ライフサイエンスコーパス: bind to

1 small activators PA28alphabeta and PA28gamma bound to 20S particles.

2 t are recruited by RNA-binding proteins that bind to 3'-UTR cis-elements.

3 The NFkappaB dimers bind to a myriad of genomic sites and switch the targete

4 l six complementarity-determining regions to bind to a quaternary epitope on each side of the dimeric

5 In all four complexes, the VHHs bind to a site on the top surface of the capsid protein

6 ility of the various domains and isoforms to bind to a variety of integrins result in a wide range of

7 romoting serum response transcription factor binding to a cryptic cis-element.

8 ne specific antibody and permitted NF-kappaB binding to a DNA duplex sequence corresponding to its bi

9 BPA exposure increased Nrf2 binding to a putative antioxidant response element conse

10 We concluded that BeauIII binds to a putative active site responsible for SOAT1 th

11 Antagonist AZ3451 binds to a remote allosteric site outside the helical bu

12 ialic acids preferentially, the HA190 mutant bound to a broad spectrum of glycans with alpha2,6/8/9-l

13 An X-ray crystal structure of caspase-7 bound to a fragment hit and a thorough kinetic character

14 e trimeric, prefusion ectodomain of Lassa GP bound to a neutralizing antibody from a human survivor a

15 We determined a crystal structure of CaM bound to a peptide encompassing its binding site in AKAP

16 The purified phosphorylated protein bound to a phosphotyrosine specific antibody and permitt

17 Here we present the structure of the beta2AR bound to a polyethylene glycol-carboxylic acid derivativ

18 ectrum of 7 suggests the presence of a Co(I) bound to a radical anionic ligand.

19 re of the SNX5-PX:IncE complex, showing IncE bound to a unique and highly conserved hydrophobic groov

20 y study, we have used our structure of Cdc42 bound to ACK via an intrinsically disordered ACK region

21 BTP2, a small molecule inhibitor of drebrin binding to actin filaments, reduced the invasion of pros

22 We now report that ShcD binds to active Ret, TrkA, and TrkB neurotrophic factor

23 ses the amount of p110alpha-p85 heterodimers bound to active receptors, augmenting PI3K signaling and

24 ls of the interplay between membrane and CaM binding to Akt may help in the development of potential

25 Our findings support a model by which CaM binds to Akt to facilitate its translocation to the memb

26 sialosides and reduced, but still dominant, binding to alpha2,3-linked sialic acids (SIAs) compared

27 a human isolate revealed modestly increased binding to alpha2,6 sialosides and reduced, but still do

28 Cocrystal structures revealed 3 binds to an unexpected allosteric site between the C-ter

29 /or product of the reaction is an acyl chain bound to an acyl carrier protein, are classified so that

30 e we report crystal structures of human AT2R bound to an AT2R-selective ligand and to an AT1R/AT2R du

31 e crystal structure of GLIC shows R-ketamine bound to an extracellular intersubunit cavity.

32 Many drugs bind to and activate human pregnane X receptor (hPXR) to

33 c response, ensues when multivalent antigens bind to and cross-link the cells' receptor-bound IgE ant

34 cate that some HIV-1 gp120 envelope proteins bind to and signal through alpha4beta7, which may help e

35 ifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modif

36 Id1 suppresses BAT thermogenesis by binding to and suppressing PGC1alpha transcriptional act

37 Lpg1137 binds to and cleaves syntaxin 17, a soluble N-ethylmalei

38 We showed that rigosertib indeed directly binds to and destabilizes microtubules using cell biolog

39 d C-terminal structural loop, preferentially binds to and fills-in short gapped DNA intermediates wit

40 ort a role for CML36 as a Ca(2+) sensor that binds to and modulates ACA8, uncovering a possible invol

41 mpensation complex (DCC), which specifically binds to and represses transcription from the hermaphrod

42 graphic and biochemical studies that K-80003 binds to and stabilizes tRXRalpha tetramers via a 'three

43 CaM binds to and stimulates PI3Kalpha/Akt signaling, promoti

44 normal conditions, insulin decreases dynein binding to APC to stimulate minus end-directed transport

45 Rab6a-GTP, either in solution or bound to artificial liposomes, released BICD2 from an au

46 otein POP2 inhibits inflammasome assembly by binding to ASC and interfering with the recruitment of A

47 e ERK1 N terminus, adjacent to Lys-71, which binds to ATP, suggesting that acetylation status of Lys-

48 SLMAP binding to autophosphorylated MST2 linker recruits STRIP

49 f serum inhibitory activity for allergen-IgE binding to B cells (IgE-facilitated allergen binding).

50 ique amongst the MKP family in being able to bind to both ERK3 and ERK4.

51 Ambra1 binds to both FAK and Src in cancer cells.

52 emical data on WRC mutants confirm that Rac1 binds to both sites, with the newly identified site havi

53 imetry, we found that Munc18c, like Munc18a, binds to both the closed conformation and the N-peptide

54 Structures of the enzyme bound to both substrates and biophysical analysis charac

55 Bezlotoxumab, a human monoclonal antibody, binds to C. difficile toxin B (TcdB), reducing recurrenc

56 The decrease of C5 binding to C3b clusters in the presence of C5 inhibitors

57 d that 3-unsubstituted 2,4-oxazolidinediones bound to CA II via an interaction of the acidic ring nit

58 terneuron AVG: BAM-2/neurexin-related in HOA binds to CASY-1/calsyntenin in AVG; SAX-7/L1CAM in senso

59 ion and the inflammatory response, while IgE binding to CD23 is involved in the regulation of IgE syn

60 ides a novel mechanism due to its ability to bind to CdGAP and Rac1 via distinct domains and influenc

61 cell-penetrating peptides (CPPs) are able to bind to cell membranes, thus promoting cell internalizat

62 rus prosurvival protein FPV039 promiscuously binds to cellular proapoptotic Bcl-2 and engages all maj

63 elements of the pathways that couple agonist binding to channel gating.

64 the LAT1 transporter that have been shown to bind to cholesterol/CHS in Drosophila melanogaster dopam

65 show that Mcm7 ubiquitylation and CRL2(Lrr1) binding to chromatin are temporally linked and occur onl

66 tor that appears to negatively modulate Chd1 binding to chromatin.

67 We found that Abeta oligomer binding to CNS synaptosomes isolated from wild type (wt)

68 p63 bound to consensus sites within the PFKFB3 gene and was

69 our data suggest that pTRS1 inhibits PKR by binding to conserved amino acids in the PKR eIF2alpha bi

70 RSV binding to CX3CR1 contributes to disease pathogenesis; t

71 t to CX4C ((182)CWAIAC(187)), known to block binding to CX3CR1, might decrease disease.

72 as two NPxY motifs that mediate functions by binding to cytoplasmic signaling and scaffolding molecul

73 Many have proposed that calcium ions binding to daptomycin is a precondition for membrane int

74 Striatal (123)I-FP-CIT binding to DAT and hypothalamic (123)I-FP-CIT binding to

75 re, we report that increased erythrocyte S1P binds to deoxygenated sickle Hb (deoxyHbS), facilitates

76 GCAP1 and GCAP2 bound to different regions on the target guanylate cycla

77 s are formed by presynaptic neurexins, which bind to diverse postsynaptic ligands.

78 in the TR DNA-binding domain that abrogates binding to DNA and leads to complete loss of canonical T

79 to canonical models, we observed that Bicoid binds to DNA with a rapid off rate throughout the embryo

80 eceptor alpha (RARbeta-RXRalpha) heterodimer bound to DNA, ligands and coactivator peptides, which sh

81 , while having reduced ability to block bNAb binding to E2, and neutralization was largely toward the

82 A crystal structure of the p107 CTD bound to E2F5 and its dimer partner DP1 reveals the mole

83 -length splice variants, EDA1 and EDA2, that bind to EDA receptor (EDAR) and X-linked EDA receptor (X

84 HED), contained low levels of EDA capable of binding to EDAR.

85 57-469)(D253A,D418A), a mutant that does not bind to eIF4A, failed to inhibit Sin1 translation, and c

86 for stimulating DDK phosphorylation of Mcm2, binding to eighty-nucleotide ssDNA, and recruiting pol a

87 On soft substrates, most paxillin binds to endocytic factors and facilitates vesicle invag

88 were most selective for EphA4, with residual binding to EphA7 only.

89 key roles in cellular protein homeostasis by binding to exposed hydrophobic regions of incompletely f

90 The results suggest that lacosamide binds to fast-inactivated states in a manner similar to

91 m inefficient internal scaffolding protein B binding to faulty procapsid elongation reactions mediate

92 tes TRF1 on Ser114, which prevents TRF1 from binding to Fbx4, an Skp1-Cul1-F box E3 ligase subunit, t

93 scribed a monoclonal antibody (DX-2507) that binds to FcRn with high affinity at both neutral and aci

94 The crystal structure of NCS-1 bound to FD44 and the structure-function studies perform

95 Omalizumab binds to free IgE, which lowers free IgE levels and caus

96 olipid syndrome (APS) display higher avidity binding to FXa with greater coagulant effects compared t

97 Thus, binding to GAGs in the extracellular matrix can direct a

98 r cells through the action of GBA2, directly binds to GBA2 and inhibits its activity.

99 multimerization of MYO6 on endosomes through binding to GIPC is required for this cellular activity a

100 PlexinD1 binding to GIPC1 releases the autoinhibition, promoting

101 t the first X-ray structures of barbiturates bound to GLIC, a cationic prokaryotic pLGIC with excelle

102 ptides to interact with (e.g., noncovalently bind to) graphene at one end, while simultaneously expos

103 and (nat)Ga-, (nat)In-, and (nat)Lu-NeoBOMB1 bound to GRPR with high affinity (half maximal inhibitor

104 photoreactive moiety for UV-induced covalent binding to GSTs and GSH-binding enzymes.

105 m826 binds to H7N9 HA with subnanomolar affinity at acidic pH

106 tation (Ser301Phe) in HA that abolishes 46B8 binding to HA at low pH.

107 no acid Nogo-A region, named Nogo-A-Delta20, binds to heparin and brain-derived heparan sulfate glyco

108 MOB1 residues mediating MOB1's differential binding to Hippo core kinases, thereby establishing MOB1

109 We have examined the extent to which C1q-binding to HLA-class I single-antigen beads (SAB) is inf

110 ng to accumulation of Insig-2 protein, which binds to HMGCR and triggers its accelerated ubiquitinati

111 oduces N-terminal polypeptides, which remain bound to holocomplex III.

112 alivary glycoproteins named "evasins," which bind to host chemokines, thereby inhibiting the recruitm

113 the nine candidates exhibited high-affinity binding to human chemokines.

114 In this article, we report that rhAPC binds to human neutrophils via integrin VLA-3 (CD49c/CD2

115 lized using the X-ray crystal structure of 6 bound to human IDO-1, which shows that 6, differently fr

116 otransformation products can be irreversibly bound to humin in soils as a remediation strategy, which

117 reated cells, there was no decrease in HIF-1 binding to hypoxia response elements.

118 are directly related to their free energy of binding to ice.

119 lical fold characteristic of type I IFNs and bound to IFNalpha/beta receptor 1 (IFNAR1) and IFNAR2, b

120 e characterization of the dominant bacteria, bound to IgA or not, in infant stool samples in relation

121 p53 competes with IkappaBalpha for substrate binding to IKKbeta and thereby blocks IkappaBalpha phosp

122 onal role on other RNABPs that competitively bind to inflammatory targets of TTP in both endometrioti

123 esulting monomeric peptide (brHis2) does not bind to its consensus target DNA site (5'-GTCAT-3').

124 was linked to an improved capacity of E11 to bind to its host cells, which was further attributed to

125 6) was identified as a regulator of mIndy by binding to its cognate receptor.

126 Typhoid toxin binding to its glycan receptor Neu5Ac is central, but, d

127 POL5551 inhibited CXCR4 binding to its ligand, stromal cell-derived factor-1alph

128 . cholerae repressed vieSAB transcription by binding to its promoter.

129 functions as an extracellular ligand through binding to its specific receptor on osteoclastic lineage

130 that Lis1, a conserved regulator of dynein, binds to its motor domain and induces a tight microtubul

131 n the "angiogenic signal" produced when VEGF binds to its receptors on tumor endothelial cells.

132 ering of a protein scaffold for preferential binding to K-Ras G12D.

133 WNK4 levels are regulated by binding to Kelch-like 3, targeting WNK4 for ubiquitylati

134 Binding to LC3s/GABARAPs is essential for the fragmentat

135 RvE1 binds to leukotriene B4 (BLT-1) on neutrophils and to ER

136 usly used to investigate peptide and protein binding to lipid membranes, as it allows for very low am

137 SIRT2 bound to LKB1 and deacetylated it at lysine 48, which pr

138 Domain 4 exhibited low-affinity binding to LRP6 in in vitro binding assays, and inhibiti

139 A minority (17.5%) of patients' IgG also bound to MAP1A.

140 ponents, but cannot reactivate APC/C already bound to MCC.

141 ation calorimetry experiments revealed tight binding to McpX(PR) with dissociation constants (Kd ) in

142 t some of the tested bacterial effectors can bind to membrane phospholipids and may regulate membrane

143 in rodents, respectively) displayed impaired binding to membrane-associated guanylate kinase (MAGUK)

144 contrast, the protein stably and statically binds to methylated CpG (mCpG) regions.

145 MBD1 binds to methylated cytosine-guanine dinucleotides (mCGs

146 9(1.1) are trapped in an inactive state when bound to mismatched targets.

147 A co-crystal structure of PvPKG bound to ML10, reveals intimate molecular contacts that

148 Its binding to mRNA is regulated by tyrosine 396 phosphoryla

149 urface of Vpu TMD has been selected for weak binding to multiple targets.

150 h Rab11(+) endosomes, and depended on Ca(2+) binding to Munc13-4.

151 identification of interaction partners that bind to mutated EGFR can help identify novel targets for

152 However, the effect of non-covalent binding to Nedd8 remains unknown.

153 s in the conserved sequence are required for binding to Nedd8.

154 el method of kinetic analysis of radioligand binding to neuroreceptors in brain in vivo, here applied

155 1d-lipid-TCR complexes, while excluding CD1d bound to nonantigenic lipids, followed by direct biochem

156 cline and rifamycin SV exert their effect by binding to oligomeric species both in solution and in ga

157 borders, while dCP enhancers are more often bound to one or two TSSs and are enriched at chromatin l

158 IN-like3 and OsNIN-like4) were identified as binding to OsNHX1 promoter.

159 or synthetic ligands and knowledge of ligand binding to other receptors with similar binding pockets

160 Here we report a 2-pyridone ligand that binds to palladium and accelerates non-directed C-H func

161 On the other hand, C3 strongly binds to PapMV nanoparticles and its depletion significa

162 rmined crystal structures of these compounds bound to PARP1 or PARP2.

163 concentrations decline, DBC1 is increasingly bound to PARP1, causing DNA damage to accumulate, a proc

164 microglial and PC12 surfaces, enabling Gal-3 binding to PC12 cells and their phagocytosis via MerTK.

165 say demonstrated estradiol (E2) induced ESR1 binding to Pck-1, G6Pase, Fas and Acc1 promoters.

166 They recognize defective cells by binding to peptides presented on the cell surface by MHC

167 ted forms of Rab8A and Rab10, whereas RILPL2 binds to phosphorylated Rab8A, Rab10, and Rab12.

168 s lacking PIP2, but the C2B domain dominates binding to PIP2-containing membranes.

169 Furthermore, we found that beta-arrestin2 binds to PKC-phosphorylated AT1R in a distinct active co

170 In addition, pTRS1 binding to PKR inhibited PKR kinase activity.

171 a diverse range of host molecules, and when bound to plasminogen, was able to convert plasminogen to

172 uenza induced cytotoxicity and showed strong binding to platelets within thrombi in infected mouse lu

173 Consequently, Arl8b binding to PLEKHM1 is required for its function in deliv

174 ively used to obtain epitope maps of ligands binding to protein receptors, thereby revealing structur

175 hts into the molecular evolution of c-di-GMP binding to proteins.

176 ion by serving as an attachment receptor for binding to PS exposed on the HCV envelope.

177 Instead, mTOMT binds to putative components of the mechanotransduction

178 ls or Kupffer cells, or inhibiting S100A8/A9 binding to RAGE (using paquinimod), all reduced diabetes

179 llowing Rap1 to couple to ERKs through B-Raf binding to Rap1 independently of its Ras-binding domain.

180 ith the glucosamine, insulin can efficiently bind to RBC membranes.

181 ducts their initial synthesis and subsequent binding to recipient proteins.

182 Purified PP1c bound to recombinant Gbeta1-GST protein, and PP1c co-imm

183 We found FXR to bind to regulatory sites of genes encoding these protein

184 Heme binding to Rev-erbbeta indirectly facilitates its intera

185 tic cancer cells by means of small molecules binding to RG4s in the 5'-UTR of mRNA.

186 in in AVG; SAX-7/L1CAM in sensory neuron PHC binds to RIG-6/contactin in AVG.

187 5S ribosomal RNA pseudogene 141 (RNA5SP141), bound to RIG-I during infection with herpes simplex viru

188 ure of a twelve-subunit nuclear Mpp6 exosome bound to RNA shows the central region of Mpp6 bound to t

189 elements (rSBEs), which prevented Smad3 from binding to SBE DNA in TGF-beta-responsive SMC gene promo

190 , or polymersomes, which are internalized by binding to scavenger receptors and subsequently escape t

191 ese structures illustrate the flexibility of binding to sequences outside of-but adjacent to-the kina

192 IgE and IgG4 binding to sequential epitopes derived from five major C

193 We demonstrate that clemizole binds to serotonin receptors and its antiepileptic activ

194 inding to DAT and hypothalamic (123)I-FP-CIT binding to SERT are significantly lower in MSA-P and PSP

195 Here, we study the effect of spermine binding to short duplex RNA and DNA, and compare our fin

196 t activation by competitive inhibition of FH binding to some surfaces and immune proteins.

197 ranscription factors (TFs) are proteins that bind to specific DNA sequences and regulate expression o

198 We show that the mtSSB tetramer can bind to ssDNA in two distinct binding modes: (SSB)30 and

199 coli, these results suggest that SSB likely binds to ssDNA with high cooperativity in vivo.

200 is effected by specific phage proteins that bind to Stl, initiating the SaPI cycle.

201 ent of the surrounding loops is required for binding to substrate ssDNA.

202 Specific ion binding to such sites induces changes in the filter conf

203 wells on more stable GQ for longer times and binds to such GQ with higher frequency.

204 Overall, iRhom2 binds to TACE throughout its lifecycle, implying that iR

205 into two split fragments that could tandemly bind to target mRNA.

206 mouse pre-B cell nuclei triggered immediate binding to target gene promoters.

207 by destabilizing R-loops while Pif1 and Rrm3 binding to tDNAs is increased upon R-loop stabilization.

208 n and tumor growth by competing with YAP for binding to TEA-domain proteins (TEADs).

209 findings are as follows: (1) Ku specifically binds to telomerase RNA in a distinct, yet related, mann

210 and TH receptors (TRs) alpha and beta act by binding to TH response elements (TREs) in regulatory reg

211 ed, these elements form 5'-RNA aptamers that bind to the added tetracycline, which represses translat

212 TSPY and TSPX competitively bind to the androgen receptor (AR) and AR variants, such

213 trated that these low-affinity anti-IgE mAbs bind to the cell surface-bound IgE without triggering an

214 ation experiments showed that HES1 and NR3C1 bind to the CLDN1 promoter in rat colon crypts.

215 at the GGDP site, and that both isomers may bind to the enzyme simultaneously.

216 nhibiting protein synthesis, and ricin B can bind to the galactose ligand on the cell membrane of hos

217 IDO-1 inhibitors described so far, does not bind to the heme iron atom and has a novel binding mode.

218 rvations establish that small molecules that bind to the interface between TAM Ig1 domain and Gas6 Lg

219 nteraction with EIN2, and more EIN3 proteins bind to the loci where ENAP1 is enriched for a quick res

220 es SMAD3 signaling, causing phospho-SMAD3 to bind to the miR-140 locus and inhibit miR-140 transcript

221 In vitro, leptospiral PerR could bind to the perR promoter region in a metal-dependent ma

222 Pathogenic hantaviruses bind to the plexin-semaphorin-integrin (PSI) domain of i

223 r-beta1 precursor (pro-TGF-beta1), integrins bind to the prodomain, apply force, and release the TGF-

224 herein report that manganese and cobalt can bind to the same nonheme site and confer HCO activity in

225 Bulk RNA and substrate ssDNA bind to the same three A3G tryptic peptides (amino acids

226 uble mutant (N682A, D683A; mPA) which cannot bind to the two natural anthrax receptors.

227 signaling, presumably through its ability to bind to the Wise (Sostdc1)/sclerostin (Sost) family of W

228 uorescence anisotropy, we report that TRIP8b binding to the CNBD of HCN2 channels decreases the appar

229 w that blocking of the Galpha13 protein from binding to the cytoplasmic domain of the beta3 integrin

230 A1 by >/=75% and were evaluated for in vitro binding to the enzyme active site and for inhibition con

231 a Grotthuss shuttling and reveal that proton binding to the extracellular side of the transporter fac

232 POS1 competes with Stx2 binding to the Gb3 receptor based on ELISA results, unde

233 ld-type enzyme, demonstrating that substrate binding to the high-energy state is not occluded by ster

234 sembly process shepherds primary transposase binding to the inner 12DRs (where cleavage does not occu

235 ctions of ABA in mammals are mediated by its binding to the LANCL-2 receptor protein.

236 in suggest a two-state model in which ligand binding to the lectin domain closes loop 83-89 around th

237 D in an interaction that is competitive with binding to the LRS.

238 eration of angiotensin-(1-7) by ACE2 and its binding to the Mas receptor (MasR) improves glucose home

239 reatment of breast cancer cells increased ER binding to the NEMO promoter, thereby increasing NEMO ex

240 Moreover, poly(ADP-ribose) binding to the Parp9 macrodomains increases E3 activity.

241 onserved amino acids that couple RNA and ATP binding to the protein (Motif III).

242 hich reduces severe malaria risk, reduced IE binding to the receptors CD36 and integrin alpha5beta1,

243 Finally, DDX21 was shown to enhance Rev binding to the RRE in a manner similar to that previousl

244 rted similar effects as progesterone, likely binding to the same site.

245 phylococcal pathogenicity islands (SaPIs) by binding to the SaPI-encoded Stl repressor.

246 and membranes compete for mutually exclusive binding to the tetratricopeptide repeat domain of CHIP.

247 as the bridging molecule that mediates IL-37 binding to the TGF-beta receptor complex.

248 d conditions, is inhibited by intramolecular binding to the Vms1 leucine-rich sequence (LRS).

249 AhR activity depends on its binding to the xenobiotic response element (XRE) in part

250 We determined that the xRRM of LARP7 binds to the 3 stem loop of 7SK and inhibits the methylt

251 The Cu(2+) complex binds to the active sites of SlyD, which suppresses its

252 PsAvh23 binds to the ADA2 subunit of the HAT complex SAGA and di

253 HIV encodes the Vif protein, which binds to the APOBEC3 proteins and leads to their proteas

254 that calcium and integrin-binding protein 2 binds to the components of the hair cell mechanotransduc

255 We show that STYX binds to the F-box domain of FBXW7 and disables its recr

256 DGC component dystroglycan 1 (Dag1) directly binds to the Hippo pathway effector Yap to inhibit cardi

257 rst, JNK-mediated activation of c-jun, which binds to the IFN-beta promoter, and second, p38-mediated

258 fferent channel domains, we found that SMIT1 binds to the KCNQ2 pore module.

259 Also, we discover that Smurf1 directly binds to the kinase domain of PIPKIgamma via its C2 doma

260 The hormone methyl farnesoate binds to the MfR to regulate various aspects of reproduc

261 Previous reports showed that LEF1 binds to the MMP13 promoter and transactivates its expre

262 Casein kinase 2 (CK2) binds to the NHE3 C-terminus and constitutively phosphor

263 ed by a TRPV1-selective tarantula toxin that binds to the outer pore of the channel.

264 NF-kappaB complex signaling component, p65, binds to the proximal region of the IL22 promoter and pr

265 ntified the AVR-Pia interaction surface that binds to the RATX1 domain.

266 ry analyses further reveal that nitric oxide binds to the reduced [2Fe-2S] clusters in Miner2, with e

267 and JUN/FOS also contact MED25; FOS strongly binds to the same MED25 site as ETV4 AD and JUN interact

268 ound in several plus-strand RNA viruses that binds to the small molecule ADP-ribose.

269 ture at 1.9 A resolution deciphered that S1P binds to the surface of 2,3-BPG-deoxyHbA and causes addi

270 -associated nascent polypeptide chains, also binds to the TPR domain of Sec72, even though it lacks t

271 SAM binds to the unique iron atom of a site-differentiated [

272 (-)3TC-MP, with a second (-)3TC-TP molecule bound to the active site in the absence of PPi, suggests

273 e D4 dopamine receptor in its inactive state bound to the antipsychotic drug nemonapride, with resolu

274 ed by DegP but were toxic because they first bound to the Bam complex, an essential heteroligomer tha

275 We present the structure of FBXW7 bound to the DISC1 phosphodegron motif and exploit this

276 tructurally destabilized Miz1-4(A86K) mutant bound to the DNA consensus with a 30-fold increase in af

277 ound to RNA shows the central region of Mpp6 bound to the exosome core, positioning its Mtr4 recruitm

278 Here, we show that TIGIT bound to the immunoglobulin domain of nectin-2 that is m

279 se there was an additional amount of protein bound to the surface.

280 ut predominantly in its protonated form when bound to the variants.

281 and how strongly a range of small molecules bind to their respective protein targets.

282 neurotransmitter release by virtue of Ca(2+)-binding to their two C2 domains, but their mechanisms of

283 Crystal structures of affimers bound to their cognate chain types reveal mechanisms of

284 omains of myosin from the thick filaments to bind to them and induce filament sliding.

285 e are found to exhibit markedly differential binding to these GusR orthologs.

286 Snail binds to three E-boxes present in the human 4E-BP1 promo

287 tal retinal pigment epithelium cells, ligand binding to TLR2 induced robust expression of proinflamma

288 Iron-loaded transferrin binds to transferrin receptor 1 on the surface of most b

289 4 and Pdcd4(157-469), a deletion mutant that binds to translation initiation factor 4A (eIF4A), suffi

290 ain barrier (BBB) in rodents and selectively binds to TrkB/C receptors in vivo, as evidenced by entre

291 +) regulates TRPA1 through calmodulin, which binds to TRPA1 in a Ca(2+)-dependent manner.

292 observed BAT contrast was due to (64)Cu-Dis binding to TSPO, which was further confirmed as a specif

293 (18)F-BMS-986192 bound to tumor tissues as a function of PD-L1 expression

294 iques, we show that these molecules directly bind to two distinct sites of the SMN2 pre-mRNA, thereby

295 U1 and TB1 overlap in axillary buds, and TB1 binds to two locations in the tru1 gene as shown by chro

296 Mechanistically, SRPK2 promotes SR protein binding to U1-70K to induce splicing of lipogenic pre-mR

297 ting sequence 1 (UAS1), then it subsequently binds to UAS2 (a critical cis-regulatory site located ap

298 >5 mum in diameter) of bioaerosol settle and bind to various surfaces depending on the geographical s

299 ination of ILV cargoes is inhibited via Doa4 binding to Vps20, which is the subunit of ESCRT-III that

300 predominantly in its deprotonated form when bound to wild-type VAO, but predominantly in its protona