ライフサイエンスコーパス: biliary excretion

1 e at the gut and blood-brain barrier and via biliary excretion.

2 in knockout mice despite markedly decreased biliary excretion.

3 t in the mechanisms of sterol absorption and biliary excretion.

4 oxorubicin and doxorubicinol elimination was biliary excretion.

5 from hepatocytes than from Kupffer cells, by biliary excretion.

6 n either E(2)17G-mediated cholestasis or its biliary excretion.

7 sA pretreatment was primarily due to lowered biliary excretion.

8 The percent biliary excretion (15.8 +/- 4.4%) and plasma half-life i

9 cromol/h) was similar to the total bile acid biliary excretion (286+/-84 micromol/hr, P = 0.06).

10 nd may compete with other organic anions for biliary excretion and 2) Mrp2 protein expression and fun

11 Knockdown of vipar in zebrafish resulted in biliary excretion and E-cadherin defects similar to thos

12 e low urinary recovery indicates substantial biliary excretion and supports the significant correlati

13 Intestinal absorption, biliary excretion, and urinary excretion of P-gp substra

14 he paracellular and transcytotic pathways of biliary excretion, assessed by horseradish peroxidase (H

15 mechanism may involve direct competition for biliary excretion by PB and/or a PB metabolite.

16 sed to determine organ uptake (CLuptake) and biliary excretion (CLbile) clearances of radioactivity.

17 Compared with medications without biliary excretion, compounds with biliary excretion (n =

18 lted in an approximately 45% decrease in the biliary excretion index of carboxydichlorofluorescein (C

19 nt with an approximately 60% increase in the biliary excretion index of carboxydichlorofluorescein.

20 ns and xenobiotics under conditions in which biliary excretion is impaired.

21 ns without biliary excretion, compounds with biliary excretion (n = 50) had significantly higher freq

22 ed in auxiliary livers, including uptake and biliary excretion of (99m)Tc-mebrofenin in syngeneic rec

23 ole of Mrp2, Bcrp, and P-glycoprotein in the biliary excretion of acetaminophen sulfate (AS) and gluc

24 tion of Mrp2 expression may explain impaired biliary excretion of amphiphilic anionic conjugates in t

25 No differences were found in the biliary excretion of APAP, APAP-sulfate, and APAP-glutat

26 icient mouse livers, resulting in negligible biliary excretion of AS, 4MUS, and HS.

27 nterventions that targeted the synthesis and biliary excretion of bile acids prevented the rise in fe

28 important in the hepatic glucuronidation and biliary excretion of bilirubin and of this series of aci

29 se-1 (BUGT1)-deficient Gunn rats resulted in biliary excretion of bilirubin glucuronides and a 70% re

30 enzyme is essential for glucuronidation and biliary excretion of bilirubin, and its absence can be f

31 x 5 d) before liver isolation decreased the biliary excretion of both VPA (1.06E-04 +/- 0.27E-04 vs.

32 Intestinal absorption and biliary excretion of cholesterol represent two major pat

33 The hepatic concentration and biliary excretion of conjugated and unconjugated BAs wer

34 As expected, biliary excretion of conjugates was not impaired in P-gl

35 ncreased intestinal absorption and decreased biliary excretion of dietary sterols, hypercholesterolem

36 r membrane and the recovery of bile flow and biliary excretion of DNP-SG.

37 rotubule destabilizer, nocodazole, decreased biliary excretion of DNR.

38 In the presence of GF120918, the biliary excretion of doxorubicin and doxorubicinol was d

39 data supported the hypothesis that decreased biliary excretion of doxorubicin in the isolated perfuse

40 In the presence of quinidine, the biliary excretion of doxorubicin was reduced significant

41 ht) gave a similar degree of cholestasis and biliary excretion of E(2)17G-equivalents in wild-type an

42 Neither Taxol nor daunorubicin decreased the biliary excretion of E(2)17G.

43 Additionally, PCA reduced the biliary excretion of FL-Glu by 55%.

44 ndependent bile flow primarily by inhibiting biliary excretion of glutathione and to a lesser extent

45 this dislocation of apical transporters, the biliary excretion of glutathione-methylfluorescein and c

46 Biliary excretion of intact as well as partially degrade

47 However, biliary excretion of intravenously infused TC was signif

48 mechanism of inhibitory effect of CsA on the biliary excretion of irinotecan and its metabolites.

49 nalicular membrane by P-glycoprotein, on the biliary excretion of irinotecan and its metabolites.

50 cy and kinetics of food- and hormone-induced biliary excretion of L. monocytogenes from the murine ga

51 Taurolithocholate (TLC) acutely inhibits the biliary excretion of multidrug-resistant associated prot

52 that limit intestinal absorption and promote biliary excretion of neutral sterols.

53 patic synthesis of lecithin was similar, but biliary excretion of newly synthesized lecithin was sign

54 esistance-associated protein 2 (Mrp2) in the biliary excretion of PB and metabolites was studied usin

55 The low oral bioavailability and rapid biliary excretion of peptide-derived HIV protease inhibi

56 ificantly increased, suggesting that reduced biliary excretion of PhIP and PhIP metabolites leads to

57 The biliary excretion of rosuvastatin was very fast, with 60

58 ea, which is believed to be secondary to the biliary excretion of SN-38, the extent of which is deter

59 ese data support two mechanisms for impaired biliary excretion of some organic anions by PB treatment

60 Phenobarbital (PB) treatment impairs the biliary excretion of some organic anions.

61 o limit intestinal absorption and to promote biliary excretion of sterols, and that mutated forms of

62 itive inhibition of P-gp transport may alter biliary excretion of substrates.

63 edominantly by Mrp2, mouse Bcrp mediated the biliary excretion of sulfate metabolites and also played

64 cluded that EFA deficiency leads to impaired biliary excretion of taurocholate, lecithin, and water,

65 The biliary excretion of the bile acid, taurocholate ([3H]-l

66 cells to study the cellular localization and biliary excretion of the fluorescent cation, daunorubici

67 abolites and also played a major role in the biliary excretion of the glucuronide metabolites, with s

68 iver ratios remained >1, due to fairly rapid biliary excretion of the label.

69 The 120-min cumulative biliary excretion of the Mrp2 substrate 5-(and-6)-carbox

70 ing the transporter MRP2 contributing to the biliary excretion of the reactive metabolite.

71 activity of 80 +/- 30 s, followed by prompt biliary excretion of the tracer.

72 A label showing rapid biliary excretion only after delivery to hepatocytes, (1

73 icantly blocked both E(2)17G cholestasis and biliary excretion, such that 16 micromol E(2)17G decreas

74 MOAT in E(2)17G-mediated cholestasis and its biliary excretion using the isolated perfused rat liver.

75 The percent biliary excretion was significantly lower for the phosph

76 trointestinal absorption, hepatic uptake, or biliary excretion were observed in these animals.

77 droxy-tert-butyl carbamate (HDTX) metabolite biliary excretion, were best fit by a two compartment mo

78 ites, SN-38 and SN-38G, by possibly reducing biliary excretion, which in turn could lower irinotecan