ライフサイエンスコーパス: bind

1 gNP aggregation responses upon biomolecular binding.

2 es for local structure, dynamics, and ligand binding.

3 litic-specific motifs implicated in receptor binding.

4 Striatal dopamine transporter binding, VMAT2 binding, (18)F-FDOPA uptake, and serotonin transporter b

5 Here we show that in mice DND1 binds a UU(A/U) trinucleotide motif predominantly in the

6 Hsp20 binds AC9 in a Yotiao-independent manner and deletion of

7 been well studied for over a decade, the DNA-binding activities and the biological functions of these

8 general principle that confers the substrate binding adaptability and specificity to OGA in O-GlcNAc

9 mechanism by which Cmpd-15 modulates agonist binding affinity and signalling.

10 Of interest, the binding affinity between Sesn2 and AMPK upstream LKB1 is

11 ination of the sedimentation coefficient and binding affinity of proteins in the micromolar range, th

12 ted membrane fusion and had higher levels of binding affinity with NHR peptide N46.

13 ency directly correlated with target tubulin binding affinity, and the reduction in differential func

14 This intricate modulation of binding affinity, and thus cooperativity, renders our ne

15 metal-induced alterations decrease RcnR-DNA binding affinity, leading to rcnAB expression.

16 differences in striatal dopamine transporter binding (all age ranges in caudate and putamen, p<0.0001

17 PC4 can bind alternative G4DNA topologies with a low nanomolar K

18 mphocytes, which exhibit variable E-selectin binding among CD4(+) and CD8(+) T cells but no binding b

19 antibody to ERBB2 quantitatively detects the bound analyte.

20 Importantly, through in vitro binding and activity assays, we showed that CML36 intera

21 identify the residues of WRN involved in the binding and ATPase-driven unwinding of G4 DNA.

22 emia significantly enhanced [(3) H]ryanodine binding and Ca(2+) /calmodulin-dependent protein kinase

23 vealing dynamic structural changes upon iron binding and core formation, as reflected by a quick alte

24 beta-III-spectrin causes high-affinity actin binding and decreased thermal stability in vitro.

25 time the dynamic connection between FTO RNA binding and demethylation activity that influences sever

26 o pg/ml range with insignificant nonspecific binding and false signal in undiluted serum.

27 ccessfully eliminated Fc-associated effector binding and functions.

28 oop in a conformation that sterically blocks binding and neutralization by MAb PL-2.

29 h I mutations had only modest effects on GTP binding and on GTPase activity and did not perturb stabi

30 losteric regulation of polypeptide substrate binding and release.

31 homodimer (or "lysibody") with high-affinity binding and specificity for carbohydrate determinants on

32 DNA binding and transcription assays demonstrated that the m

33 that these residues participate in substrate binding and/or catalysis.

34 uences to probe contributions to folding and binding, and identified 2,618 high-affinity binders.

35 that the crystal structures of free, Mg(2+)-bound, and beryllofluoridated CKI1RD (a stable analogue

36 acterize how an anti-idiotypic antibody (E1) binds antibody HM14c10, which potently neutralizes DENV

37 ns linked to the function of the Erythrocyte binding antigen family and P. falciparum reticulocyte bi

38 the crystal structure of human XPNPEP3 with bound apstatin product at 1.65 A resolution, and we comp

39 Substrate recognition and binding are critical for the regulation of this reaction

40 Changes in Nab3 binding are largely independent of alterations in transc

41 igned to identify ligands that block protein binding are much more challenging to develop; attenuatin

42 10 bp of DNA was sufficient to support PU.1 binding as a monomer, additional flanking bases were req

43 engineered sequence is used to detect ligand binding as blocking events during DNA unzipping, allowin

44 A URAT1 binding assay using radiolabeled verinurad revealed that

45 ted low-affinity binding to LRP6 in in vitro binding assays, and inhibition of LRP6 or critical signa

46 vity relationship (SAR) effort, and specific binding assessment using a LC-MS/MS "cold tracer" method

47 entify active sites, we first predict the CO binding at a large number of sites and select four exhib

48 additional mechanisms that interfere with GR binding at promoters.

49 degradation, the potentially different ADAR1 binding behaviors related to its editing activity, as we

50 st demonstration that an SRRP is required to bind beta-1,4-linked galactose and the first time that o

51 The ligand-binding betaI and alphaI domains of integrin are the bes

52 Specific binding between biomolecules, i.e., molecular recognitio

53 Higher-order states, such as bound biexcitons, are possible but are difficult to iden

54 nding among CD4(+) and CD8(+) T cells but no binding by B cells.

55 face form pathways that facilitate glutamate binding by effectively reducing a three-dimensional diff

56 ar affinity and is saturable in vitro Sterol binding by MpPR-1 requires the presence of a flexible lo

57 Lipid binding by purified MpPR-1 occurs with micromolar affini

58 nt in the dissolved form as a result of iron binding by the organic exudate.

59 nding sites overlap significantly with those bound by the S-phase gene transcription factor E2F1.

60 Fragments of Ef-Tu retain binding capabilities to host proteins.

61 -alphaPEG, hybrid-type cells) to improve the binding capacity and detection limit for free PEG and PE

62 d (palmitic acid analog) to Uox with the HSA binding capacity and retained enzyme activity.

63 B4 (MDR3) is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed at the cana

64 The subfamily C ATP-binding cassette (ABCC) transporters mediate multidrug r

65 s a heterotrimeric transcription factor that binds CCAAT elements.

66 actions, hexamer formation, and CDC after Ab binds cell-surface Ag.

67 a consequence, it is possible that collagen-binding cells may change their phenotypic traits.

68 How tightly bound charge transfer (CT) excitons dissociate at organi

69 Similar to ECM proteins, matrix-bound chemokines, cytokines, and growth factors (GFs) in

70 nal theory (DFT)-optimized structures, which binds choline in a unique dual-site-binding mode.

71 Although several microRNAs were predicted to bind CircPVT1, only let-7 was found enriched after pulld

72 ific amino acid polymorphisms in the antigen-binding clefts.

73 cellular pathogen that resides in a membrane-bound compartment, the inclusion.

74 y prevalent, neutralizing antibodies did not bind, conferred a selective advantage in the immune syst

75 affinity of SA to BSA was demonstrated by a binding constant value (1.09x10(3) at 310 degrees K).

76 the N-terminal domains of PHF1 and MTF2 with bound CpG-containing DNAs in the presence of H3K36me3-co

77 over, 1B6 recognized glycosaminoglycan (GAG)-bound CXCL10, resulting in target-mediated clearance, wh

78 m the heme iron can be affected in activator-bound CYP46A1.

79 ress high levels of the canonical E-selectin binding determinant sialyl Lewis X (sLe(X)) and display

80 ssociated proteins and show that this region binds directly to the rDNA-associated protein Csm1.

81 formation that allows this short motif to be bound directly by both CPSF-30 and WDR33.

82 ia type 5 (SCA5) L253P mutation in the actin-binding domain (ABD) of beta-III-spectrin causes high-af

83 able docking and undocking of its nucleotide-binding domain (NBD) and substrate-binding domain (SBD).

84 ucleotide-binding domain (NBD) and substrate-binding domain (SBD).

85 t has similarities to the cysteine-rich zinc-binding domain of DnaJ chaperones.

86 d knockin mice with a mutation in the TR DNA-binding domain that abrogates binding to DNA and leads t

87 that TRIP8b binds the HCN cyclic nucleotide-binding domain through a 37-residue domain and the HCN C

88 bits the NLS and the neighboring microtubule-binding domain, and RhoA-GTP binding may relieve this in

89 Anillin contains a RhoA-GTP binding domain, which autoinhibits the NLS and the neigh

90 of an rcSso7d binding module and a cellulose-binding domain.

91 o its coiled-coil 2-leucine zipper ubiquitin binding domain.

92 In this study, we demonstrate that binding domains from autolysins and lysins can be fused

93 a-2 and IFN-gamma-inducible protein (IFI)16, bind dsDNA and form caspase-1-activating inflammasomes t

94 regulatory functions of RBPs, including the binding effects of the RNA helicase MOV10 on mRNA degrad

95 tes provides a remarkable enhancement of its binding efficiency.

96 cking studies suggested that these compounds bind efficiently to beta-tubulin at the colchicine bindi

97 using electric fields by employing the donor-bound electron as a quantum transducer, much in the spir

98 miniscent of XeO4 : an octet of electrons to bind electronegative ligands, and no low-lying acceptor

99 the proton is 938 MeV) also revealed a large binding energy of about 130 MeV between the two charm qu

100 g strong photoluminescence and large exciton binding energy.

101 lision point contribute significantly to the binding energy.

102 reaction proceeds via the generation of NHC-bound enolate intermediates formed from the ketoacids in

103 carrier recombination arising from strongly bound excitons and low carrier mobility.

104 SA-15 bound exclusively to the dimeric form of the toxin, sugg

105 at the enzyme represents a new class of zinc-binding flavin-dependent halogenases and provides new in

106 ctivators and blockers with strong, specific binding for engineering and therapeutic applications.

107 hich was primarily presented in its membrane-bound form by follicular dendritic cells.

108 trophysiology to measure resting affinities (binding free energies) of these and other agonists in ad

109 hich block substrate access to the substrate-binding groove.

110 SdrF bound human keratins 1 and 10 and adhered to keratinocyt

111 a 97-amino-acid peptide of human origin that binds hyaluronan, a major macromolecular component of th

112 in T cells, trans-presentation of IL-6 by DC-bound IL-6Ralpha (called 'IL-6 cluster signaling' here)

113 her investigation into the basis for ASO-FUS binding illustrated the importance of ASO backbone and h

114 18)F-FDOPA uptake, and serotonin transporter binding in multiple brain regions were compared by ANCOV

115 ast six (35%) alter transcription factor-DNA binding in neuroblastoma cells.

116 found an overall reduction in D1 and 5-HT2A binding in the hippocampus of zQ175 compared with WT ani

117 However, ketoconazole binds in an orientation that disrupts the BC-loop region

118 We report that BH3-only proteins bind inactive full-length BAK at mitochondria and then d

119 In the absence of vivax invasion assays, binding-inhibitory activity of antibodies has been repor

120 her affinity compared with other Arg-Gly-Asp binding integrins.

121 nd an X-ray cocrystal structure reveals that binding is biased toward occupation of the adenine subpo

122 when working with dynamic proteins or weakly binding ligands.

123 ntigen family and P. falciparum reticulocyte binding-like families.

124 Cell-bound lysibodies induced the fixation of complement on t

125 ing microtubule-binding domain, and RhoA-GTP binding may relieve this inhibition during mitosis.

126 ssue) with the agonist whereas 12 had a high binding (mean density, 4,447 +/- 1,128 dpm/mg of tissue)

127 In 13 breast cancers, 8 had a low binding (mean density, 844 +/- 168 dpm/mg of tissue) wit

128 fold of SH3 domains, they display different binding mechanisms and affinities for their interaction

129 re recruited to the cellulosome via a single-binding mode mechanism with an adaptor scaffoldin.

130 ed on the apex of the molecule; the receptor-binding mode might be different from that of retroviruse

131 s, which binds choline in a unique dual-site-binding mode.

132 a fusion construct consisting of an rcSso7d binding module and a cellulose-binding domain.

133 ted in multiple key residues in the receptor-binding motif (RBM) of RBD and demonstrated their strong

134 RNA binding motif protein 25 (RBM25) is a putative splicing

135 ontaining aromatic amino acids, the caveolin-binding motif.

136 tedly, we identified PABPN1-dependent ALYREF binding near the 3' end of the mRNA.

137 We investigated whether variation in binding of a transcription factor, the vitamin D recepto

138 We observe that binding of agonists to VFD2 of TAS1R2 leads to major con

139 on of the signal transduction cascade, after binding of all investigated products to the receptor pre

140 novel mechanism of MAPK activation requiring binding of an activator and also shows that MAPKs can be

141 (ii) Selective and cooperative binding of both an acetato ligand and an amino ligand to

142 species in human-inflamed tissue and allows binding of complement factor 1q (C1q) and activation of

143 in its coiled-coil 1 domain that impedes the binding of linear (M1-linked) di-ubiquitin to its coiled

144 e adhesins has been shown to be required for binding of multiple glycan receptors.

145 jacent residues that facilitate the specific binding of proteins and modulate the global folding and

146 Thus, we demonstrated peptide-dependent binding of the activating NK cell receptor KIR2DS1, prov

147 Glycan array analysis confirmed selective binding of the CRD to glycans that contain Manalpha1-2Ma

148 Competitive binding of the human monoclonal antibody (mAb) LE2E9 rev

149 riments revealed that Spt6 could compete for binding of the PRC2 methyltransferase Ezh2 to Suz12 and

150 al at the RI, hypoxia-induced expression and binding of the splicing factor SRSF3, and increased bind

151 of the splicing factor SRSF3, and increased binding of total and phospho-Ser2 RNA polymerase II spec

152 ise that stereospecific but necessarily weak binding of tropomyosin to F-actin is required for effect

153 's disease susceptibility protein nucleotide-binding oligomerization domain-containing 2 (NOD2); howe

154 y, as well as the antagonizing effect of RBP binding on miRNA repression.

155 omodulation with a TLR-7 agonist and albumin bound paclitaxel is effective in inducing disease regres

156 The endothelial binding parameter Kb varied highly across brain regions.

157 ent induced c-FOS to replace JDP2 as a c-JUN binding partner, forming transcriptionally active AP-1.

158 olved information and probe multiple protein binding partners simultaneously, using small amounts of

159 he N-terminus of MerA is able to extract the bound Pb(VI) but not the bound Sn(IV).

160 nitial prediction of human leukocyte antigen-binding peptides by in silico algorithms, but the predic

161 (18)F-florbetapir (Amyvid) is an amyloid-binding PET ligand with a half-life suitable for clinica

162 In this work, free, esterified and insoluble-bound phenolics were extracted from defatted camelina an

163 sibly involved in biogenesis of the membrane-bound photosynthetic apparatus and one for phosphatidylc

164 Large-scale RNA-binding pockets on protein surfaces are grouped by measu

165 e use of NMR to distinguish between free and bound polymer and to characterize the degree to which th

166 s revealed that these ligands adopt distinct binding poses and engage different subsets of residues,

167 This broad set of ligand-bound poses is then used to investigate general properti

168 methods to estimate the distribution volume, binding potential (BPND), and SUVR.

169 SMAD2 can bind pre-acetylated nucleosome-depleted sites.

170 We found that CNOT3 was bound primarily to genes whose expression was affected b

171 ional complexation with human growth hormone binding protein (hGHBp) to the different NOTA-modified s

172 er-inducing interferon-beta (TRIF) and Z-DNA-binding protein 1 (ZBP1)/DNA-dependent activator of IFN-

173 tion initiation factor 4E, phosphorylated 4E-binding protein 1, and p-S6 ribosomal protein.

174 encoding the transcription factor Methyl CpG Binding Protein 2 (MECP2).

175 hermore, we report that calcium and integrin-binding protein 2 binds to the components of the hair ce

176 2 coactivated the transcription factors GATA-binding protein 4 (GATA-4) and hypoxia-inducible factor

177 3p must be in complex with the small calcium-binding protein Cdc31p to be active.

178 ring a cavity resembling that of the choline-binding protein ChoX, as revealed by crystal and density

179 nitrite reductase gene (aniA), the factor H-binding protein gene (fHbp), and the capsule biosyntheti

180 ce, we show that TERF1 evolved as a telomere-binding protein in the common stem lineage of marsupial

181 tubule network and the microtubule minus end-binding protein, Patronin.

182 ncy, B cell-specific CD79a-Cre x XBP1 (X-box binding protein-1) floxed mice (XBP1-conditional knockou

183 ), a negative regulator of the Ras small GTP-binding protein.

184 red to invoke sequential dimerization of the bound protein.

185 RNA-binding proteins of the Musashi (Msi) have been implicat

186 ) is a member of the fragile X family of RNA-binding proteins, which includes FMRP and FXR2P.

187 eukaryotes, and recognized as small-molecule binding proteins.

188 ants with known inactive GDP- and active GTP-bound RAB11B mutants, we modeled the variants on the thr

189 with standardized parameters before striatal binding ratios were quantified against a normal database

190 Further, DNA-bound RecA protein increases the rate of ATP hydrolysis

191 GIF may have an independent input into HOXA1-bound regions.

192 Collectively, our results indicate that ZO-1 binding regulates channel accrual, while disengagement f

193 Stoichiometric binding requires conditions consistent with coalescence

194 Ca(2+) binding rigidifies elements along this pathway, thereby

195 The Ctk1 kinase complex binds RNA in vitro, consistent with direct EF-RNA intera

196 e, it has proven challenging to achieve high binding selectivity for different isoforms of this prote

197 e and were correlated with the thermodynamic binding selectivity.

198 peptide inhibitor (HL2-m5) was obtained that binds Shh with a KD of 170 nM, which corresponds to a 12

199 ormation capable of transmitting the hormone binding signal to the catalytic domain.

200 eceptor (NMDAR) is controlled by a glutamate-binding site and a distinct, independently regulated, co

201 est the potential existence of an additional binding site and provide new insights into GB1:IgG compl

202 Nonetheless, the evolution of the receptor-binding site and the stem region on HA is severely const

203 pation of the adenine subpocket of the AcCoA binding site by an aromatic ring.

204 otein by a conserved kinase, DDK, provides a binding site for the Scc2/4 cohesin loading complex, the

205 2149092 was predicted to disrupt a consensus binding site for the transcription factor ETS within an

206 Results demonstrated that a miR398 binding site is eliminated in AhCSD1-2.2 as a consequenc

207 sPs and PtdInsPs interact with the polyanion-binding site located on an inner chamber wall of the enz

208 Finally, analysis of transcription factor-binding site motifs of differentially dysregulated genes

209 he N terminus of chECL1, suggesting that the binding site of ALV-J gp85 on chNHE1 is probably located

210 Although it shares a binding site with other imide-based natural product tran

211 und -260 and -230 mV, respectively, in the Q-binding site, respectively, suggesting that release of t

212 istinct, independently regulated, co-agonist-binding site.

213 fficiently to beta-tubulin at the colchicine binding site.

214 which was reduced after mutation of the Sp-1-binding site.

215 Published data reveal TET2 binding sites and hydroxymethylcytosine proximal to KLK3

216 ence motifs enriched in the PREs are cognate binding sites for the identified transcription factors a

217 o identify canonical and non-canonical miRNA-binding sites from peaks identified by Ago2 Cross-Linked

218 al, 7622 proteins from the scPDB database of binding sites have been evaluated using both a distance

219 nalysis of enriched transcription factor DNA-binding sites in the promoters of differentially express

220 nteraction energy is weak because only a few binding sites near the collision point contribute signif

221 cers active in liver cells, enriched for the binding sites of the FOXA1, FOXA2 and HNF4A transcriptio

222 tation-sequencing analysis reveals that LSD1 binding sites overlap significantly with those bound by

223 ethod for prediction of transcription factor binding sites using an integrative energy function that

224 (1)h interactions and identify their genomic binding sites.

225 ChRs having a mutation(s) at the transmitter-binding sites.

226 ner, preventing its recruitment to canonical binding-sites in the promoters of Nanog, Oct4 and Sox2.

227 able to extract the bound Pb(VI) but not the bound Sn(IV).

228 Characterizing the binding specificities of transcription factors (TFs) is

229 de constitutes a key signature providing PIC binding specificity in the human genome.

230 , particularly of sites corresponding to the binding specificity of the overexpressed SH2 domain.

231 SSB homotetramers bind ssDNA in several modes that differ in occluded site

232 We report here a few Zika NS1-binding ssDNA aptamers selected using the conventional S

233 d lysozyme, while alphaLA changed to its NIS-bound state instead of the native state.

234 the absence of PPi, suggests that nucleotide binding stimulates PPi dissociation and occurs before po

235 Most striking was the decline of binding stoichiometry with linking number.

236 umber of sites and select four exhibiting CO binding stronger than the (211) step surface.

237 Binding studies disclosed that the competitive inhibitor

238 enting a simple constraint of continuity for binding successive sounds in a probabilistic manner.

239 result of significant levels of cooperative binding that is present in both solvents.

240 s found to affect synaptic integrity through binding the ColQ tail of acetylcholine esterase.

241 We show that TRIP8b binds the HCN cyclic nucleotide-binding domain through a

242 mune cell culture, we demonstrate that hRetn binds the LPS receptor Toll-like receptor 4 (TLR4) throu

243 Nusinersen is a steric block ASO that binds the SMN2 messenger RNA and promotes exon 7 inclusi

244 c lethal [MSL] proteins) zinc finger protein binds these GA repeat motifs, increases chromatin access

245 desmin cytoskeleton and the attached Z-band-bound thin filaments are degraded after ubiquitination b

246 The NFkappaB dimers bind to a myriad of genomic sites and switch the targete

247 cell-penetrating peptides (CPPs) are able to bind to cell membranes, thus promoting cell internalizat

248 identification of interaction partners that bind to mutated EGFR can help identify novel targets for

249 We found FXR to bind to regulatory sites of genes encoding these protein

250 ranscription factors (TFs) are proteins that bind to specific DNA sequences and regulate expression o

251 into two split fragments that could tandemly bind to target mRNA.

252 TSPY and TSPX competitively bind to the androgen receptor (AR) and AR variants, such

253 romoting serum response transcription factor binding to a cryptic cis-element.

254 ls of the interplay between membrane and CaM binding to Akt may help in the development of potential

255 Id1 suppresses BAT thermogenesis by binding to and suppressing PGC1alpha transcriptional act

256 in the TR DNA-binding domain that abrogates binding to DNA and leads to complete loss of canonical T

257 Thus, binding to GAGs in the extracellular matrix can direct a

258 ering of a protein scaffold for preferential binding to K-Ras G12D.

259 Domain 4 exhibited low-affinity binding to LRP6 in in vitro binding assays, and inhibiti

260 Its binding to mRNA is regulated by tyrosine 396 phosphoryla

261 , or polymersomes, which are internalized by binding to scavenger receptors and subsequently escape t

262 Specific ion binding to such sites induces changes in the filter conf

263 w that blocking of the Galpha13 protein from binding to the cytoplasmic domain of the beta3 integrin

264 A1 by >/=75% and were evaluated for in vitro binding to the enzyme active site and for inhibition con

265 sembly process shepherds primary transposase binding to the inner 12DRs (where cleavage does not occu

266 eration of angiotensin-(1-7) by ACE2 and its binding to the Mas receptor (MasR) improves glucose home

267 Moreover, poly(ADP-ribose) binding to the Parp9 macrodomains increases E3 activity.

268 onserved amino acids that couple RNA and ATP binding to the protein (Motif III).

269 Finally, DDX21 was shown to enhance Rev binding to the RRE in a manner similar to that previousl

270 as the bridging molecule that mediates IL-37 binding to the TGF-beta receptor complex.

271 d conditions, is inhibited by intramolecular binding to the Vms1 leucine-rich sequence (LRS).

272 imetry, we found that Munc18c, like Munc18a, binds to both the closed conformation and the N-peptide

273 rus prosurvival protein FPV039 promiscuously binds to cellular proapoptotic Bcl-2 and engages all maj

274 On soft substrates, most paxillin binds to endocytic factors and facilitates vesicle invag

275 In this article, we report that rhAPC binds to human neutrophils via integrin VLA-3 (CD49c/CD2

276 We demonstrate that clemizole binds to serotonin receptors and its antiepileptic activ

277 that calcium and integrin-binding protein 2 binds to the components of the hair cell mechanotransduc

278 Casein kinase 2 (CK2) binds to the NHE3 C-terminus and constitutively phosphor

279 ound in several plus-strand RNA viruses that binds to the small molecule ADP-ribose.

280 4 and Pdcd4(157-469), a deletion mutant that binds to translation initiation factor 4A (eIF4A), suffi

281 U1 and TB1 overlap in axillary buds, and TB1 binds to two locations in the tru1 gene as shown by chro

282 e trimeric, prefusion ectodomain of Lassa GP bound to a neutralizing antibody from a human survivor a

283 Here we present the structure of the beta2AR bound to a polyethylene glycol-carboxylic acid derivativ

284 re of the SNX5-PX:IncE complex, showing IncE bound to a unique and highly conserved hydrophobic groov

285 ses the amount of p110alpha-p85 heterodimers bound to active receptors, augmenting PI3K signaling and

286 e characterization of the dominant bacteria, bound to IgA or not, in infant stool samples in relation

287 5S ribosomal RNA pseudogene 141 (RNA5SP141), bound to RIG-I during infection with herpes simplex viru

288 (-)3TC-MP, with a second (-)3TC-TP molecule bound to the active site in the absence of PPi, suggests

289 ed by DegP but were toxic because they first bound to the Bam complex, an essential heteroligomer tha

290 We present the structure of FBXW7 bound to the DISC1 phosphodegron motif and exploit this

291 ut predominantly in its protonated form when bound to the variants.

292 predominantly in its deprotonated form when bound to wild-type VAO, but predominantly in its protona

293 ues in the C-terminal helix to engage in DNA binding, triggering a major reprogramming of gene expres

294 yrazone and probenecid all inhibit verinurad binding via a competitive mechanism.

295 Striatal dopamine transporter binding, VMAT2 binding, (18)F-FDOPA uptake, and serotoni

296 to investigate general properties of ligand binding: we observe both a direct stabilizing effect of

297 a 50% reduction of (11)C-BMT-136088 specific binding were 73 +/- 30 nmol/kg and 28 +/- 12 nM, respect

298 rocedure to purify trypsin based on affinity binding with ferromagnetic particles of azocasein compos

299 Furthermore, we find that GDF15 binds with high affinity to GDNF family receptor alpha-l

300 c small-molecule tracer for PET imaging that binds with high affinity to GPIIb/IIIa receptors and has