ライフサイエンスコーパス: binding interface

1 ensity at their N termini (a proposed myosin-binding interface).

2 and chemical features of the ligand-protein binding interfaces).

3 domain that are located distal to the Galpha-binding interface.

4 substitutions at the DNase-Immunity protein binding interface.

5 ces flanking the platelet GPIbalpha receptor binding interface.

6 mer with a flat and extensive cationic lipid binding interface.

7 rypsin cleavage sites, are excluded from the binding interface.

8 -helix that sterically blocks its ETS domain binding interface.

9 these residues line a potential nucleic acid-binding interface.

10 surface of the beta-region in A2 as the MurA-binding interface.

11 racterize because they are hidden inside the binding interface.

12 membrane surfaces through a protein-protein binding interface.

13 e and Arg2320 is poised at the center of the binding interface.

14 inhibitor and is located along the substrate-binding interface.

15 ed carboxy-terminal tail and burying its PER-binding interface.

16 bilayers through a positively charged lipid-binding interface.

17 -terminal extension, altering the Psb27-CP43 binding interface.

18 protein known to form part of the substrate-binding interface.

19 Their assembly required a cadherin cis-binding interface.

20 m which we define accurately the CAP-Gly/EB1 binding interface.

21 s a result of only two mutations outside the binding interface.

22 that both the P- and D-loop form part of the binding interface.

23 hromoshadow domain does not provide a direct binding interface.

24 (5F)W was substituted for residues near the binding interface.

25 teractions taking place at the TNF-alpha-Fab binding interface.

26 n the protein that the position is part of a binding interface.

27 ith the surface of a protein and augment the binding interface.

28 merous symmetry and distortion at a receptor-binding interface.

29 en interactions with PML and an emergent MRN binding interface.

30 site and lie close to the clamp loader-clamp-binding interface.

31 ns of numerous residues at the Nop10 and RNA binding interface.

32 erous side chain interactions at the CheY-P2 binding interface.

33 PPI was attributable to changes outside the binding interface.

34 rather than through the evolution of a novel binding interface.

35 l compounds capable of inhibiting the RPA70N binding interface.

36 structural changes, in regions far from the binding interface.

37 ossible steric hindrance/perturbation at the binding interface.

38 ve motion of water molecules to create a dry binding interface.

39 ional changes and formation of the G-protein-binding interface.

40 of the PLC-beta PH domain as the Gbetagamma binding interface.

41 to a conformational switch distant from the binding interface.

42 ially overlaps the well-characterized EB1:MT binding interface.

43 ctions by stabilizing the PECAM-1 homophilic binding interface.

44 rinsic heterogeneity at its BH3-only protein binding interface.

45 parameters were used to map the cytb 5-cyt c binding interface.

46 bility to sterically occlude the M-CSF.c-FMS binding interface.

47 xisting methods for mapping kinase-substrate binding interfaces.

48 (L249-S252 and Y254) that can act as direct binding interfaces.

49 ed one binding site delineated by 3 putative binding interfaces.

50 bridge linking the primary and complementary binding interfaces.

51 combination of both in stabilizing specific binding interfaces.

52 even among protein complexes with identical binding interfaces.

53 e protein surface regions to identify ligand binding interfaces.

54 imilar surface regions should create similar binding interfaces.

55 s than ribose 2'-OH in both the RIalpha-cAMP binding interfaces.

56 s rolling, typically to alternate and weaker binding interfaces.

57 rization and the availability of alternative binding interfaces.

58 ow these plant viruses maximize their use of binding interfaces.

59 set of secondary-structure-based packing at binding interfaces.

60 tease dimers that reveal a putative collagen-binding interface aided by glycosaminoglycans.

61 here a myosin structure possessing an actin-binding interface and a tunnel (back door) that creates

62 tated all histidine residues in the collagen binding interface and additionally all of those that wer

63 ic residues that alternately serve as a p120-binding interface and an endocytic signal.

64 Cys(820) thiolate within the low dielectric binding interface and Arg(506) functions to orient Glu(5

65 ctrometry validated the identified substrate-binding interface and demonstrate that TRiC contacts ful

66 M variants with mutations both in the direct binding interface and distant from the binding site.

67 mapped Bro1 residues that constitute the NC binding interface and found that they are critical for f

68 be a combination of studies that explore the binding interface and functional role of a previously id

69 specificity were far from the proteins' DNA-binding interface and interacted epistatically to change

70 x complexes formed in the MOM, including the binding interface and membrane topology, using site-spec

71 ication between the active site, microtubule-binding interface and neck-linker via loop7 and loop13.

72 ry may challenge our view of the protein-RNA binding interface and provide a unique solution for futu

73 es reflects their functions in forming a Cdk binding interface and that the ability of these prolines

74 4-Gly295 hinge region to the opposite serine binding interface and that this is most likely propagate

75 des the communication link between the actin-binding interface and the nucleotide pocket.

76 two functional sites of the betaSBD-the NBD binding interface and the substrate-binding site-confers

77 for TNF-R1 is closely linked with the TRAF2 binding interface, and (iii) the assembly of homomeric T

78 f MeCP2-DNA for mutations around the MBD-DNA binding interface, and defective chromatin clustering fo

79 enuation and a more specific protein-protein binding interface are observed in bicelles as compared w

80 ates across the protein structure and at the binding interface are reflective of those observed in SH

81 ternary complexes where unnatural symmetric binding interfaces are favored over canonical antibody i

82 However, binding interfaces are frequently affected by amino acid

83 phylogenetic differences in the sequences of binding interfaces are not the result of adaptive fine t

84 and that the overall domain arrangements and binding interfaces are preserved on passing from the cry

85 howed that the locations of the carbohydrate binding interfaces are shared with the sialic acid-depen

86 Met257 and Met433 were located near the FcRn binding interface as indicated by HDX MS and structural

87 KMN) network acts as the primary microtubule-binding interface at kinetochores [3] and provides a pla

88 A11 altered Foxo1a's access to the conserved binding interface at the HoxA11 homeodomain.

89 rent affinities for DNA, despite the CAP-DNA-binding interfaces being essentially identical in the va

90 hich we challenged our students to study the binding interface between 2 important biosynthetic prote

91 , replacing CENP-A S68 with E68 disrupts the binding interface between CENP-A and HJURP in all-atom M

92 molecular simulations, we predicted that the binding interface between DARPin off7 and its ligand (ma

93 ions involving eIF5B and eIF1A: (i) a second binding interface between eIF5B and eIF1A; (ii) a dynami

94 semen, suggesting that interfering with the binding interface between fibronectin and the amyloids c

95 n interacting region (PPIR), which forms the binding interface between interacting polypeptide chains

96 ving key residues in the active site and the binding interface between kinesin and microtubule.

97 The binding interface between LmP and LmCytc has one strong

98 P gamma-phosphate is found at the nucleotide-binding interface between RAD51 subunits of the NPF know

99 oulombic interactions across the nonspecific-binding interface between RNA and protonated histidine o

100 tabilized alpha-helix designed to target the binding interface between the C-terminal transactivation

101 We show a binding interface between the GFI1 linker and the SP-RIN

102 We show that the circular binding interface between the pore lumen and the folded

103 Surprisingly, we also observed a second binding interface between the two proteins that involves

104 50 amino acids) that can naturally mimic the binding interfaces between proteins and thus, influence

105 ificant reduction in loop flexibility at the binding interface, but in a number of cases it can also

106 is found to be important in determining the binding interface, but it is insufficient.

107 e ligand and received by the receptor at the binding interface; but their transmission over space and

108 g approach to map the CR4/5-TRBD RNA-protein binding interface by identifying RNA and protein residue

109 thout the need to disrupt the strand-swapped binding interface by mutagenesis.

110 erefore we targeted specific residues in the binding interface by rational design generating improved

111 o an allosteric creation of a more favorable binding interface by the first ligand.

112 core mutations in MarA (distant from the DNA-binding interface) change the relative affinities of its

113 e Sgf73 ZnF, binds to nucleosomal DNA with a binding interface composed of arginine residues located

114 the VEGF-A protein molecule showed that the binding interface comprised a contact surface area of ap

115 The binding interface comprises a central tryptophan within

116 ss-Tipin interaction is based on a composite binding interface comprising different domains of Timele

117 4C revealed an untwisted, flat, carbohydrate-binding interface comprising the side chains of four try

118 N-glycan termini, which are distal from the binding interface, contribute to the affinity.

119 f BAP1, which generate a composite ubiquitin-binding interface (CUBI).

120 nd that A3A binds ssRNA, but the RNA and DNA binding interfaces differ and no deamination of ssRNA is

121 Mutations at the binding interface disrupt the Vps33A-Vps16 interaction b

122 Mutations in the TDP2 UBA-Ub binding interface do not affect nuclear import of TDP2,

123 markable analytical platform for bioaffinity binding interface due to its favorable combination of ex

124 re of the additional carboxyl-amino terminal binding interface during self-assembly, are important as

125 tation of either the dimerisation or the DNA binding interface eliminates ParB-GFP foci formation in

126 We show how the physical simplicity of this binding interface enabled the evolution of a new protein

127 This discrete binding interface enables the PAR glycohydrolase (PARG)

128 Examination of a set of protein binding interfaces establishes good agreement between re

129 This is the first binding interface experiment to successfully demonstrate

130 Remarkably, the optimization of binding interfaces favors networks in which a few protei

131 3, and Thr345) could act as membrane anchor, binding interface for a second rhodopsin, or rearrange c

132 emphasizing the importance of the NCAM/EphA3 binding interface for cluster formation.

133 by occupying the activation function (AF)-2 binding interface for coactivators and N-terminal AR AF-

134 To identify "hot spot" residues in the ETON binding interface for STIM1 interaction, numerous Orai1

135 The recent identification of a functional binding interface for the E3-ubiquitin ligase CHIP withi

136 nal half (residues 1-440) of TRUSS, (ii) the binding interface for TNF-R1 is closely linked with the

137 ycles, we mapped the energy landscape of the binding interface for two interacting disordered domains

138 ffold in infected cells and creates distinct binding interfaces for different cellular target protein

139 of short linear motifs (SLiMs) that serve as binding interfaces for modular protein domains.

140 inding site at helices 1 and 2 of UBXD1-N as binding interfaces for p97.

141 ing, we present a description of a potential binding interface formed between the E2 protein and CD81

142 While the STIM1 and Orai1 binding interfaces have been mapped, signaling mechanism

143 nments of protein-ligand and protein-protein binding interfaces, identifying individual amino acids t

144 itical host defense protein have altered its binding interface in a way that has resulted in a qualit

145 The CaM-binding interface in Akt(PHD) was mapped to two loops ad

146 43 that are crucial for the formation of the binding interface in Arabidopsis.

147 The structures revealed a conserved ligand-binding interface in D2 and a unique mechanism for VEGFR

148 Complementarily, a 106-A-long substrate-binding interface in Hsp90 enables many low-affinity con

149 We previously characterized the TRN-SR2 binding interface in IN and introduced mutations at thes

150 evealed that this region defines a major RNA binding interface in MHV with site-directed spin labelin

151 Although the SH2 domain is a less common binding interface in Shc proteins, we demonstrate that i

152 mpeting small molecule interact at the known binding interface in solution.

153 egulatory mechanism of GCAPs including their binding interface in the target is unresolved.

154 How the three unique potential receptor-binding interfaces in LTalpha1beta2 trigger signaling vi

155 The binding interface involves all elements of the zinc fing

156 ith Ca(2+) or thapsigargin suggests that the binding interface is altered by SERCA conformational cha

157 Our results suggest that the MtrC/E binding interface is an important modulator of MtrE func

158 at a prevalence of high loop rigidity at the binding interface is an indicator of increased binding s

159 The binding interface is centered on the C-terminal domain o

160 The significance of this membrane-binding interface is established through SOD1 activity a

161 m other forms of oligomerization in that the binding interface is formed by reciprocal exchange of po

162 Each binding interface is highly electrostatic, with positive

163 lex with 1918/H1 HA revealed that the actual binding interface is nearly identical to that in the com

164 The binding interface is organized to arrange contacts betwe

165 ue that is positioned distal to the TCR-pMHC binding interface is shown to contribute to the peptide

166 region 5Y-CAP (R94A, D95A, Y98F) and the DNA-binding interface (K201A, G202E, R209A, K242A).

167 bstitutions at residues in the predicted RNA-binding interface (K42C/C71V, R46C/C71V, V95C/C71V) were

168 The extensive capsid-binding interface maps on the structurally divergent fac

169 We discuss how such a complex microtubule-binding interface may facilitate the coupling of depolym

170 Detailed knowledge of the binding interface now at hand gives the potential to exp

171 he results support that the BH3-only protein binding interface of Bcl-xL is much more dynamic compare

172 inking loops L1 and L2, which constitute the binding interface of BPTI.

173 -terminal helix of the receptor, whereas the binding interface of CheW is placed between the beta-str

174 DISC1 polymorphisms at the binding interface of DISC1-NDEL1 complex have been impli

175 e use a chemical biology approach to map the binding interface of ERK and Cic.

176 Here, we identified the MAD2-binding interface of FAT10 to be located on its first ub

177 se it links centromeres with the microtubule-binding interface of kinetochores.

178 at CTD is a part of an extensive kinetochore-binding interface of Mad1, and rationalize graded kineto

179 ments provide evidence that the observed DNA-binding interface of MHF is important for cellular resis

180 ion of a single glycine within the GPIbalpha binding interface of normal VWF enhances the probability

181 "free head" can bind to actin, but the actin binding interface of the "blocked head" is involved in i

182 By targeting the binding interface of the gammac and cytokines, we succes

183 We propose an RNA binding interface of the MthRnl based on the mutational

184 ation, and water molecules structured in the binding interface of the nSH3:PRM complex.

185 on, NMR experiments are used to identify the binding interface of the P450-cytb5 complex in the nanod

186 stitution disrupted the high-affinity ligand-binding interface of the prolactin receptor, resulting i

187 PCNA-binding interface of the Rev1-BRCT domain comprises cons

188 ariations in interaction strength across the binding interface of the two complexes.

189 e morphogenetic protein subfamily, where the binding interface of the type I receptor is highly flexi

190 4A and G1324S) within the platelet GPIbalpha binding interface of the VWF A1 domain impair the hemost

191 The binding interface of ubiquitin with liposomes is mapped

192 larity of Sk(i) values, we conclude that the binding interfaces of all three modes involve the same r

193 upon filament formation monitor the specific binding interfaces of ASC-PYD association.

194 Here, we map the binding interfaces of complexes formed between RT and ap

195 chemical shift perturbation to identify the binding interfaces of IscX and IscU in their complex.

196 ludes both the N- and C-terminal Gtbetagamma binding interfaces of phosphorylated Pdc, thus providing

197 The DNA-binding interfaces of the androgen (AR) and glucocortico

198 t collection, effectively target the dynamic binding interfaces of the GACKIX domain of the coactivat

199 tron resonance, has been utilized to map the binding interfaces of the two proteins in the complex an

200 The binding interfaces of transient interactions frequently

201 The binding interface on AGB1 was deduced using a comparativ

202 ognate receptor(s) have revealed a conserved binding interface on hIL-18.

203 spectroscopy experiments validated the ACPS binding interface on holo-ACPP using chemical shift pert

204 h mass spectrometry to define a multiprotein binding interface on IRF-1 (Mf2 domain; amino acids 106-

205 tational analyses confirmed an extended VipD-binding interface on Rab5, explaining why this L. pneumo

206 We conclude that the main RetGC-binding interface on RD3 required for the negative regul

207 truction we describe a previously overlooked binding interface on the actin filament targeted by PfAD

208 The binding interface on the large ribosomal subunit is buri

209 aIIb peptide), and successfully detected the binding interface on the larger binding partner Ca(2+)-C

210 ons and fission identified potential protein-binding interfaces on the Mdv1 beta-propeller domain.

211 ational changes, including changes away from binding interface, on electrostatics are mimicked with a

212 Moreover, our data show that the C-terminal binding interface only plays a subsidiary role in trigge

213 are often caused by mutations affecting the binding interface or leading to biochemically dysfunctio

214 dependencies between nucleotides within the binding interface or multiple modes of binding.

215 charge interactions through residues at the binding interface or N-glycan composition of IL-7Ralpha,

216 omatically pinpoint on the three-dimensional binding interfaces pharmacophore-like features that act

217 This enhanced linker-mediated binding interface plays a significant role in the determ

218 ctions-were identified within host and viral binding interfaces predicted by our models.

219 tware produced by scoring those models using binding interfaces predicted by the interface predictor,

220 rediction using the provided protein-protein binding interface prediction as constraints, which is fo

221 ithm that utilizes imperfect protein-protein binding interface prediction for guiding protein docking

222 orithm, which uses imperfect protein-protein binding interface prediction to improve docking accuracy

223 f EF/LF to the protective antigen C-terminal binding interface, preventing toxin entry into the cell.

224 The binding interface profiling approach should find useful

225 We identify the phosphoubiquitin-binding interface, provide a model for the phosphoubiqui

226 ucture, including the position in C3d of the binding interface, remained controversial because of dis

227 nus of PilM, and binding PilN abrogates this binding interface, resulting in PilM monomerization.

228 he residues of ILY and hCD59 that form their binding interface revealed a remarkably deep corresponde

229 h mutational analysis, we validated the RPN2-binding interface revealed by our structures and quantif

230 e to recognize SPNR and Zfr through the same binding interface, revealing that NF45 is able to form a

231 Mutational analysis of amino acids in the binding interface showed that residues contributing to I

232 h is located at a site remote from the PBD46 binding interface, shows a significant dynamic response

233 ch that constitutes a putative high-affinity binding interface spanning both DBL domains.

234 akin mutations have been discovered to alter binding interfaces, structures, and stabilities of folde

235 n-25) is located within the trans homophilic-binding interface, suggesting a role for an Asn-25-assoc

236 Analysis of the AMPAR-STZ binding interfaces suggests that electrostatic interacti

237 al enzymes generally present two similar Coh-binding interfaces supporting a dual-binding mode, which

238 r to disrupt that protomer's TPR-U-box tight binding interface, swiftly exposing and activating one o

239 its a 7 degrees rotation about the substrate-binding interface, termed the quaternary shift.

240 led a 1:1 stoichiometry and a more extensive binding interface than anticipated from the paradigmatic

241 In a more stringent test, an engineered binding interface that achieves wild-type-like charge co

242 lso defined a new host protein-viral protein binding interface that can potentially be targeted for t

243 f the 60S-Listerin complex that identifies a binding interface that clashes with the 40S ribosomal su

244 nd identify a new host protein-virus protein binding interface that could become a useful target in f

245 rrounding the previously defined eVP24-KPNA5 binding interface that decrease eVP24-KPNA affinity or b

246 vergent amino acid residues within the E1-E2 binding interface that define organism-specific enzyme i

247 single amino acid mutations targeted at the binding interface that disrupted the MCPH1-pCdc27 intera

248 affinity variant of Jagged1 (Jag1) reveals a binding interface that extends 120 angstroms along five

249 -shift NMR of P[19] VP8* identified a ligand binding interface that has shifted away from the known R

250 ped to one of the loops (L3) in the membrane binding interface that help anchor the toxin monomers to

251 ssays to investigate this important IFN-beta binding interface that is centered on IFNAR1 residues Ty

252 (47')) in the RHH domain remote from the DNA binding interface that is required for high affinity bin

253 Finally, our model predicts a novel binding interface that is well-populated in the Ca(2+)-b

254 e enzyme-substrate pair of GEF-RhoA at their binding interface that leads to enhanced efficacy and sp

255 1UEA), we see substantial differences at the binding interface that provide insight into the differen

256 h for identifying features of ligand-protein binding interfaces that predict binding selectivity and

257 rally, dockerins present two similar cohesin-binding interfaces that support a dual binding mode.

258 The multiregion IC binding interface, the partial disorder of region 2 and

259 c transcription factors create a new protein-binding interface through dimerization/oligomerization.

260 the metal binding residue, His97, to the DNA binding interface through the alphaR helix that is prese

261 e electrostatic surface potential at the DNA binding interface to become less favorable toward DNA bi

262 ts reveal that PARP3 employs a conserved DNA-binding interface to detect and stably bind DNA breaks a

263 ch critically contribute to the LRPPRC-SLIRP binding interface to enhance its stability.

264 y, we systematically dissected the LMO2/LDB1-binding interface to investigate the role of this intera

265 results reveal how the FHA1 uses a canonical binding interface to recognize the Cdc7 phosphopeptide a

266 The receptor-CheW complex shares a similar binding interface to that found in the "trimer-of-dimers

267 ow that NTNHA provides large and multivalent binding interfaces to protect BoNT from gastrointestinal

268 show by Ala-scanning mutagenesis of the ZPI-binding interface, together with native PAGE and kinetic

269 d centrally in the proposed protein receptor binding interface (Tyr1189, Phe1202, Ala1204, Pro1205, a

270 The crystallographically observed binding interface was confirmed by a comprehensive cell-

271 The binding interface was further refined through molecular

272 The binding interface was identified by small angle x-ray sc

273 The binding interface was probed with point mutations, none

274 A novel membrane binding interface was revealed adjacent to the exposed H

275 and mutagenesis analyses of the heterodimer binding interface, we identified a peptide that mimics t

276 rientation of the PECAM-1-PECAM-1 homophilic-binding interface, we undertook studies aimed at determi

277 as fragment-centric topographical mapping of binding interfaces, we have clarified current controvers

278 In addition, two alternative binding interfaces were discovered, which are essential

279 changes demonstrate plasticity in the PA-PB1 binding interface which may be exploited in the developm

280 iopoietin P domain, adjacent to the receptor-binding interface, which confers the specific agonist/an

281 31L mutant exhibits a disordering of the RIF binding interface, which effectively reduces the RMP aff

282 oss the beta2-beta3 hairpin in the GPIbalpha binding interface, which restrains the conformational de

283 based on the charge distribution within the binding interface, which shows good correlation with Del

284 t cell surface dockerins contain two cohesin-binding interfaces, which can present different or ident

285 ependent interactions allow substitutions in binding interfaces while the specificity of binding is m

286 bNAbs cause only localized effects at their binding interface, while the binding of less potent anti

287 ture and augmenting our understanding of the binding interface with atomic-level detail.

288 ce quenching of a tryptophan on the membrane-binding interface with brominated lipids along with muta

289 g identified residues of FBD involved in the binding interface with cyt c, most of which are located

290 Its predicted binding interface with FKBP consists primarily of electr

291 L-7Ralpha do not participate directly in the binding interface with IL-7.

292 Metazoan eIF4Gs share this extended binding interface with m4E-BPs, with significant implica

293 Revealing the telomerase CR4/5-TRBD binding interface with single-residue resolution provide

294 affinity maturation techniques targeting its binding interface with SIRPalpha.

295 proteins with an enrichment of mutations at binding interfaces with a protein, nucleic acid, or smal

296 mutations in NRF2 localize to one of its two binding interfaces with KEAP1, an E3 ubiquitin ligase th

297 tly in the formation of the trans homophilic-binding interface, with a total buried interface area of

298 n egg white lysozyme revealed an extended VH binding interface, with complementarity-determining regi

299 and GII) demonstrated highly conserved HBGA binding interfaces within the two groups but not between

300 interacts with this domain through the large binding interface without inducing any dramatic conforma