ライフサイエンスコーパス: biliary atresia

1 tal mice, resulting in an attenuated form of biliary atresia.

2 11 years after liver transplantation due to biliary atresia.

3 be a contributing factor in the etiology of biliary atresia.

4 ct the ability to induce the murine model of biliary atresia.

5 duct injury and obstruction in experimental biliary atresia.

6 o block disease progression in patients with biliary atresia.

7 ase using a mouse model of rotavirus-induced biliary atresia.

8 or the pathogenesis of the embryonic form of biliary atresia.

9 contributor to the pathogenesis of neonatal biliary atresia.

10 MR cholangiography in depicting extrahepatic biliary atresia.

11 tion genes within the livers of infants with biliary atresia.

12 and 77% specific for depicting extrahepatic biliary atresia.

13 n the etiology, diagnosis, and management of biliary atresia.

14 an diseases, including chronic cirrhosis and biliary atresia.

15 or a failed Kasai operation for extrahepatic biliary atresia.

16 the left lobe was grafted into a child with biliary atresia.

17 he initial surgical therapy for infants with biliary atresia.

18 orthotopic liver transplants for congenital biliary atresia.

19 but not from the HCV-seronegative liver with biliary atresia.

20 etaplasia and proliferation were observed in biliary atresia.

21 itial treatment for children with congenital biliary atresia.

22 with the ductules formed during extrahepatic biliary atresia.

23 ers and bile ducts of mice with experimental biliary atresia.

24 including sphincter-of-Oddi dysfunction and biliary atresia.

25 t of serious adverse events in children with biliary atresia.

26 lt synthesis and possible therapy for infant biliary atresia.

27 was 0.86 years (IQR 0.58-3.0) and 64.3% had biliary atresia.

28 t, sea lamprey thrives despite developmental biliary atresia.

29 y a key role in pathogenesis in experimental biliary atresia.

30 thelium drives the phenotype of experimental biliary atresia.

31 in addition to primary biliary cirrhosis and biliary atresia.

32 nnate immune response in the pathogenesis of biliary atresia.

33 tion in the early pathogenesis of congenital biliary atresia.

34 activation of apoptosis in a mouse model of biliary atresia.

35 ths that have furthered our understanding of biliary atresia.

36 poptosis in the pathogenesis of experimental biliary atresia.

37 significant clinical problem in infants with biliary atresia.

38 neonatal mice using an experimental model of biliary atresia.

39 of outcomes, screening, and pathogenesis of biliary atresia.

40 The cause of liver failure included biliary atresia (11), alpha 1-antitrypsin deficiency (1)

41 pient survival was obtained in children with biliary atresia (82%, 79%, and 78% at 1, 5, and 10 years

42 Rhesus rotavirus (RRV) can also lead to biliary atresia (a neonatal human disease) in mice.

43 Biliary atresia, a progressive obliterative process invo

44 ed interest in whether rotavirus could cause biliary atresia, an idiopathic, obliterative infantile d

45 Eleven children with end-stage extrahepatic biliary atresia and 11 controls (liver donors) were stud

46 e risk of variceal bleeding in children with biliary atresia and high-risk gastroesophageal varices.

47 st common causes of cholestatic jaundice are biliary atresia and idiopathic neonatal hepatitis (INH).

48 Advances in treatments for biliary atresia and necrotising enterocolitis have been

49 n of interferon gamma in 65% of infants with biliary atresia and no diseased control.

50 er or bile duct remnant in all patients with biliary atresia and only 1 control.

51 bile duct remnants, and peripheral blood of biliary atresia and other cholestatic disease controls w

52 f cellular and humoral autoimmunity in human biliary atresia and possible interventional strategies t

53 ; new information for assessing prognosis in biliary atresia and primary biliary cirrhosis; and impor

54 Indications for transplantation were biliary atresia and progressive familial intrahepatic ch

55 born procedures such as portoenterostomy for biliary atresia and repair of esophageal atresia and tra

56 ses that affect infants and children-such as biliary atresia and Reye's syndrome; and (3) redefinitio

57 ed based on concepts from the mouse model of biliary atresia and rotavirus vaccination programs.

58 inylated cRNA from livers of 14 infants with biliary atresia and six with neonatal intrahepatic chole

59 In general, children <2 years with biliary atresia and those with the most growth delay at

60 the rotavirus (RRV)- induced murine model of biliary atresia and whether the T cells are sufficient t

61 Recipient survival was best in children with biliary atresia and worst in adults with malignancy.

62 isease, 4 with cryptogenic cirrhosis, 4 with biliary atresia, and 10 normal subjects.

63 uch as erythroblastosis fetalis, septicemia, biliary atresia, and other causes of hyperbilirubinemia.

64 irrhosis, familial intrahepatic cholestasis, biliary atresia, and primary sclerosing cholangitis, and

65 y cirrhosis, primary sclerosing cholangitis, biliary atresia, and progressive familial intrahepatic c

66 l components of autoimmunity exist in murine biliary atresia, and the progressive bile duct injury is

67 The pathogenesis of biliary atresia appears to involve immune-mediated fibro

68 conclusion, embryonic and perinatal forms of biliary atresia are distinguished by gene expression pro

69 is of bile duct obstruction in children with biliary atresia are largely unknown.

70 irrhosis, primary sclerosing cholangitis and biliary atresia are thought to be immune-mediated cholan

71 is a genetically programmed animal model for biliary atresia, as it loses its bile ducts and gallblad

72 o underwent hepatoportoenterostomy (HPE) for biliary atresia at 9 U.S. pediatric centers between 1997

73 yonic (n = 5) and perinatal (n = 6) forms of biliary atresia at the time of diagnosis and hybridized

74 scular complications of portal hypoplasia in biliary atresia (BA) and acute rejection (AR) are still

75 undergoing Kasai portoenterostomy (KPE) for biliary atresia (BA) and to examine associations between

76 are present in infants with cirrhosis due to biliary atresia (BA) as early as the time of evaluation

77 Children with biliary atresia (BA) have increased maternal cells in th

78 Biliary atresia (BA) is a destructive cholangiopathy of

79 Biliary atresia (BA) is a devastating disease of childho

80 Extrahepatic biliary atresia (BA) is a devastating disease of the neo

81 Biliary atresia (BA) is a fibroinflammatory obstruction

82 Biliary atresia (BA) is a neonatal cholangiopathy of unk

83 Biliary atresia (BA) is a neonatal obstructive cholangio

84 Biliary atresia (BA) is a progressive fibroinflammatory

85 Biliary atresia (BA) is a progressive fibroinflammatory

86 Biliary atresia (BA) is a progressive, inflammatory chol

87 Biliary atresia (BA) is a rare disease in infants, with

88 Biliary atresia (BA) is notable for marked ductular reac

89 leading theory regarding the pathogenesis of biliary atresia (BA) is that bile duct injury is initiat

90 Biliary atresia (BA) is the end result of a destructive,

91 The etiology of biliary atresia (BA) is unknown.

92 atal mice, rhesus rotavirus (RRV) can induce biliary atresia (BA), a disease resulting in inflammator

93 Biliary atresia (BA), a progressive fibroinflammatory di

94 mice with rhesus rotavirus (RRV) results in biliary atresia (BA), and this condition is influenced b

95 Biliary atresia (BA), the most common cause of end-stage

96 of ultrasonography (US) in the diagnosis of biliary atresia (BA), with surgery as the reference stan

97 linked to naturally occurring outbreaks of a biliary atresia (BA)-like disease in livestock.

98 e in liver fibrosis, a grave complication of biliary atresia (BA).

99 rhesus rotavirus (RRV)-induced experimental biliary atresia (BA).

100 among the three main human cholangiopathies (biliary atresia [BA], primary biliary cholangitis [PBC],

101 phocytes populate the livers of infants with biliary atresia, but it is unknown whether neonatal lymp

102 ains produces a disease similar to infantile biliary atresia, but previous attempts to correlate reov

103 -fold (P = .003) and 9.6-fold (P = .0001) in biliary atresia compared with levels in controls.

104 ith either primary sclerosing cholangitis or biliary atresia, compared with only one (4%) of 24 patie

105 ariety of pediatric disorders including AGS, biliary atresia, congenital hepatic fibrosis, sclerosing

106 Biliary atresia continues to represent a major challenge

107 A 71/2-month-old girl with a history of biliary atresia developed fevers, hematochezia, tachypne

108 Extrahepatic biliary atresia (EHBA) and choledochal cysts (CDC) are i

109 going liver transplantation for extrahepatic biliary atresia (EHBA) and fulminant hepatic failure (FH

110 During and after developmental biliary atresia, expression of cyp7a1 in intestine incre

111 ns for transplantation had been extrahepatic biliary atresia (four patients), Alagille's syndrome (on

112 hotopic liver transplantation for congenital biliary atresia from July 1, 1984 to February 29, 1996 w

113 Discovery of the pathogenic mechanisms of biliary atresia has been limited by the inability to stu

114 Livers of infants with biliary atresia have a coordinated activation of genes i

115 children and neonatal mice with experimental biliary atresia have shown increased expression of proap

116 s were found in 11 independent patients with biliary atresia, hepatitis BC, alcohol, primary biliary

117 Relatively common conditions such as biliary atresia, however, remain largely unexplained and

118 Bile ductular proliferation in biliary atresia, however, was less than that seen in hep

119 Patients with biliary atresia (i.e., obliteration of the biliary tree)

120 samples were obtained from the children with biliary atresia immediately before orthotopic liver tran

121 o treat end-stage liver disease secondary to biliary atresia in a child with polysplenia syndrome.

122 eings, we searched for genomic signatures of biliary atresia in affected infants.

123 most common indications for transplant were biliary atresia in children (56%) and hepatitis C in adu

124 aches to re-examine whether rotavirus causes biliary atresia in children are discussed based on conce

125 Since 1999, all infants with suspected biliary atresia in England and Wales, UK, have been refe

126 ducts, pathology analogous to that found in biliary atresia in humans, and high levels of T3SA+ anti

127 relationship between rotavirus infection and biliary atresia in humans.

128 e 4, are important for biliary infection and biliary atresia in mice.

129 in the serum of mice and children and causes biliary atresia in neonatal mice.

130 Using a model of rotavirus-induced biliary atresia in newborn mice, we found that activated

131 and the indications for transplantation were biliary atresia in seven, fulminant hepatic failure in s

132 p between group C rotavirus and extrahepatic biliary atresia in the 10 patients in whom virus RNA was

133 outcome of a 2-year cohort of children with biliary atresia in the UK and Ireland was assessed to fi

134 bile salts in intestine after developmental biliary atresia, in addition to known mechanisms, such a

135 Studies in the rotavirus mouse model of biliary atresia indicate that infection of biliary epith

136 ve familial intrahepatic cholestasis type 1, biliary atresia, intrahepatic cholestasis of pregnancy,

137 Biliary atresia is a devastating disorder of the newborn

138 Biliary atresia is a fibro-inflammatory cholangiopathy t

139 Biliary atresia is a neonatal obstructive cholangiopathy

140 Biliary atresia is a rare disease of infancy, which has

141 Biliary atresia is an inflammatory fibrosclerosing lesio

142 Biliary atresia is an inflammatory, fibrosclerosing neon

143 Biliary atresia is an obliterative cholangiopathy of inf

144 Biliary atresia is associated with oligoclonal expansion

145 in the majority of children with congenital biliary atresia is definitive correction with orthotopic

146 The outcome after portoenterostomy for biliary atresia is determined by age at surgery and anat

147 hotopic liver transplantation for congenital biliary atresia is excellent and is independent of recip

148 he embryonic and perinatal clinical forms of biliary atresia is largely undefined.

149 The pathogenesis of biliary atresia is not known; one theory is that of a vi

150 The outcome of children with biliary atresia is related to the caseload of the surgic

151 Biliary atresia is the commonest cause of pathological j

152 Biliary atresia is the leading cause of cholestasis in i

153 Biliary atresia is the most common cause of end-stage li

154 Biliary atresia is the most common cause of end-stage li

155 Biliary atresia is the most common cholangiopathy of chi

156 Biliary atresia is the most common indication for liver

157 e loops and are associated with extrahepatic biliary atresia, lead to a loss of membrane recognition,

158 Sox17 haploinsufficiency causes biliary atresia-like phenotypes and hepatitis in late or

159 epatobiliary disease, including extrahepatic biliary atresia, liver disease and transplantation in cy

160 Although much is known about management of biliary atresia, many aspects are poorly understood, inc

161 In biliary atresia (n = 6) and 1, anti-trypsin deficiency (

162 ons; two were abnormal but not suggestive of biliary atresia (one false-negative finding); 12 were co

163 Samples from 32 subjects (20 with biliary atresia or choledochal cyst and 12 controls) wer

164 ction, and 123 (39.9%) an operation to treat biliary atresia or choledochal cyst in the preceding yea

165 of common bile duct (CBD) disorders, such as biliary atresia or ischemic strictures, is restricted by

166 However, in contrast to patients with biliary atresia or other forms of cholestasis who develo

167 of five patients (one lost to follow-up) had biliary atresia or other surgical lesions; two were abno

168 patients with primary biliary cirrhosis and biliary atresia or with Alagille syndrome, two major ped

169 diatric cases for which 39 (93%) were due to biliary atresia (P<0.001).

170 Th2-activating cytokine IL-33 is elevated in biliary atresia patient serum and in the livers and bile

171 a group of 23 pre- and postportoenterostomy biliary atresia patients were inversely related to total

172 Ten of 20 biliary atresia patients were positive for group C rotav

173 In the murine model of biliary atresia, perinatal exposure to rhesus rotavirus

174 Senescence may play a role in biliary atresia, primary sclerosing cholangitis, cellula

175 Recent advances in the understanding of biliary atresia published between December 1995 and Nove

176 S: The multicenter, double-blind Steroids in Biliary Atresia Randomized Trial (START) was conducted i

177 romol/L) as an early outcome in all cases of biliary atresia referred from one of the three centres.

178 The etiology of biliary atresia remains poorly understood.

179 lantation, neonatal hemochromatosis, and the Biliary Atresia Research Consortium have been summarized

180 Children with biliary atresia should be managed in surgical centres wi

181 ological networks previously unrecognized in biliary atresia, such as the complement components C3ar-

182 ic transplantation, done more frequently for biliary atresia than for any other cause of liver failur

183 Biliary atresia, the most common cause of childhood cirr

184 ogenesis; however, a subset of patients with biliary atresia, the most common childhood cholangiopath

185 IGFBP-1 levels and reduced IGFBP-3 levels in biliary atresia, there was no change in either IGFBP-1 o

186 e-negative finding); 12 were consistent with biliary atresia (three false-positive findings); four de

187 We discovered that the sea lamprey adapts to biliary atresia through a unique mechanism of de novo sy

188 al disorders such as oesophageal atresia and biliary atresia through clinical trials because of the r

189 lium, and drive the phenotypic expression of biliary atresia, thus constituting a potential therapeut

190 We hypothesized that the T cells in biliary atresia tissue expressed related TCRs, suggestin

191 Here, we used a rotavirus-induced model of biliary atresia to investigate the entire biliary transc

192 ctors for failure after portoenterostomy for biliary atresia using univariate and multivariable metho

193 ly transplantation or death in children with biliary atresia was determined.

194 Biliary atresia was the most common cause (50.4%) of end

195 1999, infants born in the UK with suspected biliary atresia were investigated in regional centres, a

196 148 infants with biliary atresia were treated between January, 1999, and

197 ease, and chronic biliary disorders, such as biliary atresia, which remains the most common paediatri

198 Among infants with biliary atresia who have undergone hepatoportoenterostom

199 (10 of 13) for the detection of extrahepatic biliary atresia, with a positive predictive value of 75%