ライフサイエンスコーパス: binding affinity to

1 state, and exhibits a significantly enhanced binding affinity to 1-aminoadamantane in aqueous solutio

2 n mutation does not disrupt the pH-dependent binding affinity to 16AP.

3 disulfide A10-A15 by a peptide bond reduced binding affinity to 32% and lowered potency to 7% but ma

4 mers derived from a monomer ( 3) showed high binding affinity to 5-HT 1D (for example, K i approximat

5 ligand physiochemical properties and ligand binding affinity to a biological transporter.

6 ning of this library to select aptamers with binding affinity to a desired small molecule.

7 ribonucleic acid (RNA) molecules with a high binding affinity to a large variety of target analytes.

8 lly profiled for the targeted and off-target binding affinity to a panel of 25 pre-selected protein k

9 e assay also allows for determination of the binding affinity to a particular sequence.

10 nd deep sequencing, was used to optimize its binding affinity to a picomolar level, and X-ray co-crys

11 anges in SH2, the I568F mutant reduces SH2's binding affinity to a pTyr-containing peptide.

12 5 mutant EKLF proteins and quantitated their binding affinity to a range of EKLF-regulated genes.

13 oduces a complex with high sequence-specific binding affinity to a single-stranded capture oligonucle

14 ide greatly increases alpha-helical content, binding affinity to a target protein, cell penetration t

15 , where genes in a linear chain have ordered binding affinity to a transcription factor, suggesting a

16 three MAbs (6C, 12C, and 12F) displayed high binding affinities to A33 (K(d) of 0.14 nM to 20 nM) and

17 s discrepant residues resulting in different binding affinity to ABA.

18 clic 1,4-diphenyltriazoles showing excellent binding affinities to Abeta aggregates (Ki = 4-30 nM), w

19 (18)F-AV-45 displayed excellent binding affinity to Abeta plaques in the AD brain by ex

20 on toward the cell cytoplasm, diminishes its binding affinity to actin skeleton, and alters the numbe

21 stability than wild-type TRB3 and increased binding affinity to Akt.

22 at solvate H-bond donor solutes with similar binding affinity to alcohol monomers.

23 lutes, and these interactions have a similar binding affinity to alcohol monomers.

24 o properties of an ideal RAF inhibitor: high-binding affinity to all RAF paralogs and maintenance of

25 design enabled a 50-fold enhancement of the binding affinity to alpha(v)beta(3) integrin receptors w

26 s have been shown previously to possess high binding affinity to alpha4beta2 but not to alpha7 nAChRs

27 soDGRFC, and CisoDGRC), which have different binding affinity to alphavbeta3 integrin, are reported f

28 ch solvate H-bond donor solutes with similar binding affinity to amide monomers.

29 , which displays enhanced hydrophobicity and binding affinity to amyloid fibrils.

30 ressed in BALB/c mice and exhibits increased binding affinity to and increased cytotoxic activity aga

31 The repeating H2A sequence enhances the binding affinity to anionic nucleic acids, forming more

32 ed annexin II receptor cDNA showed a similar binding affinity to annexin II as that observed in PSV10

33 cal response by alterations in, for example, binding affinity to another protein or enzymatic activit

34 t the juxtamembrane region of L1-CT has some binding affinity to AP2-mu2, although the specificity of

35 both time and resources spent in determining binding affinities to ASGP-R.

36 he additional glycosylation sequon increases binding affinity to avian-type alpha2-3-linked sialoside

37 two mAbs (8AH8AL and 8AH7AL) displayed high binding affinities to B5 (Kd of 0.2 and 0.7 nM).

38 hough similar in structure, showed different binding affinities to Bak and Bad BH3 peptides.

39 ps in the ligand that significantly enhanced binding affinity to Bcl-XL.

40 lso have to cause an increase in calcium-ion-binding affinity to be effective therapeutically inside

41 ied a series of small molecules showing high binding affinities to BET proteins and low nanomolar pot

42 BD2 provides a structural basis for its high binding affinity to BET proteins.

43 stituted biphenyltrienes that displayed high binding affinities to beta-amyloid plaques.

44 , which were further characterized for their binding affinity to biotin-4-fluorescein (B4F) by fluore

45 la) or Trp-127 (with Phe) did not affect the binding affinity to bombykol.

46 en prepared and evaluated for their apparent binding affinity to both Cu(I) and Cu(II).

47 used N terminus (GST-sClC3-NT) exhibited low binding affinity to both G- and F-actin.

48 ximately 4- and 80-fold improvements in pH 6-binding affinity to both human and nonhuman primate FcRn

49 l series of ligands are known for their high binding affinity to both KOR and MOR, but efficacy at th

50 However, RF2a and RF2b have different DNA-binding affinities to Box II, show distinctive expressio

51 ational change, significantly increasing the binding affinity to BTE.

52 The aptamer BT10 exhibited the highest binding affinity to BTX-2, with a dissociation constant

53 were selected for experimental validation of binding affinity to C3d, using microscale thermophoresis

54 Binding affinity to CA-IX and other CA isoforms was dete

55 utant CAP (CAP-K26Bpy-Ala) showed comparable binding affinity to CAP-WT for the consensus operator se

56 rtificial glycosylation sites, can alter CBM binding affinity to carbohydrates and may thus be a gene

57 solvate H-bond donor solutes with a similar binding affinity to carboxylic acid monomers.

58 ly, we showed that ORG27569 enhances agonist binding affinity to CB1 but inhibits G protein-dependent

59 to test labeling efficiency, stability, and binding affinity to CD56.

60 To engineer CTLA4-Ig variants with altered binding affinity to CD80 and CD86, we employed a high-th

61 ion 180-200 of the KSHV-cyclin decreases the binding affinity to Cdk6 in U2OS cells but increases the

62 O-4-amino)propan-2-ol (TOTAPOL) has a strong binding affinity to cell wall polymers (peptidoglycan).

63 d with Eu(III)-DOTA was synthesized, and the binding affinity to cells overexpressing the human melan

64 ited by cello-oligosaccharides and displayed binding affinity to cellulose although no activity was o

65 BMs target specific polysaccharides, and CBM binding affinity to cellulose is known to be proportiona

66 ion reduces SIRT2 catalytic activity and its binding affinity to centrosomes and mitotic spindles, pr

67 tations that are predicted to reduce peptide binding affinity to chromosomes, suggesting that excessi

68 the sn-2 position suffices to generate high binding affinity to class B scavenger receptors.

69 HMGB1a in particular exhibits higher binding affinity to CP-GG adducts, and the extent of dis

70 ding by HMGB1a, which may explain its higher binding affinity to CP-GG adducts, while these conformat

71 oscillations that uses differential calcium binding affinities to create a robust molecular switch t

72 oth mutations significantly increased Ca(2+) binding affinity to cTn (KCa) and KC-I.

73 tion of truncated cTnI did not affect Ca(2+) binding affinity to cTn alone.

74 ion induced a significant increase in Ca(2+) binding affinity to cTn.

75 splayed an approximately 40-fold increase in binding affinity to cynomolgus monkey FcRn (C-FcRn) at p

76 been observed previously for Pdx in terms of binding affinities to CYP101, NMR spectral differences,

77 ix-membered lactone of bufadienolides caused binding affinity to decline but inhibitory potency to in

78 of the nitrogen atoms at lower pH causes the binding affinity to decrease, releasing the alpha-CD and

79 tion of 14-3-3 proteins is the wide range of binding affinity to different ligands.

80 h separates histones based on their relative binding affinity to DNA and relative hydrophobicity.

81 The Zn2 domain exhibits high binding affinity to DNA compared with the Zn1 domain.

82 However, whereas the binding affinity to DNA of halophilic TBPs increases wit

83 heir spatial organization in nucleosomes for binding affinity to DNA.

84 wild-type (WT) HIV-1 RT would have decreased binding affinity to dTTP analogues lacking 3'-OH, compar

85 re differences in the biological actions, in binding affinities to E-cadherin promoter, and in the ta

86 the flanking acidic residues "fine tune" the binding affinity to EHD1.

87 TNYL-RAW and its derivatives displayed high binding affinity to EphB4, with equilibrium dissociation

88 phorylation of LD4 results in a reduction of binding affinity to FAK.

89 2 and IgG4 isotypes have significantly lower binding affinity to Fcgamma receptors.

90 with a low amount of fucose displayed higher binding affinity to FcgammaRIIIa and FcgammaRIIIb, but n

91 hypersialylated glycans exhibited unchanged binding affinity to FcgammaRIIIA.

92 arginine at position 435, which reduces its binding affinity to FcRn in vitro.

93 n of the gp41 ectodomain and measuring their binding affinity to fluorescein-labeled ENF.

94 sing CHO cells were only partly reflected in binding affinities to FRalpha and FRbeta or in the docki

95 MinC effects on FtsZ-GTP protofilaments and binding affinity to FtsZ-GDP were strongly dependent on

96 bazole conjugates and demonstrate their high binding affinity to G4 DNA.

97 resulted in five hits which exhibited strong binding affinities to GAB1 PH domain.

98 that a tight cavity can generate a stronger binding affinity to gas molecules than open metal sites.

99 lation by changing transcription factor (TF) binding affinities to genomic sequences.

100 at the exocyclic sulfur moiety improves tRNA binding affinity to GlnRS 10-fold compared with the unmo

101 tand in regard to human adaptation since its binding affinity to glycan receptors has not yet been qu

102 of the HIV-1 gp41 bNAb 2F5 for their antigen binding affinities to gp41 linear peptide and conformati

103 l lobe of DmAgo1 and DmAgo2 had no effect on binding affinity to guide RNAs, we observed a loss of pr

104 Increasing the binding affinity to h-Syt II may improve botulinum neuro

105 Wide variation in the SP-D binding affinity to H. pylori has been observed in clini

106 es clonally related to known antibodies with binding affinity to H7 hemagglutinin could be identified

107 Individual somatic mutations that enhance binding affinity to hapten decrease the stability of the

108 pying the hCD1d F' channel in modulating TCR binding affinity to hCD1d-lipid complexes, the formation

109 and a subset of macrophages and has similar binding affinity to HCV E2 glycoprotein.

110 Hx is the plasma protein with the highest binding affinity to heme and controls heme-iron availabi

111 pAcF IgG polymer conjugate, despite its high binding affinity to HER2 antigen, did not induce a signi

112 de toxin with known NMR structure and a high binding affinity to hERG.

113 s shown to destabilize pVHL and decrease its binding affinity to HIF.

114 resulting phosphonate analogs maintain high binding affinity to HIV-1 protease, potent antiretrovira

115 biased toward epitopes with lower predicted binding affinities to HLA-DR molecules, pointing at the

116 enhanced altered peptide ligands (CPLs) for binding affinity to HLA-A*0201.

117 ee of 10 epitopes exhibited high-to-moderate binding affinity to HLA-A*02:01 molecules.

118 Since the binding affinity to hPNP for 6-thio-ImmH is decreased 44

119 e-fold higher promoter activity and stronger binding affinity to HSF1 than the C allele.

120 SNX-7081 showed strong binding affinity to Hsp90 and expected induction of Hsp7

121 -one derived 2-aminobenzamides showed strong binding affinity to Hsp90, and optimized analogues exhib

122 everal small 2-helix proteins with excellent binding affinities to human epidermal growth factor rece

123 The SEFL variants tested showed decreased binding affinity to human and cynomolgus FcgammaRs compa

124 activity against human iNKT cells in vitro, binding affinity to human and murine CD1d molecules, and

125 us receptor binding specificity but enhances binding affinity to human cells and lung tissues from mo

126 y, several human IgG1 mutants with increased binding affinity to human FcRn at pH 6.0 were generated

127 These compounds show comparable binding affinity to human Hsp90 and its endoplasmic reti

128 ing site of H7 HA substantially increase its binding affinity to human receptor.

129 ategy to engineer DNA structures with strong binding affinity to human serum albumin (HSA).

130 ned through solid phase synthesis, and their binding affinity to hydroxyapatite, TiO2, ZrO2, CeO2, Fe

131 Consistent with its potent binding affinities to IAPs, 7 effectively antagonizes XI

132 ation of DC-SIGNR resulted in no increase in binding affinity to ICAM-3.

133 nd evaluated for their monoamine transporter binding affinities to identify potent and selective comp

134 to create a CL7 tag, which retained the full binding affinity to Im7 but was inactivated as a DNase.

135 dle of the protein exhibited higher apparent binding affinity to integrin-expressing tumor cells comp

136 r the design of linear epitopes of specified binding affinity to Intravenous Immunoglobulin (IVIg).

137 Purified AbGSC90 showed a high binding affinity to isolated SQR.

138 ides with both high-binding affinity and low binding affinity to IVIg.

139 the KIAA1549-BRAF fusion displays increased binding affinity to kinase suppressor of RAS (KSR), an R

140 The isoforms varied in their binding affinities to known downstream targets and diffe

141 804M, N806D, I813L, S815K) reduces tadalafil binding affinity to levels characteristic of PDE6.

142 11H, on the other hand, had a slightly lower binding affinity to LF (dissociation constant of 7.4 nM)

143 Single-stranded (ss) DNA aptamers with binding affinity to Listeria spp. were selected using a

144 Although 13 showed potent binding affinity to LXRbeta (IC(50) = 53 nM), it had lit

145 s of m4-1BB disclosed a very tight nanomolar binding affinity to m4-1BBL with an unexpectedly strong

146 Analogue peptides with enhanced binding affinity to major histocompatibility class (MHC)

147 bridged compound 14 demonstrates very potent binding affinity to matriptase.

148 xplains how increasing disorder can tune the binding affinity to maximize the specificity of promiscu

149 ot transported by MalFGK2 despite their high binding affinity to MBP.

150 (ReCCMSH(Arg(11))), has shown high in vitro binding affinity to MC1R and excellent in vivo melanoma-

151 These novel inhibitors exhibit low nanomolar binding affinities to Mcl-1 and >500-fold selectivity ov

152 hibitors that exhibit single digit nanomolar binding affinity to Mcl-1 and greater than 1700-fold sel

153 nd bacterial evasion, we have calculated the binding affinity to MD-2 of agonistic and antagonistic L

154 ass of compounds has a major effect on their binding affinities to MDM2, with >100-fold difference be

155 his mercury ion nucleation due to their high binding affinity to mercury.

156 ructure due to a mutation influences protein binding affinity to metabolites and/or drug molecules, a

157 Finally, MuLV RT has a 3.8-fold lower binding affinity to mismatched template/primer (T/P) sub

158 e resulting antibody fusion exhibited strong binding affinity to Motavizumab, an RSV neutralizing ant

159 High binding affinity to mu, kappa, and delta opioid receptor

160 RF-responsive transcription by enhancing its binding affinity to multiple different SRE sequences.

161 We assessed B. pseudomallei FliC peptide binding affinity to multiple HLA class II alleles and th

162 nity for zwitterionic DMPC, but had moderate binding affinity to negatively charged DMPG in 100% aque

163 oximal AP-1 motif was found to have a higher binding affinity to nontypeable H. influenzae-activated

164 NRP/B mutations that resulted in low binding affinity to NRF2 were unable to activate NRF2-mo

165 lacement of Trp-97 with tyrosine reduced the binding affinity to NTP and the catalysis step.

166 Mutant AMPK showed reduced binding affinity to nucleotides in vitro raising the pos

167 -linking of whole IgG, result in the greater binding affinity to OAPs.

168 mismatch sites with high specificities; DNA binding affinities to oligonucleotides containing single

169 h transcription factor, we measured relative binding affinities to oligonucleotides covering all poss

170 ated FcgammaRIII isoforms, without affecting binding affinity to other FcgammaRs.

171 backbone flexibility, mechanical stability, binding affinity to other interacting ligands and enzyma

172 To improve the binding affinity to p185(her2/neu) and the antitumor eff

173 characterization of ssDNA aptamers with high binding affinity to P4.

174 body (H3L2) maintained similar structure and binding affinity to parental MMGZ01 after back mutation

175 Binding affinities to peanut agglutinin and human galect

176 This mature PfPM1 showed comparable binding affinity to peptide substrates and inhibitors wi

177 f the Q1L mutant showed that the increase in binding affinity to PfPM2 was due to improvements in bot

178 oreover, Akt phosphorylation enhances merlin binding affinity to phosphatidylinositols and inhibits i

179 dy showed that bis-DOTA-hypericin had higher binding affinity to phosphatidylserine and phosphatidyle

180 Merle 46 and Merle 47 exhibited binding affinity to PKC alpha with Ki values of 7000 +/-

181 ucleotide addition and that it exhibits weak binding affinity to PPi relative to NTP, suggesting a me

182 provide novel evidence that LIL3 shows high binding affinity to protochlorophyllide, the substrate o

183 LEDGF PWWP exhibits nanomolar binding affinity to purified native MNs, but displays ma

184 Because of their high binding affinity to pyrin's B-box, PAPA-associated PSTPI

185 ranslocation to lysosomes via increased mTOR binding affinity to Rag GTPases in an Akt-independent ma

186 ir parent compound JV-1-36 and had increased binding affinities to rat pituitary GHRH receptors, but

187 trophil and macrophage migration, Met-RANTES binding affinity to rat receptors, proinflammatory cytok

188 a cell lines were generated and compared for binding affinities to recombinant human IL13Ralpha2 (rhI

189 oalloying Pt7 with boron modifies the alkene-binding affinity to reduce coking.

190 sphorylated by CDK2-cyclin E acquires a high binding affinity to Rho-associated kinase (ROCK II), and

191 nt of reconstituted powdered milk has a high binding affinity to ricin.

192 havior in addition to providing an increased binding affinity to RNA.

193 d on Thr199 by CDK2-cyclin E acquires a high binding affinity to ROCK II kinase.

194 o NPM/B23 and that NPM/B23 acquires a higher binding affinity to ROCK II upon phosphorylation on Thr(

195 channel open probability and showed enhanced binding affinity to RyR2.

196 coli GusR's preferential DNA and glucuronide binding affinity to S. enterica GusR.

197 r sequencing of the pool showing the highest binding affinity to S. enteritidis, a DNA sequence of hi

198 inding domain, we demonstrate low micromolar binding affinity to S100A1.

199 peptide, MSal 020417, demonstrated a higher binding affinity to Salmonella spp. than the commerciall

200 Its binding affinity to selectins is modulated by posttransl

201 tracyclic butyrophenones that exhibit potent binding affinities to serotonin 5-HT(2A) and dopamine D2

202 The new ligands displayed high binding affinities to SERT (Ki ranging from 0.03 to 1.4

203 e PRL promoter, and it selectively increases binding affinity to sites within the hGH-LCR.

204 Moreover, SUMO-RhoGDI had a much higher binding affinity to small Rho GTPase compared with the u

205 that alpha2,6-linked sialosides exhibit high binding affinity to SNA, while alteration in sialyl link

206 They exhibited high binding affinities to somatostatin receptor-positive tum

207 hy purification, exhibited unexpectedly high binding affinity to somatostatin receptor subtype 2, and

208 lls express inhibitory receptors with varied binding affinities to specific major histocompatibility

209 udies, the clicked bioconjugates showed high binding affinities to sstr2, with Kd values ranging from

210 st assay and exhibited about a 10-fold lower binding affinity to Ste2p.

211 5C12 (r5C12) showed similar specificity and binding affinity to Stx2 as the parent hybridoma-produce

212 e half-sites, as shown by decreased PrrA DNA binding affinities to synthetic DNA sequences without sp

213 27q, 27r, and 27t, which have low-nanomolar binding affinity to TcCYP51 and significant activity aga

214 ations, the Vgll4-4A mutant possessed higher-binding affinity to TEAD1 than wild-type Vgll4.

215 rboring both TRF2 and POT1 has the strongest binding affinity to telomeric DNA substrates comprised o

216 caused by gp2-mediated decrease of the RNAP binding affinity to template and non-template strand seg

217 teraction is highly similar in structure and binding affinity to that between SNX17 and P-selectin.

218 between H1(0) and H1c changed their overall binding affinity to that of the other variant.

219 The binding affinities to the classical AATT sequence were s

220 M, 3-5 orders of magnitude higher than their binding affinities to the corresponding mature protease.

221 incubation mixture were prioritized by their binding affinities to the FIXa protein.

222 the bound nucleotide (GDP and GTP), modulate binding affinities to the Gbetagamma subunits, receptor,

223 ecules as model systems and determined their binding affinities to the hD2 receptor.

224 AR (K324A) mutant were correlated with their binding affinities to the K324A mutant.

225 gions showed no striking difference in their binding affinities to the most frequent HLA-DR alleles.

226 iety of compound classes and evaluated their binding affinities to the neuronal voltage-gated sodium

227 es that HF2(-) and Cl(-) should have similar binding affinities to the parent triazolophane in the ga

228 nding peptide PIFtide, suggesting comparable binding affinities to the PIF pocket.

229 In addition to reporting their binding affinities to the sigma-1 and sigma-2 receptors,

230 ng substituents and have characterized their binding affinities to the sigma-1 receptor.

231 d 11 (IC(50) = 1.1-1.5 microM) showed higher binding affinities to the Src SH2 domain relative to the

232 horylation of KLF13 by PRP4 results in lower binding affinity to the A/B site of the CCL5 promoter, c

233 tive compound, 3g, had a >3-fold increase of binding affinity to the antiapoptotic Bcl-2 proteins and

234 standard antiandrogen, bicalutamide, in both binding affinity to the AR and inhibition of AR-mediated

235 The DNA sequence showing the highest binding affinity to the bacteria was further integrated

236 t-PA, the results being used as measures of binding affinity to the betaC hole.

237 of phosphorylation of the LD4 peptide on its binding affinity to the C-terminal domain of FAK.

238 act that both of these compounds have a high binding affinity to the calcium channel alpha(2)-delta p

239 Its structure, location and high binding affinity to the capsid indicate that the gp10 di

240 Although RsmA exhibited the highest binding affinity to the cfcR transcript, single deletion

241 xidases, probably because of their different binding affinity to the copper center and the relatively

242 d23 proteins demonstrate approximately equal binding affinity to the damaged DNA duplex (K(D) approxi

243 ISX that interact epistatically to increase binding affinity to the dosage compensation complex.

244 odynamic availability of the peptide and its binding affinity to the enzyme are important for TPST su

245 o potency and in vivo efficacy, although its binding affinity to the EPOR was lower than that of the

246 The order of the metabolites' binding affinity to the Factor IXa protein from the ALIS

247 These analogues were tested for their binding affinity to the five human somatostatin receptor

248 Furthermore, after PEGylation, ConA's binding affinity to the fluorescent competing ligand pre

249 We link this differential binding affinity to the free energy of deforming (bendin

250 rbohydrates and glycoproteins based on their binding affinity to the FRET sensing particles as well a

251 and Lys78Ala showed little if any change in binding affinity to the FVIII substrates.

252 te show that the s(2)U modification enhances binding affinity to the glutamine codons CAA and CAG and

253 IGF-2R with high affinity but which has low binding affinity to the IGF-1R and to the A isoform of t

254 ppearance of new oncogenic species with high binding affinity to the insulin-like growth factor 1 (IG

255 Importantly, a large difference in binding affinity to the interchangeable isomers is obser

256 nity to human and murine CD1d molecules, and binding affinity to the invariant t cell receptor of hum

257 ift assay indicated that P-RhpR has a higher binding affinity to the IR motif than RhpR.

258 oximately 10.5 has been determined for sugar-binding affinity to the lactose permease of Escherichia

259 ple molecules of Dda or due to the increased binding affinity to the longer overhangs, DNA unwinding

260 in, which has been associated with increased binding affinity to the mammalian alpha2,6Gal-linked sia

261 Receptor specific changes in binding affinity to the melanocortin receptors were obse

262 tive biochemical properties in terms of cAMP binding affinity to the N-terminal cyclic nucleotide bin

263 ntagonists displaying not only low nanomolar binding affinity to the P2Y(1)(2) receptor but also a lo

264 cetylation of HNF4alpha, which decreased its binding affinity to the PEPCK-C gene promoter.

265 VP30 showed low binding affinity to the predicted stem-loop alone or to

266 Linkage of conformational changes and binding affinity to the presence and spacing of these ad

267 nylpyridin-2-one series exhibited comparable binding affinity to the reference compound, 1-(4-methoxy

268 hanced voltage-sensor trapping via increased binding affinity to the resting state, whereas L1439A in

269 ed with each other, but not with the epitope binding affinity to the restricting HLA allele.

270 nd a glycoprotein VI (GPVI) domain with high binding affinity to the SDF-1 receptor CXCR4 and extrace

271 Because fenpropimorph has high-binding affinity to the sigma-1 receptor, we have synthe

272 ega6) with mutant omega showed a decrease in binding affinity to the sigma-factors (sigma(70), sigma(

273 cid (S77D) in the PDZ I domain decreased the binding affinity to the sodium-dependent phosphate trans

274 l predicts that a reduction in the effective binding affinity to the substrate coupled with an increa

275 the basic side chains to alanine lowered the binding affinity to the surface but did not perturb the

276 for its increased infection may be a higher binding affinity to the surface of airway epithelia than

277 orresponding unconstrained MP derivatives in binding affinity to the three transporters.

278 d in eNOS, corresponding to higher and lower binding affinity to the two isoforms, respectively.

279 Specifically, we quantify C16-KGGK's binding affinity to the two types of membrane by umbrell

280 ne fragment was found to have low micromolar binding affinity to the zinc metalloenzyme carbonic anhy

281 By comparing germinant apparent binding affinities to their known in vivo concentrations

282 t the end of the 3'-(dT)n tail increases the binding affinities to their maximum values (i.e. the sam

283 ns were evaluated for surface expression and binding affinity to their HLA-C group 1 and 2 ligands.

284 ibodies modified using the pi-clamp retained binding affinity to their targets, enabling the synthesi

285 ued for the purpose of comparing their metal binding affinities to those of other R2s.

286 f both mutations (HA190+HA212) increased the binding affinity to those glycans recognized by the HA19

287 with selectivity from 3-folds difference in binding affinity to total discrimination (K(D) of 50 nM

288 ctors harboring RT mutants with reduced dNTP binding affinity to transduce human lung fibroblasts (HL

289 e difference between TraM2 and TraM in their binding affinities to TraR and provide a structural basi

290 type was demonstrated to be important in its binding affinity to TRH receptors; the most potent stere

291 ot (knottin) miniproteins with low-picomolar binding affinity to tumor cells.

292 In addition, ING4 variants had different binding affinities to two cytoplasmic proteins, protein-

293 The probe also shows in-gel binding affinity to two lactate dehydrogenase isozymes a

294 , the N-terminal helix of Arl3 increases the binding affinity to UNC119a.

295 All three mutants show similar metal binding affinities to wild type TbetaM in the oxidized e

296 subset of 16 representative inhibitors with binding affinities to wild-type protease ranging from 58

297 For the TRTK-12 complexes, the Ca(2+)-binding affinity to wild type ((WT+TRTK)K(D)=12+/-10 muM

298 titution mutant (K143R/K146R) showed similar binding affinity to wild type apoE3, indicating that bas

299 Sera of MS patients exhibited similar binding affinity to wild-type and GrB-cleaved TAL.

300 thinylestradiol) correlated with their known binding affinities to zebrafish androgen receptor.