cardiomyopathy (HCM) by generating bigenic mice in which expression of the mutant transgene

47 , the Abeta amyloid plaques in the brains of bigenic mice inoculated with Abeta42 prions prepared in

48 TBK1 on tauopathy in vivo, we have developed bigenic mice overexpressing full-length TTBK1 and the P3

49 The bigenic mice presented with an elevated accumulation of

50 The bigenic mice provide a model with cooperative aberration

51 f cyclin D2 level in the cyclin D3/cyclin D2 bigenic mice results in a complete reversion of the inhi

52 The bigenic mice show enhanced tau phosphorylation at multip

53 The bigenic mice show significant locomotor dysfunction as d

54 t with the reduction in spheroid number, the bigenic mice showed delayed accumulation of insoluble ta

55 rlier disease, and spinal cords of paralyzed bigenic mice showed YFP fluorescent inclusion-like struc

56 ion of alpha-synuclein neurotoxicity in such bigenic mice to the ability of beta-synuclein to reduce

57 on was evaluated in Pdx1(lacZ/+)/MT-TGFalpha bigenic mice treated with zinc.

58 erally to the hippocampi of APP+presenilin-1 bigenic mice via an adenoassociated virus serotype 2/1 h

59 of metastatic lesions was widespread in old bigenic mice we did not detect IGF-1(des) in poorly diff

60 PrP-floxed-SCA7-92Q BAC;CAGGS-Cre-ER bigenic mice were treated with a single dose of tamoxife

61 Myc-induced cell growth on CycD2, we created bigenic mice where Myc can be selectively activated in C

62 ely 4 times greater than those of TRAMP/SSAT bigenic mice, and by 36 weeks, they were approximately 1

63 protein is absent in tumors from Nrdp1/ErbB2 bigenic mice, and real time PCR analysis indicates that

64 two transgenic lines were mated to generate bigenic mice, and TGFbeta1 transgene expression was cont

65 rn granule neurons are unaffected in the APP bigenic mice, despite abundant amyloid pathology and rob

66 In the bigenic mice, iFGFR1 activation dramatically enhanced ma

67 increase in SSAT activity in the TRAMP/SSAT bigenic mice, prostatic N(1)-acetylspermidine and putres

68 In either combination of these bigenic mice, the severity of fibrillar inclusion pathol

69 We generated ligand-inducible bigenic mice, turned on and off expression of cardiac tr

70 ta40 and Abeta42 in the brains of inoculated bigenic mice, whereas synthetic Abeta42 prions stimulate

71 /Neu + MMTV/transforming growth factor alpha bigenic mice.

72 et of clinical IDDM was not present in these bigenic mice.

73 to self-propagate following inoculation into bigenic mice.

74 essing APP(E693Q) or APP(E693Q) X PS1DeltaE9 bigenic mice.

75 racteristic of AD, were also reversed in the bigenic mice.

76 c Min/+ S1p3r(-/-), and Apc Min/+ S1p1r(+/-) bigenic mice.

77 Ep2-/- mice and studied tumor development in bigenic mice.

78 model is ameliorated in BACE1(-/-).Tg2576(+) bigenic mice.

79 h KDNR mice to generate ARR2PBi-caFGFR1/KDNR bigenic mice.

80 ressing mice did not develop mammary tumors, bigenic MMTV-Alk(T204D) x Neu mice developed cancers tha

81 tumors arising in MMTV-TGF-alpha compared to bigenic MMTV-DNIIR/MMTV-TGF-alpha was the marked suppres

82 Bigenic MMTV-MAT/neu female offspring developed primary

83 Expression of eYFP in the bigenic mouse brain was observed only in neuronal mitoch

84 We tested this hypothesis using a bigenic mouse in which transgenic expression of APP was

85 We have created a new fluorescent bigenic mouse model of AD by crossing "H-line" yellow fl

86 tate cancer development, and present a novel bigenic mouse model that mimics the human condition, whe

87 Using the GT-tg bigenic mouse model, where brain-selective Tat expressio

88 address this question, we developed a novel bigenic mouse that overexpresses both amyloid precursor

89 from HG type 7, which further validates the bigenic nature of this resistance.

90 ore, a progesterone receptor (PR)-Cre Notch1 bigenic (Notch1(d/d)) confirmed a Notch1-dependent hypom

91 Bigenic (NT) and Neu-induced mammary tumors developed wi

92 analysis using heterozygous Pdx1(lacZ/+) and bigenic Pdx1(lacZ/+)/MT-TGFalpha mice.

93 Bigenic PRAI-SRC-1(-/-) mice revealed that SRC-1 modulat

94 e that recognize the hemoglobin epitope, the bigenic progeny developed dense, pseudo-follicular lymph

95 ion resulted in exuberant hyperplasia of all bigenic prostatic lobes typified by epithelial stratific

96 PiggyBac or Sleeping Beauty transposase bigenic rats bred with wild-type albino rats yielded off

97 Bigenic rats carrying single-copy transposons at known l

98 Pdx1(lacZ/+)/MT-TGFalpha bigenics showed up-regulated Pdx1 expression in premalig

99 this uncertainty, we developed an innovative bigenic system for the doxycycline-inducible expression

100 In this PRKO bigenic system, acute doxycycline-induced expression of

101 xpressed in all chondrocytes by the UAS-GAL4 bigenic system.

102 amyloid precursor protein (Tg2576) leads to bigenic (TAPP) mice with enhanced neurofibrillary pathol

103 luminescence imaging signal in the brains of bigenic Tg(APP23:Gfap-luc) mice, indicative of astrocyti

104 of Abeta trimers in vivo, we created a novel bigenic Tg-Abeta+Tau mouse line by crossing Tg2576 (Tg-A

105 rons and elevated activated microglia in the bigenic Tg-SwDI/Tg-5xFAD mice.

106 enance of genome stability) and showing that bigenic Tg.AC/Wrn(Deltahel/Deltahel) mice experience an

107 Harlequin patterning is a bigenic trait, resulting from the interaction of the mer

108 NeuYD;MMTV-VEGF(164) bigenic, tumor-bearing animals resulted in an average of

109 The bigenic tumors and their metastases were less proliferat

110 ly, in spite of their more malignant nature, bigenic tumors are more secretory and differentiated.

111 mo*) specifically in the cartilage using the bigenic UAS-Gal4 system, we demonstrate that activation

112 these phenotypes, profound disorders of the bigenic Wolffian duct derivatives were observed.