ライフサイエンスコーパス: binding constant

1 BP), suggesting a reduction in the inhibitor binding constant.

2 at a near one-to-one ratio with a micromolar binding constant.

3 eads over several orders of magnitude of the binding constant.

4 ics, it also leads to a decrease in the zinc binding constant.

5 quences typically causes a large decrease in binding constant.

6 g and derived an integrative heterodimer DNA binding constant.

7 diffusion methodology is utilized to obtain binding constants.

8 nd allowed the determination of the stepwise binding constants.

9 omposition and have yielded widely different binding constants.

10 immobilization artifacts and do not provide binding constants.

11 orporated into a new procedure for computing binding constants.

12 tration technique is applied to obtain their binding constants.

13 to analyze binding interactions and extract binding constants.

14 preferred means of measuring solution phase binding constants.

15 ge of specific values for rate constants and binding constants.

16 dues at the P-2 position with low micromolar binding constants.

17 ds, respectively, lowering significantly the binding constants.

18 se large compounds and their median Langmuir binding constants.

19 rs reveals ca. 10,000-fold variation Zur-DNA binding constants.

20 o antibodies with a wide range of monovalent binding constants (0.1 microM to 0.1 nM).

21 equilibrium constant (~20 mum) and the CXCR2 binding constant (1 nm) indicate that WT CXCL1 is active

22 These latter modes exhibit smaller binding constants (1.1+/-0.2x10(5) M(-1) for the 10 bp m

23 Among them, the binding constant [(2.7 +/- 0.3) x 10(8) M(-1)] of 2 with

24 body-antigen interactions with low picomolar binding constants, 2 orders of magnitude lower than prev

25 The large binding constants (3.7-5.1x10(5)M(-1)) suggest that Res

26 rates as well as the calculated equilibrium binding constant, 3.0 +/- 1.3 x 10(6) M(-1) obtained fro

27 bited FLT3-internal tandem duplication (ITD; binding constant, 70 nmol/L) and the viability of five A

28 In solution, the binding constant affording 1@3 is exceptionally high.

29 For ubiquitin, the on-rate binding constant and binding affinity for a site located

30 geometry and orientation as revealed by the binding constant and computational optimized structure.

31 Using this technique, the binding constant and packing density of the model ligand

32 retinol and retinoic acid binding sites, the binding constant and the effect of retinoid complexation

33 he effect of the dendrimer generation on the binding constant and the stoichiometry is discussed.

34 Both MOSCs show comparable binding constants and adsorb ca. 7 equiv of methylene bl

35 Binding constants and co-crystal structures of the AHIII

36 actions and a balance between the nucleotide binding constants and concentrations, complex I combines

37 he electrochemical assay demonstrated higher binding constants and dynamic range.

38 ration kinetics permitting determinations of binding constants and first-order oxidation rate constan

39 4 was also established and used to determine binding constants and kinetics of unlabeled ligands.

40 eriments are used to establish thermodynamic binding constants and poly[2]pseudorotaxane/dibenzylammo

41 Temperature-dependent functions for the binding constants and rate constants were determined for

42 onal studies were performed to determine the binding constants and suggest 1:1 complexation stoichiom

43 re-associations exist in solution, for which binding constants and thermodynamic parameters have been

44 t on the (i) concentration of MAbs, (ii) MAb binding constant, and (iii) IgG subclass.

45 ecific binding constant, the median Langmuir binding constant, and two global sorbent parameters; the

46 lts in a binding stoichiometry of 1:1 with a binding constant approximately 10(8) M(-1) at 100 mM KCl

47 The corresponding binding constants are 0.44(+/-0.05) M(-1) for Na(+) and

48 Measured PFAA binding constants are approximately 10% of those values

49 model of adduct formation is presented, and binding constants are calculated, which is based on a sp

50 At the first level, the apparent association binding constants are extracted from the measured intens

51 Binding constants are often measured by a series of expe

52 are different even though their steady state binding constants are similar.

53 F-actin binding constants are traditionally determined by centri

54 copy in the gas phase, computations, and its binding constant as a function of temperature in acetoni

55 Binding constants as high as 6 x 10(9) M(-1) have been m

56 e voltage-dependent response, we extract the binding constant, as well as the changes of the surface

57 of the mitochondrial matrix, weak nucleotide binding constants assist product dissociation.

58 average, which is an order of magnitude in a binding constant at 37 degrees C.

59 From these observations, the apparent binding constant between a single-layer of Rituximab and

60 e is demonstrated for the measurement of the binding constant between a small molecule and serum albu

61 Evaluation of the binding constant between an aptamer and a small molecule

62 ntification of interaction stoichiometry and binding constant between bacteria (or other microorganis

63 ination of the interaction stoichiometry and binding constant between bacteria and (macro)molecules.

64 rates show a two orders of magnitude larger binding constant between DNA and T7 RNA polymerase, and

65 The binding constant between SEB and peptide-nanoparticle co

66 ophoresis (CE) is also used to determine the binding constant between the doxepin E and Z geometric i

67 (8) ITC-derived binding constants between 3 and DNA duplexes have the fo

68 used to create a device capable of measuring binding constants between a protein and a small ion base

69 However, precise determination of binding constants between partners is not highly reliabl

70 2:1 binding model, yielding estimates of 2:1 binding constants between some of the macrocycles and MA

71 The binding parameters such as binding constant, binding site size and diffusion coeffi

72 possible to compute the in vivo equilibrium-binding constant but not binding on- and off-rates.

73 hows charge disproportionation increases the binding constant by no less than approximately 5 orders

74 id species is able to change the equilibrium binding constant by orders of magnitude.

75 mg of Cu/mg of DOM, the measured conditional binding constant ((c)K(CuDOM)) decreased from 10(11.5) t

76 y bound pelargonidin at both pH 7.0 and 3.0 (binding constants ca. 1.0x10(5) at 25.0 degrees C).

77 p-LFER below the cutoff, the median Langmuir binding constants can be predicted with a root-mean squa

78 to O(R)2 produced equal increase in RNAP-DNA binding constant (compared to wild-type increase in the

79 Binding constants confirm that the inward-facing electro

80 of pectic polysaccharide the copigmentation binding constants decreased.

81 Inhibitor binding constants derived from steady-state kinetic expe

82 The highest binding constant detected in this study was 3.3 x 10(6)

83 negative ion photoelectron spectroscopy and binding constant determinations with Cl(-).

84 Comparison between the macroscopic Ca(2+)-binding constants, directly measured by competition with

85 he residence times and, correspondingly, the binding constants dropped by more than an order of magni

86 Experimental binding constants, enthalpies, and entropies of interact

87 Binding constants exceeding 10(14) M(-1) have been measu

88 The binding constant for A2E and purified RPE65 was calculat

89 arboxylates with four-carbon chains, and the binding constant for association of fumaric acid and 4 i

90 The binding constant for CYP2B4 Compound I was about 1 order

91 itrocellulose filter binding reveal that the binding constant for I(1) at 25 degrees C is approximate

92 thyl viologen, MeV) suggests that the higher binding constant for intercalation of DAAQ may be partia

93 We find a high binding constant for iron(III) (log beta2=35).

94 ine the protein-induced Delta Lk and the DNA-binding constant for lambda O and GalR, but also we demo

95 s confirm that ExsA enhances the equilibrium binding constant for RNAP while having only a modest eff

96 In contrast, the binding constant for the active site docking step is str

97 hat explains the roughness dependence of the binding constant for the anchored proteins from membrane

98 eals a 3 orders of magnitude decrease in the binding constant for the capture of a free oligonucleoti

99 eraction in cell lysates and the equilibrium binding constant for the interaction in vitro.

100 a single NMR titration suffices to determine binding constants for all other detectable and resolvabl

101 Multiphoton FRAP provided the specific binding constants for alpha-synuclein's binding to synap

102 Metal binding constants for BDP, determined by competition iso

103 n had been previously shown to retain low nM binding constants for both the GDNF receptor and the mou

104 e first time, resulting in the estimation of binding constants for C4P with the ion pairs of A336(+)

105 Their respective binding constants for Ca2+, for example, are 1.5 x 10(6)

106 Transition state binding constants for catalysts in the specific base rea

107 ion specific by comparing relative metal ion binding constants for Cd(2+) and Zn(2+).

108 ts into the large discrepancies reported for binding constants for cellulases and suggest that produc

109 a seventh-order polynomial to calculate five binding constants for each of the individual steps in pr

110 antagonist model to determine the antagonist binding constants for each site, L(alphaepsilon) and L(a

111 g pH, permeability coefficients and membrane binding constants for each species of TPT were determine

112 l electrophysiology to measure independently binding constants for four different agonists, to both r

113 en constants for disassembly, and SNAP-SNARE binding constants for four different ternary SNARE compl

114 (pp-LFER) is able to predict median Langmuir binding constants for graphite, charcoal, and Darco gran

115 derivatives vs mu-oxo dimeric heme, measure binding constants for monomeric vs dimeric heme, and qua

116 Substrate binding constants for P450 Compound I are important for

117 ion that are centred near the characteristic binding constants for polyacid interactions.

118 vities of soluble and immobilized ligand and binding constants for the association of immobilized pro

119 Binding constants for the complexation between Na-Cas an

120 ally, determine by microscale thermophoresis binding constants for the interaction of A46 with the TI

121 The binding constants for the interaction of teicoplanin and

122 0 mM displayed saturation kinetics that gave binding constants for the substrate in the Compound I sp

123 the T state without affecting the intrinsic binding constants for the two Ca(2+) sites.

124 sing a Michaelis-Menten approach, the oxygen binding constants for the two catalyst systems were dete

125 their N(3)H units provided greater apparent binding constants for their complexes with receptor 1a,

126 te that the pronounced difference in surface binding constants for these two similar antibodies is du

127 Differential measurements have quantified binding constants for vancomycin-sensitive and vancomyci

128 f the mutant on catalytic rate constants and binding constants for various substrates are the same as

129 a complementing set of cooperative networks, binding constants from approximately 0.1 nM to approxima

130 -state enzyme kinetic parameters and product binding constants from non-linear kinetic time courses w

131 Detailed boron binding constants have been measured for vibrioferrin, r

132 almost independently of the ligand-receptor binding constant in a broad range of this parameter.

133 omplex 1-FMes2B-2-MePh2P-(C6H4) (2-F) with a binding constant in MeOH exceeding that of 1-Mes2B-4-MeP

134 N53S showed a binding constant in the low micromolar range, similar to

135 al hydrophobic cavity of the channel, with a binding constant in the range of ~0.1-1 muM.

136 a1L-CTT forms oligomers cooperatively with a binding constant in the submicromolar range.

137 A binding constant in this range is necessary but not suff

138 al in primary structure but differ in oxygen binding constants in accordance with their distinct phys

139 ron spectroscopy, and determination of their binding constants in acetonitrile.

140 With Ca(2+)- and Mg(2+)-binding constants in excess of 10(8) and 10(4) M(-1), re

141 The binding constants in solution were obtained from fluores

142 ing constant (Qax), a ratio of the substrate binding constants in the absence versus presence of an a

143 ncompetitive nature of these inhibitors with binding constants in the low micromolar range.

144 Equilibrium binding constants in the micromolar to picomolar range w

145 The binding constant increases from glu(2-) to adi(2-) and t

146 on experiments reveal that the corresponding binding constant is about 3 orders of magnitude higher t

147 bserved in both cell lines that the PBAE-DNA binding constant is biphasic with the transfection effic

148 ITC is determined less by c (the product of binding constant K and titrand concentration [M](0)) tha

149 The largest decrease in binding constant K(A) (8-fold) for a single mutation was

150 for template binding and a lower equilibrium binding constant K(d) for the template, leading to a tem

151 Both the binding constant K(obs) and enthalpy Delta H degrees (ob

152 ned their equilibrium dissociation GPIbalpha binding constants ( K Ds) of 64, 0.74, and 31 nM, respec

153 nts, equal to the product of the equilibrium binding constant (K(bind)) and the first-order oxidation

154 jor features of any enzymatic catalysis: the binding constant (K(D)) and the catalytic turnover rate,

155 intensity on the addition of glucose, with a binding constant (K(d)) of 11 mM, an operating range of

156 itration calorimetry experiments indicated a binding constant (K(d)) of 380 nM.

157 PDGF receptors on VSMCs without altering the binding constant (K(d)), raising the possibility that ES

158 n addition, we estimate that the equilibrium binding constant (K(eq)) for 15 nm DNA-Au NPs (3 base pa

159 Equilibrium binding constant (K(i)) determinations using [(14)C]epot

160 The equilibrium O(2) binding constant (K(O(2)), DeltaH degrees , DeltaS degre

161 is enthalpy driven and highly stable, with a binding constant (K(obs)) of 5.5x10(6) M(-1) and enthalp

162 queous solutions containing 95% water with a binding constant (K) of 700+/-30 M(-1).

163 due to the formation of AR-BSA complex, with binding constant (K) ranging from 3.26+/-0.09 to 8.08+/-

164 The binding constant (K) value calculated for MTX was 3.821x

165 H(2)O/MeOH (9:1 vol.) show that the fluoride binding constants (K = 840(+/-50) M(-1) for [1](+), 2500

166 n kinetics, which permitted solution of both binding constants (K(bind)) and first-order oxidation ra

167 ribing triplex formation include equilibrium binding constants (K(eq)) and association/dissociation r

168 We evaluated the DNA binding constant, K(b), for each dye.

169 For both HWKK and KWKK, equilibrium binding constants, K(obs), and magnitudes of log-log sal

170 S in a 2:1 stoichiometry and with an average binding constant Ka = (2.0 +/- 0.2) x 10(8) M(-1) or Kd

171 hort-armed" cryptand 3, did display a higher binding constant (Ka = 2.4 x 10(5) M(-1)) with paraquats

172 The binding constants (Ka) associated with the complexation

173 We report the measurement of the binding constants (Ka) for cucurbit[n]uril (n = 7, 8) to

174 t RA binds CD with a 1:1 stoichiometry and a binding constant Kb of 445 (+/-53) M(-1) or 465 (+/-81)

175 a comparison between these and experimental binding constants (Kb) for binding of a series of radica

176 ntate urea derivatives, in order to estimate binding constants (Kb) for the hydrogen-bonding process.

177 The copigmentation binding constants (KCP) for the interaction between malv

178 The measured binding constant (Kd = 5.645 x 10(3) M(-1)) indicated st

179 t, whose stoichiometry (1:1) and equilibrium binding constant (KD approximately 6.4 muM) were determi

180 The binding constant (Kd) discerned for the dye and HRP-II t

181 ty >800-fold lower (equilibrium dissociation binding constant [KD] = 7.56 x 10(-8)M) than its BoNT/F

182 logen, with high selectivity and equilibrium binding constants (Keq up to 10(14) M(-2)).

183 parameters, specifically the median Langmuir binding constants, KL, obtained utilizing the single-che

184 Relative binding constant (Krel) determinations revealed that the

185 ve analogue of Fe(III), provided conditional binding constant log beta(12)' = 13.3 +/- 0.2 for a [Ga(

186 A comparison of the binding constants measured by CLE-SPE with those measure

187 cy cannot be explained solely by the p53-DNA binding constants measured in vitro.

188 beginning of the curves using the inhibitor-binding constants measured under the same experimental c

189 ism are evidenced from emission, NMR, FT-IR, binding constant measurement, Job's plot, ICD spectra, E

190 The binding constant measurements are consistent with earlie

191 cryptands, is responsible for the very high binding constants observed for their complexes with Grou

192 cific binding events are fit to the apparent binding constants obtained from the first level of model

193 Binding constants obtained via GFET and AFM were compara

194 A strong binding constant of 0.55x10(6) L mole(-1) between the HS

195 ly 1 binding site per casein molecule, and a binding constant of 0.6-5.6 x 10(4)M(-1).

196 The results demonstrate a binding constant of 1.1 muM for the Ca(2+)/CaM pair and

197 isotropy measurements yielded an equilibrium binding constant of 1.4 or 10.7 muM for the alkaline pho

198 r cage can encapsulate xenon in water with a binding constant of 16 M(-1).

199 uBAT mutant binds the SSRI sertraline with a binding constant of 18 nM and displays high-affinity bin

200 We determined the binding constant of 2-fluoro-5-aminophenyl boronic acid

201 s a noncooperative 34 bp binding mode with a binding constant of 2.1+/-0.4x10(6) M(-1), and a binding

202 in monomers per betaCaMKII holoenzyme with a binding constant of 2.4 x 10(5) m(-1).

203 ell based quartz-crystal microbalance, and a binding constant of 2.5 x 10(5) M(-1) was calculated on

204 a concentration-dependent manner, yielding a binding constant of 2.9 x 10(5) m(-1), consistent with t

205 ery high affinity for xenon in water, with a binding constant of 2.9(2) x 10(4) M(-1) as measured by

206 bands of the uranyl cation yielded a uranyl binding constant of 3(1) x 10(7) M(-1), corresponding to

207 tom frustule biosilica had a half-saturation binding constant of 6.4 +/- 2.4.10(-8)M and statisticall

208 o which it binds in 1:1 stoichiometry with a binding constant of approximately 1.0 x 10(5)M(-1).

209 own to interact in vitro with an equilibrium binding constant of approximately 310 nM.

210 The binding constant of APSAL for H(2)AsO(4)(-) has been det

211 ith each other, and UV titrations revealed a binding constant of ca. 10(3) for the guest Pd(II) ions,

212 Cl(-) anions can be attributed to the higher binding constant of Cl(-) with the anion receptor and th

213 ght but significant (p=0.05) increase in the binding constant of curcumin to processed PC, which may

214 The apparent binding constant of curcuminoids to whole buttermilk was

215 The binding constant of diquat 4 by cryptand 12 is nearly 6-

216 xceptionally high substrate affinity, with a binding constant of K = 5.0 x 10(6) M(-1) for its best s

217 omposed of SiO2 NPs of 300nm diameter with a binding constant of k=1.7(pM)(-1), sensitivity of 6.9nm/

218 The result was a binding constant of Ka >10(5) M(-1) from ammonium-carbox

219 esults provide a useful route to compute the binding constant of membrane-anchored receptor and ligan

220 n can substantially increase the equilibrium binding constant of MPG toward Hx, but under single-turn

221 n calorimetry measurements revealed that the binding constant of NADPH to the C298S mutant is decreas

222 nimal fluorescence-quenching effect and weak binding constant of nucleozin to the swine-origin influe

223 y fluorescence correlation spectroscopy, the binding constant of purified AKAP18delta fragments to la

224 The binding constant of RecF protein, in the presence of the

225 Because the binding constant of soluble proteins is readily accessib

226 nement and that relates this constant to the binding constant of soluble proteins without membrane an

227 orescence spectroscopy is used to obtain the binding constant of the analog intermediate, equilenin.

228 We find that the binding constant of the anchored proteins strongly decre

229 x 10-6 M) similar in magnitude to the pseudo-binding constant of the bicyclic ent-copalyl diphosphate

230 adhesion processes depend sensitively on the binding constant of the membrane-anchored receptor and l

231 showed saturation kinetics with an apparent binding constant of Zn(II) to the [enzyme-TPPS] complex

232 ry (ITC) and UV/vis spectroscopy, leading to binding constants of (5.0 +/- 0.6) x 10(4) M(-1) and (7.

233 +, Ca2+, and the unprotonated ionophore with binding constants of 10(3.5), 10(1.8), 10(6.8), and 10(4

234 Binding constants of 10(5)-10(7) M(-1) magnitude and 1:1

235 ibution, it is possible to determine all the binding constants of a ligand to a highly multimeric coo

236 The Hammett plot for the binding constants of AcO(-) with 3- and 4-substituted ph

237 The values of the 14 binding constants of ATP to GroEL were determined, and t

238 here is no comparative data available on the binding constants of Concanavalin A (Con A) and glycogen

239 The overall binding constants of DNA-theophylline = 3.5x10(3) M(-1),

240 ing specificity of cyclase activation, tuned binding constants of effector proteins, and physical int

241 ution assay method based on BSI to determine binding constants of GCAP1 and GCAP2 to the full-length

242 es a powerful approach to accurately measure binding constants of interactions between membrane bound

243 anes of the endoplasmic reticulum, obtaining binding constants of k(on) approximately 255/s and k(off

244 philic and hydrophobic contacts with overall binding constants of K(retinol-)(alpha)(-caseins)=1.21 (

245 plateau is observed for the median Langmuir binding constants of larger molecular volume sorbates.

246 In a single experiment, the binding constants of one protein interacting with all li

247 We report the direct measurement of ligand-binding constants of organolithium complexes using a (1)

248 Using this method, we measured the binding constants of potassium and strontium cations wit

249 is approach allowed direct comparison of the binding constants of prothrombin, factor X, activated fa

250 o monitor receptor activity and characterize binding constants of small-molecule antagonists spanning

251 AC assay can be employed to determine ligand binding constants of systems where the lanthanide platfo

252 form, BSI, we then studied the effect on the binding constants of the ConA-carbohydrate interactions

253 Furthermore, the binding constants of the host guest complexes were estim

254 While the binding constants of the metal cations to the XFs were l

255 tion rates and specific-nonspecific relative binding constants of the restriction nuclease EcoRI enab

256 The binding constants of the so-prepared cross-linked polyme

257 The binding constants of these triols with zero to three CF3

258 g force to the association, and resulting in binding constants of up to 10(6) M(-1) for aromatic anal

259 Binding constants of up to 90 300+/-8700 m(-1) were obta

260 to a Langmuir isotherm yielded a calculated binding constant on the order of approximately 10(7) M(-

261 effect of Mg(2+) was observed for either the binding constant or the enthalpy of binding (Delta H(obs

262 binding strength have generally not measured binding constants over the same Cu:DOM ratios.

263 g only yield minor changes in rate until the binding constant passes a threshold value.

264 ), which compares favorably to the intrinsic binding constant presented in the literature for the mon

265 h a serine hydrolase probe (with equilibrium binding constants ranging from 4 to 120 muM).

266 terface in the homotetrameric structure with binding constants relative to dioleoylphosphatidylcholin

267 ration calorimetry, the determination of the binding constants requires a significant amount of time

268 og-log salt concentration derivatives of the binding constants (Sk(i)) even though their binding site

269 purposes, reacted with benzphetamine with a binding constant that was nearly an order of magnitude s

270 mbrane surface, displays considerably larger binding constants that are largely attributed to loss of

271 ion factors bound to a DNA promoter, (2) the binding constants that describe the affinity of the prot

272 A single sorbate-specific binding constant, the median Langmuir binding constant,

273 uch as the stoichiometry of the complex, the binding constant, the relative degrees of occupancy of t

274 cal temperature and decreases the ring-stalk binding constant, thereby unblocking the pore and releas

275 tra and molecular modeling increase the BPDE binding constant to G in codon 248 consistent with a pat

276 utions, which enables a determination of the binding constant to the diamine via luminescence quenchi

277 ous DMSO and pure water correlate with their binding constants to 4-nitrophenyl phosphate dianion (K(

278 propagation velocity on the ligand receptor binding constant under influence of the convective trans

279 affinity of SA to BSA was demonstrated by a binding constant value (1.09x10(3) at 310 degrees K).

280 inside the CD cavity, which is evident from binding constant values and molecular modeling studies.

281 on, but experimental measurements of product-binding constants vary significantly, and there is littl

282 The CN- binding constant was 2.3 x 10(6) (mol/kg)(-1), which is

283 N:P of 2 and was positively cooperative; the binding constant was calculated in the range of 10(5) M(

284 mplex was determined by a Job's plot and the binding constant was estimated from a linear regression

285 atrol interacted with both proteins, but the binding constant was higher for zein than for gliadin at

286 The binding constant was of the order of 10(5)L.mol(-1) by f

287 degrees C for 10min; a similar trend in the binding constants was also observed with casein micelles

288 Comparison of these binding constants was used to establish positive coopera

289 To decrease the enzyme binding constant, we propose to shield the substrate bin

290 y and the standard deviation of the Langmuir binding constant were employed.

291 Although significant differences in binding constant were not observed between surfaces with

292 cting" hydroxyl groups on the structures and binding constants were also explored, and surprisingly t

293 For COS ligands with a DP of 2-3 the binding constants were around 10(5) m(-1), and for longe

294 o investigate the underlying thermodynamics, binding constants were determined at 25.0, 35.0, and 45.

295 The surface binding constants were determined by microfluidic techni

296 Thermodynamic parameters and the binding constants were obtained following titration of t

297 s of pH and structure of anthocyanins on the binding constants were studied.

298 of the film broadens the range of the cation-binding constants, which leads to wide sensitivity range

299 efficacy and that the optimal values of the binding constant with respect to the transfection effica

300 nding kinetics for comparison of equilibrium binding constants with other SBP domain proteins.