ライフサイエンスコーパス: binder

1 hene act as active materials and conductive "binders".

2 r to the buried pigments or to the inorganic binder.

3 on rotating disk electrode using Nafion as a binder.

4 ith the assistance of ionic liquid (IL) as a binder.

5 g of the magnetic particles from the polymer binder.

6 comprising a novel triaminopyrimidine hinge binder.

7 ulcers associated with use of this phosphate binder.

8 the full-length protein to identify the best binder.

9 le of a reduction-activated G-quadruplex DNA binder.

10 identify PWWP2A as a novel H2A.Z-nucleosome binder.

11 ectly employed as conductive ink without any binder.

12 be the most selectively enriched oAbeta1-42 binder.

13 aphite electrodes containing a thermoplastic binder.

14 hibitors incorporating the indazole as hinge binder.

15 binding, and identified 2,618 high-affinity binders.

16 plications as food emulsifiers and bile acid binders.

17 y intractable fragment hits into more potent binders.

18 re synthesized and evaluated as G-quadruplex binders.

19 roader repertoire of alternative MHC class I binders.

20 edge to yield two more strong MIF inhibitors/binders.

21 ows fine quantitative discrimination between binders.

22 all subjects in high, mixed and low affinity binders.

23 atalyst-free malleable polyimine networks as binders.

24 aries is a powerful tool to identify protein binders.

25 entified short phosphopeptides as tight BRCT binders.

26 residues Trp, Tyr, and Phe in rcSso7d-based binders.

27 tics of three different classes as selective binders.

28 ceptors, and they resemble known promiscuous binders.

29 rolled "capture and release" of the specific binders.

30 ate nanostructures of the conductive polymer binders.

31 tocol to more confidently identify egg based binders.

32 other methods may identify a wider range of binders.

33 safety profile similar to that of available binders.

34 w paradigm for regulating the affinity of MT binders.

35 ngth of high-, medium-, and low-affinity RGD-binders.

36 ss predictions among the native nucleic acid binders.

37 rials, without conductive additives or other binders.

38 ning on an in house database, dual MDM2/MDM4 binders.

39 rase (CA) in the presence of hundreds of non-binders.

40 Grb2-associated binder 1 (GAB1) is an important docking protein responsi

41 s, whereas proteins such as Grb2-associated binder-1 (Gab1) and SH2-containing tyrosine phosphatase

42 eptor ErbB2 and its effector Grb2-Associated Binder-1 (Gab1), thereby elevating the expression of the

43 r 3 is more Brr2-selective than the RNA site binder 12.

44 Among the 192 predicted binders, 12 representatives were selected, and their TTR

45 We recently reported the first dual binder 3 possessing a higher anticancer effect in GBM ce

46 The binder, a cationic polyelectrolyte, is shown to both fac

47 and genomic imprinting at birth.-Tserga, A., Binder, A.

48 assess binding potency; and c) the stronger binders (AC50 < 1 muM) are screened in vivo.

49 We identified a suitable binder additive, methyl cellulose, which offers suitable

50 ting processes need a large concentration of binder additives, which often render a detrimental effec

51 arbon matrix and their processing obligatory binders, additives and solvents.

52 gate the mechanism of how these minor-groove binders affect pol II transcription elongation.

53 nstrated that intercalators and minor groove binders affect the conformation of the DNA and RNA oligo

54 stable human VH domains and the selection of binders against a diverse set of antigens.

55 vitro selection to ensure rapid discovery of binders against a wide range of targets.

56 f this receptor, we aimed to select specific binders against FcgammaRIIB and to generate a bispecific

57 d can be engineered to develop high-affinity binders against specific targets of interest.

58 mRPs onto the surface of dArmRPs resulted in binders against the expected peptide with low nanomolar

59 Even in the presence of the three binders, allergic patients' polyclonal IgE reacted with

60 e hypothesis that the relative number of ELT binders alone could be used to assess the ligandability

61 These pyrene-based methacrylate binders also enhance the stability of the solid electrol

62 xed affinity binders and high+mixed affinity binders Alzheimer's disease groups compared to controls,

63 ecific molecules containing a target protein binder and an ubiquitin ligase binder connected by a lin

64 ostructured conductive gel framework as both binder and conductive framework for lithium ion batterie

65 We studied ferric citrate as a phosphorus binder and iron source.

66 ments of weight and oxygen saturation into a binder and requires families to assume a surveillance ro

67 that an indazole would be the stronger hinge binder and would impart increased potency when substitut

68 distribution (VT) was 0.17 in high-affinity binders and 0.12 in mixed-affinity binders using the kin

69 Fifteen healthy subjects (9 high-affinity binders and 6 mixed-affinity binders) underwent (18)F-DP

70 nd biaryl moieties) were identified as cN-II binders and a fragment growing strategy guided by molecu

71 od major histocompatibility complex class II binders and at the same time show high population covera

72 temperature processes without any templates, binders and conductive additives, which possesses the po

73 inguishing antibody-antigen binders from non-binders and demonstrates the challenges to address for t

74 olunteers receiving phosphate supplements or binders and endothelial function measured by flow mediat

75 ntaining side chains (CATDs) as G-quadruplex binders and have examined their anticancer activity in T

76 her in high affinity binders, mixed affinity binders and high+mixed affinity binders Alzheimer's dise

77 dihaloacetates are identified as potent PDK2 binders and matched their efficiency with dichloroacetic

78 MBINE Study: The CKD Optimal Management With BInders and NicotinamidE study.

79 binders to be higher than that of two single binders and to be maximized when the binding sites are a

80 n the solid phase after polymerization, poor binders and unproductive polymer are removed, so the fin

81 trodes, current collectors, electrolyte, and binders) and examine specific materials.

82 heterodimer of NFkappaB is the strongest DNA binder, and its unbinding is controlled kinetically by m

83 Ten healthy controls, 6 TSPO high-affinity binders, and 4 mixed-affinity binders were recruited.

84 pproaches are generalizable to other protein binders, and enable the rapid generation of single-polyp

85 ropy penalty, compared with other more rigid binders, and highlights a new strategy for inhibitor des

86 type Bi0.5Sb1.5Te3 or n-type Bi2Te2.7Se0.3), binders, and organic solvents.

87 the specific ligands and known, nonspecific binders, and we demonstrated that intercalators and mino

88 cy of aromatic residues, these rcSso7d-based binders are highly expressed, thermostable, and monomeri

89 However, genetically expressed protein binders are stable regardless of antigen expression, com

90 Specific GFP-binders are thus of great utility for detection, immobil

91 with end-stage renal disease, and phosphate binders are usually needed.

92 igand binding modes even in the case of weak binders as well as to the location of protein-bound wate

93 le genomic loci in parallel, and the protein binders at each locus are eluted in a programmable and s

94 The recombinant head region binder based assays yield superior analytical sensitivit

95 neered a series of ultra-high affinity siRNA binders based on the viral protein p19 and developed the

96 ization resulted in 11 new submicromolar KOR binders (best Ki = 90 nM).

97 velopment of CD4-binding site (CD4bs), HCDR3-binder bnAbs via sequential HIV-1 Env vaccination.

98 Compared to the dyad binders, bulkier fragments occupy these regions.

99 the nanoscale defects left behind after the binder burnt off became effective phonon scattering cent

100 not bind sterols can be converted to sterol binders by a single point mutation in the caveolin-bindi

101 recruitment of outer kinetochore microtubule binders by centromere proteins C and T (CENP-C and CENP-

102 for the 3,5-diaryl-pyrazin-2-ones as DFG-in binders by using a phenolic OH function to replace a str

103 es beyond what is inherent in the individual binders, by bringing together different target molecules

104 The protocol uses small binders called nanobodies and an enzymatic labeling stra

105 These electric conductive polymeric binders can maintain the electrode mechanical integrity

106 In addition, no binders, carbon additives or current collectors are adde

107 layed some role, the NP capping agent/fabric binder combination was a key factor in release.

108 A conductive, elastic, electroactive binder composed of polypyrrole and polyurethane is adopt

109 the combustion flame of a Mg/Sr(NO3 )2 /Epon-binder composition and reduce the amount of both condens

110 ram of cellulose, yielding a volume-averaged binder concentration of up to 760muM within the resultin

111 arget protein binder and an ubiquitin ligase binder connected by a linker.

112 somes were labeled with the DNA minor groove binder, DAPI, followed by measurement and imaging of the

113 ive amyloid scans (n = 6 high+mixed affinity binders), defined as amyloidosis controls, and were anal

114 he development of recombinant antibodies and binders derived from natural protein scaffolds has expan

115 For stronger binders (described here as AC50 < 1 muM), we also examin

116 s that distinguish an active polyelectrolyte binder designed for lithium-sulfur batteries from a pass

117 physical characterization of a subset of the binder designs showed that they are extremely stable and

118 cale required for the features of the carbon binder domain to become discernible, confirming the need

119 OX occurs (1) upon addition of a competitive binder (e.g., adamantane ammonium (ADA)) for CB[7], (2)

120 The thermoplastic binder enables the electrodes to be hot embossed, molded

121 oughput screening to identify small-molecule binders, enzymatic activity measurements to identify inh

122 , extremely suitable as a conductive polymer binder for lithium battery electrodes.

123 Polyacrylic acid (PAA) was used as a binder for the DE-based nanoSi anodes for the first time

124 P when paired with SCN(-), which is a strong binder for the ELP.

125 st report of DCC applied to the discovery of binders for a protein, this elegant tool has been employ

126 of mono- or divalent small-molecule albumin binders for half-life extension of peptides.

127 thin-layer of CMO NPs by conducting coating binders for the development of selective and sensitive t

128 Binder free nanostructured NiCo2O4 were grown using a fa

129 The potential application of binder free NiCo2O4 as an electrode for supercapacitor d

130 on nanofiber paper anodes offer a completely binder-free and Cu current collector-free approach to el

131 and excellent electrical conductivity, this binder-free anode was found to effectively enhance the e

132 Our binder-free ink suppresses coffee ring formation through

133 s the Portobello mushroom, as free-standing, binder-free, and current collector-free Li-ion battery a

134 he membrane is demonstrated to function as a binder-free, high-performance gas diffusion electrode fo

135 rous architecture was prepared and used as a binder-free, low-cost, high-performance anode for lithiu

136 molecule 1 (ICAM-1), allowing us to predict binders from a specific sequence motif alone.

137 Selection of protein binders from highly diverse combinatorial libraries of D

138 mpt aimed at distinguishing antibody-antigen binders from non-binders and demonstrates the challenges

139 Development of strong and selective binders from promiscuous lead compounds represents one o

140 ormance and were able to accurately separate binders from random peptides.

141 ith low nanomolar affinities, similar to the binders from the consensus-design series.

142 fficient tool for the discovery of novel TTR-binders from the Tox21 inventory.

143 n bind simultaneously: by linkage of the two binders, fusion constructs were obtained that "wrap arou

144 nding domain and is independent of minus-end binders gamma-TuRC, CAMSAP1, and KANSL1/3.

145 th a 40%-50% increase in BP in high-affinity binders (HABs) compared with mixed-affinity binders (MAB

146 Nine healthy volunteers-3 high-affinity binders (HABs), 3 mixed-affinity binders (MABs), and 3 l

147 Ten controls (7 high-affinity binders [HABs] and 3 mixed-affinity binders [MABs]) unde

148 -affinity binders [MABs] and 8 high-affinity binders [HABs] twice with an interval of 35 +/- 15 d).

149 -affinity binders [MABs] and 8 high-affinity binders [HABs] twice with an interval of 35 +/- 15 d).

150 Kinetics revealed that the strongest binders had subnanomolar affinities with low dissociatio

151 fluidics for screening high-affinity peptide binders has not been demonstrated due to the lack of a s

152 1970s, alternative biological and synthetic binders have been emerged as a promising alternative to

153 targeting the ubiquitin system, very few E2 binders have currently been discovered.

154 similarity to known selective tau aggregate binders identified N-(6-methylpyridin-2-yl)quinolin-2-am

155 d, the distribution of responses of the best binders in a library follows a simple scaling law.

156 es, metallic current collectors, and polymer binders in addition to the high weight percent silicon a

157 Polymer binders in battery electrodes may be either active or pa

158 library based on fine discrimination between binders in BeSD were followed by analysis of 200 full-le

159 Dylation occurs for known endogenous protein binders in complex cell lysates.

160 neous detection of the use of these cold-set binders in raw and heated samples.

161 We test the best oligonucleotide binders in surface plasmon resonance studies to analyze

162 termination of binding modes of low affinity binders in the protein-ligand interface and reveals suit

163 ficacy of patiromer, a nonabsorbed potassium binder, in a multicenter, prospective trial.

164 blockers, reflux-reducing agents, bile acid binders, injection of inert substances into the esophago

165 ine-type scaffold are not the most enthalpic binders; instead a chloro-thiophene fragment binds more

166 ng, manufacturing and screening mini-protein binders, integrating large-scale computational design, o

167 Molecular analysis also showed that the binder is composed of an allophane-like clay.

168 fluoroplastics (PTFE AF 2400) as a particle binder is presented.

169 sulfide (MoS2 ) nanoassemblies and polymeric binder is reported.

170 The binder is used with a simple carbon/sulfur composite to

171 The design of new strong and selective binders is a key step towards the development of new sen

172 The affinity of two coupled binders is therefore predicted to increase non linearly

173 id binding surface of enriched rcSso7d-based binders is very different from that generally found in m

174 Importantly, the consensus binder isolated from directed evolution experiments (6.2

175 aphy), powder bed fusion (SLS), material and binder jetting (inkjet and aerosol 3D printing), sheet l

176 ffinity binders (MABs), whereas low-affinity binders (LABs) are unsuitable for evaluation.

177 -affinity binders (MABs), and 3 low-affinity binders (LABs)-were studied with whole-body (11)C-ER176

178 Thin, binder-less zeolite NaX laminates, with thicknesses rang

179 s with CKD stages 3-4 suggest that phosphate binders, low phosphate diets, or vitamin B3 derivatives,

180 gh-affinity binders (HABs), 3 mixed-affinity binders (MABs), and 3 low-affinity binders (LABs)-were s

181 binders (HABs) compared with mixed-affinity binders (MABs), whereas low-affinity binders (LABs) are

182 healthy controls (9 women, 8 mixed-affinity binders [MABs] and 8 high-affinity binders [HABs] twice

183 healthy controls (9 women, 8 mixed-affinity binders [MABs] and 8 high-affinity binders [HABs] twice

184 affinity binders [HABs] and 3 mixed-affinity binders [MABs]) underwent (18)F-DPA-714 PET with arteria

185 anic nanoparticles within a flexible polymer binder matrix, the rationally designed artificial SEI no

186 nsplant immunomes for strong myeloma surface binders may open up avenues for myeloma immunotherapy.

187 Furthermore, we show how allosteric binders may overcome the beta-catenin side effects assoc

188 elongation by sequence-specific minor groove binders may present opportunities to target transcriptio

189 rimers and corresponding TaqMan Minor Groove Binder (MGB) probes were designed to target Agrobacteriu

190 protein-binding was higher in high affinity binders, mixed affinity binders and high+mixed affinity

191 formation mediated by Mats, a conserved Mps1-binder (Mob) protein.

192 Using statistical mechanics, a random-binder model without fitting parameters, with genomic DN

193 racterize the composition of their inorganic binders (mordants).

194 Single domain heavychain binders (nanobodies) obtained from camelid antibody libr

195 nges of DNA upon binding of the minor groove binder netropsin.

196 unds into silicone oil, acting as lipophilic binder of glassy carbon paste electrode, with subsequent

197 f the coumarinyl molecule to develop a tight binder of hbeta4GalT7.

198 The most effective compound 19 is a tight binder of MDM2 and activates p53 in cancer cells that ex

199 etic analysis revealed that Tmeff2 is a weak binder of PDGFA, and not required for OL differentiation

200 n control protein 42) and its effector Borg (binder of Rho GTPases), which act as up-stream regulator

201 -terminal LRLRGG of ISG15 interacts with the binder of ubiquitin zinc finger (BUZ) domain of histone

202 was applied for the characterization of the binders of a historical fresco of the XVI century from t

203 e comparable with those of the most powerful binders of albumin, and more favourable than the values

204 ue was used to make potent di- and trivalent binders of ASGPR.

205 ty that AREG and other low- or high-affinity binders of EGFR might serve as potential targets for can

206 some of the strongest synthetic noncovalent binders of halide anions measured to date, comparable in

207 We prove the enhanced ability of double binders of keeping their target with a simple model wher

208 terial surface display to identify selective binders of KSBcl-2 or BHRF1.

209 evelopment of extremely powerful multivalent binders of the Influenza virus and other viruses, compar

210 2-adamantyl)piperidines, identified as dual binders of the wild-type and V27A mutant M2 channels of

211 The method was validated by detecting known binders of three proteins, pepsin, maltose binding prote

212 In our screens, we identified 20 binders, of which 14 performed as potent and selective i

213 protein levels, cinacalcet use, or phosphate binder or calcitriol dose in either study arm.

214 ndwich-type configuration without additional binders or conductive agents improves energy/power densi

215 The use of insulating polymers as binders or matrices is proposed, which permit the adjust

216 Thirty high+mixed affinity binders patients with Alzheimer's disease were dichotomi

217 ure alumina powder has been used without any binder phase, enabling more precise dimensional control

218 We also identified a novel CA binder, pifithrin-micro, which could not have been ident

219 ochemically generated NaO2 and the electrode binder, polyvinylidene fluoride (PVDF).

220 screening of the clones obtained to evaluate binders precisely.

221 from the large concentration of non-specific binders (proteins, lipids, nucleic acids and saccharides

222 Designed Bfl-1 binders provide reagents for cellular profiling and lead

223 a novel H2A.Z-specific multivalent chromatin binder providing a surprising link between H2A.Z, chromo

224 as the Ebola Zaire Target 1 and major groove binder quantitative reverse-transcription polymerase cha

225 ntibodies allows to obtain highly functional binders, rapidly and at lower cost.

226 These small binders readily penetrate through the yeast cell wall an

227 including Ebola Zaire Target 1, major groove binder real-time-polymerase chain reaction assays, and o

228 uch as metal current collector and polymeric binder reduces the total electrode weight and may provid

229 In addition, the small size of the binders reduces the distance of the dye to the target pr

230 Hence, the first X-bonded nucleic acid binder remains to be discovered.

231 igands, their evolution into higher affinity binders remains a major hurdle.

232 However, analysis of potent binders remains a significant hurdle due to limited sens

233 ligand screening, the selection of specific binders requires the validation of the hits through comp

234 conclusion, treatment with FC as a phosphate binder results in increased iron parameters apparent aft

235 o-crystal structures of the highest affinity binder reveal a highly preorganized binding site, and an

236 synthesis and amplification of its strongest binder(s) from the library of interconverting compounds.

237 Ts1, we have chemically synthesized a novel binder [S14R, W50Pra]Ts1 for Nav with high affinity, low

238 She had been treated with the phosphate binder sevelamer for two months.

239 In this work, a polyelectrolyte binder, SiO2 nanoparticles, and a fluorosurfactant are s

240 Polyelectrolyte binder, SiO2 nanoparticles, and silane or fluorosurfacta

241 reatment with gefitinib (active conformation binder) stabilizes the EGFR ligand-bound homodimer.

242 1.34 x 10(7) CEID50/mL for the mixed and all binder stacks, respectively.

243 nd by the incorporation of high affinity RNA binders such as 2', 4'-bridged nucleic acids (also known

244 Protein binders such as nanobodies (Nbs) can target untagged pro

245 acceptor, ReAsH (resorufin arsenical hairpin binder), targeted to each alpha1S intracellular loop, wi

246 l domain-4 (BRD4) ligand JQ-1 (3) and ligase binders targeting cereblon (CRBN) and Von Hippel-Lindau

247 uctions of MTs stabilized by the taxane-site binders Taxol and zampanolide, and by peloruside, which

248 citrate is an efficacious and safe phosphate binder that increases iron stores and reduces intravenou

249 nt, K(d), and the unknown concentration of a binder that we call a target, T.

250 ng interactions as well as identifying novel binders that modulate their structure and function.

251 ntibodies often require careful selection of binders that recognize specific epitopes on the target m

252 cription, which is distinct from other Kelch binders that regulate Nrf2 activity.

253 polyester-urethane as the magnetic particle binder, the degradation of which threatens the playabili

254 of the screenings yielded clear-cut surface binders, the majority of screenings did not, suggesting

255 ally explore the possibility of coupling two binders through a flexible linker.

256 was synthesized and applied as an electrode binder to fabricate a silicon (Si) electrode.

257 n-2-yl)quinolin-2-amine 10 as a novel potent binder to human AD aggregated tau with modest selectivit

258 printed electrodes using a chitosan hydrogel binder to prepare an inexpensive electrochemical fibrino

259 peptidic molecules that act as substrates or binders to a protein of interest.

260 he potential to identify efficiently peptide binders to a protein target in a drug discovery program.

261 tifs and demonstrated its ability to isolate binders to a wide panel of antigens.

262 w the binding free energy of flexible double binders to be higher than that of two single binders and

263 ectrometer, which allowed pigments and paint binders to be identified and mapped.

264 mics simulations for the characterization of binders to different isoforms of the cyclophilin (Cyp) p

265 ffold facilitated evolutionary adaptation of binders to differentially charged epitopes on mouse seru

266 Patients on dialysis require phosphorus binders to prevent hyperphosphatemia and are iron defici

267 apply this method to stepwise evolve peptide binders to streptavidin, a protein studied for over two

268 A two-dimensional NMR fragment screen for binders to the bromodomains of BRD4 identified a phenylp

269 library enabling selection of high-affinity binders to various proteins.

270 cal dye FlAsH (fluorescein arsenical hairpin binder) to detect soluble oligomers and mature fibrils f

271 Phosphate binder treatment (predominantly calcium-based) was assoc

272 9 high-affinity binders and 6 mixed-affinity binders) underwent (18)F-DPA-714 PET scans with arterial

273 greater risk of fracture, whereas phosphate binder use was protective in this cohort.

274 itamin D dose, cinacalcet use, and phosphate binder use.

275 -affinity binders and 0.12 in mixed-affinity binders using the kinetic model.

276 thout suffering any influences of insulating binders usually used to fix nanomaterials on conductive

277 addition to conventional therapy (phosphate binders/vitamin D) in patients receiving hemodialysis wi

278 The lead binder was chosen on the basis of comparisons of binding

279 Further selection for faster binders was achieved by drastically decreasing the libra

280 multaneous allergen recognition of all three binders was demonstrated.

281 A DNA library encoding potential peptide binders was encapsulated with IVT2H such that single DNA

282 ichment of indel mutations for high-affinity binders was three times that of non-synonymous SNV mutat

283 After a 1- to 3-week washout of phosphate binders, we randomly assigned 162 eligible patients (ser

284 In all cases, specific binders were generated using a Fab phage display library

285 Six strong CYP27A1 inhibitors/binders were identified.

286 high-affinity binders, and 4 mixed-affinity binders were recruited.

287 Following printing, the binders were subsequently burnt off via sintering and ho

288 ed from existing classes of DNA minor groove binders, were designed, synthesized, and evaluated for t

289 at ionizes well, not by detecting the ligand binder, which may not ionize.

290 the unbound equilibrium fraction, R, for the binder with a known concentration that we call a ligand,

291 avoid the parasitic reactions of carbon and binder with discharge products and reaction intermediate

292 nd resulted in identification of a nanomolar binder with improved proteolytic stability and cell perm

293 ine 75, a potent and selective tau aggregate binder with potential as a tau PET tracer.

294 Ferric citrate (FC) is a phosphate binder with shown efficacy and additional effects on iro

295 stretches lays the ground for the design of binders with different specificities and tailored affini

296 To address these challenges, polymer latex binders with diverse particle morphologies have been dev

297 ligands can be exploited to search for weak binders with large dissociation constants KD > 1 mM that

298 uced charge Sso7d (rcSso7d) scaffold yielded binders with low nanomolar affinities against mouse seru

299 olefin thermoplastic blend (elastomer matrix binder) with bulk-produced carbon nanofibres (charge per

300 ighly diverse library provides high affinity binders without animal immunization.