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3 -TRAP, the intracellular folding and antigen-binding activity of a human single-chain antibody fragme
4 results suggest that EGF regulates the actin binding activity of ACTN4 by inducing tyrosyl-directed p
5 ied as selective materials for assessing the binding activity of agonist and antagonist of dopamine D
8 ylation are associated with a loss of ligand-binding activity of alpha-DG and are causal for various
9 alpha-dystroglycan glycosylation and laminin binding activity of alpha-dystroglycan in the morphants.
10 utation analyses demonstrate that the ligand-binding activity of alpha-dystroglycan is conferred prim
11 rated ROS enhanced the activation and ligand-binding activity of alphaMbeta2 integrin following N-for
12 Hippo pathway negatively regulates the actin-binding activity of Amot family members through direct p
13 help elucidate this process, we examined the binding activities of an MA mutant that stabilizes MA tr
15 we hypothesize that RNPC1 modulates the RNA-binding activity of, and cooperates with, HuR to regulat
16 demonstrate by microarray analyses distinct binding activities of antibodies and a lectin toward var
17 mRNA was associated with an increase in the binding activity of AP-1 but the activities of NF-kappaB
20 receptor-binding region ablated the heparin-binding activity of apoE, as determined by an in vitro h
22 reporter assay for rapidly screening the DNA-binding activities of assembled multi-finger arrays.
23 s are promising leads for suppression of DNA binding activities of B-ZIP and B-HLH-ZIP transcription
26 targeted to endosomal membranes by the lipid-binding activities of both the Vps36 GLUE domain and the
30 for optimal DNA binding or can stimulate the binding activity of CAP variants that only transiently p
31 multidomain proteins that regulate the actin-binding activity of capping protein (CP), a major capper
32 dicate that impairment of the membrane lipid binding activity of Cb and a consequent defect in inhibi
33 10 by arsenic is associated with reduced DNA-binding activity of CCAAT/enhancer-binding protein beta
34 a point mutation (C169A) that abolishes DNA-binding activity of Cfp1 ablates the rescue activity of
35 pression of hmuO and the hrtAB genes and the binding activity of ChrA is dependent on phosphorylation
36 ity of other members of this family, the DNA-binding activity of Clp is allosterically inhibited by i
41 e at pH 7.0, for example, the phosphocholine-binding activity of CRP, which was reduced at acidic pH,
46 lis, a model Gram-positive organism, the DNA binding activity of CtsR is regulated by McsAB-mediated
48 formation about the domain structure and DNA-binding activity of D5, the poxvirus helicase-primase.
50 vivo, enzymatic (ATPase or helicase) or ATP binding activities of Dhh1 or those of any its many high
52 srupting TGFbeta signaling decreased the DNA binding activity of DNA methyltransferase DNMT1, suggest
53 tide exchange predominantly regulate the DNA binding activity of DnaA and that those with low rates o
54 mpared the previously documented microtubule binding activity of dystrophin with utrophin and analyze
56 om a variety of sources, we measured protein-binding activities of each individual compound against e
58 findings indicate that the site-specific DNA-binding activity of EBNA1 or its derivatives when expres
61 ing protein (eIF4E-BP), lowered the cap site binding activity of eIF4E and directly inhibited activit
66 Thus, it is likely that the lower ethylene binding activity of ETR1 with silver is due to fewer eth
68 -induced RPA foci formation requires the DNA-binding activity of FAAP24 but not the DNA translocase a
69 attachment had no effect on the plasminogen binding activity of FBA-tb, it competed with the natural
72 genesis reveals that reducing the barbed-end binding activity of FRL1 and mDia2 greatly enhances the
76 sion in CD4(+) T cells by regulating the DNA-binding activity of GATA-3 and limiting GATA-3 regulatio
78 ts cognate binding site can increase the DNA binding activity of GEF to Domain I, suggesting a novel
79 nt on the SMN mRNA with Gemin5, but the mRNA-binding activity of Gemin5 is dependent on SMN levels, p
82 lective pathology of CMT2D to the neomorphic binding activity of GlyRS(CMT2D) that antagonizes the VE
83 onal signaling also required the G betagamma binding activity of GRK2 but did not involve the GRK2 N-
85 ticular mutants, we found that the porphyrin binding activity of GUN4 and Mg-chelatase contribute to
87 red to as Hand2(EDE)) that abolished the DNA-binding activity of Hand2, leaving the remainder of the
90 tivity and mRNA expression by inhibiting DNA-binding activity of hepatocyte nuclear factor 4alpha (HN
91 gest that Aurora-A modulates the microtubule binding activity of Hice1 in a spatiotemporal manner for
93 deprivation significantly suppressed the DNA-binding activities of HNF-4alpha and PPAR-alpha, and red
106 effects appear to depend on the G-quadruplex binding activity of HXDV as its non-G-quadruplex binding
108 e PAR polymer binding site abolishes the PAR binding activity of Iduna and attenuates its protective
109 evidence that the cell cycle arrest and DNA binding activities of IE2 appear to be responsible for t
113 ty, and invasion are regulated by the ligand-binding activity of integrin receptors, transmembrane pr
117 uppression activated iron-responsive element-binding activity of iron regulatory protein 1, increased
118 ed, the iron-responsive element-binding (IRE-binding) activity of iron regulatory protein 1 (IRP1) wa
120 cellular glucose deprivation reduces the RNA-binding activity of IRP2 but not IRP2-C512S or IRP2-C516
121 n (DNAm) profiles, we infer the landscape of binding activity of lung-specific transcription factors
123 ctivated HSCs have higher nuclear levels and binding activity of MafG to the antioxidant response ele
124 NA species at least partly by disrupting the binding activities of many transcription factors which g
126 d the low-resolution molecular structure and binding activity of Merlin and a Merlin(S518D) mutant th
128 H melting profiles showed 24-35% of enhanced binding activity of methylxanthines during helix-coil tr
130 scuss the possible implications of the lipid-binding activity of MpPR-1 family members with regard to
131 indicate that the ATP- and MuA-regulated DNA-binding activity of MuB is not essential for target deli
133 eover, downregulation of TCEAL7 promotes DNA-binding activity of Myc-Max, and upregulates the promote
136 ylation, of p38 MAPK phosphorylation, of DNA binding activity of NF-kappaB and ATP content of Kupffer
137 hermore, IL-1alpha depletion reduced the DNA binding activity of NF-kappaB and C/EBPbeta, which stimu
139 f p65 with corresponding increase in the DNA-binding activity of NF-kappaB as detected by electrophor
141 apoptotic cell death and suppressed the DNA binding activity of NF-kappaB in a concentration depende
142 y silencing SOD and catalase reduced the DNA binding activity of NF-kappaB in the transformed cells.
144 Ref-1 decrease correlated with decreased DNA-binding activity of NF-kappaB mediated by soy isoflavone
146 p-Akt, VEGF, Ang-1, Bcl-2, survivin and DNA binding activity of NF-kappaB were observed in the Grx-1
148 overexpression led to an increase in the DNA-binding activity of NF-kappaB, which, in turn, led to in
151 ephrine stimulated the Ca(2+) -dependent DNA-binding activities of NFAT2, NFAT4, and Sp1 (but not Sp3
156 plication system to demonstrate that the RNA-binding activity of NP is not required for the unprimed
157 s out two models that postulate that the RNA-binding activity of NP mediates the switch from capped R
159 nd its binding with Keap1, but decreased DNA-binding activity of Nrf2 and also its binding at the pro
160 Nrf2 protein stability, compromised the DNA-binding activity of Nrf2 in a promoter-specific manner.
161 the function of both the VEGF and Semaphorin binding activities of NRP-1 has important roles in the d
163 rostate cancer cells, and suppressed the DNA-binding activity of nuclear factor-kappaB (NF-kappaB) tr
164 lso found that B-DIM treatment inhibited DNA binding activity of nuclear factor-kappaB (NF-kappaB), w
165 combination gene therapy stimulated the DNA binding activity of nuclear factor-kappaB in the diabeti
172 ParB/parS partition complex requires the DNA-binding activity of ParA, which transiently tethers the
173 Z2 nor PDZ3 nor the canonical target peptide binding activity of PDZ4 were necessary for hepatic SR-B
179 e conclude that promiscuous and specific RNA-binding activities of PRC2 in vitro are not mutually exc
181 ecognition of apoptotic T cells, whereas the binding activity of properdin in the serum appeared to b
182 ed formation is tightly regulated by the DNA binding activity of protagonist basic leucine zipper 53
184 binding assay was performed to determine the binding activity of purified allergens and allergen extr
186 ancy, using compounds that stimulate the DNA-binding activity of RAD51 to promote cancer cell death.
189 ctedly found that ATP inhibited the oriCIIvc binding activity of RctB, suggesting that the ATP-bound
192 ore, arginine methylation fine-tunes the RNA-binding activity of REF such that the RNA-protein intera
193 egulate the phosphorylation level or the DNA-binding activity of response regulators such as Spo0F, i
197 xpressed had the general single-stranded DNA binding activity of RPA complexes, unlike the telomere-s
198 hat inhibits the in vitro and cellular ssDNA-binding activity of RPA, prevents cell cycle progression
200 on of RPT6 with XopJ is dependent on the ATP-binding activity of RPT6, but proteolytic cleavage addit
202 readouts allowed us to characterize the DNA-binding activity of SaCas9 and to optimize its sgRNA sca
203 uted across the adjacent introns and the RNA binding activity of Sam68 are necessary to repress the S
204 r factor 1, which is able to enhance the DNA binding activity of several transcription factors throug
205 we have developed assays to measure the DNA binding activity of Shelterin complexes in human cell ex
210 neutralize the Fcgamma and the V(H)3(+) Fab binding activities of SpA and provide protection from st
215 concentrations of SsoRal3 increase the ssDNA binding activity of SsoRadA approximately 9-fold and als
216 nds directly to the DBD and inhibits the DNA-binding activity of STAT3 both in vitro and in situ but
218 cells indicated that the promiscuous antigen-binding activity of subset #8 mAbs could lead to signifi
219 onsistently inhibited the expression and DNA-binding activity of T-bet, a key regulator of interferon
222 nd neurofilaments, and decreased microtubule-binding activity of tau in the brains of streptozotocin-
224 chanism by which the 5mC hydroxylase and DNA binding activities of Tet3 cooperate to control target g
225 g pERK expression also declined the promoter binding activity of TFII-I to the GRP78 promoter and in
232 eting of the complex relies on the chromatin binding activities of the MRG15 (MRG stands for mortalit
233 e nuclear retention, nuclear export, and RNA-binding activities of the multifunctional La protein and
235 ted form of B. subtilis GS regulates the DNA-binding activities of the TnrA and GlnR nitrogen transcr
237 njugation methods retained most of the EphB4 binding activity of the antibodies (83.85% +/- 3.82%, 76
242 This is likely mediated by a novel lipid binding activity of the first BRCA1 C terminus domain of
243 ng the telomeric single-stranded DNA (ssDNA)-binding activity of the human telomeric protein POT1 ind
247 hysically interact with and modulate the DNA-binding activity of the major mitochondrial nucleoid, DN
249 It is generally accepted that global DNA binding activity of the NF-kappaB avian reticuloendothel
250 y complementary roles in determining the DNA-binding activity of the NF-kappaB proteins encoded by th
251 fied that at least some component of the LPS binding activity of the PACs is via the lipid A moiety.
255 high levels in mammalian cells, retained the binding activity of the respective parental Fv domains a
258 urthermore, the data establish that the zinc-binding activity of the S100A12 protein represses the ac
259 u E10 splicing is mainly mediated by the RNA-binding activity of the second RRM and involves an intro
264 A) for characterization of the integrity and binding activity of the three mAbs in the drug product.
267 We examined the expression, structure, and binding activity of the two major S. aureus fibronectin-
270 recognition by Itk highlights a nonclassical binding activity of the well-studied SH2 domain providin
271 se activities having a role in vivo, the DNA binding activity of the Xilf3-containing CBTF complex an
273 fic B-cell populations and the sequences and binding activities of their antibodies before and during
274 ral basis of the alterations in the receptor binding activities of these mutants is also discussed.
277 el to further examine the porin and integrin-binding activities of this OMP as they relate to B. burg
280 osphorylation of PRH by CK2 inhibits the DNA binding activity of this protein and dephosphorylation r
282 y disrupting the double-stranded RNA (dsRNA)-binding activity of TLR3 ablated the chemokine/cytokine
285 ator of transcription 3 (Stat3); (b) the DNA-binding activity of transcription factors activator prot
287 iated with an increase in expression and RNA binding activity of tristetraprolin, an mRNA-binding pro
288 pes of structures, we evaluated the in vitro binding activities of two well-characterized DNA repair
289 In support of the observed host membrane binding activity of VapA, we also found that rVapA(32-18
292 ere we describe the conformations and ligand binding activities of water-soluble and membrane-bound B
296 performed to examine the transactivation and binding activities of WT, mutant, and chimeric AIREs on
298 These data suggest that the intrinsic DNA-binding activities of XRCC4 and XLF may be subject to re
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